scholarly journals The effect of combination probiotic lactobacillus brevis and leuconostoc mesenteroides on tgf-β and il-12 expression in ileum

2022 ◽  
Vol 21 (1) ◽  
pp. 175-183
Author(s):  
- Pujiati ◽  
Dono Indarto ◽  
- Susilorini ◽  
Diani Retno Widyatuti ◽  
Haneda Ilzafira Damayanti ◽  
...  
Keyword(s):  
Leuconostoc Mesenteroides ◽  
Lactobacillus Brevis ◽  
Combination Group ◽  
Control Group ◽  
P Value ◽  
Anova Test ◽  
Significant Difference ◽  
Post Hoc ◽  
One Way Anova ◽  
Asthma Group

Background: Asthma is a disease of the respiratory tract in the form of chronic inflammation. Chronic inflammation is one of them characterized by the remodeling of the airways mediated by the anti-inflammatory cytokine TGF-β. In addition there are also several immune cells that play a role such as macrophages, dendritic, neutrophils as producers of IL-12. The presence of the gut-lung axis allows the spread of inflammatory cytokines from the lungs to the intestines and vice versa. Lactobacillus brevis and Leuconostoc mesenteroides have the potential to modulate the immune system through its colonization of the gut. The study aimed to look at the effect of probiotics combined Lactobacillus brevis and Leuconostoc mesenteroides on the expression of TGF-β and IL-12 in the asthma model mouse ileum. Method: This experimental post-test only control group design study used 18 Sprague-Dawley mice. The mice were divided into 3 groups at random: control group (KI), asthma treatment (KII), asthma treatment with a combination of Lactobacillus brevis and Leuconostoc mesenteroides (KIII). Sensitization of asthma with OVA through intraperitoneal injection on days 0 and 14 and through inhalation on days 21 -63. Administration of combination probiotics per oral per day on days 21-63 after inhalation of OVA. The ileum network was taken on the 64th day and measured the expression of TGF-βand IL-12 with immunohistochemical methods and analyzed the percentage proportion of TGF-βand IL-12. Data analysis were conducted by One way ANOVA test and continued post hoc tests. Results: The percentage calculation of the proportion of TGF-βin thecontrol group (KI), asthma group (KII), and the combination group of L.brevis and L.mesenteroides (KIII) is 22.4 ± 15.27; 1.6 ± 2.12; 19.4 ± 6.65. While the percentage calculation of il-12 proportion in each group consecutively were 24.3 ± 19.67; 64.63 ± 9.90; 51 ± 16.62. One way ANOVA Test results on the percentage proportion of TGF-βhave a p value of 0.013 (p<0.05) which means there is a significant difference in the entire group. Furthermore, the Post Hoc Games-Howell test was conducted and obtained a p value of 0.003 (p<0.05) between the asthma group (KII) and the combination group of L.brevis and L.mesenteroides (KIII) which means there are significant differences between the two groups. One way ANOVA Test results on the percentage proportion of IL-12 have a p value of 0.011 (p<0.05) which means there is a significant difference in the entire group. Furthermore, the Post Hoc LSD test was conducted and obtained a p value of 0.001 (p<0.05) between the control group Post Hoc analyses was conducted and obtained a p value of 0.002 (p<0.05) with number of errors was 11.353 between the control group (KI) and asthma group (KII) which means there are significant differences between the two groups. Conclusion: The probiotic administration of lactobacillus brevis and Leuconostoc mesenteroides had no effect on the expression of TGF-β and had no effect on il-12 expression in the asthma model mouse ileum. It is necessary to do research on mice with asthma using combinations with other bacteria in order to get maximum effect. Bangladesh Journal of Medical Science Vol. 21(1) 2022 Page : 175-183

scholarly journals The Effectiveness of Blood Loss Measuring Mattress in Maternity

2021 ◽  
Vol 8 (10) ◽  
pp. 429-439
Author(s):  
Elsa Noftalina ◽  
Intan Purnamasari ◽  
Firdha Kusuma Wulandari
Keyword(s):  
Blood Loss ◽  
Maternal Mortality ◽  
Postpartum Hemorrhage ◽  
P Value ◽  
Average Difference ◽  
Important Indicator ◽  
Anova Test ◽  
Significant Difference ◽  
Post Hoc ◽  
One Way Anova

Background: Maternal mortality rate (MMR) is an important indicator that describes the health status and welfare of the people in a nation. WHO estimates MMR in the world every day is at 817 people. Maternal mortality is mostly caused by complications during pregnancy, childbirth, and postpartum where these complications are direct obstetric complications. Postpartum hemorrhage is the main cause of maternal death. Factors causing postpartum hemorrhage are uterine atony, retained placenta, laceration of the birth canal, and blood disorders. The delay in diagnosis and treatment of postpartum hemorrhage is mostly caused by the estimated volume of blood loss in labor that is too low and the lack of equipment or clinical skills to solve the problem. Errors in calculating the volume of bleeding lost during delivery are too late to recognize bleeding that can lead to death due to lack of skills to prevent and treat postpartum hemorrhage. Research objective to determine the effectiveness of the product (mattress) in measuring blood loss in maternity. Research Method: The type of research used was experimental research, namely one shot case study. The study was conducted in two Independent Midwife Practices located in the city of Pontianak, West Kalimantan, Indonesia from May to September 2021. The subjects of the study were maternity mothers and birth attendant midwives with a consecutive sampling technique of 30 samples divided into 3 groups with 10 samples respectively of each product. The instrument used to collect data was a questionnaire with a Likert scale which was distributed to maternity mothers as direct users of the mattress and midwives who helped use the mattress. Statistical analysis used was one way ANOVA test. Research results Based on the one way ANOVA test, it was found that the average assessment given by patients and midwives on the three mattress models had a significant difference with a p value of 0.000. In the Post Hoc Turkey HSD test, it was found that there was no difference in the mean of patient assessments between model 1 and model 2 with p value = 0.239. The case was different between model 1 and model 3 and model 2 and model 3, namely, there was a significant difference. Model 1 and model 3 have a p value = 0.009 with an average difference of 2,700 while model 2 and model 3 have a p value = 0.000 with an average difference of 4,100. In the Post Hoc Turkey HSD test, there was a significant difference in the average of the midwives' assessments on the three mattress models. Model 1 and model 2 have a p value = 0.000 with an average difference of 5,800, model 1 and model 3 have a p value = 0.000 with an average difference of 6,900, while model 2 and model 3 have a p value = 0.000 with an average difference of 12,700. Keywords: [Maternity bleeding, Measuring mattress].

scholarly journals Pengaruh Senam Nifas terhadap Penurunan Tinggi Fundus Uteri dan Lochea pada Ibu Pasca Bersalin yang Mendapatkan Inisiasi Menyusu Dini dan Mobilisasi Dini

2020 ◽  
Vol 19 (03) ◽  
pp. 126-133
Author(s):  
Siska Toloan Toloan ◽  
Harimat Hendarwan
Keyword(s):  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Group Design ◽  
Consecutive Sampling ◽  
Post Test ◽  
Post Hoc ◽  
One Way Anova

Masa nifas adalah hal sangat penting untuk diperhatikan guna untuk menurunkan angka kematian ibu dan bayi di Indonesia. Penelitian ini bertujuan untuk Mengetahui Pengaruh Senam Nifas Terhadap Penurunan Tinggi Fundus Uteri Dan Lochea Pada Ibu Pasca Bersalin Yang Mendapatkan Inisiasi Menyusu Dini Dan Mobilisasi Dini Di Praktek Bidan Mandiri Kota Depok Tahun 2019. Penelitian ini menggunakan penelitian kuantitatif yang menggunakan desain penelitian Quasy Exsperimental dengan pendekatan post test only control group design. Populasi yang diambil yaitu 65 ibu pasca bersalin. Sampel diambil dengan metode consecutive sampling besar sampel ditentukan dengan menggunakan rumus Federer setiap variabel bebas terdiri atas 3 kelompok dan setiap kelompok sebanyak 9 sampel sehingga jumlah total sampel 27 ibu pasca bersalin. Pengumpulan data berupa data primer dan uji yang digunakan yaitu uji One Way Anova. Dapat dilihat dari nilai signifikan uji One Way Anova pada penurunan tinggi fundus uteri hari pertama sampai hari kesepuluh dengan nilai signifikan yaitu p-value < 0,05 yang artinya H0 ditolak atau ada perbedaan secara signifikan dan dilihat. Hasil post hoc test tidak terdapat perbedaan signifikan pada kelompok inisiasi menyusu dini, inisiasi menyusu dini dan mobilisasi dini dan kelompok inisiasi menyusu dini, mobilisasi dini dan senam nifas terhadap penurunan tinggi fundus uteri.

scholarly journals Quality of Life in Children with Asthma versus Healthy Children

2018 ◽  
Vol 6 (8) ◽  
pp. 1413-1418 ◽  
Author(s):  
Samaneh Kouzegaran ◽  
Parisa Samimi ◽  
Hamid Ahanchian ◽  
Maryam Khoshkhui ◽  
Fatemeh Behmanesh
Keyword(s):  
Quality Of Life ◽  
Physical Performance ◽  
Control Group ◽  
P Value ◽  
Healthy Children ◽  
Significant Difference ◽  
Children With Asthma ◽  
And Performance ◽  
Asthma Group

BACKGROUND: Asthma is the most prevalent chronic disease in the pediatric age group. The disease affects different aspects of the children's lives, such as physical, emotional, social and educational aspects. Thus, more focus has been on the quality of life in these patients rather than the duration of their illness in recent years.AIM: This study examined the different aspects of quality of life in asthmatic children for the first time in this geographic area.METHODS: The study was cross-sectional conducted in 2015-2016. The asthmatic group was 100 patients aged 8 to 12 admitted to the Asthma and Allergy Clinic of Ghaem Hospital (as) in Mashhad with the control group composed of 100 healthy children of the same age and gender. The standard questionnaire pedsQLTM was used for comparing the quality of life of children in the two groups. Statistical analysis was SPSS23 with P-value less than 0.05, which was statistically significant.RESULTS: In each group, 58 patients were boys, and 42 were girls. In a comparison of the quality of life of children, the asthma group with a mean total score of Peds QL 20.99 ± 12.54 compared to the healthy children with a mean total score of Peds QL of 8.8 ± 5.41 had a lower quality of life (P < 0.001). Moreover, regarding various aspects of quality of life asthma group had a lower quality of life in physical performance, emotional performance and performance in school (P < 0.001). Nonetheless, there was no significant difference between the two groups considering social function (P = 0.267). Examining the relationship between Peds QL score of patients with asthma with various variables was indicative of the fact that Peds QL scores were significantly correlated with the gender of the patients, showing better quality of life in the girls (P = 0.001).CONCLUSION: The results indicated that children with asthma have a significantly lower quality of life compared with healthy children of the same age. Also, in examining the different aspects of quality of life, these children had a lower quality of life in physical performance, emotional performance, and performance at school, and were at the level as that of healthy children only in social performance.

scholarly journals ANTIBACTERIAL EFFECTIVITY OF KASTURI LEAF EXTRACT (Mangifera casturi) AGAINST THE GROWTH OF Streptococcus sanguinis BACTERIA

2020 ◽  
Vol 5 (1) ◽  
pp. 33
Author(s):  
Dita Puspita Sari ◽  
Didit Aspriyanto ◽  
Irham Taufiqurrahman
Keyword(s):  
Leaf Extract ◽  
Periodontal Diseases ◽  
Tooth Surface ◽  
Control Group ◽  
Dilution Method ◽  
Control Group Design ◽  
Streptococcus Sanguinis ◽  
Significant Difference ◽  
Post Hoc ◽  
One Way Anova

Background: Caries is a disease that occurs because of the fermentation carbohydrates process by microorganisms in the oral cavity. One of the bacteria that causes caries is Streptococcus sanguinis. These bacteria will colonize on the tooth surface, then form dental plaques and contribute to the causes of caries and other periodontal diseases. Kasturi leaf extract (Mangifera casturi) has various compounds such as tannins, terpenoids, alkaloids, and flavonoids that have antimicrobial substances. Purpose: The aim of this study was to determine antibacterial effectivity of kasturi leaf extract (Mangifera casturi) against the growth of Streptococcus sanguinis bacteria. Method: This research was an experimental method laboratory (true experimental), with a randomized pre test and post test with control group design using 5 treatments: kasturi leaf extract (concentration: 20 mg/ml, 25 mg/ml, and 30 mg/ml); and two groups of control: positive control and negative control. Each treatment was repeated 5 times. Antibacterial activity testing used a liquid dilution method. Measurement of minimum inhibitory concentration (MIC) used a Uv-Vis Spectrophotometer and measurement of the minimum bactericidal concentration (MBC) used a colony counter. The MIC data were analyzed using One Way Anova and continued with the Dunnet Post Hoc test. MBC data were analyzed using the Kruskal-Wallis test and continued with the Mann-Whitney Post Hoc test. Result: One-Way Anova test showed that MIC had a significant difference, and the Kruskal-Wallis test showed that MBC also had significant differences. MIC was obtained at the concentration of 20 mg/ml and MBC was obtained at the concentration of 30 mg / ml. Conclusion: There is antibacterial effectiveness in kasturi leaf extract (Mangifera casturi) against the growth of Streptococcus sanguinis.

scholarly journals EFFECT OF NATURE SOUND THERAPY ON THE LEVEL OF CORTISOL IN POSTPARTUM PRIMIPARA

2018 ◽  
Vol 4 (1) ◽  
pp. 26-30
Author(s):  
Yulinda Laska ◽  
Suryono Suryono ◽  
Melyana Nurul Widyawati ◽  
Ari Suwondo ◽  
Suryati Kusworowulan
Keyword(s):  
Music Therapy ◽  
Alternative Therapy ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Brain Wave ◽  
Anova Test ◽  
Sound Therapy ◽  
Cortisol Levels ◽  
One Way Anova

Background: Prevalence of postpartum blues for Asia between 26-85%, while the prevalence in Indonesia is 50-70%. Of all women postpartum can experience this is experiencing stress, almost 80% of primiparous moms experience feelings of sadness after childbirth. These stresses can trigger an increase in cortisol. Music raises changes in brain wave status and stress hormones. Nature Sound music is music that has a slow tempo and can cause feelings relaxed and comfortable.Objective: To examine the effect of the nature music therapy on on cortisol levels in postpartum primipara.Methods: This was a true experimental study with pretest-posttest control group design. The study was conducted in the postpartum ward in the General Hospital of Semarang from November 2016 to January 2017. There were 39 postpartum primipara recruited in this study using simple random sampling divided into three groups: 1) the experiment group who received the nature music therapy for 15 minutes, 2) the experiment group who received the nature music therapy for 30 minutes, and 3) the control group. One-way ANOVA test was performed for data analysis.Results: One-way anova test showed p-value 0.010 (<0.05), which indicated that there was a statistically significant effect of the nature sound therapy on the cortisol level in the postpartum primipara.Conclusion: There was a significant effect of the nature music therapy on the cortisol levels in postpartum primipara. Thus, the application of nature music therapy can be an alternative therapy especially for postpartum primipara who experience emotional stress, physical, anxiety, and fatigue.

PERBEDAAN METODE SIMULASI DENGAN METODE DEMONSTRASI TERHADAP KEBERHASILAN BELAJAR PRAKTEK PALPASI LEOPOLD PADA MAHASISWA TINGKAT I AKBID NGUDI WALUYO UNGARAN SEMARANG TAHUN 2011

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Intan Sari Intan Sari
Keyword(s):  
Sampling Technique ◽  
Simulation Method ◽  
First Grade ◽  
Control Group ◽  
P Value ◽  
Grade Point ◽  
Purposive Sampling ◽  
Learning Success ◽  
Post Hoc ◽  
One Way Anova

ABSTRACT A Method is a component of learning that has a very important role. Based on the preliminary studies, the grade point of Midwifery Care I in academic year of 2009/2010  from 119 people showed that 60 people got C, 38 people got B and 21 people got A . During this time, Leopold palpation practice in the laboratory used simulation method and demonstration method. The purpose of this study was to know the difference between simulation and demonstration methods to learning success practicing Leopold palpation of first grade students Ngudi Waluyo Academy of Midwifery in 2011. This study used pre-experimental research design. The design of this study was the Static Group Comparison. The population of study consisted of 138 students taken by purposive sampling technique, as many as 35 students. The results of One Way ANOVA statistical test obtained the p value which was 0.000 < a, and it could be concluded that there were significant differences of learning success of first grade students in practicing Leopold palpation by using three group, and then it was followed by Post Hoc test obtaining p value = 0.009 > a. It could be concluded that there was difference between simulation and demonstration learning methods to the learning success practicing Leopold palpation of first grade students in of Ngudi Waluyo Academy of Midwifery in 2011.Lecturers should be expected Ngudi Waluyo Academy of Midwifery prefers  use of the demonstration method in practicing Leopold palpation because of the research results proved that the use of demonstration methods to improve student learning success..   ABSTRAK Metode merupakan komponen pengajaran yang memiliki peranan yang sangat penting. Berdasarkan studi pendahuluan nilai Askeb I Tahun Ajaran 2009/2010 dari 119 mahasiswa yang mendapatkan nilai C ada 60 orang, nilai B sebanyak 38 orang dan mendapatkan nilai A berjumlah 21 orang. Selama ini praktek palpasi Leopold di laboratorium menggunakan metode simulasi dan metode demonstrasi. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan metode simulasi dengan metode demonstrasi terhadap keberhasilan belajar praktek palpasi Leopold pada mahasiswa tingkat I Akbid Ngudi Waluyo Ungaran Semarang Tahun 2011. Penelitian ini menggunakan rancangan penelitian eksperimen semu. Desain penelitian ini adalah Non-randomized Control Group Pretest-Postest Design). Populasi penelitian ini berjumlah 138 mahasiswa. Pengambilan sampel menggunakan tehnik Purposive Sampling yang berjumlah 35  mahasiswa. Dari hasil uji statistik One Way ANOVA didapatkan nilai p value 0,000 < a, dapat disimpulkan ada perbedaan keberhasilan belajar (post test) yang bermakna pada tiga kelompok. kemudian dilanjutkan dengan Uji Post Hoc didapatkan nilai p value 0,009 > a, dapat disimpulkan ada perbedaan antara metode simulasi dengan metode demonstrasi terhadap keberhasilan belajar praktek palpasi Leopold pada mahasiswa tingkat I Akbid Ngudi Waluyo Ungaran Semarang Tahun 2011. Diharapkan sebaiknya tenaga pengajar di Akbid Ngudi Waluyo Ungaran Semarang lebih mengutamakan penggunaan metode demonstrasi pada praktek Palpasi Leopold karena dari hasil penelitian terbukti bahwa penggunaan metode demonstrasi mampu meningkatkan keberhasilan belajar mahasiswa..

scholarly journals Efektifitas Variasi Umpan Pada Fly Trap Dalam Pengendalian Kepadatan Lalat Di Tempat Pembuangan Sementara (TPS) Jalan Andong Yogyakarta

2020 ◽  
Vol 20 (1) ◽  
pp. 59-64
Author(s):  
Eva Fitriana ◽  
Surahma Asti Mulasari
Keyword(s):  
Experimental Study ◽  
High Population ◽  
Disposal Site ◽  
P Value ◽  
Significant Difference ◽  
The One ◽  
Post Hoc ◽  
One Way Anova

Latar Belakang: Lalat merupakan salah satu serangga yang memiliki populasi tinggi di lingkungan masyarakat. Lalat berperan dalam penularan penyakit pada manusia seperti disentri, tifoid, kolera infeksi cacing, conjungtivitis, trachoma kusta, mikosis, dan difteri kutaneus. Fly trap digunakan untuk pengendalian lalat dewasa dalam jumlah besar dan padat. Penerapan Fly trap dilakukan diluar rumah pada udara terbuka dan tidak terhindar dari pepohonan. Penggunaan alat ini berpasangan dengan umpan yang digunakan untuk menarik lalat dengan bau dan kandungan pada umpan. Penelitian ini dilakukan untuk mengetahui efektifitas variasi umpan pada Fly trap dalam pengendalian lalat di tempat pembuangan sementara (TPS) Jalan Andong Yogyakarta.Metode: Penelitian ini merupakan penelitian eksperimen dengan variasi umpan ikan, udang, buah nangka, terasi, dan buah mangga. Pengukuran dilakukan pada radius ± 1 Meter dari tumpukan sampah dan dibiarkan selama 2 jam selanjutnya lalat yang terperangkap dihitung menggunakan handcounter. Data yang diperoleh dianalisis menggunakan uji One Way Anova dengan derajat kesalahan α 0.05 dan dilanjutkan uji Post hoc Tamhanne.Hasil: Hasil penelitian menunjukan terdapat hasil yang signifikan rata-rata lalat yang terperangkap pada Fly trap dengan umpan terasi dan umpan udang diperoleh nilai p=0,042 (p<α). Terdapat perbedaan bermakna antara umpan terasi dan umpan udang. Lalat yang terperangkap pada Fly trap umpan terasi sebanyak 69 ekor lalat, dan lalat yang terperanfkap pada Fly trap umpan udang sebanyak 1123 ekor lalat.Simpulan: Ada perbedaan rata-rata lalat yang terperangkap pada Fly trap umpan ikan, udang, buah nangka, terasi dan buah mangga. Terdapat perbedaan bermakna rata-rata lalat yang terperangkap antara Fly trap umpan terasi dan umpan udang. ABSTRACT Title: The Effectivennes of various feed variations in the fly trap as a control of fly density at the Andong street Yogyakarta.Background: Flies are one of the insects that have a high population in the community. Flies play a role in transmitting disease to humans such a dysentery, typoid, cholera, worm infection, conjungtivitis, leprosy trachoma, mycosis and cutaneus diphteria. Fly traps are used fpr the control of large and dense adult flies. The application on fly traps is carried out outside the house in the open air and is not spared from trees. The use of this tool is paired with the bait used the attract flies to get closer to the smell and content of the bait, this research was conducted to determine the effectiveness of bait varians in the fly trap in controlling flies at the temporary disposal site (TPS) at the Andong street Yogyakarta.Method: This research was a experimental study with a variety of bait fish, shrimp, jackfruit, shrimp paste, and mango. Measurements were made at radius of ± 1 meter from the garbage pile. The data obtained were analyzed using the One Way Anova tesy with an error degree of α=0,05 and continued with the Post hoc Tamhanne test.Result: The result showed that there were significant result on the average of flies trapped in the fly trap with the shrimp paste bait and shrimp bait obtained p value = 0.042 (p<α). That there was a significant difference between shrimp paste bait and shrimp bait.Conclusions: There was a difference in the average number of flies trapped in fly traps for fish, shrimp, jackfruit, shrimp paste, mango. There was a significant difference of flies trapped between shrimp paste bait and shrimp bait. Fly trap shrimp bait is the most preferred bait by flies shrimp paste bait is the least preferred bait by flies.  

scholarly journals Pengaruh Tawas dan Waktu Pengadukan Terhadap Kadar Fosfat pada Limbah Cair Laundry di Martapura Kabupaten Banjar

2017 ◽  
Vol 14 (1) ◽  
pp. 431
Author(s):  
Rifani Alfian ◽  
Sulaiman Hamzani ◽  
Abdul Khair
Keyword(s):  
Liquid Waste ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Anova Test ◽  
Washing Process ◽  
Central District ◽  
Stirring Time ◽  
Laundry Washing ◽  
One Way Anova

Abstract: Effect of Stirring Time Alum And Phosphate Levels In Liquid Waste Martapura Laundry In Central District. One of the wastes produced is phosphate. Disposal of waste which contains phosphates in the water can cause eutrophication processes in the aquatic environment. Therefore it needs proper methods for treating waste that contains a lot of laundry phosphate compounds that safely discharged into the environment. This study aims to determine the effect of the use of alum and alum stirring time on levels of phosphate in laundry wastewater XXX in Martapura, Banjar.This type of research is shaped Experimental research. Design The study design is randomized pretest-posttest control group design. The sample was liquid waste from the laundry XXX Laundry washing process that represents the entire population of data analysis using One Way ANOVA Test. The result of a decrease in the average levels of phosphate in sequence on each variation of stirring time, ie 92.7%; 99.6%; and 96.7%. The statistical test used is One Way Anova test. Based on an analysis using One Way ANOVA in the treatment group p-value (0.00

scholarly journals Evaluasi Pengaruh Konsentrasi Pati Biji Cempedak (Artocarpus champeden) sebagai Bahan Pengisi pada Formulasi Tablet Paracetamol

2021 ◽  
Vol 6 (2) ◽  
pp. 111-118
Author(s):  
Noval Noval ◽  
Rizka Appriliani ◽  
Husda Oktaviannoor
Keyword(s):  
Control Group ◽  
P Value ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Anova Test ◽  
Whitney Test ◽  
Mann Whitney Test ◽  
The One ◽  
Artocarpus Champeden ◽  
One Way Anova

Cempedak plants are widely distributed in Indonesia, one of which is Kalimantan. Cempedak is a tropical plant, so its potential can be used as an additive in the manufacture of pharmaceutical preparations. Previous studies used cempedak seed starch as a binding agent in tablet formulations. This study aims to determine the effect of variations in concentration and optimum concentration of Cempedak seed starch (Artocarpus champeden) as a filler for Paracetamol tablets. The study used a True Experimental Design design with a posttest-only control group design. Making tablets using the wet granulation method. Data analysis used the one-way ANOVA test followed by the LSD test and the Kruskal-Wallis H test which continued with the Mann Whitney Test as a derivative test of the one-way ANOVA. Granule evaluation includes organoleptic, flow properties, tapping test, and stationary angle test. The results of the evaluation of the granules produced granules produced from each formulation are in accordance with the requirements. Tablet evaluation included organoleptic, uniformity in weight, the hardness of tablet, friability, and disintegration time. The results of the tablet evaluation showed that the maximum concentration of cempedak seeds was found in F1 because it showed the evaluation results that were in accordance with the requirements. In evaluating the uniformity of weight and hardness of tablets with the Kruskal Wallis H test and the Mann Whitney test, the results show that there are differences in each formula with a P-value <0.05. The results of the evaluation of tablet friability and disintegration time with one-way ANOVA test and LSD test showed differences in each formula with a P-value <0.05. Cempedak seed starch (Artocarpus champeden) can be used as a filler in the loading of Paracetamol tablets by the wet granulation method.

scholarly journals Pengaruh Perendaman Kopi Robusta dan Arabika terhadap Kekerasan Resin Komposit Nanofiller

e-GIGI ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Fransiska M. Pardosi ◽  
Darmawati A. Indraswari ◽  
Lusiana Batubara ◽  
Nadia Hardini
Keyword(s):  
Composite Resin ◽  
Artificial Saliva ◽  
Control Group ◽  
Arabica Coffee ◽  
Treatment Groups ◽  
Hardness Tester ◽  
Robusta Coffee ◽  
Significant Difference ◽  
Post Hoc ◽  
One Way Anova

Abstract: Nanofiller composite resin has small filler size which enhances its properties. However, these properties could decrease due to several factors. Acidic liquid such as coffee could reduce the hardness of composite resin. This study was aimed to analyze the effect of robusta and arabica coffee immersion on the hardness of nanofiller composite resin. A total of 27 composite resin samples were used and then were polished by using a soflex disc for 30 seconds on each roughness level. Samples were then divided into three groups, as follows: the control group with artificial saliva and the treatment groups with robusta coffee and arabica coffee. The composite resin molds were immersed in the three groups for 5 days. After five days of immersion, the hardness of the sample was tested by using a Vickers hardness tester. Artificial saliva as the control group had the highest mean hardness value of 112.98±8.67 VHN, followed by robusta coffee, and then by arabica coffee. The One Way Anova and post hoc LSD test showed that there were significant differences in all groups (p<0.05) except for the two treatment groups, namely robusta and arabica coffee groups which did not show any significant difference in the resin hardness (p>0.05). In conclusion, robusta and arabica coffee affect the hardness of the nanofiller composite resin, but there is no significant difference in the hardness between the robusta and arabica coffee groups.Keywords: composite resin hardness, nanofiller, robusta coffee, arabica coffee Abstrak: Resin komposit nanofiller memiliki ukuran filler kecil yang dapat meningkatkan fungsinya namun fungsi tersebut dapat menurun oleh beberapa hal. Cairan asam yang dikonsumsi seperti kopi dapat menurunkan kekerasan resin komposit. Penelitian ini bertujuan untuk mengetahui pengaruh perendaman kopi robusta dan arabika terhadap kekerasan resin komposit nanofiller. Sampel resin komposit yang digunakan sebanyak 27 buah dan dilanjutkan dengan pemolesan menggunakan soflex disc selama 30 detik setiap tingkat kekasarannya. Sampel kemudian dibagi dalam tiga kelompok, yaitu kelompok kontrol dengan saliva buatan dan dua kelompok perlakuan dengan kopi robusta dan arabika. Sebanyak 27 buah resin komposit direndam ke dalam tiga kelompok tersebut selama lima hari kemudian diuji kekerasannya dengan vickers hardness tester. Saliva buatan sebagai kelompok kontrol memiliki nilai rerata kekerasan tertinggi sebesar 112,98±8,67 VHN, diikuti kopi robusta, dan nilai terendah yaitu kopi arabika. Hasil uji One Way Anova dan post hoc LSD menunjukkan terdapat perbedaan bermakna pada semua kelompok (p<0,05) kecuali pada kedua kelompok perlakuan yaitu antara kopi robusta dan arabika tidak menunjukkan adanya perbedaan kekerasan yang bermakna (p>0,05). Simpulan penelitian ini ialah kopi robusta dan arabika memengaruhi kekerasan resin komposit nanofiller namun tidak terdapat perbedaan kekerasan antara keduanya.Kata kunci: kekerasan resin komposit, nanofiller, kopi robusta, kopi arabika

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