scholarly journals Inhibition and Removal of Calculus Deposits in a 3-Month Randomized Clinical Trial

2021 ◽  
Vol 5 (3) ◽  
Keyword(s):  
Test Group ◽  
Study Groups ◽  
Parametric Model ◽  
Control Group ◽  
Test Results ◽  
Percent Change ◽  
Friedman's Test ◽  
Baseline Levels ◽  
Single Blind ◽  
Over Time

Aim: To evaluate the safety and efficacy of ToothWave™ a novel RF-utilizing toothbrush for inhibition and removal of calculus deposits. Methods: This was a single-blind, double arm prospective study. Subjects were randomized to one of two study groups, receiving either ToothWave™ or a control sonic vibrating toothbrush (Philips Sonicare 4100 Protective Clean), and performed twice-daily brushing during a test period of 12 weeks. Calculus was assessed at Baseline and again after 3, 6 and 12 weeks using the Volpe-Manhold Index (V-MI). Results were compared within each group between the different visits and between the groups; percent change from baseline was also compared between the groups. The differences between groups were compared using Mann Whitney non-parametric model. Differences within each group over time were compared using Friedman’s test followed by Dunn’s test. Results: A total of 87 subjects (42 in the test group and 45 in the control) completed the study, having fully evaluable data. At Baseline, the groups did not differ significantly in the efficacy measurement mean scores. While the control group exhibited a statistically significant increase in calculus levels (p≤0.001) the test group maintained the original baseline levels and exhibited a slight negative percent change in the VMI score as compared to baseline (not significant). Both toothbrushes were well-tolerated and no device related adverse events were reported during the study. Conclusions: The ToothWave™ RF-utilizing toothbrush demonstrated statistically significant calculus reductions when compared to a powered control toothbrush while maintaining the initial calculus levels and preventing the additional calculus accumulations.

scholarly journals Topical Mastic Oil for Treatment of Functional Dyspepsia: A Randomized Triple-Blind Controlled Trial

2021 ◽  
Vol 10 ◽  
pp. 1965
Author(s):  
Mahsa Baradaran Sattarzadeh ◽  
Asie Shojaii ◽  
Mohssen Nassiri Toosi ◽  
Mehri Abdollahi-Fard ◽  
Foroogh Alborzi Avanaki ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Epigastric Pain ◽  
Controlled Trial ◽  
Study Groups ◽  
Control Group ◽  
Test Results ◽  
Postprandial Fullness ◽  
Friedman's Test ◽  
Early Satiation ◽  
Better Than

Background: The main goal of the present study was to evaluate the effect of topical mastic oil, compared to placebo on treatment of functional dyspepsia (FD). Materials and Methods: Sixty-three patients with FD were included. Thirty-two subjects received the topical mastic oil (10 drops/TDS after meal) with massage and 31 patients received topical sesame oil with massage. Both groups received pantoprazole (40 mg daily) along with oil and massage. The severity of early satiation, postprandial fullness, epigastric pain and epigastric burning was assessed after 4 weeks using the Visual Analogue Scale (VAS) as well as frequency of symptoms. Satisfaction with the treatment was also assessed using a researcher-made questionnaire. Changes in the severity of symptoms were evaluated by Friedman’s test. Results: Mean and standard deviation of age of the subjects were equal to 36.95±13.64 and 50 (79.4%) patients were female. Both groups experienced a significant decrease in the severity of all the four symptoms (P<0.001). The percentage of decrease in the severity of early satiation was significantly higher in the mastic group than the control group (76.03±34.91% vs. 37.24±38.86%, P=0.003). No significant differences were found in the percentage of decrease in the severity of postprandial fullness, epigastric pain and burning between the study groups (P=0.05, 0.06, and 0.13, respectively). The frequency of symptoms was decreased similarly in both groups. Satisfaction with the treatment was reported to be significantly higher in the mastic group than the sesame group (P=0.01). There were no intolerable side effects in both groups. Conclusion: Mastic oil reduced early satiation better than the placebo. In addition, satisfaction with the treatment was higher in the mastic group than the sesame group. [GMJ.2021;10:e1965]

scholarly journals Intravesical prostaglandin e2 effectiveness in the prevention of urinary retention after transvaginal reconstruction of the pubo-cervical fascia and short arm sling according to Lahodny: a prospective randomized clinical trial

2010 ◽  
Vol 14 (1) ◽  
pp. 15 ◽  
Author(s):  
G. QUADRI ◽  
N. NATALE ◽  
C. SPREAFICO ◽  
C. BELLONI ◽  
D. BARISANI ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Urinary Retention ◽  
Study Groups ◽  
T Test ◽  
Control Group ◽  
Fisher Exact Test ◽  
Test Results ◽  
Exact Test ◽  
Student’S T ◽  
Student’S T Test

Intravesical prostaglandin E2 is effective in the recovery of spontaneous voiding after transvaginal reconstruction of the pubocervical fascia and short arm sling according to Lahodny. The aim of the study was to compare the effects of intravesical prostaglandin E2 in the prevention of urinary retention after transvaginal reconstruction of the pubocervical fascia and short arm sling according to Lahodny. STUDY DESIGN: From November 1996 to June 1999 fifty women underwent the Lahodny procedure for moderate/severe cystocele and stress urinary incontinence. Women were randomly assigned to 1 of the 2 study groups: intravesical prostaglandin E2 versus controls. Data obtained were analyzed with the Student t test and the Fisher exact test. RESULTS: Two patients of the treatment group had to be excluded from the study, one because of the wrong measurement of the post-voidal residual volume and another due to a fastidious burning sensation which appeared immediately after prostaglandin instillation and required the suspension of the treatment. No other side effects such as nausea, vomiting, diarrhea or hyperthermia were observed. Patients who underwent the prostaglandin E2 treatment showed a recovery of spontaneous voiding after 7.9&plusmn;6.7 days, whereas this interval was significantly longer in the control group, being 12.9&plusmn;9.7 days (p=0.04, Two tailed Unpaired Student's T test). CONCLUSION: The effectiveness and the low associated morbidity mark the treatment with intravesical prostaglandin E2 useful in the recovery of normal voiding after transvaginal pubocervical fascia reconstruction and short arm sling with the procedure according to Lahodny.

scholarly journals Shortening of bones using novel contraction osteogenesis device: An experimental study

2021 ◽  
Vol 11 (Suppl. 1) ◽  
pp. 26-31
Author(s):  
Hakan Ocak ◽  
Erdem Kılıç ◽  
Alper Alkan
Keyword(s):  
Experimental Study ◽  
Maxillofacial Surgery ◽  
Latency Period ◽  
Test Group ◽  
Study Groups ◽  
Skin Incision ◽  
Alternative Methods ◽  
Control Group ◽  
Oral And Maxillofacial Surgery ◽  
Complication Rates

Aim: Given the high complication rates associated with orthognathic surgery for the correction of maxillomandibular malformations, studies have focused on alternative methods of strengthening the jaw, such as distraction osteogenesis. However, methods of shortening of the jaw are not well-elucidated in oral and maxillofacial surgery practice. This study aims to investigate the efficacy of a new method of shortening osteotomized jaws. Methodology: A 2.5–3 cm skin incision was made on the left tibia of each of 15 New Zealand white rabbits aged 12–18 months, followed by fixation of 15 mm pre-opened distractor devices to the tibia after osteotomy. After a five-day latency period, the distractors were activated to a total of 8 mm, with closure of the device set at a rate of 0.25 mm/day in the test group. After a five-day latency period, the distractors closed at a rate of 0.125 mm/day, achieving a total contraction of 5 mm. The distractors were not activated in the control group. The bone at the contraction range was evaluated, and the resultant shortening was measured. Results: The tibia was shortened by an average of 4.32 mm. Exaggerated bone formation was identified around the osteotomized cortical bone in all rabbits in the control and study groups, and there were minimal complication rates. Conclusion: This study verified that the jaw can be shortened by performing slow, controlled contraction with a bone resorption pattern.   How to cite this article: Ocak H, Kılıç E. Alkan A, Shortening of the bones using a novel contraction osteogenesis device: An experimental study. Int Dent Res 2021;11(Suppl.1):26-31. https://doi.org/10.5577/intdentres.2021.vol11.suppl1.5   Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

De rol van Taal Variatie en Taalafstand in de Communicatie Tussen Zweden, Noren en Denen

2003 ◽  
Vol 69 ◽  
pp. 131-142
Author(s):  
Gerard Doetjes
Keyword(s):  
Language Variation ◽  
Intermediate Position ◽  
Linguistic Variation ◽  
Control Group ◽  
Specific Situation ◽  
Test Results ◽  
Lingua Franca ◽  
What Is Said ◽  
Ma Thesis ◽  
Over Time

The typological and lexical similarities between the major Scandinavian languages Danish, Norwegian and Swedish as well as a feeling of economic, political and cultural togetherness, facilitate direct interscandinavian communication. Communication participants use their own languages, both in speaking or writing and in decoding what is said or written. This specific situation is called semicommunication. There are, however, problems in semicommunication, too. The pronunciation of Danish has changed strongly over time, and English has strengthened its position as a global lingua franca. The question of how well Scandinavians really understand one another is, therefore, an interesting one. Research has shown that Norwegians have a better understanding than other Scandinavians. This can be accounted for by their language's intermediate position. Another explanation is the linguistic variation in Norway, making Norwegians more experienced in interpreting small differences between language variants. In my MA-thesis, I have focussed on the differences as regards Norwegian language variation experience between the smaller and more experienced Nynorsk group and the bigger and less experienced Bokmål group. Both groups' understanding of written Swedish was tested. A Danish control group took the same test. Results show that the Norwegian group in general had few problems understanding written Swedish. A difference between the Nynorsk group and the Bokmål group, however, could not be found.

scholarly journals Research on the Effect of 5Why-Based Nursing Intervention in Blood Purification Nursing

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Ru Cai ◽  
Yun Fei ◽  
XiaoPing Li ◽  
LinFang Xu ◽  
Chun Lei Wu ◽  
...  
Keyword(s):  
Experimental Analysis ◽  
Test Group ◽  
Nursing Intervention ◽  
Blood Purification ◽  
Mathematical Statistics ◽  
Control Group ◽  
Controlled Trials ◽  
Test Results ◽  
The Past ◽  
Intervention Method

In order to explore the effectiveness of the 5Why-based nursing intervention method in blood purification nursing, this paper takes 108 patients from Changzhou Second Hospital in the past three years as an example for experimental analysis. Moreover, this paper uses mathematical statistics to group patients into groups, and the two groups of patients are comparable. After grouping, this paper conducts preexperiment processing and then conducts patient grooming through various basic tasks so that the test results have a certain degree of reliability. On this basis, this paper verifies the nursing intervention methods through controlled trials. Among them, the control group is treated with the hospital’s conventional nursing methods and allowed patients to master self-nursing methods, while the test group is treated with 5Why-based nursing intervention on the basis of traditional nursing methods. Finally, this paper combines mathematical statistics to evaluate the effect of blood purification nursing. From the research results, it can be known that the 5Why-based nursing intervention method has certain effectiveness in blood purification nursing.

scholarly journals EFFECT OF "VETOM 21.77" PREPARATION ON SERUM BIOCHEMICAL PATTERN IN MICE

2018 ◽  
pp. 57-60
Author(s):  
E. R. Rafikova
Keyword(s):  
Body Weight ◽  
Maximum Dose ◽  
Test Group ◽  
Control Group ◽  
Not Given ◽  
Test Results ◽  
Laboratory Mice ◽  
Duddingtonia Flagrans ◽  
Physiological Limits ◽  
Serum Biochemical

It is known that predatory Hyphomycetes fungi play an important role in measures taken for helminthic infestation prevention. There is little evidence on properties of compounds contained in predatory fungi and their effect on animals. Results of tests of "Vetom 21.77", new microbiological preparation based on Duddingtonia flagrans, for its effect on serum biochemical pattern of laboratory mice are presented. The preparation was administered to the animals at the dose of 2, 5, 50 and 300 µl/kg of body weight. The animals were examined for tested parameters prior and 2 and 7 days after daily administration of the preparation. The parameters remained within the normal physiological limits in all test group as well as in control group not given the preparation. The test results indicated safety of the said microbiological preparation. Significant increase in total protein and albumin contents was recorded in mice given the maximum dose of the preparation as compared with those of control group.

scholarly journals Anti-retroviral therapy and serum protein levels in HIV-1 seropositive patients: a five-year retrospective study

2020 ◽  
Author(s):  
Akor Egbunu Shedrac ◽  
Musa Haruna ◽  
Eneojo-Abah Eleojo Gloria ◽  
Yisa Benjamin Nma ◽  
Emmanuel Friday Titus ◽  
...  
Keyword(s):  
Liver Function ◽  
Serum Proteins ◽  
Roc Curves ◽  
Study Groups ◽  
Control Group ◽  
Protein Levels ◽  
Art Initiation ◽  
Baseline Levels ◽  
Significant Change ◽  
Hiv 1

AbstractBackgroundSerum proteins designated as liver function biomarkers are used to evaluate patients for hepatic dysfunction. Hepatic effect of Anti-Retroviral Therapy (ART) needs further studies in HIV mono-infected patients. In this study, clinically defined patient datasets were analysed for protein levels in HIV-1 mono-infected seropositive patients with and without ART.Materials and MethodsData were collected for the study groups, consisting of the control group and HIV-1 mono-infected seropositive patients with and without ART and were analysed statistically for differences among the groups. All subjects in the patient groups attended University of Maiduguri Teaching Hospital, Nigeria for a period of 5 years.ResultThe protein levels on initiation of ART were significantly higher than baseline levels (prior to ART). However, continuous use of ART for 5-year period did not induce any further significant change in protein levels. Receiver Operating Characteristic (ROC) curves shows that both Albumin (ALB) and Total protein (TP) levels discriminated among the study groups. The baseline levels of ALB in seropositive patients are significantly lower to levels on initiation of ART.ConclusionContinuous ART did not cause any further significant change in levels of liver function proteins than was observed on ART initiation. Hence, liver damage on continuous ART is not implied. Both ALB and TP levels could be important in HIV management of patients. Initiation of ART appears to elevate the low ALB level via a yet unknown mechanism and indicates possible role of ALB in ART mechanism of action.

scholarly journals Deficits in central auditory processing among migraine patients

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Somia Tawfik ◽  
Randa Amin ◽  
Sahar Ibrahim ◽  
Tayseer Taha Abdel Rahman
Keyword(s):  
Auditory Processing ◽  
Study Groups ◽  
Statistical Correlation ◽  
Control Group ◽  
Study Group ◽  
Central Auditory Processing ◽  
Test Results ◽  
Memory Tests ◽  
Significant Difference ◽  
Noise Test

Abstract Background Migraine is a neurological disease associated with abnormal excitability in visual, somatosensory, and motor cortex. This study aimed to verify and compare auditory processing performance in migraine patients with and without dizziness and healthy controls. Results Sixty subjects were divided into 3 groups: control group, twenty normal healthy subjects, and study group I (twenty subjects diagnosed with migraine) and study group II (twenty subjects diagnosed with vestibular migraine). They were evaluated using the Central Auditory Processing Questionnaire for adults, tympanometry, pure tone audiometry, Psychophysical Central Auditory Tests, including Arabic Speech Intelligibility in Noise Test for adults, Arabic Dichotic Digit Test [version II], Gap in Noise Test, Duration Pattern Test, and Arabic Memory Tests. No significant difference was found between the two study groups I and II, but the significant difference was found between the study groups and the control group in all central auditory test results. Statistically significant difference was found between the control group and study groups I and II regarding all memory tests. The highest percentage of abnormality was present in temporal resolution and selective auditory attention in both study groups. There was no significant statistical correlation between the number of attacks/month and central auditory test results. There was no significant statistical correlation between the frequency of attacks in VM patients and central auditory test results. Conclusions Patients with migraine and vestibular migraine had an inferior performance in all psychophysical central auditory tests when compared with control. Also, there was no significant difference between the 2 study groups regarding central auditory test results which may support that both migraine with and without dizziness have the same pathophysiology.

scholarly journals The Role of RANKL/RANK/OPG System in the Canine Model of Hip Periprosthetic Infection Osteolysis

2016 ◽  
Vol 39 (12) ◽  
pp. 619-624 ◽  
Author(s):  
Hao-Wei Zhang ◽  
Li Peng ◽  
Wen-Bo Li ◽  
Ke-Guan Song
Keyword(s):  
Synovial Fluid ◽  
Test Group ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Upward Trend ◽  
Septic Loosening ◽  
Periprosthetic Osteolysis ◽  
Significant Upward Trend ◽  
And Control ◽  
Over Time

Purpose We aimed to investigate whether the RANKL/RANK/OPG system is associated with the incidence of periprosthetic osteolysis with septic loosening, and to investigate the differences of RANKL/RANK/OPG system expression in synovial fluid surrounding the normal and septic loosening hip prosthesis in canine models. Methods Twelve healthy adult mongrel canines were divided into two groups: experimental and control. Femoral head and stem replacements were conducted on the right side in both groups. The experimental group received the bacteria fluid intra-articular injection and the other group received the same amount of saline in the same day. The synovial fluid samples were gathered at the 1st, 2nd, 4th, 8th, 12th, 16th and 19th week after the bacteria fluid intra-articular injection for enzyme-linked immunosorbent assay (ELISA), the expression of the RANKL/RANK/OPG system. Results Surgery on all animals was successful. Two dogs were excluded from the analysis of the result because of a surgery infection or death. The ELISA of the synovial fluid revealed that the ratio of RANKL/OPG showed a significant upward trend (p≤0.05) with time in the test group but the ratio of RANKL/OPG in the control group changed slowly over time (p>0.05). The ratio of RANKL/OPG value between the test and control group showed a significant upward trend, but had no statistical difference (p>0.05) over time. Conclusions It could be concluded that the RANKL/RANK/OPG system is correlated with the incidence of periprosthetic osteolysis with septic loosening. Consequently, imbalance RANKL/RANK/OPG system was related to periprosthetic osteolysis with septic loosening.

Effect of tablets containing probiotic bacteria (Lactobacillus reuteri) on early caries lesions in adolescents: a pilot study

2014 ◽  
Vol 5 (4) ◽  
pp. 403-407 ◽  
Author(s):  
M.K. Keller ◽  
I. Nøhr Larsen ◽  
I. Karlsson ◽  
S. Twetman
Keyword(s):  
Placebo Group ◽  
Pilot Study ◽  
Lactobacillus Reuteri ◽  
Clinical Signs ◽  
Test Group ◽  
Control Group ◽  
Lesion Area ◽  
Early Caries ◽  
Caries Lesions ◽  
Over Time

The objective of the study was to investigate the effect of tablets containing probiotic lactobacilli on early caries lesions in adolescents with quantitative light-induced fluorescence (QLF). 36 healthy adolescents of both sexes (12-17 years of age) were enrolled and randomly allocated to a placebo-controlled trial with two parallel groups. The test group received two tablets daily containing two strains of Lactobacillus reuteri (DSM 17938 and ATCC PTA 5289) for a period of three months, while the control group got identical placebo tablets without live bacteria. The primary outcome was QLF-readings (change in fluorescence, ΔF and lesion area, mm2) at baseline and after 3 months, conducted at two buccal sites of each individual, pre-selected with clearly visible clinical signs of enamel demineralisation (white spots). Significantly more premolars were allocated to the placebo group, while the test group had more incisors (P<0.05). There were no statistically significant differences in fluorescence values between the groups, neither at baseline, nor at the follow-up. There was however a significant decrease in fluorescence over time in the test group, but not in the placebo group (P<0.05). No alterations of the lesion area (ΔA) were found in any group. The inter-examiner intra-class correlation coefficient-value for QLF-readings was excellent. No side- or adverse effects were reported during the intervention period. This pilot study found a significant decrease over time in the test group. However, no statistically significant differences in fluorescence values between the groups were found. Hence, the null hypothesis could not be rejected.

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