scholarly journals Efektivitas Ekstrak Daun Kelor ( Moringa Oleifera) terhadap Penurunan Kadar Kolesterol Total pada Tikus Putih ( Rattus Novergicus)

2019 ◽  
Vol 1 (1) ◽  
pp. 97-110
Author(s):  
Sri Wahyu ◽  
Andi Sitti Fahirah Arsal ◽  
Indah Chintya Maharani

Introduction: The prevalence of hypercholesterolemia in Indonesia is estimated to increased continously. One of the traditional medicines used to reduce blood cholesterol levels is Moringa oleifera Lam, After using the extract of Moringa leaves, the cholesterol levels slowly reduced, it because by the active substance component on Moringa leaves such as flavanoid, tannin saponin and β-sitosterol. Objective : To determine the effect of Moringa leaf extract on reduce total cholesterol levels. Methods : The research is an analytical research, using pre-experimental design with one group pre-test method post-test approach. By comparing treatment groups and control groups where the treatment group was treated on the form of Moringa leaf extract. Results: The Paired T test showed that in the treatment group using Moringa leaf extract obtained before intervention the average cholesterol level was 307.40 mg/dl and after the interval was 209.00 mg/dl. Statistical test results obtained p value (0.00041) <0.05 which means that there is a difference of the mean cholesterol level between before and after treatment. Besides, the group using simvastatin was obtained before the intervention of the average cholesterol level was 271.20 mg/dl and after the interval was 127.40 mg/dl. Statistical test results obtained p value (0.009) <0.05 which means that there is a difference of the mean cholesterol level between before and after treatment. Conclusion: There wasn’t any significant differences between the Moringa leaves and simvastatin use to reduce the total blood cholesterol levels.

2020 ◽  
Vol 1 (2) ◽  
pp. 22-29
Author(s):  
Yulni Yulni ◽  
Veni Hadju ◽  
Burhanuddin Bahar ◽  
Citrakesumasari Citrakesumasari ◽  
Rahayu Indriasari ◽  
...  

The aim of this study was to determine the effect of Moringa oleifera leaf extract supplements, Moringa oleifera leaf extract plus royal jelly and placebo on hemoglobin levels in anemic pregnant women. This research is a randomized controlled double blind design study which was conducted in Polombangkeng Utara District, Takalar Regency for 2 months. The subjects of this study were pregnant women with anemia, the majority of which were 20-35 years old, primigravida parity, income less than UMR, unemployment, higher education, pregnancy distance of more than 2 years with p value> 0.05. Then divided into three groups, namely Moringa capsules plus royal jelly (KRJ) (n = 24), Moringa capsules (KTR) (n = 24) and placeco (PLC) (n = 21). Before and after the intervention, measurements of hemoglobin levels were carried out using the Hemocue tool and interviewing the characteristics of the respondents. The results showed that the average Hb level increased from each group (mean SD): KRJ 10.06 ± 0.75 to 11.42 ± 1.23, P = 0.001, KTR 10.40 ± 0.46 to 11.15 ± 0 , 90 P = 0.001 and PLC 10.43 ± 0.42 becomes 11.14 ± 0.88 P = 0.002. but there was no significant difference from the difference in the average increase in Hb levels in the three groups, but there was a tendency that KRJ was superior to the KTR and PLC groups with an increase of 1.36 gr / dl, KTR 0.75 gr / dl and PLC 0.71 gr / dl. So it can be concluded that KRJ is better than KTR and PLC in increasing Hb levels in anemic pregnant women in Takalar Regency.


2017 ◽  
Vol 4 (3) ◽  
pp. 197
Author(s):  
Dian Samitra ◽  
Zico Fakhrur Rozi

Tetracera indica Merr. locally known as Mampelas is commonly used in traditional remedies. It believed to have the potential to cure hypercholesterolemia. The potential use of this plant to lower blood cholesterol level was understudied; therefore this study aimed to determine the effect of the infusion of fresh leaves of Tetracera indica to the blood cholesterol levels of mice. This research was true experimental design, a post-test only design with nonequivalent (control) groups. This study used 25 male mice divided into five categories, i.e., P0 mice were administered with 0 g of infusion, P1 mice with 2 g infusion, P2 mice with 5 g infusion, P3 mice with 10 g infusion, and P4 mice without Tetracera indica infusion but 10 mg of simvastatin. The treatment in all categories were given continuously for seven days. The results showed the mean of the blood cholesterol levels were 169.4 ± 59.37 mg/dL in P0, 121.8 ± 7.62 mg/dL in P1, 136.2 ± 15.69 mg/dL in P2, 110.6 ± 37 , 01 mg/dL in P3 , and 179,0 ± 35,24 mg/dL in P4. Kruskal Wallis test was calculated to determine the difference of blood cholesterol level among all groups, and it reported p < 0.05. The results of this study showed that infusion of Tetracera indica leaf was significantly lowered the level of blood cholesterol in mice.


Biomedika ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 136-141
Author(s):  
Norma Farizah Fahmi ◽  
Sitti Zahratul Uyuni

Smoking causes an increase in cholesterol in the blood. It is well known that tobacco contains nicotine has a considerable influence on the increase of blood lipid levels. Normally, lipids play an important role in all aspects of biological life, but excessive cholesterol causes changes in lipid composition, induces ROS formation and lipid oxidation. This process can also cause damage to proteins and DNA, changing cellular function, which causes tissue damage. This research using  analytic survey, with analytic cross sectional design with 30 subjects. The mean cholesterol level between tobacco smokers is 210.0 mg / dl and electric smokers is 123.73 mg / dl. The average difference in cholesterol levels among smokers was tested using One way ANOVA, p value = 0.000 (p <0.05). The cholesterol level of the tobacco smoker group was significantly higher when compared to the electronic smoker group.


2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Li Ping Pontoh ◽  
Damajanty H. C. Pangemanan ◽  
Herlina I. S. Wungouw

Abstract: Risks of coronary heart diseases (CHD), degenerative diseases, and metabolic disorders have increased in the elderly. Exercise and physical activity are beneficial to improve their physical fitness which can prevent or delay the occurences of the diseases. This study aimed to determine the effect of aerobic exercise for the eldery on blood cholesterol levels. This was a field experimental study with one group pre-post test design. Subjects were elderly who lived in BPLU Senja Cerah Manado. Blood cholesterol examinations were carried out before and after excercise. Thirty elderly were treated with elderly aerobic exercise routinely 3 times weekly for 3 consecutive weeks. Data were analyzed by using paired sample t-tests. The results showed that the mean cholesterol levels of the elderly before the designated exercise was 236.23 mg/dL and after the excercise was 195.63 mg/dL. Conclusion: The elderly aerobic exercises reduced blood cholesterol levels of the elderly. Keywords: elderly, exercise, cholesterol, elderly aerobic exercise.     Abstrak: Pada lanjut usia (lansia) terdapat peningkatan risiko penyakit jantung koroner (PJK), berbagai penyakit degeneratif, serta gangguan metabolisme. Kebugaran jasmani lansia sangat dibutuhkan untuk mencegah atau menunda perlangsungan penyakit-penyakit tersebut. Olahraga dan aktifitas fisik merupakan salah satu solusi untuk meningkatkan kebugaran jasmani. Penelitian ini bertujuan untuk mengetahui pengaruh senam bugar lansia terhadap kadar kolesterol darah. Penelitian ini bersifat eksperimental lapangan dengan rancangan pre-post one group test. Subyek penelitian ialah lansia yang berdiam di BPLU Senja Cerah Manado. Pengambilan darah dilakukan sebelum dan sesudah diberikan perlakuan. Subyek penelitian sejumlah 30 orang lansia yang diberi perlakuan berupa senam bugar lansia secara rutin 3 kali seminggu selama 3 minggu. Analisis statistik menggunakan paired sample t-test untuk menentukan pengaruh senam bugar lansia terhadap kadar kolesterol sebelum dan sesudah perlakuan dengan α = 0,05. Hasil penelitian menunjukkan bahwa rerata kadar kolesterol sebelum senam bugar lansia 236,23 mg/dL sedangkan sesudah senam bugar lansia selama 3 minggu 195,63 mg/dL. Simpulan: Senam bugar lansia yang dilakukan secara teratur dapat  menurunkan kadar kolesterol darah pada lansia. Kata kunci: lansia, olahraga, kolesterol, senam bugar lansia.


2020 ◽  
Vol 2 (2) ◽  
pp. 81-87
Author(s):  
Yessi Andriani ◽  
Maidaliza Maidaliza ◽  
Rinona Iverta Alvaensi

The purpose of this study was to determine the effect of providing health education through telenursing on increasing knowledge and prevention of pathological vaginal discharge in adolescents at SMK Negeri 2 Bukittinggi in 2020. This study used a quasy experimental method with a group pre-post test design. The results showed an increase in the mean level of knowledge and prevention of leucorrhoea, where the mean level of knowledge before and after health education was 12.77 and 27.18, while the mean prevention of vaginal discharge before and after health education was 18.55 and 33.82. The statistical test results obtained a p-value of 0.000 for the level of knowledge and a p-value of 0.000 for the prevention of pathological leucorrhoea. In conclusion, there is an effect of providing health education through telenursing on increasing knowledge and preventing pathological vaginal discharge.   Keywords: Leucorrhoea, Health Education, Telenursing  


2020 ◽  
Vol 32 (3) ◽  
pp. 178
Author(s):  
Anisa Nurhanifah ◽  
Gilang Yubiliana ◽  
Aulia Iskandarsyah

Pendahuluan: Hipnosis adalah penembusan faktor kritis pikiran sadar dan diikuti dengan adanya penerimaan suatu sugesti/ide atau pemikiran sehingga menyebabkan perubahan perilaku, dan susunan mental emosional. Hipnosis sangat menguntungkan  jika diintegrasikan dengan praktik dokter gigi. Dokter gigi harus dipersiapkan dengan baik untuk memberikan dukungan yang efektif melalui hipnosis bagi pasien. Persiapan dokter gigi dapat dilakukan dengan mempersiapkan mahasiswa preklinik kedokteran gigi dalam tahapan menempuh  pendidikan dokter gigi. Tujuan penelitian untuk menganalisis efektivitas mata kuliah elektif dental hypnosis dalam meningkatkan kemampuan praktik dental hypnosis pada mahasiswa preklinik kedokteran gigi di Universitas Jenderal Achmad Yani Cimahi. Metode: Penelitian ini menggunakan metode pre-eksperimental design berjenis one-group pre-test and post-test design pada mahasiswa preklinik kedokteran gigi dengan metode total sampling sehingga didapatkan sampel sebanyak 18 orang mahasiswa Universitas Jenderal Achmad Yani Cimahi yang bersedia. Penelitian dilakukan dengan mengukur kemampuan mahasiswa melakukan praktik dental hypnosis sebelum dan sesudah mengikuti mata kuliah elektif dental hypnosis dengan menggunakan alat ukur kemampuan dental hypnosis. Data tersebut kemudian dianalisis menggunakan analisis statistik non parametrik yaitu uji Wilcoxon. Hasil: Nilai pre-test sebelum kuliah elektif dental hypnosis adalah 10, 11 (kategori kurang) sedangkan rerata nilai hasil post test adalah 31,61 (kategori baik) dengan nilai p sebesar 0,0001. Simpulan: Elektif dental hypnosis merupakan mata kuliah yang efektif dalam meningkatkan kemampuan praktik dental hypnosis pada mahasiswa preklinik kedokteran gigi.Kata kunci: Praktik dental hypnosis, perkuliahan, mahasiswa preklinik kedokteran gigi.                                           ABSTRACTIntroduction: Hypnosis is the penetration of critical factors of the conscious mind and followed by accepting a suggestion/idea or thought that causes changes in behaviour and mental-emotional structure. Hypnosis is very beneficial when integrated with the dental practice. The dentist must be well prepared to provide effective support for the patient through hypnosis. Preparation can be done by preparing preclinical dentistry students. The research objective was to analyse the effectiveness of dental hypnosis elective course in improving the ability of dental hypnosis practice in preclinical dentistry students at Jendral Achmad Yani University Cimahi. Methods: This study used a pre-experimental design with one group pre-test and post-test design in preclinical dentistry students with a total sampling method that obtained 18 students from the Jendral Achmad Yani Cimahi University. The study was conducted by measuring students’ ability to practice dental hypnosis before and after participating in the dental hypnosis elective course using a dental hypnosis ability measuring instrument. The data were then analysed using non-parametric statistical analysis, namely the Wilcoxon test. Results: The pre-test score before the elective course of dental hypnosis was 10, 11 (poor category) while the mean post-test score was 31.61 (good category) with a p-value of 0.0001. Conclusion: Dental hypnosis elective is an effective course in improving dental hypnosis practice ability in preclinical dentistry students.Keywords: Dental hypnosis practice, lectures, preclinical dentistry students.


2014 ◽  
Vol 10 (2) ◽  
Author(s):  
Egi Supriyadi ◽  
Roslizawaty Roslizawaty ◽  
Zuhrawati Zuhrawati

This study aimed to determine the effect of bandotan (Ageratum conyzoides L) leaf extract on total blood cholesterol level of broiler. This study used 15 broiler aged of 25 days. This study was an experimental study using completely randomized design (CRD) unidirectional pattern with 3 treatment groups and 5replications each. Group 0 (P0) was not given bandotan leaf extract, group 1 (P1) was given 3 ml bandotan leaf extract, and group 2 (P 2) was given 5 ml bandotan leaf extract. The administration of Bandotan leaf extract was carried out once a day for 5 consecutive days. On day 6 after treatment, the blood was collected then examined for total blood cholesterol level by precipitation method. Data was analyzed using analysis of variance. The result showed that the average of total cholesterol level on group P0, P1, and P2 was 134.20+10.50, 125.15+8.20, and 113.34+7.50 mg/dl, respectively. In conclusion, bandotan leaf extract decrease blood cholesterol levels of broiler.Key words: broiler, bandotan leaf extract, total cholesterol level


2018 ◽  
Vol 5 (3) ◽  
pp. 652
Author(s):  
Jeyasuriya A. ◽  
Badrinath A. K. ◽  
Saranya Nagalingam

Background: The aims of the study were to monitor the total cholesterol levels at different time intervals in ICU patients and to analogize the values with the outcome of disease, to study the prevalence of hypocholesterolemia among ICU patients and to assess the trend of hypocholesterolemia among various diseases.Methods: Present study populace consists of 55 patients admitted in ICU.  For these patients, lipid profile was done on the day of admission and day-3 of admission. The total cholesterol levels done on day 1 and 3 were compared with disease outcome.Results: The mean cholesterol value among 33 survivors on day 1 was 120.76(±18.54) and day 3 was 145.30 (±55.65) with p value of 0.019, that is statistically significant. As the total cholesterol value increases during the period of ICU stay, it proves to be an  early prognostic indicator of disease outcome. The patients showing increasing trend of total cholesterol levels has increased chances of survival. Similarly, HDL value among 33 survivors on day 1 was 31.70 (±3.98) and day 3 was 36.39 (±11.98), with p value of 0.033, that is statistically significant and also, the mean LDL value among 33 survivors on day 1 was 68.25 (±17.14) and day 3 was 78.78 (±24.74), with p value of 0.009, which was also found to be statistically significant. The mean cholesterol value among 22 non-survivors on day 1 was 131.64 (±15.24) and day 3 was 122.09 (±26.23), the mean HDL among 22 non-survivors on day 1 was 33.14 (±3.79) and day 3 was 31.32 (±4.23).Conclusions: Present study’s intend of monitoring the total cholesterol level was successfully demonstrated that it can be used as prognostic tool in ICU patients. The increasing trend in total cholesterol level indicates better prognosis of disease outcome. Similarly, the increasing trend in HDL and LDL levels also can be used as prognostic tool to determine the survival rate of patient.


2017 ◽  
Vol 4 (2) ◽  
pp. 111-122
Author(s):  
Dwi Agustina ◽  
Nikky Novannisa

The prevalence of obesity is tend to increase both in the world and in Indonesia, and a higher prevalence in women. Obesity is a risk factor of various degenerative diseases such as coronary heart disease and stroke, musculoskeletal disorders, especially osteoarthritis, diabetes mellitus and cancer. One exercise that is appropriate for treating obesity is Pilates exercise which is a muscle contraction exercises that are low impact. The aim of this study was to determine the effect of Pilates Exercise on obese level 1 women's body mass index. The type of research was experimental with pre-experimental research design. The experiment was conducted in late April-May 2016 in Bumi Dirgantara Permai. The number of sample was 15 obese level 1women. Pilates exercises was given for one hour three times a week for 5 weeks. Analysis of the data include univariate and bivariate with the Kolmogorov-Smirnov test for checking normality data and Paired t-test for testing IMT different before and after intervention. Results: The mean BMI before intervention was 25.74 kg / m2 and after the intervention of 26.44 kg / m2. The reduction in BMI of 0.7 kg / m2, with test results p value of 0.0001 indicated the difference in IMT before and after the intervention were significant. Conclusion:To maintain the IMT and improve posture, Pilates Exercise should be done regularly.


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