scholarly journals Molecular Structure, Pathophysiology, and Diagnosis of COVID-19

2020 ◽  
Vol 11 (3) ◽  
pp. 10215-10237
Keyword(s):  
Molecular Structure ◽  
Immune System ◽  
Mortality Rate ◽  
Molecular Biology ◽  
Severe Acute Respiratory Syndrome ◽  
Diagnostic Tests ◽  
Transmission Mode ◽  
Global Epidemic ◽  
The World ◽  
Significant Mortality

Recently, a new coronavirus, named Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) has emerged in Wuhan, Hubei province, China. SARS-CoV-2 caused a global epidemic (COVID-19), which continues to kill thousands of people around the world today. With an exclusively interhuman transmission mode, in the absence of a vaccine, the spreading of this new coronavirus is accelerating remarkably. With the studies of the molecular biology of the virus, molecular and serological diagnostic tests are implemented. However, the pathophysiology is not well understood and variable, which gives different symptoms, with a significant mortality rate. Indeed, several organs such as the lungs, brain, kidneys, immune system, and heart are affected directly and/or indirectly.

scholarly journals Therapeutic Strategies of COVID-19: from Natural Compounds to Vaccine Trials

2020 ◽  
Vol 11 (1) ◽  
pp. 8318-8373
Keyword(s):  
Monoclonal Antibodies ◽  
Immune System ◽  
Severe Acute Respiratory Syndrome ◽  
Natural Compounds ◽  
Therapeutic Strategies ◽  
Plasma Therapy ◽  
Global Epidemic ◽  
Vaccine Trials ◽  
The World ◽  
Novel Coronavirus

Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) is a novel coronavirus that caused a global epidemic named COVID-19. This disease continues to kill thousands of people around the world. Physiopathological studies showed that different organs such as lungs, brain, kidneys, immune system, and heart are affected directly and/or indirectly by this disease. With the absence of a vaccine, several treatments have been proposed, including old antiviral drugs, synthetic pharmacophores, and natural antiviral bioactive compounds. These molecules presented promising results with specific action on the virus. Moreover, other strategies are underway, such as the use of monoclonal antibodies, cell therapy, plasma therapy, and vaccine trials. In this work, we highlight the therapeutic strategies of COVID-19 natural compounds to vaccine trials.

scholarly journals COVID-19: A positive prospect of pandemic situation

2021 ◽  
Vol 58 (1) ◽  
pp. 2912-2914
Author(s):  
Vinod Kumar Et al.
Keyword(s):  
Air Pollution ◽  
Mortality Rate ◽  
Severe Acute Respiratory Syndrome ◽  
East Asian ◽  
Preventive Measure ◽  
Human Race ◽  
Wuhan City ◽  
Significant Drop ◽  
The World ◽  
Short Span

In 2019, human race again came across a highly transmittable and pathogenic viral infection viz. COVID-19 and along with its pandemic nature, caused severe acute respiratory syndrome (SARS), and owes its emergence from the local seafood market of Wuhan city, China. Corona virus is currently prevalent all over the world wherein it caused infection in more than 1,30,000 individuals worldwide with mortality rate nearby 3% in approximately 120 countries within a short span of time and the infection due to this virus is still on a higher verge. Apart from this as per WHO report on air pollution revealed around 2.4 and 2.2 million deaths in South East Asian and Western Pacific regions respectively. Both conditions are deadly in their respective prospects, although lockdown, preventive measure which avoid spreading of COVID-19 infection, indirectly lead to significant drop down in air pollution globally. However, this effect is not permanent and it is for being a time but it develops a hope that together we can fight against both.

scholarly journals COVID-19: Evolving from Myths and Trials to a Potentially Treatable Disease

BioMedica ◽  
2020 ◽  
Vol 36 (2S) ◽  
pp. 130-136
Author(s):  
Afshan Mehvish Naz ◽  
Samina Kausar ◽  
Mansoor Ghani ◽  
Saima Kousar
Keyword(s):  
Clinical Trials ◽  
Immune System ◽  
High Risk ◽  
Mortality Rate ◽  
Randomized Trials ◽  
Fatal Outcome ◽  
The World ◽  
Morbid Conditions

<p>Since the COVID-19 outbreak has emerged, every nation and every government are trying its best to combat the disease and develop strategies for better prevention, diagnosis, treatment and management of this lethal virus. Though the mortality rate is far less than any other pandemic the world has experienced, still patients with co-morbid conditions and immune system disorders are at high risk of fatal outcome. There are no approved treatments for COVID-19; thus, people with COVID-19 should be referred to clinical trials. Several agents have been touted as treatments for COVID-19, but at this point, the data are insufficient to inform a recommendation for or against the use of these agents outside of clinical trials; well-conducted randomized trials will be critical in determining how COVID-19 should be treated.</p>

scholarly journals Milieu Relevance of Melanin’s Antiviral Effects and Interventions to the COVID-19 Pandemic

2021 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Immune System ◽  
Severe Acute Respiratory Syndrome ◽  
White Supremacy ◽  
Healthcare Providers ◽  
Institutional Racism ◽  
Preventative Treatment ◽  
Dietary Practices ◽  
Antiviral Effects ◽  
The World

The COVID-19 pandemic has disproportionately affected melanin dominant people, while on the continent of Africa, this novel strain does not appear to have decimated the population. Contrary to many scientific expectations, native Africans on the continent are less impacted compared to the global number of infections in other regions of the world. Therefore, an analysis of the role of melanin and milieu should be assessed by healthcare providers who have a concern for melanin-dominant populations. Questions are raised that Melanin has antiviral effects and there are additional factors derived from comorbidity that impact the susceptibility to Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) embedded in institutional racism (aka the system of white supremacy-Milieu). Dietary practices, access to healthcare, lifestyle and genetics can influence the severity of illnesses associated with contracting this virulent coronavirus via intense erratic activation of the immune system among those subjected to a plethora of chronic societal stressors. In summary, this article will address the effects of this crisis on people of African descent and suggest alternative treatments as an intermediary, rather than exclusive reliance on a vaccine as preventative treatment. The relevance of such discourse is critical given America’s medical history, which has fostered profound distrust among her melanin-dominant citizenry.

Role of Vitamins, Minerals and Herbs in Strengthening immune system against the newly Emerging Viral Disease SARS-CoV-2

2021 ◽  
pp. 309-315
Author(s):  
Ajay I. Patel ◽  
Pooja R. Maru ◽  
Ashok B. Patel ◽  
Amitkumar J. Vyas ◽  
Nilesh K. Patel
Keyword(s):  
Immune System ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Infection ◽  
Viral Disease ◽  
The Body ◽  
Primary Stage ◽  
The Social ◽  
The World

The Coronavirus Disease 2019 (COVID-19) is caused by severe acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection Attack mainly on the immune system of the body. The current pandemic situation of COVID-19 has broken the social-economical Condition of the World. The Available Allopathic drug Paramedical system is attempting to manage the symptoms. But, there are no significant effects of the available drug system. So, it is better to move toward a supplement system that improves the body's immune system. Herbs, Minerals, and Vitamins can be boosting body immunity and prevent the respiratory Viral Disease SARS-CoV-2. It gives its response in the Primary Stage of COVID-19. So, it is better to towards the natural herbals, Minerals, and vitamins which can improve the immunity of the body and it can possibly prevent the viral infection.

Revisiting the antiviral efficacy of terpenoids: Plausible adjunct therapeutics for novel SARS-CoV-2?

2021 ◽  
Vol 21 ◽  
Author(s):  
Afza Ahmad ◽  
Rohit Kumar Tiwari ◽  
Irfan Ahmad Ansari
Keyword(s):  
Mortality Rate ◽  
Severe Acute Respiratory Syndrome ◽  
Scientific Literature ◽  
Bioactive Constituents ◽  
Plant Metabolites ◽  
Secondary Plant Metabolites ◽  
Chemical Structures ◽  
Antiviral Efficacy ◽  
The World ◽  
History Of

: Presently the world is witnessing most devastating pandemic in the history of mankind caused due to Severe Acute Respiratory Syndrome or SARS-CoV-2. This dreaded pandemic is responsible for escalated mortality rate across the globe and thus is the worst catastrophes in the history of mankind. Since its outbreak, substantial scientific explorations focusing on formulation of novel therapeutical and/or adjunct intervention against the disease are continuously in pipeline. However, till date no effective therapy has been approved and hence the present alarming situation urges the necessity of exploring novel, safe and efficient interventional strategies. Functionally, terpenoids are a class of secondary plant metabolites having multi facet chemical structures and are categorically documented to be the largest reservoir of bioactive constituents, predominant in nature. Intriguingly, very little is scientifically explored or reviewed in regards with the anti-CoV-2 attributes of terpenoids. The present article thus aims to revisit the antiviral efficacy of terpenoids by reviewing the current scientific literature and thereby provide an opinion on the plausibility of exploring them as potential therapeutical intervention to deal with ongoing CoV-2 pandemic.

scholarly journals Novel corona Virus (2019-nCoV) - An Ancient Ayurveda Epidemiology Literature Review.

2020 ◽  
Vol 8 (02) ◽  
Author(s):  
GANGAPRASAD ANANTRAO WAGHMARE
Keyword(s):  
Mortality Rate ◽  
Severe Acute Respiratory Syndrome ◽  
World Health Organization ◽  
Communicable Disease ◽  
World Health ◽  
Rate Estimate ◽  
Corona Virus ◽  
The World ◽  
Health Organization ◽  
Epidemic Diseases

 Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). In more severe cases, infection can cause pneumonia, severe acute respiratory syndrome, kidney failure and even death   Initially, the World Health Organization (WHO) had mentioned 2% as a mortality rate estimate in a press conference on Wednesday, January 29 and again on February 10. However, on January 29 2020 WHO specified that this was a very early and provisional estimate that might have changed. 3.4% Mortality Rate estimate by the World Health Organization (WHO) as of March 3 2020.                           The concept of epidemic was very much well defined in Ayurveda, Acharya Charaka the great physician of all ages had mentioned the epidemic diseases under the heading of “Janapadodhwans”.The aim of this review study is to understand the ancient Ayurveda epidemic literature , to prevent people from getting affected by epidemic diseases and to enlighten on epidemic diseases prevention & Management through Ayurveda. Keywords: Novel corona Virus (2019-nCoV),severe acute respiratory syndrome,Janapadodhwans,Ayurveda,epidemic Diseases,communicable disease,Panchakarma, Rasayan .  

Detection of parasites in food

Parasitology ◽  
1999 ◽  
Vol 117 (7) ◽  
pp. 97-111 ◽  
Author(s):  
H. R. GAMBLE ◽  
K. D. MURRELL
Keyword(s):  
Molecular Biology ◽  
Diagnostic Tests ◽  
Potential Application ◽  
Developed Countries ◽  
The World ◽  
Control Programmes ◽  
Parasitic Zoonoses

The importance of foodborne parasitic zoonoses remains high in many regions of the world. Although control efforts have been exerted for quite some time, overall progress has not been satisfactory, even in many well developed countries. An important drawback in control programmes for parasites such as Trichinella, Toxoplasma and Taenia has been the absence of rapid, accurate and sensitive diagnostic tests for these meatborne parasites. However, the rapid advances in the molecular biology of these organisms has yielded concomitant gains in precision of detection. This review highlights these advances and their impact or potential application to the control of foodborne parasites.

scholarly journals Immunosenescence and the Susceptibility of the Elderly to Coronavirus Disease 2019 (COVID-19)

2020 ◽  
Vol 40 (3) ◽  
pp. 182-191
Author(s):  
Widya Wasityastuti ◽  
Andika Dhamarjati ◽  
Siswanto Siswanto
Keyword(s):  
Immune System ◽  
Severe Acute Respiratory Syndrome ◽  
Literature Review ◽  
The Elderly ◽  
World Health ◽  
New Disease ◽  
Risk Of Infection ◽  
The World ◽  
Long Time ◽  
Health Organization

A new disease caused by a newly-found coronavirus, known as Coronavirus Disease 2019 (COVID-19), has been declared as a pandemic by World Health Organization (WHO). This new disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The outbreak started in late December of 2019 and it did not take a long time until it spread to more than 200 countries in the world with over 4 million confirmed cases to date. The number keeps skyrocketing as day passes, followed by the increasing number of fatalities. Among all of the infected patients, elderly is one of the vulnerable populations. Studies reported that the risk of infection is doubled in older people. This infection-susceptible characteristic may be due to the weak immune system, therefore they lack the capabilities to fight the infection. The deterioration of immune system in elderly is known as immunosenescence. The aim of this literature review is to understand the effect of immunosenescence in the immunopathogenesis and susceptibility of elderly who are exposed to COVID-19 infection. (J Respir Indo. 2020; 40(3): 182-91)

Covid-19, SARS -CoV-2, Origin, transmission and treatment aspects, a brief review

2020 ◽  
Vol 20 ◽  
Author(s):  
Shahid Nawaz
Keyword(s):  
Mortality Rate ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Manifestation ◽  
Virus Disease ◽  
The Novel ◽  
Research Activities ◽  
Corona Virus ◽  
Global Pandemic ◽  
The World

: The emergence of severe acute respiratory syndrome (SARS) in Wuhan (china) named as corona virus disease 19(covid-19) caused by the novel corona virus SARS-CoV-2 has caused hundreds of thousands of mortalities across the world ,while the mortality rate is in millions, leading it to be declared as a global pandemic. Numerous research activities are undergoing to reveal the disease and etiological features of covid-19. In this review, some of the interesting aspects of covid-19 are discussed, that includes, the origin of the SARS-CoV-2, clinical manifestation, treatment and future aspects of the disease.

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