scholarly journals FORMULATION AND INVITRO EVALUATION OF MOUTH DISSOLVING FILMS OF DICLOFENAC SODIUM USING SOLVENT CASTING TECHNIQUE

2021 ◽  
Vol 11 (3) ◽  
Author(s):  
K. L. Deepthi ◽  
J. Panda ◽  
M. Alekhya ◽  
B. Ojaswi ◽  
B. Akhila ◽  
...  
Keyword(s):  
Diclofenac Sodium ◽  
Solvent Casting ◽  
Casting Technique

scholarly journals Antimicrobial Active Bioplastics Using Triangular Silver Nanoplate Integrated Polycaprolactone and Polylactic Acid Films

Materials ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1132
Author(s):  
Eduardo Lanzagorta Garcia ◽  
Olivia A. Attallah ◽  
Marija Mojicevic ◽  
Declan M Devine ◽  
Margaret Brennan Fournet
Keyword(s):  
Polylactic Acid ◽  
Scale Up ◽  
Composite Films ◽  
Antimicrobial Properties ◽  
Morphological Structure ◽  
Antimicrobial Effect ◽  
Solvent Casting ◽  
Local Surface Plasmon Resonance ◽  
Casting Technique ◽  
Triangular Silver Nanoplates

An innovative antimicrobial technology for plastic surfaces is presented. We report the synthesis and scale-up of triangular silver nanoplates (TSNPs) and their integration into polycaprolactone (PCL) and polylactic acid (PLA) polymers through a solvent-casting technique. The TSNPs have a high geometric aspect ratio and strong local surface plasmon resonance (LSPR) response, which provides an effective tool for monitoring their integrity during processing and integration with the biodegradable plastics. An aqueous-based seed-mediated chemical method was used to synthesize the TSNPs, and characterisation was carried out using TEM and UV (Ultraviolet)-VIS (Visible) spectroscopy to measure LSPR profiles. The UV-VIS spectra of silver seeds and TSNPs exhibited characteristic peaks at 395 and 600 nm respectively. Synthesized TSNPs were coated with thiol-terminated polyethylene glycol (SH-PEG) and transferred into chloroform in order to effect compatibility with PCL and PLA. TSNP/PCL and TSNP/PLA composite films were prepared by solvent casting. The morphological structure, thermal, mechanical, and antimicrobial properties of the TSNP-incorporated composite films were evaluated. Results showed the TSNP-treated films had a rougher surface than the bare films. Insignificant changes in the thermal properties of TSNP-treated films compared to bare ones were also observed, which indicated the thermal stability of the composite films. The tensile strength and antimicrobial properties of the composite films were increased after TSNP incorporation. TSNP/PCL and TSNP/PLA films exhibited improved antimicrobial activity against Escherichia coli and Staphylococcus aureus with antimicrobial effect (AE) values ranging between 0.10 and 0.35. The obtained results and demonstrated TSNP production scalability validate the TSNP treated PCL and PLA films as a composite material with desirable antimicrobial effect for wide-ranging surface applications.

Development and Evaluation of Trans Buccal Patches based on Natural and Synthetic Polymers Loaded with Rivastigmine using Solvent Casting Technique

2021 ◽  
pp. 5133-5140
Author(s):  
Prasanta Kumar Mohapatra ◽  
Boddu Pavan Kumar ◽  
Pankaj Singh Patel ◽  
Harish Chandra Verma ◽  
Satyajit Sahoo
Keyword(s):  
Drug Release ◽  
Kinetic Equations ◽  
Moisture Loss ◽  
Release Mechanism ◽  
Solvent Casting ◽  
Casting Technique ◽  
Weight Variation ◽  
Zero Order Release ◽  
Buccal Films

Mucoadhesive buccal films of rivastigmine were prepared by the solvent casting technique using HPMC K15M, sodium alginate, glycerine, and Eudragit RL100. Arranged films assessed for weight variation, thickness, % drug substance, % moisture loss, % moisture take-up, folding endurance, in-vitro medicament release, and Fourier transform Infrared spectroscopy (FTIR). The films showed a controlled release (CR) over 8 h. The preparation observed to be a worthy candidate for the development of buccal patches for therapeutic purposes. Drug-polymer compatibility considers FTIR demonstrated no contradiction between the medicament and the polymers. The optimized formulation found F7 indicated drug release 85% at the end of 8 h. Thinking about the correlation coefficient (R2) values got from the kinetic equations, the drug release from the formulations F1-F8 has discovered zero-order release mechanism. It can be concluded that oral buccal patches of rivastigmine, for treatment of Alzheimer’s and Parkinson’s disease, can be formulated. The study suggests that rivastigmine can be conveniently administered orally in the form of buccal patches, with the lesser occurrence of its side effects and improved bioavailability.

scholarly journals STUDIES ON EFFECT OF FORMULATION AND PROCESSING PARAMETERS ON STABILITY OF KETOROLAC TROMETHAMINE ORALLY DISSOLVING FILMS

2019 ◽  
pp. 230-235
Author(s):  
NIDHI P. SAPKAL ◽  
MINAL N. BONDE ◽  
MANGESH GAWANDE ◽  
ANWAR S. DAUD
Keyword(s):  
Solid State ◽  
Chemical Analysis ◽  
Ketorolac Tromethamine ◽  
Acidic Ph ◽  
Solvent Casting ◽  
Interaction Study ◽  
Casting Method ◽  
Casting Technique ◽  
Higher Temperature ◽  
The Stability

Objective: The objective of the proposed work was to study the effect of various formulation and process parameters of solvent casting method on the physical and chemical stability of Ketorolac Tromethamine (KT) in the orally dissolving film dosage form. Methods: KT-excipient interaction study was carried out both in solid state and by processing samples through the solvent casting technique. The samples were evaluated using IR spectroscopy (IR) and X-ray diffractometry (XRD). Solvent casting method was used to prepare KT films using different film-forming polymers, and solvents. The drying temperature and pH of the dispersion were also varied to study the effect of these parameters on the stability of KT. All the formulations were analysed chemically initially and after one month of storage at 40 °C/75% RH. Results: During KT-excipient interaction study in solid state KT was found to be stable. No significant changes were observed in its impurity profile. Interaction between different polymers and KT was observed after the solvent casting process as revealed by IR and XRD analysis. The interaction was further confirmed in the film formulations upon chemical analysis. The polymers showing interaction with KT in XRD and IR were making it unstable chemically and were responsible for its chemical degradation as revealed by chemical analysis. It was also revealed that KT is most stable when processed using water as the solvent. KT was found to be stable when processed at a higher temperature and at acidic pH during film formation. It was found that chemical stability is more when Polyethylene oxide (PEO) and water under acidic pH are used and films are dried at a higher temperature. Conclusion: Both formulation parameters and processing conditions of the solvent casting technique affects the stability of drugs and hence should be studied as part of pre-formulation studies while developing orally dissolving films of drugs.

scholarly journals PVP Based Materials: Biodegradation in Different Environments

2017 ◽  
Vol 24 (2) ◽  
pp. 299-309 ◽  
Author(s):  
Ludmila Vanharova ◽  
Marketa Julinova ◽  
Roman Slavik
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Fourier Transform Infrared Spectroscopy ◽  
Polylactic Acid ◽  
Fourier Transform Infrared ◽  
Solvent Casting ◽  
Casting Technique ◽  
Scanning Electron

AbstractThe research deals with biodegradation of films prepared from polyvinylpyrrolidone and polylactic acid (PVP/PLA). Biodegradation of PVP/PLA films was supported by the following additives: 1-methyl-2-pyrrolidone, 1-octyl-2-pyrrolidone, acrylamide and N-acetyl-L-phenylalanine according to the previous study. The films were prepared by a solvent casting technique. Biodegradation was observed using the respirometric method in different environments. The films subjected to biodegradation were analyzed by scanning electron microscopy and Fourier transform infrared spectroscopy. It was found that the films are substantially degraded, but not in the biological way; PVP was quickly removed in presence of water because of its easy solubility. In contrast, this fact could support biodegradation of PLA, which becomes more available for microorganisms when PVP leaves PLA matrix.

Development of biocomposites from coir fibre and poly (caprolactone) by solvent casting technique

2017 ◽  
Vol 75 (5) ◽  
pp. 1775-1787 ◽  
Author(s):  
Henry Chinedu Obasi ◽  
Aqif Anwar Chaudhry ◽  
Kashif Ijaz ◽  
Hafsah Akhtar ◽  
Muhammad Hamza Malik
Keyword(s):  
Solvent Casting ◽  
Casting Technique ◽  
Coir Fibre ◽  
Poly Caprolactone

scholarly journals Improving the Tensile and Tear Properties of Thermoplastic Starch/Dolomite Biocomposite Film through Sonication Process

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 274
Author(s):  
Azlin Fazlina Osman ◽  
Lilian Siah ◽  
Awad A. Alrashdi ◽  
Anwar Ul-Hamid ◽  
Ismail Ibrahim
Keyword(s):  
Mechanical Properties ◽  
Xrd Analysis ◽  
Thermoplastic Starch ◽  
Solvent Casting ◽  
X Ray Diffraction ◽  
Packaging Film ◽  
X Ray ◽  
Casting Technique ◽  
Biocomposite Film ◽  
Tear Properties

In this work, dolomite filler was introduced into thermoplastic starch (TPS) matrix to form TPS-dolomite (TPS-DOL) biocomposites. TPS-DOL biocomposites were prepared at different dolomite loadings (1 wt%, 2 wt%, 3 wt%, 4 wt% and 5 wt%) and by using two different forms of dolomite (pristine (DOL(P) and sonicated dolomite (DOL(U)) via the solvent casting technique. The effects of dolomite loading and sonication process on the mechanical properties of the TPS-DOL biocomposites were analyzed using tensile and tear tests. The chemistry aspect of the TPS-DOL biocomposites was analyzed using Fourier transform infrared spectroscopy (FTIR) and X-Ray Diffraction (XRD) analysis. According to the mechanical data, biocomposites with a high loading of dolomite (4 and 5 wt%) possess greater tensile and tear properties as compared to the biocomposites with a low loading of dolomite (1 and 2 wt%). Furthermore, it is also proved that the TPS-DOL(U) biocomposites have better mechanical properties when compared to the TPS-DOL(P) biocomposites. Reduction in the dolomite particle size upon the sonication process assisted in its dispersion and distribution throughout the TPS matrix. Thus, this led to the improvement of the tensile and tear properties of the biocomposite. Based on the findings, it is proven that the sonication process is a simple yet beneficial technique in the production of the TPS-dolomite biocomposites with improved tensile and tear properties for use as packaging film.

scholarly journals Enrichment a Study of Structural, Optical and Dielectric Properties of Mowiol 4-88 (Pva) Filled Zno Nanocomposites

2021 ◽  
Vol 18 (14) ◽  
Author(s):  
Sahebagouda JAMBALADINNI ◽  
Jeddu Sadashiva BHAT
Keyword(s):  
Particle Size ◽  
Dielectric Constant ◽  
Zno Nanoparticles ◽  
Energy Gap ◽  
Sol Gel ◽  
Solvent Casting ◽  
Optical Studies ◽  
X Ray ◽  
Casting Technique ◽  
Complex Particle

The use of ZnO nanoparticles in the fabrication of PVA (Mowiol 4-88) nanocomposites with different ‘x’ filling compositions through solvent casting technique leading to the enrichment of the host's physical properties is presented. The sol-gel approach synthesizes Zinc Oxide (ZnO) nanoparticles. The formation of ZnO nanoparticles of size 100 nm was confirmed through X-ray powder diffraction (XRD) and Field Effect Scanning Electron Microscope (FESEM) techniques. The XRD technique determines the appearance of nanocomposites and their structural properties. The improvement in filling concentration enhances the particle size up to 150 nm and percentage crystallinity by 41 % for optimum filler composition. The FTIR spectra demonstrate ZnO nanofillers' binding with OH group of host Mowiol 4-88 through intra or inter hydrogen bonding leading to a complex conformation. The optical studies indicate a decrease in the energy gap with the rise in filler composition up to 15 wt%, and frequency-dependent dielectric constant characterization shows the enhancement in the dielectric constant with an optimum filling concentration 15 wt% ZnO nanofillers. FESEM image confirms homogenous distribution and complex particle size of incorporated ZnO nanoparticles in the PVA matrix. HIGHLIGHTS ZnO nanoparticles with Fabrication of PVA (Mowiol 4-88) nanocomposites through solvent casting technique ZnO nanoparticles of size 100 nm was confirmed Filling concentration enhances the particle size and percentage crystallinity SEM and EDS illustrate ZnO nanofiller’s systematic distribution Dielectric measurements show that these fabricated polymeric composites are polar GRAPHICAL ABSTRACT

scholarly journals The influence of barium ferrite nanoparticles on morphological and mechanical properties of ethyl cellulose based nanocomposites

2019 ◽  
Vol 51 (3) ◽  
pp. 277-283 ◽  
Author(s):  
Aleksandar Stajcic ◽  
Ivana Radovic ◽  
Vladan Cosovic ◽  
Aleksandar Grujic ◽  
Jasna Stajic-Trosic ◽  
...  
Keyword(s):  
Thin Films ◽  
Mechanical Properties ◽  
Ethyl Cellulose ◽  
Barium Ferrite ◽  
Ferrite Nanoparticles ◽  
Solvent Casting ◽  
Magnetic Powder ◽  
Casting Technique ◽  
Nanocomposite Thin Films

This study presents preparation and characterization of ethyl cellulose based nanocomposites. Successful use of simple solvent casting technique provided nanocomposites with high loads of barium ferrite magnetic nanopowder in the polymer matrix, promising significant improvement of mechanical properties. Investigation of morphology revealed formation of agglomerates that are still on nanoscopic level. Nanocomposite thin films with a higher content of the magnetic powder showed substantial enhancement of break strength, elongation and microhardness compared to the pure ethyl cellulose, which was the primary aim of this research.

scholarly journals FORMULATION AND EVALUATION OF CILNIDIPINE MUCOADHESIVE BUCCAL FILM BY SOLVENT CASTING TECHNIQUE FOR THE TREATMENT OF HYPERTENSION

2021 ◽  
pp. 34-43
Author(s):  
SHIFA SHAUKAT HAJU ◽  
SHEELA YADAV
Keyword(s):  
Tensile Strength ◽  
Drug Release ◽  
Calcium Channel ◽  
Content Uniformity ◽  
Solvent Casting ◽  
Casting Technique ◽  
Drug Content ◽  
Buccal Drug Delivery ◽  
Folding Endurance

Objective: Buccal drug delivery is the most suited route for local as well as systemic delivery of drugs. Cilnidipine is an L/N type dihydropyridine 4th generation calcium channel blocker (CCB), which decreases hypertension by blocking the N-type calcium channel to attenuate vascular sympathetic neurotransmission. It has high first-pass metabolism leading to low bioavailability. Hence the present research work was undertaken to formulate mucoadhesive buccal film of Cilnidipine with an objective to enhance therapeutic efficacy, bioavailability and was developed to administer into the unconscious and less-co-operative patients. Methods: Cilnidipine buccal films were prepared by a solvent-casting technique using various concentrations of mucoadhesive-polymers such as Hydroxyl propyl methylcellulose (HPMC) E15 and K4M and ethyl-cellulose as backing-layer, which acts like a patch providing unidirectional drug release. Prepared films were evaluated for their weight variation, thickness, surface-pH, swelling-index, drug content uniformity, in vitro residence time, folding endurance, tensile strength, in vitro release and permeability studies. Results: The infra-red (IR) spectra showed no interaction, and Physico-chemical characteristics were found within the limit. Swelling of the film increases with increasing concentration of polymers and %drug content of all formulations found to be in the range of 92.13%±0.94% to 97.92%±0.35%. The formulation F5, showed a promising tensile strength, folding endurance and in vitro drug release of about 95.18±0.03%, thus can be selected as an optimized formulation of mucoadhesive buccal film. Conclusion: The formulation of Cilnidipine mucoadhesive buccal film was found to be satisfactory and reasonable.

scholarly journals Impedance Behavior of Conducting Piezoresistive Polymer Composite

2020 ◽  
Vol 9 (3) ◽  
pp. 1197-1200
Keyword(s):  
Polyvinylidene Fluoride ◽  
Electronic Devices ◽  
Solvent Casting ◽  
Impedance Analyzer ◽  
Casting Technique ◽  
Piezoresistive Sensors ◽  
Biomedical Device ◽  
Sample Composition ◽  
Nano Fiber ◽  
Device Applications

Conducting polymers (CP) are used as piezoresistive sensors for the various application of monitoring human and structural health monitoring, flexible electronic devices, automobile, aerospace and for biomedical device applications. In the present work we have developed the polyvinylidene fluoride (PVDF) based CP using Carbon Nano Fiber (CNF). The samples were prepared using the solvent casting technique. The conductivity plays crucial role in improving the sensitivity of the sensors. The impedance behavior of the developed PVDF/CNF membranes was analysed using the E4900A impedance analyzer using the parallel plate probes. The impedance was measured as the function of frequency in the range of 20 Hz-1 MHz. The piezoresistive behavior of PVDF is an important parameter for sensing application. The objective of the present work was to study the impedance spectroscopy of the PVDF/CNF samples. The sample composition of PVDF/CNF (90/10) and PVDF/CNF (85/15) showed better results with lower resistance and higher conductivity

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