scholarly journals INCIDENCE OF TBRV AND ArMV VIRUSES IN NEW CHERRY PLANTATIONS FROM AREA OF ROMANIA

2021 ◽  
Vol 37 (37) ◽  
pp. 136-140
Author(s):  
Catita Plopa ◽  
◽  
Adina Iancu ◽  
Madalina Butac ◽  
◽  
...  
Keyword(s):  
The Netherlands ◽  
Viral Infections ◽  
External Source ◽  
Viral Diseases ◽  
The South ◽  
Planting Material ◽  
Elisa Technique ◽  
Set Up ◽  
Infected Material ◽  
Das Elisa

Viral diseases can influence negatively a good evolution of cherry plantations. Two of the viral diseases that attack this species are caused by the ArMV virus, which spreads by multiplying the infected propagating material, by seed and nematodes, and by the TBRV virus, which spreads by multiplying the infected material and nematodes. In order to study the incidence of the two viruses, 10 cherry plantations located in the south of the country were evaluated, in the district of Argeș, Dolj, Ialomița, Ilfov, Călărași, Dâmbovița, Buzău. The planting material used to set up the plantations was both from Romania and from an external source: the Netherlands, Greece, Italy. Viral evaluation performed visually and serologically by DAS-ELISA technique, identified viral infections in 2 of the 10 plantations. In one plantation, TBRV was identified in 20% of the tested samples and in the second, ArMV viruses were identified in 20% of the samples and TBRV in 5% of the samples.

Antibody Therapy for the Control of Viral Diseases: An Update

2019 ◽  
Vol 20 (13) ◽  
pp. 1108-1121 ◽  
Author(s):  
Miriam Dibo ◽  
Eduardo C. Battocchio ◽  
Lucas M. dos Santos Souza ◽  
Matheus D. Veloso da Silva ◽  
Bruna K. Banin-Hirata ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Monoclonal Antibodies ◽  
Viral Antigen ◽  
Viral Infections ◽  
Antibody Therapy ◽  
Therapeutic Strategies ◽  
Viral Diseases ◽  
Specific Antibodies ◽  
The Status ◽  
Epidemiological Impact

The epidemiological impact of viral diseases, combined with the emergence and reemergence of some viruses, and the difficulties in identifying effective therapies, have encouraged several studies to develop new therapeutic strategies for viral infections. In this context, the use of immunotherapy for the treatment of viral diseases is increasing. One of the strategies of immunotherapy is the use of antibodies, particularly the monoclonal antibodies (mAbs) and multi-specific antibodies, which bind directly to the viral antigen and bring about activation of the immune system. With current advancements in science and technology, several such antibodies are being tested, and some are already approved and are undergoing clinical trials. The present work aims to review the status of mAb development for the treatment of viral diseases.

MODELING THE SOUTH ATLANTIC OCEAN FROM MEDIUM TO HIGH RESOLUTION

2014 ◽  
Vol 31 (2) ◽  
Author(s):  
Mariela Gabioux ◽  
Vladimir Santos da Costa ◽  
Joao Marcos Azevedo Correia de Souza ◽  
Bruna Faria de Oliveira ◽  
Afonso De Moraes Paiva
Keyword(s):  
High Resolution ◽  
Atlantic Ocean ◽  
Large Scale ◽  
South Atlantic ◽  
Surface Relaxation ◽  
The South ◽  
Small Surface ◽  
Basic Model ◽  
Basic Set ◽  
Set Up

Results of the basic model configuration of the REMO project, a Brazilian approach towards operational oceanography, are discussed. This configuration consists basically of a high-resolution eddy-resolving, 1/12 degree model for the Metarea V, nested in a medium-resolution eddy-permitting, 1/4 degree model of the Atlantic Ocean. These simulations performed with HYCOM model, aim for: a) creating a basic set-up for implementation of assimilation techniques leading to ocean prediction; b) the development of hydrodynamics bases for environmental studies; c) providing boundary conditions for regional domains with increased resolution. The 1/4 degree simulation was able to simulate realistic equatorial and south Atlantic large scale circulation, both the wind-driven and the thermohaline components. The high resolution simulation was able to generate mesoscale and represent well the variability pattern within the Metarea V domain. The BC mean transport values were well represented in the southwestern region (between Vitória-Trinidade sea mount and 29S), in contrast to higher latitudes (higher than 30S) where it was slightly underestimated. Important issues for the simulation of the South Atlantic with high resolution are discussed, like the ideal place for boundaries, improvements in the bathymetric representation and the control of bias SST, by the introducing of a small surface relaxation. In order to make a preliminary assessment of the model behavior when submitted to data assimilation, the Cooper & Haines (1996) method was used to extrapolate SSH anomalies fields to deeper layers every 7 days, with encouraging results.

scholarly journals Palynological indications for Silurian – earliest Devonian age strata in the Netherlands

2021 ◽  
Vol 100 ◽  
Author(s):  
Alexander J.P. Houben ◽  
Geert-Jan Vis
Keyword(s):  
The Netherlands ◽  
Core Material ◽  
Late Devonian ◽  
Time Interval ◽  
The South ◽  
Early Devonian ◽  
The North ◽  
Depositional Settings ◽  
Palynological Study ◽  
Devonian Age

Abstract Knowledge of the stratigraphic development of pre-Carboniferous strata in the subsurface of the Netherlands is very limited, leaving the lithostratigraphic nomenclature for this time interval informal. In two wells from the southwestern Netherlands, Silurian strata have repeatedly been reported, suggesting that these are the oldest ever recovered in the Netherlands. The hypothesised presence of Silurian-aged strata has not been tested by biostratigraphic analysis. A similar lack of biostratigraphic control applies to the overlying Devonian succession. We present the results of a palynological study of core material from wells KTG-01 and S05-01. Relatively low-diversity and poorly preserved miospore associations were recorded. These, nonetheless, provide new insights into the regional stratigraphic development of the pre-Carboniferous of the SW Netherlands. The lower two cores from well KTG-01 are of a late Silurian (Ludlow–Pridoli Epoch) to earliest Devonian (Lochkovian) age, confirming that these are the oldest sedimentary strata ever recovered in the Netherlands. The results from the upper cored section from the pre-Carboniferous succession in well KTG-01 and the cored sections from the pre-Carboniferous succession in well S05-01 are more ambiguous. This inferred Devonian succession is, in the current informal lithostratigraphy of the Netherlands, assigned to the Banjaard group and its subordinate Bollen Claystone formation, of presumed Frasnian (i.e. early Late Devonian) age. Age-indicative Middle to Late Devonian palynomorphs were, however, not recorded, and the overall character of the poorly preserved palynological associations in wells KTG-01 and S05-01 may also suggest an Early Devonian age. In terms of lithofacies, however, the cores in well S05-01 can be correlated to the upper Frasnian – lower Famennian Falisolle Formation in the Campine Basin in Belgium. Hence, it remains plausible that an unconformity separates Silurian to Lower Devonian strata from Upper Devonian (Frasnian–Famennian) strata in the SW Netherlands. In general, the abundance of miospore associations points to the presence of a vegetated hinterland and a relatively proximal yet relatively deep marine setting during late Silurian and Early Devonian times. This differs markedly from the open marine depositional settings reported from the Brabant Massif area to the south in present-day Belgium, suggesting a sediment source to the north. The episodic presence of reworked (marine) acritarchs of Ordovician age suggests the influx of sedimentary material from uplifted elements on the present-day Brabant Massif to the south, possibly in relation to the activation of a Brabant Arch system.

scholarly journals Role of Mitochondria in Viral Infections

Life ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 232
Author(s):  
Srikanth Elesela ◽  
Nicholas W. Lukacs
Keyword(s):  
Viral Infections ◽  
Mitochondrial Dynamics ◽  
The Body ◽  
Viral Diseases ◽  
Multiple Organs ◽  
Innate Immune Signaling ◽  
Mitochondrial Functions ◽  
Host Virus Interactions ◽  
Virus Interactions

Viral diseases account for an increasing proportion of deaths worldwide. Viruses maneuver host cell machinery in an attempt to subvert the intracellular environment favorable for their replication. The mitochondrial network is highly susceptible to physiological and environmental insults, including viral infections. Viruses affect mitochondrial functions and impact mitochondrial metabolism, and innate immune signaling. Resurgence of host-virus interactions in recent literature emphasizes the key role of mitochondria and host metabolism on viral life processes. Mitochondrial dysfunction leads to damage of mitochondria that generate toxic compounds, importantly mitochondrial DNA, inducing systemic toxicity, leading to damage of multiple organs in the body. Mitochondrial dynamics and mitophagy are essential for the maintenance of mitochondrial quality control and homeostasis. Therefore, metabolic antagonists may be essential to gain a better understanding of viral diseases and develop effective antiviral therapeutics. This review briefly discusses how viruses exploit mitochondrial dynamics for virus proliferation and induce associated diseases.

scholarly journals Antimalarial drugs—are they beneficial in rheumatic and viral diseases?—considerations in COVID-19 pandemic

2021 ◽  
Author(s):  
Bogna Grygiel-Górniak
Keyword(s):  
Connective Tissue ◽  
Viral Infections ◽  
Current Knowledge ◽  
Inflammatory Diseases ◽  
Antiviral Drugs ◽  
In Vivo Studies ◽  
Viral Diseases ◽  
Cardiac Complications

AbstractThe majority of the medical fraternity is continuously involved in finding new therapeutic schemes, including antimalarial medications (AMDs), which can be useful in combating the 2019-nCoV: coronavirus disease (COVID-19). For many decades, AMDs have been widely used in the treatment of malaria and various other anti-inflammatory diseases, particularly to treat autoimmune disorders of the connective tissue. The review comprises in vitro and in vivo studies, original studies, clinical trials, and consensus reports for the analysis, which were available in medical databases (e.g., PubMed). This manuscript summarizes the current knowledge about chloroquine (CQ)/hydroxychloroquine (HCQ) and shows the difference between their use, activity, recommendation, doses, and adverse effects on two groups of patients: those with rheumatic and viral diseases (including COVID-19). In the case of connective tissue disorders, AMDs are prescribed for a prolonged duration in small doses, and their effect is observed after few weeks, whereas in the case of viral infections, they are prescribed in larger doses for a short duration to achieve a quick saturation effect. In rheumatic diseases, AMDs are well tolerated, and their side effects are rare. However, in some viral diseases, the effect of AMDs is questionable or not so noticeable as suggested during the initial prognosis. They are mainly used as an additive therapy to antiviral drugs, but recent studies have shown that AMDs can diminish the efficacy of some antiviral drugs and may cause respiratory, kidney, liver, and cardiac complications.

Operational storm surge forecasting in the Netherlands: developments in the last decade

2005 ◽  
Vol 363 (1831) ◽  
pp. 1441-1453 ◽  
Author(s):  
Martin Verlaan ◽  
Annette Zijderveld ◽  
Hans de Vries ◽  
Jan Kroos
Keyword(s):  
Quality Assurance ◽  
The Netherlands ◽  
Kalman Filtering ◽  
Model Calibration ◽  
Storm Surges ◽  
Operational Environment ◽  
Hydrodynamic Models ◽  
Future Developments ◽  
Set Up ◽  
Storm Surge Forecasting

The accurate forecasting of storm surges is an important issue in the Netherlands. With the emergence of the first numerical hydrodynamic models for surge forecasting at the beginning of the 1980s, new demands and possibilities were raised. This article describes the main phases of the development and the present operational set-up of the Dutch continental shelf model, which is the main hydrodynamic model for storm surges in the Netherlands. It includes a brief discussion of applied data-assimilation techniques, such as Kalman filtering, the model calibration process and some thoughts on quality assurance in an operational environment. After further describing some select recent investigations, the paper concludes with some remarks on future developments in a European context.

Emerging viral diseases

2021 ◽  
Vol 1 (2) ◽  
pp. 020-027
Author(s):  
Angel San Miguel Hernández ◽  
María San Miguel Rodríguez ◽  
Angel San Miguel Rodriguez
Keyword(s):  
Geographic Distribution ◽  
Viral Infections ◽  
Viral Diseases ◽  
Social Changes ◽  
Emerging Viruses ◽  
Susceptible Population ◽  
Exponential Increase ◽  
Emerging Virus ◽  
Virus Model ◽  
Emerging Viral Diseases

Emerging viral diseases encompass two types, those of new appearance in the population and those that we previously knew about or re-emerging, but that at a certain moment present an exponential increase in incidence or geographic distribution in the form of epidemics or outbreaks. These emerging and re-emerging viruses share a series of characteristics that establish the emerging virus model, such as having an RNA genome, being zoonotic, transmitted by vectors and transmissible to humans, that the virus is able to recognize and provoke a response in receptors. Conserved in several species and inhabiting ecosystems that undergo ecological, demographic or social changes that favor the spread of the virus. There are different factors that contribute to facilitating the emergence of viral infections, although this is made up of three fundamental aspects such as the susceptible population, the virus itself and the environment where both can interact.

scholarly journals A southern North Sea Miocene dinoflagellate cyst zonation

2004 ◽  
Vol 83 (4) ◽  
pp. 267-285 ◽  
Author(s):  
D.K. Munsterman ◽  
H. Brinkhuis
Keyword(s):  
The Netherlands ◽  
North Sea ◽  
North Atlantic ◽  
The South ◽  
Dinoflagellate Cyst ◽  
South Eastern ◽  
Southern North Sea ◽  
Age Model

AbstractAn integrated stratigraphical analysis emphasizing organic-walled dinoflagellate cyst (dinocyst) distribution has been carried out on multiple boreholes penetrating the Miocene in the subsurface of the Netherlands (southern North Sea Basin). The bulk of the investigated successions is attributed to the Breda Formation, a regional lithostatigraphical unit most complete in the south-eastern part of the Netherlands. In concert with a first regional integrated bio (chrono) sequence-stratigraphical framework, fourteen informal dinocyst zones for the southern North Sea Miocene (SNSM), and three subzones are proposed for the Breda Formation. By also integrating (chrono)stratigraphic information from Mediterranean and North Atlantic dinocyst studies a first ever detailed age-model is here proposed for the Miocene in the subsurface of the Netherlands.

The Japanese Occupation of Hainan

1980 ◽  
Vol 14 (1) ◽  
pp. 93-109
Author(s):  
R. T. Phillips
Keyword(s):  
South China ◽  
Full Range ◽  
Japanese Economy ◽  
Chinese Government ◽  
The South ◽  
Sharp Rise ◽  
Japanese Occupation ◽  
Set Up ◽  
Special Sales ◽  
The Tropics

Japanese interest in Hainan stemmed from the desire to emulate the success which they had achieved in Taiwan in an area further south which could offer a full range of tropical products for theuse of the Japanese economy. The naval importance of Hainan was also recognized, because it could dominate the South China Sea from the excellent harbour of San-ya ( Samah) Bay, and there were indications that the island was rich in minerals. The development of official Japanese interest in the island was largely the work of the governor-general's office in Taiwan. Thus in 1918 and 1919 an official from Taiwan called Kaku () was sent to Hainan to observe conditions under the title of special sales office head. In the 1920's the Taiwan government sponsored conferences o the South China Japanese consuls to discuss plans for the area, and in 1935 a conference was held production in the tropics, to coordinate research on the economy, production possibilities and culture of the tropical part of China.Meanwhile Chinese government interest in Hainan began to be aroused in the 1930's, culminating in the visit of T.V. Soong, one of the highest ministers of e Kuintang government, in 1936. Thereafter a rail route a west of the island was surveyed but no furthe progress was made. Private businessmen in the 1930's began to develop rubber plantations to join those set up with overseas Chinese capital in the 1910's,and there was a sharp rise in the area planted to sugar in 1936 as the price of sugar rose. Hence when war broke out between China and Japa,the possibilities for the development were just beginning to be explored.1

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