scholarly journals Adding web-based behavioural support to exercise referral schemes for inactive adults with chronic health conditions: the e-coachER RCT

2020 ◽  
Vol 24 (63) ◽  
pp. 1-106
Author(s):  
Adrian H Taylor ◽  
Rod S Taylor ◽  
Wendy M Ingram ◽  
Nana Anokye ◽  
Sarah Dean ◽  
...  

Background There is modest evidence that exercise referral schemes increase physical activity in inactive individuals with chronic health conditions. There is a need to identify additional ways to improve the effects of exercise referral schemes on long-term physical activity. Objectives To determine if adding the e-coachER intervention to exercise referral schemes is more clinically effective and cost-effective in increasing physical activity after 1 year than usual exercise referral schemes. Design A pragmatic, multicentre, two-arm randomised controlled trial, with a mixed-methods process evaluation and health economic analysis. Participants were allocated in a 1 : 1 ratio to either exercise referral schemes plus e-coachER (intervention) or exercise referral schemes alone (control). Setting Patients were referred to exercise referral schemes in Plymouth, Birmingham and Glasgow. Participants There were 450 participants aged 16–74 years, with a body mass index of 30–40 kg/m2, with hypertension, prediabetes, type 2 diabetes, lower limb osteoarthritis or a current/recent history of treatment for depression, who were also inactive, contactable via e-mail and internet users. Intervention e-coachER was designed to augment exercise referral schemes. Participants received a pedometer and fridge magnet with physical activity recording sheets, and a user guide to access the web-based support in the form of seven ‘steps to health’. e-coachER aimed to build the use of behavioural skills (e.g. self-monitoring) while strengthening favourable beliefs in the importance of physical activity, competence, autonomy in physical activity choices and relatedness. All participants were referred to a standard exercise referral scheme. Primary outcome measure Minutes of moderate and vigorous physical activity in ≥ 10-minute bouts measured by an accelerometer over 1 week at 12 months, worn ≥ 16 hours per day for ≥ 4 days including ≥ 1 weekend day. Secondary outcomes Other accelerometer-derived physical activity measures, self-reported physical activity, exercise referral scheme attendance and EuroQol-5 Dimensions, five-level version, and Hospital Anxiety and Depression Scale scores were collected at 4 and 12 months post randomisation. Results Participants had a mean body mass index of 32.6 (standard deviation) 4.4 kg/m2, were referred primarily for weight loss and were mostly confident self-rated information technology users. Primary outcome analysis involving those with usable data showed a weak indicative effect in favour of the intervention group (n = 108) compared with the control group (n = 124); 11.8 weekly minutes of moderate and vigorous physical activity (95% confidence interval –2.1 to 26.0 minutes; p = 0.10). Sixty-four per cent of intervention participants logged on at least once; they gave generally positive feedback on the web-based support. The intervention had no effect on other physical activity outcomes, exercise referral scheme attendance (78% in the control group vs. 75% in the intervention group) or EuroQol-5 Dimensions, five-level version, or Hospital Anxiety and Depression Scale scores, but did enhance a number of process outcomes (i.e. confidence, importance and competence) compared with the control group at 4 months, but not at 12 months. At 12 months, the intervention group incurred an additional mean cost of £439 (95% confidence interval –£182 to £1060) compared with the control group, but generated more quality-adjusted life-years (mean 0.026, 95% confidence interval 0.013 to 0.040), with an incremental cost-effectiveness ratio of an additional £16,885 per quality-adjusted life-year. Limitations A significant proportion (46%) of participants were not included in the primary analysis because of study withdrawal and insufficient device wear-time, so the results must be interpreted with caution. The regression model fit for the primary outcome was poor because of the considerable proportion of participants [142/243 (58%)] who recorded no instances of ≥ 10-minute bouts of moderate and vigorous physical activity at 12 months post randomisation. Future work The design and rigorous evaluation of cost-effective and scalable ways to increase exercise referral scheme uptake and maintenance of moderate and vigorous physical activity are needed among patients with chronic conditions. Conclusions Adding e-coachER to usual exercise referral schemes had only a weak indicative effect on long-term rigorously defined, objectively assessed moderate and vigorous physical activity. The provision of the e-coachER support package led to an additional cost and has a 63% probability of being cost-effective based on the UK threshold of £30,000 per quality-adjusted life-year. The intervention did improve some process outcomes as specified in our logic model. Trial registration Current Controlled Trials ISRCTN15644451. Funding This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 24, No. 63. See the NIHR Journals Library website for further project information.

2019 ◽  
Vol 7 (15) ◽  
pp. 1-114 ◽  
Author(s):  
Ruth F Hunter ◽  
Aisling Gough ◽  
Jennifer M Murray ◽  
Jianjun Tang ◽  
Sarah F Brennan ◽  
...  

Background Increasing physical activity in the workplace can provide physical and mental health benefits for employees and economic benefits for the employer through reduced absenteeism and increased productivity. However, there is limited evidence on effective behaviour change interventions in workplace settings that led to maintained physical activity. This study aimed to address this gap and contribute to the evidence base for effective and cost-effective workplace interventions. Objectives To determine the effectiveness and cost-effectiveness of the Physical Activity Loyalty scheme, a multicomponent intervention based on concepts similar to those that underpin a high-street loyalty card, which was aimed at encouraging habitual physical activity behaviour and maintaining increases in mean number of steps per day. Design A cluster randomised controlled trial with an embedded economic evaluation, behavioural economic experiments, mediation analyses and process evaluation. Setting Office-based employees from public sector organisations in Belfast and Lisburn city centres in Northern Ireland. Participants A total of 853 participants [mean age 43.6 years (standard deviation 9.6 years); 71% of participants were female] were randomly allocated by cluster to either the intervention group or the (waiting list) control group. Intervention The 6-month intervention consisted of financial incentives (retail vouchers), feedback and other evidence-based behaviour change techniques. Sensors situated in the vicinity of the workplaces allowed participants to monitor their accumulated minutes of physical activity. Main outcome measures The primary outcome was mean number of steps per day recorded using a sealed pedometer (Yamax Digiwalker CW-701; Yamax, Tasley, UK) worn on the waist for 7 consecutive days and at 6 and 12 months post intervention. Secondary outcomes included health, mental well-being, quality of life, work absenteeism and presenteeism, and the use of health-care resources. Results The mean number of steps per day were significantly lower for the intervention group than the control group [6990 mean number of steps per day (standard deviation 3078) vs. 7576 mean number of steps per day (standard deviation 3345), respectively], with an adjusted mean difference of –336 steps (95% confidence interval –612 to –60 steps; p = 0.02) at 6 months post baseline, but not significantly lower at 12 months post baseline. There was a small but significant enhancement of mental well-being in the intervention group (difference between groups for the Warwick–Edinburgh Mental Wellbeing Scale of 1.34 points, 95% confidence interval 0.48 to 2.20 points), but not for the other secondary outcomes. An economic evaluation suggested that, overall, the scheme was not cost-effective compared with no intervention. The intervention was £25.85 (95% confidence interval –£29.89 to £81.60) more costly per participant than no intervention and had no effect on quality-adjusted life-years (incremental quality-adjusted life-years –0.0000891, 95% confidence interval –0.008 to 0.008). Limitations Significant restructuring of participating organisations during the study resulted in lower than anticipated recruitment and retention rates. Technical issues affected intervention fidelity. Conclusions Overall, assignment to the intervention group resulted in a small but significant decline in the mean pedometer-measured steps per day at 6 months relative to baseline, compared with the waiting list control group. The Physical Activity Loyalty scheme was deemed not to be cost-effective compared with no intervention, primarily because no additional quality-adjusted life-years were gained through the intervention. Research to better understand the mechanisms of physical activity behaviour change maintenance will help the design of future interventions. Trial registration Current Controlled Trials ISRCTN17975376. Funding This project was funded by the National Institute for Health Research (NIHR) Public Health Research programme and will be published in full in Public Health Research; Vol. 7, No. 15. See the NIHR Journals Library website for further project information.


2021 ◽  
Author(s):  
David Tobias Ochmann ◽  
Keito F A Philippi ◽  
Peter Zeier ◽  
Magdalena Sandner ◽  
Barlo Hillen ◽  
...  

BACKGROUND Physical activity ameliorates chronic stress. Latest research suggests a relation between resilience and physical fitness. Beneficial adaptations of the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system, the endocannabinoid system, and the tryptophan pathway, induced by an active lifestyle, are considered to be resilience conducive. However, detailed knowledge on the molecular link between the effects of acute and chronic physical exercise and an improved resilience is missing. OBJECTIVE Therefore, we implement a human exercise intervention trial addressing the main hypotheses: (1) web-based exercise training improves aerobic capacity of physically inactive adults, which (2) is accompanied by improved resilience. In this setting, we will analyze the relation of resilience parameters with innate and acquired aerobic capacity as well as circulating signaling molecules. METHODS 70 healthy physically inactive (<150min/week physical activity) adults (18-45y) will be randomly assigned to an intervention or control group. Participants in the intervention group receive weekly training utilizing progressive endurance and interval running individually adapted to their training performance via web-based physician support. A standardized incremental treadmill exercise test is performed before and after the intervention period of eight weeks to determine innate and acquired aerobic capacity. Before and after the intervention psychological tests and questionnaires that characterize parameters implicated in resilience (including impulse control, working memory, stress coping, emotion regulation) will be applied. Blood, and saliva will be sampled for analysis of lactate, cortisol, endocannabinoids, catecholamines, kynurenic acid, cell-free DNA and further circulating signal transducers. Statistical analysis will provide comprehensive knowledge on the relation of aerobic capacity and resilience, and furthermore, the capacity of peripheral factors to mediate the promoting effects of exercise on resilience. RESULTS The study was registered in October 2019. Enrollment began in September 2019. Out of 161 subjects, who were initially screened via telefon survey, 43 fulfilled the inclusion criteria and were included. Among the 17 participants in the intervention group, and 14 participants in the control group, who completed the study (total 31), no serious adverse event has been reported. Four participants withdrew during the programm (individual reasons), and 8 participants have not yet completed or begun the program due to the Covid-19 pandemic. Enrollment and data analysis are ongoing, and results are expected to be submitted for publication in October 2021. CONCLUSIONS Our study aims to demonstrate that an increase in physical activity with a simultaneous improvement in aerobic capacity is associated with an increase in resilience. This study design allows to investigate the effect of an active lifestyle on circulating molecular marker levels and their relationship to resilience factors. This will offer novel approaches for the diagnosis of depression and the therapy by exercise prescription. CLINICALTRIAL DRKS00018078, registered October 02, 2019, German Clinical Trials Register. Retrospectively registered: First participant September 10, 2019.


Author(s):  
Dandan Mo ◽  
Mi Xiang ◽  
Mengyun Luo ◽  
Yuanyuan Dong ◽  
Yue Fang ◽  
...  

Gamification and social incentives are promising strategies to increase the effectiveness of web-based physical activity (PA) interventions by improving engagement. In this study, we designed a PA intervention integrating gamification and social incentives based on the most popular social networking service in China, WeChat. A controlled trial involving 52 Chinese undergraduate students was implemented to evaluate the effectiveness of the intervention. Subjects in the intervention group received a 7-week intervention. PA behavior and related social cognitive variables according to the theory of planned behavior were measured at the baseline and after the intervention. Daily physical activity duration was measured during the intervention. The results showed that PA-related subjective norms, perceived behavior control, and intention, as well as self-reported vigorous physical activity and moderate physical activity in the intervention group, were increased after the intervention, compared with the control group (p <0.05). During the intervention, perceived daily physical activity duration in the intervention group was on the rise, while it declined in the control group (p <0.001). The findings indicate that WeChat-based intervention integrating gamification and social incentives could effectively increase subjectively measured PA and related social cognition among Chinese undergraduate students and that it is a promising way to ameliorate the problem of insufficient PA among youths.


2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A Fijalkowska ◽  
J Mazur ◽  
A Dzielska ◽  
H Nalecz ◽  
W Ostrega ◽  
...  

Abstract Introduction Healthy Me (HM) interventional study was oriented on improvement of physical activity (PA) in 15-year old girls but also included component of eating habits, smoking prevention and personal competencies. Innovative elements of the project involved usage of fitness-band with continuous monitoring of PA and special dedicated smartphone apps. Purpose To assess the effectiveness of 1-year prophylactic intervention with the use of mobile technology in girls between 14 and 15 year of age, in relation to the level of their satisfaction with the program. Methods 1198 girls 14–15 years old from 48 randomly selected schools from all over Poland participated in the HM during 2017/2018 school year. Schools were randomized to full or partial intervention and control group, respectively 636, 277 and 285 girls. Questionnaire data from the beginning and the end of the HM regarding four factors (low PA, eating sweets, smoking and stress level) were analyzed. Mean changes (MC) calculated according to the definition given in table 1 were applied as outcome measure. Satisfaction with the program was assessed after 1 year of participation in the HM as low, average and high. General linear models with main effects were estimated and adjusted for initial level of each factor. Results At the beginning of the study 87% participants did not fulfill criteria for recommended PA, 9% smoked during last 30 days and 67% ate sweets more than ones per week. Mean stress level was 6.92±2.92 points. For the entire study group, the only significant change after 1 year intervention was lower frequency of eating sweets (p=0,007). However, the higher satisfaction with the study resulted in the significantly higher effectiveness of HM intervention (table 1). Mean changes in the analyzed factors Analyzed factor Range Mean change in entire group (SE) Mean change by level of satisfaction p1 p2 low (SE) average (SE) high (SE) Physical activity (MVPA) 0–7 days −0.076 (0.063) −0.396 (0.137) −0.147 (0.068) 0.261 (0.119) 0.001 0.068 Smoking-past 0 – never 0.039 (0.028) 0.270 (0.066) 0.034 (0.033) −0.004 (0.057) 0.002 0.067 6–30 days or more Eating sweets 0 – never −0.296 (0.045) −0.047 (0.101) −0.285 (0.050) −0.313 (0.086) 0.069 0.016 6 – every day more than once Stress Cohen scale 0–16 points 0.105 (0.090) 0.498 (0.211) 0.138 (0.105) −0.424 (0.183) 0.003 0.823 SE: standard error; MVPA: moderate to vigorous physical activity; p1: main effect of the level of satisfaction; p2: main effect of the intervention group. Conclusion Program that was dedicated for improvement of PA in teenage girls could also profitably influence other factors related to health behaviours and stress level in this group but intervention must be perceived by participants as rewarding. It seems, that attractiveness of interventional program design, increased by mobile technologies, is key for its effectiveness for teens. Acknowledgement/Funding National Health Program, Ministry of Health


Author(s):  
Joonyoung Lee ◽  
Tao Zhang ◽  
Tsz Lun (Alan) Chu ◽  
Xiangli Gu ◽  
Ping Zhu

Globally, more than half of school-aged children do not engage in the recommended 60 minutes of daily moderate to vigorous physical activity (MVPA). Given that developing sufficient fundamental motor skills (FMS) competence during early elementary school years is important for a child’s physical and cognitive development, the purpose of this study was to examine the effects of an 8-week FMS-based afterschool program on physical and cognitive health outcomes among elementary children. Participants were 31 K–2 students (19 girls, 12 boys; Mage = 6.65 ± 0.98) from three public elementary schools in the southwestern United States who were assigned to the intervention group (FMS-based afterschool program; n = 20) or the control group (traditional afterschool program; n = 11). A 2 × 2 repeated measures MANOVA showed significant changes in FMS competence and MVPA between the intervention and the control group over time. However, no significant changes were found in cognitive functioning. The 8-week FMS-based afterschool program showed significant improvements in FMS competence and MVPA, compared to a traditional afterschool program. This finding suggests that structured FMS-focused strategies (e.g., fun games and goal setting) can be a critical component when implementing a physical activity program to enhance children’s motor skills and physical activity behavior.


2018 ◽  
Author(s):  
Sara B Golas ◽  
Ramya Palacholla ◽  
Amanda Centi ◽  
Odeta Dyrmishi ◽  
Stephen Agboola ◽  
...  

BACKGROUND Physical inactivity is one of the leading risk factors contributing to rising rates of chronic diseases and has been associated with deleterious health outcomes in patients with chronic disease conditions. FeatForward is a mobile phone app designed to encourage patients with cardiometabolic risk (CMR) factors to increase their levels of physical activity. OBJECTIVE To evaluate the effect of the FeatForward mobile phone app on physical activity levels (primary outcome) and global CMR factors (secondary outcomes) in patients with chronic conditions. METHODS In this 6-month, 2-arm randomized controlled trial, adult participants endorsing at least 1 study-eligible condition (obesity, [pre-]diabetes, [pre-]hypertension) were enrolled and assigned to either the intervention group (FeatForward app and standard care) or control group (standard care only). The primary and secondary outcomes were, respectively, change from baseline in physical activity (step count) and CMR factors (weight, body mass index [BMI], waist circumference, glycated hemoglobin [HbA1c], fasting blood glucose, systolic/diastolic blood pressures, serum lipids, C-reactive protein [CRP]). CMR data were collected at 3 time-points: baseline, 3 months, and 6 months. Step count data were recorded continuously by patients’ study-issued activity trackers and collected in batches at 3 and 6 months. At study end, patients’ weekly average step counts (WAS) were calculated as total steps taken divided by days of step data (0-7) for each of 26 study weeks. Mixed-effects linear regression models evaluated change over time between groups for the primary outcome and secondary outcomes. All models controlled for baseline values. The step count model additionally controlled for proportion of days without data, defined as (7 – days of data) / 7. Analyses were conducted for both groups overall, and by disease cohort (obesity, diabetes, hypertension). RESULTS Step count and CMR data were analyzed for 128 intervention and 133 control patients. There were no demographic differences between groups. While there was an overall downward trend in WAS for both groups, the intervention group decreased significantly less than the control group, with a slope of -29.3 steps per week compared to controls’ -57.9 (P=.02). Intervention patients with obesity slightly increased their step count overtime, differing significantly from controls (slope of 0.9 vs -90.2; P<.001). Intervention patients significantly lowered their BMI per study month compared to controls (slopes -0.23 vs -0.02; P=.04). Additionally, intervention patients with hypertension significantly decreased weight (P=.003), BMI (P=.002), and CRP (P=.03) per month compared to the control group. Waist circumference, HbA1c, fasting blood glucose, blood pressure, and lipids did not differ significantly by group or disease cohort over time. CONCLUSIONS While it is common for patient engagement with physical activity trackers to decrease over the course of a study, patients using the FeatFoward app had a slower decline in physical activity compared to controls. Intervention patients experienced a reduction in their BMI from a mean of 34.3 to 33.4, compared to controls’ 34.8 to 35.0. Patients with hypertension experienced significant decreases in BMI, weight, and CRP compared to controls. Future analyses will evaluate the impact of app engagement levels on step counts and CMR factors for the intervention group.


2020 ◽  
Author(s):  
Claire F Trottier ◽  
Jessica RL Lieffers ◽  
Steven T Johnson ◽  
João F Mota ◽  
Roshni K Gill ◽  
...  

BACKGROUND First-year university students are at increased risk for presenting with anxiety, depression, suicidal thoughts and poor nutritional status. Self-care plays an essential role in optimizing mental health and can prevent/treat stress, anxiety and depression. Web-based self-monitoring of diet and physical activity can lead to similar or improved health outcomes compared to conventional methods. Such tools are also popular among university students. OBJECTIVE The primary objective of this 12-week randomized control trial was to assess the impact of a web-based wellness platform on perceived stress among first-year university students. The study’s secondary outcome was to assess the effects of the platform on diet quality and exploratory outcomes were body composition, health related quality of life, mindfulness, mental wellbeing and physical activity. METHODS Ninety-seven first-year undergraduate students were randomized to either the intervention (n=48) or control (n=49) group. The intervention consisted of access to a web-based platform called My Viva Plan® (MVP) which aims to support healthy living on the topics of mindfulness, nutrition, and fitness. The platform is fully automated and is guided by principals of cognitive behavior theory. Participants in the intervention group were instructed to use MVP as frequently as possible over 12 weeks. The control group did not receive access to MVP. Perceived stress was assessed using the Stress Indicators Questionnaire at baseline, week 6 and week 12. Three day food records were used to analyze dietary intake at baseline and week 12. Health related quality of life, mindfulness, mental wellbeing and physical activity questionnaires were completed at baseline, week 6 and week 12 and body composition was assessed at baseline and week 12. Study assessments were completed in-person at baseline and week 12 and electronically at week 6. RESULTS Study recruitment started in August 2018 with batch enrollment for students registered in the fall (September 2018 to December 2018) and winter (January 2019 to April 2019) academic terms at the University of Alberta, Edmonton, Alberta. Eighty participants completed the 12-week trial (n=35 in the intervention group; n=45 in the control group). All data collection ended in May 2019. CONCLUSIONS This project is the first to explore the impact of an online platform designed to promote health and wellness; it will also shed light into its applicability in first-year university students. If successful, this may become an important health care tool for preventative care in first year university students. CLINICALTRIAL ClinicalTrials.gov NCT03579264


Retos ◽  
2020 ◽  
pp. 403-401
Author(s):  
Fernando Rodríguez-Rodríguez ◽  
Sebastián Molina Roblero ◽  
Gerson Luis De Moraes Ferrari

  El propósito del estudio fue identificar los efectos de una intervención durante recreos escolares sobre la condición física y actividad física en una muestra de adolescentes chilenos. Participaron 50 escolares voluntarios (27 chicas), con un promedio de 14,2 ± 1,3 años. Grupo control (n=21) y grupo intervención (n=29). Se realizaron actividades dirigidas en el patio del colegio durante los dos recreos de las mañanas por 12 semanas. Se evaluó el test de 20m ida-vuelta, dinamometría manual, composición corporal, cuestionario PAQ-A y acelerometría. El grupo intervención (GI), tuvo mejor nivel de actividad física que el grupo control (GC), durante los recreos, clase de Educación Física, hora de almuerzo y más pasos/día (p<0,05). En conclusión, la participación activa durante los recreos puede aumentar los minutos de actividad física moderada-vigorosa y mejorar la condición física cardiorrespiratoria. Abstract. The purpose of this project was to identify the effects of an intervention during school recesses on physical condition and physical activity in Chilean adolescents. Fifty volunteer students (27 girls) participated, with an average of 14.2 ± 1.3 years. Control group (n=21) and intervention group (n=29). Targeted activities were carried out in the schoolyard during the two recesses in the morning, for 12 weeks. Pre and post test, the 20m shuttle run test, manual dynamometry, body composition, PAQ-A questionnaire and accelerometry were evaluated. The intervention group (GI), had better levels of physical activity than the control group (GC), during recess, physical education class, lunch time and steps/day (p <0.05). In conclusion, the active participation during recesses can increase minutes of moderate-vigorous physical activity and improve cardiorespiratory fitness.


Author(s):  
Cristina Corella ◽  
Javier Zaragoza ◽  
José Antonio Julián ◽  
Víctor Hugo Rodríguez-Ontiveros ◽  
Carlos Tomás Medrano ◽  
...  

This study aimed to investigate the effects of a physical activity intervention, based on self-determination theory and the transtheoretical model, on university students in the contemplation stage. Participants: 42 students, in the contemplation stage at baseline, were randomly assigned to an experimental group (16 women, 2 men; M age = 19.1 ± 1.15) and a control group (18 women, 2 men; M age = 20.1 ± 5.7). Methods: Physical activity was measured at different moments by accelerometry. Other cognitive variables were measured by self-reported scales. Results: We did not find any significant increases in students’ physical activity in favor of the intervention group. Intragroup analyses indicate that the intervention has an effect on physical activity (moderate-to-vigorous physical activity), basic psychological needs, and intrinsic and extrinsic motivation. Conclusions: Results partially demonstrate that applying social cognitive theories seems to be effective in improving physical activity and cognitive variables in university students in the contemplation stage


2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
X H Huo ◽  
H M K Krumholz ◽  
X B Bai ◽  
E S S Spatz ◽  
Q D Ding ◽  
...  

Abstract Background Mobile health interventions hold the prospect to support risk factor and lifestyle modification and are readily scalable in healthcare systems. Purpose We aim to assess whether text messaging program can improve glycemic control in high-risk patients with coronary heart disease (CHD) and diabetes mellitus (DM). Methods The study was a multi-centre randomised clinical trial conducted at 34 clinics in China. 502 individuals with both CHD and DM were recruited and randomly assigned to either the text messaging intervention (n=251) or control group (n=251). The control group received 2 thank-you messages per month in addition to usual care. The intervention group received 6 messages per week for 6 months. Messages provided educational and motivational information related to glucose monitoring, BP control, physical activity and lifestyle recommendations. The primary outcome was change in glycemic hemoglobin (HbA1C) from baseline to 6 months. Results Follow-up rate was 99%. At 6 months, HbA1C was significantly lower in intervention group compared to control group (mean HbA1C 6.7% vs. 7.2%, P<0.001), with a mean change of −0.2% and 0.1% from baseline, respectively (mean absolute change −0.3% [95% CI −0.5 to 0.1]; P=0.003). Significantly more participants in intervention group achieved a HbA1c<7% (69.3% vs. 52.6%; P=0.004), and change in FBG was larger in intervention group (−0.5 vs. 0.1 mmol/L; P=0.011). No differences in SBP, LDL-C, BMI and physical activity were observed. Almost all patients reported messages to be easy to understand (97.1%) and useful (94.1%). Table 1. Primary and Secondary Outcomes Analyses at 6 Month Follow-up Parameter Intervention (N=251) Control (N=251) Mean Difference in Change P value for Baseline 6 Months Mean Change Baseline 6 Months Mean Change (95% CI) Difference in Change Primary Outcome HbA1C level, %, mean (SD) 6.9 (1.4) 6.7 (1.3) −0.2 (1.0) 7.1 (1.4) 7.2 (1.5) 0.1 (1.1) −0.3 (−0.5, −0.1) 0.003 Secondary Outcomes HbA1C level<7%, No. (%) 155 (62.0%) 174 (69.3%) – 139 (56.1%) 132 (52.6%) – 1.2 (1.1, 1.3)a 0.004   FBG, mmol/L, mean (SD) 8.1 (2.7) 7.5 (2.7) −0.5 (2.5) 8.5 (3.0) 8.6 (3.3) 0.1 (3.1) −0.6 (−1.1, −0.2) 0.011   SBP, mmHg, mean (SD) 135.9 (18.4) 134.7 (18.7) −1.4 (17.1) 135.9 (18.1) 132.2 (17.7) −3.5 (17.8) 2.4 (−0.8,5.5) 0.144   LDL-C, mmol/L, mean (SD) 2.6 (0.8) 2.5 (0.7) −0.1 (0.7) 2.6 (0.8) 2.5 (0.8) −0.1 (0.7) 0 (−0.1, 0.1) 0.828   BMI, mean (SD) 26.4 (3.2) 26.3 (3.5) −0.1 (2.1) 26.3 (3.2) 26.0 (3.4) −0.4 (2.5) 0.3 (−0.1, 0.7) 0.213   Physical activity (MET min/wk), 1386 1386 177 1386 1386 322 −70.7 0.784     median (IQR) (693–3066) (918–3612) (2840) (693–3066) (693–3002) (2635) (−574.9, 433.5) Conclusion Use of a simple, culturally sensitive mobile text-messaging program could be an effective and scalable way to improve disease self-management among patients with CHD and DM. Acknowledgement/Funding Research Special Fund for Public Welfare Industry of Health (201502009) from the National Health and Family Planning Commission of China


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