scholarly journals Antimicrobial evaluation of methyl 4-O-Acetyl-α-L-Rhamnopyranoside derivatives

2013 ◽  
pp. 33-43
Author(s):  
Mohammed M Matin ◽  
Mohammad Ibrahim ◽  
Md Shafiqur Rahman
Keyword(s):  
Pathogenic Bacteria ◽  
Pathogenic Fungi ◽  
Macrophomina Phaseolina ◽  
Antibacterial Activities ◽  
Salmonella Typhi ◽  
Shigella Dysenteriae ◽  
Curvularia Lunata ◽  
In Vitro Antibacterial Activity ◽  
Antimicrobial Evaluation

A number of 2,3-di-O-acyl derivatives (6-11) of methyl 4-O-acetyl-a-Lrhamnopyranoside (5) obtained by using various acylating agents were screened for in vitro antifungal activity against four plant pathogenic fungi, viz., Alternaria alternata, Curvularia lunata. Fusarium equiseti and Macrophomina phaseolina. These compounds were also screened for in vitro antibacterial activity against ten human pathogenic bacteria, viz., Bacillus subtilis, Bacillus cereus, Bacillus megaterium, Staphylococcus aureus, Escherichia coli, INABA ET (Vibrio), Pseudomonas species, Salmonella paratyphi, Shigella dysenteriae and Salmonella typhi. The study reveal that these 4-O-acetyl-?-L-rhamnopyranoside derivatives are more prone towards antifungal activities than that of antibacterial activities. DOI: http://dx.doi.org/10.3329/cujbs.v3i1.13404 The Chittagong Univ. J. B. Sci.,Vol. 3(1&2):33-43, 2008

scholarly journals Comparative Antimicrobial Activities of some Monosaccharide and Disaccharide Acetates

2013 ◽  
Vol 5 (3) ◽  
pp. 515-525 ◽  
Author(s):  
M. M. Matin ◽  
M. M. H. Bhuiyan ◽  
A. Afrin ◽  
D. C. Debnath
Keyword(s):  
Pathogenic Bacteria ◽  
Pathogenic Fungi ◽  
Salmonella Typhi ◽  
Antimicrobial Activities ◽  
Shigella Dysenteriae ◽  
Curvularia Lunata ◽  
Sucrose Octaacetate ◽  
Antimicrobial Studies ◽  
Activity Structure

A number of furanose (2,4) and pyranose (5,7,9,11,13) acetates were prepared by direct acetylation method. For comparative antimicrobial studies sucrose octaacetate (14) was also prepared. All the compounds (1-14) were screened for in vitro antibacterial activity against ten human pathogenic bacteria viz. Bacillus subtilis, Bacillus cereus, Bacillus megaterium, Staphylococcus aureus, Escherichia coli, INABA ET (Vibrio), Pseudomonas species, Salmonella paratyphi, Salmonella typhi and Shigella dysenteriae. These compounds were also screened for in vitro antifungal activity against four pathogenic fungi viz. Aspergillus niger, Alternaria alternata, Curvularia lunata and Fusarium equiseti. The study revealed that the pyranose acetate derivatives (5,7,9,11,13) are more prone towards antimicrobial functionality than those of the furanose acetates (2,4) and sucrose octaacetate (14).  Keywords: Glucofuranose; Glucopyranose; Acetylation; Antimicrobial activity; Structure activity relationship (SAR).  © 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.  doi: http://dx.doi.org/10.3329/jsr.v5i3.15695 J. Sci. Res. 5 (3), 515-525 (2013)

Synthesis, physical characterization, and antifungal and antibacterial activities of oleic acid capped nanomagnetite and cobalt-doped nanomagnetite

2020 ◽  
Vol 98 (1) ◽  
pp. 34-39 ◽  
Author(s):  
Abbas Rahdar ◽  
Hamid Beyzaei ◽  
Mohsen Saadat ◽  
Xiao Yu ◽  
John F. Trant
Keyword(s):  
Oleic Acid ◽  
Fenton Reaction ◽  
Pathogenic Bacteria ◽  
Pathogenic Fungi ◽  
Antibacterial Activities ◽  
Shigella Dysenteriae ◽  
Vibrating Sample Magnetometry ◽  
Solution Combustion ◽  
X Ray

Nanoparticles, 10–14 nm, consisting of either Fe3O4 or Co0.2Fe2.8O4 stabilized with oleic acid, were prepared using solution combustion. Their structural and magnetic properties were examined using X-ray diffractometry, scanning electron microscopy, vibrating sample magnetometry, and Fourier-transform infrared spectroscopy. The properties of both sets of materials are similar, except that the cobalt-doped particles are considerably less magnetic. The in vitro inhibitory activities of the nanoparticles were assessed against pathogenic bacteria Shigella dysenteriae, Klebsiella pneumoniae, Acinetobacter baumannii, Streptococcus pyogenes, and pathogenic fungi and molds Candida albicans, Fusarium oxysporum, and Aspergillus fumigatus. The magnetite nanoparticles were moderately effective against all tested pathogens, but the activity of the cobalt-doped nanoparticles was significantly lower, possibly due to an interruption of the Fenton reaction at the bacterial membrane. This work suggests that potentially doping magnetite with stronger metal oxidants may instead enhance their antimicrobial effects.

scholarly journals Synthesis, Characterization and Antimicrobial Evaluation of Cobalt(III) Complexes of 4-(2-Substituted Phenylimino)-2-(4-Substituted Phenyl)-4H-chromen-3-ol

2019 ◽  
Vol 31 (9) ◽  
pp. 2015-2021
Author(s):  
Ashok K. Singh ◽  
Suresh K. Patel ◽  
Asif Jafri
Keyword(s):  
Magnetic Measurements ◽  
Antibacterial Activities ◽  
Salmonella Typhi ◽  
Antimicrobial Activities ◽  
Diffusion Method ◽  
Mass Spectral ◽  
Antimicrobial Evaluation ◽  
Uv Visible ◽  
Paper Disc

A series of eight Co(III) complexes [CoL1-8(H2O)2Cl] (I-1 to I-8) incorporating 4-(2-substituted phenylimino)-2-(4-substituted phenyl)-4H-chromen-3-ol, as a tridentate imino flavone ligands (L1 to L8, 2-sub. = NH2, SH, 4-sub. = OMe, OH, Cl, NMe2) have been synthesized, characterized and the geometry of the complexes were optimized by DFT. The chemical structure of synthesized imino flavone ligands and their complexes were characterized by elemental analysis, 1H NMR, 13C NMR, UV-visible, IR, ESI-mass spectral data, conductometric and magnetic measurements. The synthesized compounds have been screened for their in vitro antibacterial activities against bacteria Vibrio cholerae, Salmonella typhi, Staphylococcus aureus, Escherichia coli and antifungal activities against fungi Candida albicans and Aspergillus flavus by paper disc diffusion method. The complexes I-3, I-4, I-7 and I-8 showed good antimicrobial activities against pathogens.

scholarly journals Synthesis and Antimicrobial Evaluation of Some Thiazole Derivatives

2010 ◽  
Vol 3 (1) ◽  
pp. 111 ◽  
Author(s):  
M. H. Bhuiyan ◽  
A. F. M. H. Rahman
Keyword(s):  
Antimicrobial Activity ◽  
Aromatic Aldehydes ◽  
Salmonella Typhi ◽  
Shigella Dysenteriae ◽  
Curvularia Lunata ◽  
Thiazole Derivatives ◽  
Penicillium Notatum ◽  
Antimicrobial Evaluation ◽  
Aspergillus Funiculosus ◽  
Acyl Halides

Reaction of 2-amino-4-phenylthiazole with various aromatic aldehydes afforded 2-arylideneamino-4-phenylthiazoles. On the other hand treatment of 2-amino-4-phenylthiazole with several acyl halides furnished N-(thiazol-2-yl)-amides. The synthesized compounds have been screened for their antimicrobial activity against Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Shigella dysenteriae, Salmonella typhi, Pseudomonous sp. bacteria and Aspergillus niger, Penicillium notatum, Aspergillus funiculosus, Collectrichum corchori Ikata (Yoshida) and Curvularia lunata fungi respectively. Some of the synthesized compounds exhibited pronounced antimicrobial activities.Keywords:  Aminothiazole; Arylideneaminothizole; N-(Thiazol-2-yl)-amide; Antimicrobial activity.© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi:10.3329/jsr.v3i1.5419                J. Sci. Res. 3 (1), 111-119 (2011)

scholarly journals Antimicrobial activity of crude extracts obtained from Chaetocarpus castanocarpus Roxb Thw. against human pathogens

2013 ◽  
pp. 83-90
Author(s):  
Sujan Dey ◽  
Md Shafiqur Rahman
Keyword(s):  
Ethyl Alcohol ◽  
Pathogenic Bacteria ◽  
Ethanol Extract ◽  
Pathogenic Fungi ◽  
Salmonella Typhi ◽  
Chloroform Extract ◽  
Shigella Dysenteriae ◽  
Human Pathogens ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

An attempt was made to investigate the antibacterial and antifungal activities of Petroleum ether, carbon tetrachloride, chloroform and ethyl alcohol extracts from Chaetocarpus castanocarpus against ten human pathogenic bacteria viz., Shigella dysenteriae, Salmonella typhi, S. paratyphi, Bacillus subtilis, B. cereus, B. megaterium, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Vibrio cholerae and three human pathogenic fungi viz., Aspergillus niger, A. ochraceus, and A. ustus using disc diffusion and poisoned food method respectively. The chloroform and ethyl alcohol extracts showed good antibacterial and antifungal activity against the tested organisms. The crude extract of chloroform exhibited the largest zone of inhibition (26 mm in diameter with 2000 mg/disc extract) against S. dysenteriae. In case of fungi, the highest percentage of inhibition (42.5.0% with 100 mg/ml medium) was recorded against A. ustus. The MICs were determined by broth macrodilution method. The lowest MIC (750 mg/ml) was recorded against B. megaterium towards chloroform and ethanol extract, and V. cholerae towards chloroform extract. In case of fungi, chloroform and ethanol extract exhibited the lowest MIC (2000 mg/ml) against A. ustus, and chloroform extract against A. niger. DOI: http://dx.doi.org/10.3329/cujbs.v4i1.13389 The Chittagong Univ. J. B. Sci.,Vol. 4(1&2):83-90, 2009

scholarly journals In vitro Antibacterial Activity of Mentha spicata Essential Oil against Some Pathogenic Bacteria

2021 ◽  
Vol 11 (1) ◽  
pp. 13-15
Author(s):  
Sara I. Othman ◽  
Fouad H. Kamel
Keyword(s):  
Pathogenic Bacteria ◽  
Antibacterial Activities ◽  
Antimicrobial Activities ◽  
Mentha Spicata ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Aerial Parts ◽  
In Vitro Antibacterial Activity ◽  
Pharmaceutical Industries

Mentha spicata (M. spicata) is within family Lamiaceae that spreads mainly in the temperate and subtemperate zones of the world. It is considered as a good source of essential oils (EOs), which is widely used in food production and pharmaceutical industries. The aim of the current study is to evaluate antibacterial activities associated with the EO of M. spicata cultivated in Iraq-Erbil city. The aerial parts of M. spicata were subjected to hydro distillation to extract the oil. Antimicrobial potential was tested against many microorganisms, signifying Gram-negative and Gram-positive bacteria. EO of M. spicata demonstrated antimicrobial activities with best susceptibility observed for Gram-negative bacteria toward the oil. The results suggest that EO of M. spicata may have potential value as antibacterial activities.

scholarly journals Isolation of a New Mexican Strain ofBacillus subtiliswith Antifungal and Antibacterial Activities

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
M. G. L. Basurto-Cadena ◽  
M. Vázquez-Arista ◽  
J. García-Jiménez ◽  
R. Salcedo-Hernández ◽  
D. K. Bideshi ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Fusarium Verticillioides ◽  
Pathogenic Fungi ◽  
Antibacterial Activities ◽  
Phytopathogenic Fungi ◽  
Antagonistic Activity ◽  
Plant Pathogenic Fungi ◽  
New Mexican ◽  
Number Of Leaves

Although several strains ofB. subtiliswith antifungal activity have been isolated worldwide, to date there are no published reports regarding the isolation of a nativeB. subtilisstrain from strawberry plants in Mexico. A native bacterium (Bacillus subtilis21) demonstratedin vitroantagonistic activity against different plant pathogenic fungi. Under greenhouse conditions, it was shown that plants infected withRhizoctonia solaniandFusarium verticillioidesand treated withB. subtilis21 produced augment in the number of leaves per plant and an increment in the length of healthy leaves in comparison with untreated plants. In addition,B. subtilis21 showed activity against pathogenic bacteria. Secreted proteins byB. subtilis21 were studied, detecting the presence of proteases and bacteriocin-like inhibitor substances that could be implicated in its antagonistic activity. Chitinases and zwittermicin production could not be detected. Then,B. subtilis21 could potentially be used to control phytopathogenic fungi that infect strawberry plants.

scholarly journals Template synthesis and characterization of biologically active transition metal complexes comprising 14-membered tetraazamacrocyclic ligand

2010 ◽  
Vol 75 (2) ◽  
pp. 217-228 ◽  
Author(s):  
Dharmpal Singh ◽  
Krishan Kumar ◽  
Ramesh Kumar ◽  
Jitender Singh
Keyword(s):  
Magnetic Measurements ◽  
Macrocyclic Ligand ◽  
Salmonella Typhi ◽  
Molar Conductance ◽  
Biologically Active ◽  
Distorted Octahedral Geometry ◽  
Bacterial Strains ◽  
In Vitro Antibacterial Activity ◽  
Active Transition

A novel series of complexes of the type [M(C28H24N4)X2], where M = Co(II), Ni(II), Cu(II), Zn(II) and Cd(II), X = Cl-, NO3 -, CH3COO- and (C28H24N4) corresponds to the tetradentate macrocyclic ligand, were synthesized by template condensation of 1,8-diaminonaphthalene and diacetyl in the presence of divalent metal salts in methanolic medium. The complexes were characterized by elemental analyses, conductance and magnetic measurements, as well as by UV/Vis, NMR, IR and MS spectroscopy. The low values of the molar conductance indicate non-electrolyte type of complexes. Based on these spectral data, a distorted octahedral geometry may be proposed for all of these complexes. All the synthesized macrocyclic complexes were tested for in vitro antibacterial activity against some pathogenic bacterial strains, viz Bacillus cereus, Salmonella typhi, Escherichia coli and Staphylococcus aureus. The MIC values shown by the complexes against these bacterial strains were compared with the MIC shown by the standard antibiotics linezolid and cefaclor.

Bioactivity of Some Natural and Semisynthetic Coumarin Derived Compounds

2021 ◽  
Vol 19 (6) ◽  
pp. 129-138
Author(s):  
Yasser Fakri Mustafa ◽  
Moath Kahtan Bashir ◽  
Mahmood Khudhayer Oglah ◽  
Raghad Riyadh Khalil ◽  
Eman Tareq Mohammed
Keyword(s):  
Pathogenic Fungi ◽  
Salmonella Typhi ◽  
Positive Influence ◽  
Shigella Dysenteriae ◽  
Klebsiella Pneumonia ◽  
Bacterial Strains ◽  
Cancerous Cell ◽  
Free Hydroxyl ◽  
Antibacterial And Antifungal ◽  
Diffusion Assay

A couple of natural coumarins was identified in the seeds of two apples’ cultivars commonly known as Granny Smith and Red Delicious. The effect of the phenolic hydroxyl moieties found in these products was evaluated on the bioactivity. This evaluation included the structural alteration of these moieties into less hydrophilic ones to explore the significance of the parent moieties on the biological activity. The investigated biopotentials were antioxidant, antiproliferative, antibacterial, and antifungal effects. The antioxidant potential was investigated by detecting the ability of the natural and semisynthetic coumarins to trap the free hydroxyl and DPPH radicals. The antiproliferative potential was assessed via an MTT-depended assay versus eight cancerous-cell lines, included HeLa, SK-OV-3, AR42J, MCF-7, AB12, KYSE-30, LC540, and AMN3. The antibacterial potential was tested versus six common pathogenic bacterial strains via a well-defined disc diffusion assay. These pathogens were Escherichia coli, Salmonella typhi, Klebsiella pneumonia, Haemophilus influenzae, Shigella dysenteriae, and Pseudomonas aeruginosa. The antifungal potential was also screened by utilizing a similar microbiological technique versus three pathogenic fungi, involved Candida albicans, Aspergillus flavus, and Aspergillus niger. It is concluded that the investigated chemical moiety has a positive influence on the antioxidant and antiproliferative potentials of the natural derivatives, and a negative one on their antibacterial and antifungal potentials.

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