scholarly journals Nephrotherapy Determination of Ethanol Extract of African Leaves (Vernonia amygdalina Delile) on with the Parameter of Male Rat Urea Induced by Gentamisin

2019 ◽  
pp. 162-169
Author(s):  
Rizqi Nur Azizah ◽  
Irma Santi ◽  
Ayu Marlian
Keyword(s):  
Antioxidant Activities ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Negative Control ◽  
Group Iv ◽  
Male Rat ◽  
Vernonia Amygdalina ◽  
Group I ◽  
Supplement Group ◽  
Post Hoc

African leaves (Vernonia amygdalina Delile.) contain flavonoids having an antioxidant activities. The research aimed to determine the nephrotherapy effect of the ethanolic extract of African leaves with the parameter of male rat urea (Rattus norvegicus) induced by gentamicin. The research used 18 rats divided into 6 groups consisting of group I as the normal group, group Il the Negative Control (gentamicin 80 mg I kgBW), group Ill the Positive Contfol (amino acid supplement), group IV, V, and VI given the ethanol extract of African leaves, each dose of 100 mg/kgBW, 250 mg/kgBW, 500 mg/kgBW. The induction of gentamicin 80 mg/kg BW was administered for eight days and the therapy for the ethanol extract of African leaves for fourteen days. The research data were statistically analyzed using the ANOVA test followed by the Post Hoc LSD test. The results showed that the ethanol extract of African leaves had the nephrotherapy effects in reducing the urea in male rat induced by gentamicin.

scholarly journals Ethanolic Extract of Xestospongia Sp. Induces CD4+ and CD14 Cells Levels on Wistar Male Rat Infected with Staphylococcus aureus

2020 ◽  
Vol 5 (2) ◽  
Author(s):  
Adryan Fristiohady ◽  
Wahyuni Wahyuni ◽  
Muhammad H Malaka ◽  
Dewiyanti Madu ◽  
Dayatriana Muthalib ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Phagocytic Activity ◽  
Ethanolic Extract ◽  
Group Iv ◽  
Male Rat ◽  
Immunomodulatory Activity ◽  
Group Iii ◽  
Elisa Kit ◽  
Group I ◽  
Group Ii

Immunomodulator is a substance that increases or suppresses the immune response through the certain mechanism. The marine sponge Xestospongia sp. has immunomodulatory activity by increasing phagocytic activity. In addition, the phagocytic activity is affected by CD4+ and CD14 cells levels. Thus, this study aims to investigate the effect of Xestopongia sp. extract toward CD4+ and CD14 cells level in model rat. Animals were divided into 4 groups (n=5) and treated for 7 days, as follow: Group I (Ethanolic extract of Xestospongia sp. dose of 300 mg/KgBW); Group II (Ethanolic extract of Xestospongia sp. dose of 400 mg/KgBW); Group III (Phylantus niruri extract); and Group IV (0.5% Na CMC). On day 8, animals were infected with Staphylococcus aureus intraperitoneally. And the blood was collected by cardiac puncture and assayed with ELISA kit CD4 (elabscience®) and ELISA kit CD14 (elabscience®). Ethanolic extract of Xestospongia sp. provided high levels of both CD4+ and CD14 cells (Group II) compared to baseline (Group IV)  (p<0.05). Group I provided similar activity to group III (p>0.05) and Group II provided significant activity with higher levels of CD4+ and CD14 cells compared to group III (p<0.05). In conclusion, both doses of Xestospongia sp. extract provide activity as immunomodulator by increasing CD4+ and CD14 cells levels, yet dose of 400 mg/KgBw provides the higher immunomodulatory activity.

scholarly journals Immunomodulator Activity of Effervescent Granule of Wualae Fruit (Etlingera elatior (Jack) R.M. Smith) Based on Specific Phagocytic Activity

2019 ◽  
Vol 2 (2) ◽  
pp. 35-40 ◽  
Author(s):  
Adryan Fristiohady ◽  
Wa Ode Siti Zubaydah ◽  
Wahyuni Wahyuni ◽  
Mirda Mirda ◽  
Saripuddin Saripuddin ◽  
...  
Keyword(s):  
Phagocytic Activity ◽  
Ethanolic Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Group Iv ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Etlingera Elatior

The previous study reported that Etlingera elatior (Wualae) has activity as immunostimulant with dose at 300 mg/kg BW and 400 mg/kg BW. Formulating natural product into effervescent granule (GE) can increase practicality and interest to consume traditional medicine. This study aims to investigate the immunostimulant activity of Wualae ethanolic extract in the effervescent granule. Wualae was macerated with ethanol then formulated into effervescent granule at dose 300 mg/kgBW and 400 mg/kgBW. Formulations were evaluated. Animals were divided into 4 groups and treated with: group I (positive control); group II (negative control); group III (GE dose at 300mg/kgBW); and group IV (GE at dose 400mg/kgBW) for 7 days and at days 8, groups were infected by Staphylococcus aureus intraperitoneally. Immunostimulant activity was measured by calculating the Specific Phagocytic Activity (SPA) of macrophage. Data collected from the evaluation and measurement of the SPA then analyzed using SPSS. Results from the evaluation were considered good except the moisture content of effervescent granule. Results from SPA was found that effervescent granule at dose 300 mg/kgBW and at dose 400 mg/kgBW have 26.33% and 32.5% consecutively with significance 0.02 (p<0.05). Thus, effervescent granule has comparable phagocytosis activity with positive control.

PENGARUH PEMBERIAN EKSTRAK ETHANOL BIJI BUAH PINANG (ARECA CATECHU L.) TERHADAP PERTUMBUHAN STAPHYLOCOCUS AUREUS SECARA IN VITRO

2018 ◽  
Vol 6 (1) ◽  
pp. 10-19 ◽  
Author(s):  
MIftakhul Baiti ◽  
Solha Elfrida ◽  
Lipinwati Lipinwati
Keyword(s):  
Staphylococcus Aureus ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Test Statistic ◽  
Group I ◽  
Areca Catechu ◽  
Amoxicillin Clavulanate ◽  
Post Hoc

ABSTRACT Background: Infectious disease is known as a global concern because of the irrational, excessive and long term use of antibiotics especially in Staphylococcus aureus infection. The unecessarily use of antibiotics can creat a resistance issue such as MSSA, MRSA, VISA and VRSA. So as a new alternative that is being developed in medicine, herbal plants are used. Areca nut (Areca catechu. L) is a herbal plant that is found in Indonesia, especially in Province of Jambi, betel nut is one of the best in the world. The aim of this study are to investigate phytochemical components and inhibition effect Staphylococcus aureus ATCC 25923 using dry ethanol extract of betel nuts at concentrations 20%, 30%, 40% and 50% in vitro. Method: Antibacterial sensitivity tests against Staphylococcus aureus ATCC 25923 were performed using dry ethanol extract of betel nuts (Areca catechu. L) with various concentrations on each group. Group I is treated nut with a concentration of 20%, Group II with a concentration of 30%, Group III with a concentration of 40%, Group IV with a concentration of 50%, the group V as a negative control (distilled) and group VI as a positive control that was given amoxicillin clavulanate 30μg. Then the inhibitory effects of these treatments are measeure and classified by the Davis and Stout classification in 1971. The data analysis began with Saphiro Wilk test and then with levent test statistic. Because distributed data is not normal, the analysis continued with Kruskal Wallis test and Post Hoc test. Results: Results of this study showed that the ethanol extract of betel nuts can inhibit the growth of S. aureus, which is a concentration of 20% with a diameter of 13,63mm, concentration of 30% with a diameter of 15mm, concentration of 40% with a diameter of 15,5mm, concentration of 50% with a diameter of 14,7mm compared to the positive control 30μg amoxicillin clavulanate in inhibiting the growth of S. aureus with a diameter of 34,25mm. Conclusion: The ethanol  extract of betel nuts can inhibit the growth of Staphylococcus aureus in vitro. Areca seed extract with concentration of 40% is the optimum concentration to inhibit the growth of Staphylococcus aureus. Keywords: Staphylococcus aureus, Areca catechu. L,  Sensitivity Test.   ABSTRAK Latar Belakang : Penyakit infeksi merupakan masalah yang menjadi perhatian global, oleh karena penggunaan antibiotik yang irasional, berlebihan dan dalam jangka waktu yang lama, terurama infeksi yang disebabkan oleh Staphylococcus aureus. Hal ini dapat menimbulkan masalah baru resistensi antibiotik seperti MSSA, MRSA, VISA dan VRSA. Maka sebagai alternatif baru yang sedang dikembangkan dalam pengobatan yaitu dengan menggunakan tanaman herbal. Pinang (Areca catechu. L) merupakan tanaman herbal yang banyak ditemukan di Indonesia terutama Propinsi Jambi, pinang ini merupakan salah satu pinang terbaik di dunia. Tujuan dari penelitian ini adalah untuk mengetahui komponen fitokimia dan daya hambat ekstrak ethanol biji buah pinang terhadap pertumbuhan Staphylococcus  aureus ATCC 25923 secara in vitro pada konsentrasi 20%, 30%, 40% dan 50%. Metode : Ekstrak ethanol biji buah pinang kering (Areca catechu. L) dilakukan uji sensitifitas antibakteri terhadap Staphylococcus  aureus ATCC 25923 dengan berbagai konsentrasi pada masing – masing kelompok. Kelompok I yaitu perlakuan pinang dengan konsentrasi 20%, kelompok II dengan konsentrasi 30%, kelompok III dengan konsentrasi 40%, kelompok IV dengan konsentrasi 50%, kelompok V sebagai kontrol negatif (Aquades) dan kelompok VI sebagai kontrol positif dengan diberikan Amoksisilin Klavulanat 30µg. Kemudian diukur efek inhibisi dari perlakuan tersebut dan digolongkan berdasarkan penggolongan Davis and Stout 1971. Analisis data diawali dengan uji Saphiro-Wilk dan dilanjutkan dengan uji Levene, oleh karena data terdistribusi tidak normal maka dilakukan uji Kruskal Wallis  dan uji  Post Hoc. Hasil : Hasi penelitian menunjukkan bahwa ekstrak ethanol  biji buah pinang dapat menghambat pertumbuhan S. aureus, yaitu konsentrasi 20%  dengan diameter 13,63mm, konsentrasi 30%  dengan diameter 15mm, konsentrasi 40%  dengan diameter 15,5mm, konsentrasi 50% dengan diameter 14,7mm. Terdapat pengaruh  Areca catechu. L dalam menghambat pertumbuhan Staphylococcus  aureus ATCC 25923. Kesimpulan : Ekstrak ethanol biji buah pinang dapat menghambat pertumbuhan Staphylococcus aureus secara in vitro. Konsentrasi ekstrak biji buah pinang 40% merupakan konsentrasi optimum dalam menghambat pertumbuhan Staphylococcus aureus. Kata Kunci : Staphylococcus aureus, Areca catechu. L,  Uji Sensitifitas.

Pengujian Efektivitas Penyembuhan Luka Mencit Diabetes Melitus Yang Diberikan Sediaan Krim Ekstrak Etanol Daun Bandotan

2016 ◽  
Vol 6 (1) ◽  
pp. 50
Author(s):  
Ria Afrianti ◽  
Dedi Nofiandi ◽  
Dira Dira ◽  
Widya Ulfa
Keyword(s):  
Wound Healing ◽  
Ethanolic Extract ◽  
Positive Control ◽  
Negative Control ◽  
Collagen Fibers ◽  
Group Iv ◽  
Ageratum Conyzoides ◽  
Group V ◽  
Group Iii ◽  
Group I

Bandotan plants (Ageratum conyzoides (L.) L.) commonly used as agent in the treatment of inflammatory, wound, and also used used as analgesic, stimulant and tonic. In this study we carried out a test of the effectiveness of the cream (w/o) of ethanolic extract of bandotan leaves in wound healing in streptozocin-induced hyperglycemia mice. Animals were divided into five groups: Group I (without induced, given cream base w/o), group II (induced, given cream base w/o), group III (induced, given cream containing 3% extract), group IV (induced, given cream containing 5% extract) and group V (induced, given cream containing 7% extract). Animals also divided into three subgroups based on time of decapitation on 7th, 14th and 21th days. The parameters observed were the percentage of wound healing and collagen fibers density scores. Results were analyzed by Two-Way ANOVA. The results showed that the cream in concentration of 3%, 5% and 7% could affect wound healing in hyperglycemia mice. The percentage of wound healing of the cream in concentration of 3%, 5% and 7% were significantly different (p<0,05) with positive control, and density scores of collagen fibers was also significantly different (p<0,05) from the positive control and negative control. However, the best results was obtained from cream containing 5% extract which perrcentage of wound healing reached 98.5% on 21th day and got a score of 3 for density of collagen fibers that had been formed on the 14th day. 

scholarly journals ANTI-ULCER ACTIVITY OF AFRICAN LEAVES (VERNONIA AMYGDALINA DEL.) ETHANOL EXTRACT ON MALE RAT

2018 ◽  
Vol 11 (3) ◽  
pp. 375
Author(s):  
Wahyudi Wahyudi ◽  
Edy Suwarso ◽  
Marline Nainggolan
Keyword(s):  
Peptic Ulcer ◽  
Oral Administration ◽  
Effective Dose ◽  
Ethanol Extract ◽  
Negative Control ◽  
Male Rat ◽  
Test Results ◽  
Vernonia Amygdalina ◽  
Leaf Powder ◽  
Suspension Preparation

 Objectives: This study aims to evaluate the anti-ulcer activity of African leaves (Vernonia amygdalina Del.) ethanol extract on male rat.Methods: African leaf powder was extracted used ethanol 96% by percolation, then made into a suspension preparation used 0.5% Na-CMC with 3 dose variations (100, 200 and 400 mg/kg). Further tested its effectiveness in healing peptic ulcer in gastric-induced rats using acetosal dose 800 mg/kg with oral administration every day until surgery at 3, 8, and 14. Observations include macroscopic (number and index of ulcer) and microscopic (histopathological test).Results: A significant healing of ulcer was observed. The extract 100, 200, and 400 mg/kg group showed significant (p<0.05) reduction in number and index of ulcer as compared to the negative control. The most effective dose is 200 mg/kg because it has the greatest ability to reduce the number and index of ulcers and has the fastest recovery day.Conclusion: Results of this study indicated that African leaves (V. amygdalina Del.) ethanol extract has potential anti-ulcer activity.

UJI AKTIVITAS ANTIOKSIDAN FRAKSI N-HEKSAN DAUN AFRIKA (Vernonia amygdalina Del.) DENGAN METODE DPPH

2020 ◽  
Vol 5 (2) ◽  
pp. 250-257
Author(s):  
Nurul Fatimah ◽  
◽  
Reksi Sundu
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Free Radicals ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Hexane Fraction ◽  
Phytochemical Screening ◽  
Vernonia Amygdalina ◽  
Tropical Africa ◽  
Ic50 Value

Free radicals and reactive species are widely believed to contribute to the development of several diseases by causing oxidative stress and eventually oxidative. Vernonia amygdalina (Astereacea) is a small shrub or tree between 1 and 5m high growing throughout tropical Africa. Plants are generally known as bitter leaves is well cultivated and is a general market for merchandise in several countries. The purpose of this study was to determine the antioxidant activity of hexane fraction from ethanol extract od Frican leaves (Vernonia amygdalina Del.). The method used in this study was the DPPH (1,1-Diphenil-2-Picrylhydrazyl) method. The result of phytochemical screening showed that ethanolic extract of African leaves contained a composition of secondary metabolites of alkaloids, flavonoids, tannins, steroids/triterpenoids and saponins. The antioxidant activity of the extract of n-hexane fraction was classified as very weak with an IC50 value of 317.98 ppm.

scholarly journals Efek Imunomodulator Ekstrak Etanol Spons Melophlus sarasinorum Terhadap Aktivitas Fagositosis Sel Makrofag Pada Mencit Jantan Balb/C

2019 ◽  
Vol 5 (2) ◽  
pp. 147-157
Author(s):  
Wahyuni Wahyuni ◽  
Muhammad Ilyas Yusuf ◽  
Fadhliyah Malik ◽  
Adryan Fristiohady Lubis ◽  
Astrid Indalifiany ◽  
...  
Keyword(s):  
Cell Activity ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Macrophage Cell ◽  
Macrophage Phagocytosis ◽  
Post Hoc ◽  
Phagocytosis Activity

Immunomodulator is an ingredient or drug that can modulate immune system functions and activities. This study was conducted to determine the effect of ethanol extract of Melophlus sarasinorum sponge on macrophage phagocytosis activity. Twenty four male mice balb/c were divided into six groups. The first group received 100 mg/kg of ethanol extract of Melophlus Sarasinorum sponge, the second group received 200 mg/kg of ethanol extract of Melophlus sarasinorum sponge, the third group received 300 mg/kg of ethanol extract of Melophlus Sarasinorum sponge and the fourth group received 400 mg/kg of ethanol extract of Melophlus Sarasinorum sponge. The positive control group received Phyllanthus niruri linn extract (Stimuno®) 0,13 mg/g and the negative control group received NaCMC 0,5%. The extract was orally administered from first day to seventh day. On the eighth day, each of the mice was injected Staphylococcus aureus bacteria (SA) 0.5 mL intraperitoneally. Macrophage cell activity is calculated from smears of peritoneal fluid of mice. Increased doses of ethanol extract of Melophlus sarasinorum sponge increase the amount of macrophage phagocytosis activity that are 25,25% (negative control), 61,5% (positive control), 55,75% (100 mg/kg), 60,75% (200 mg/kg), 62,25% (300 mg/kg) dan 66,25% (400 mg/kg). The results showed that the ethanol extract of Melophlus sarasinorum sponge has the potential as immunomodulator at a doses of 300 mg/kgBB and 400 mg/kg with no significantly different effectiveness with positive control in increasing macrophage cell phagocytosis activity based on the result of post-hoc statistical test of Tukey (sig.> 0,05).  

scholarly journals Ketoksikan Akut dari Ekstrak Etanolik Daun Jarak Pagar (Jatropa curcas) pada Mencit Jantan Galur Balb/C

2014 ◽  
Vol 15 (1) ◽  
pp. 52
Author(s):  
Hanif Nasiatul Baroroh ◽  
Eka Prasasti Nur Rachmani
Keyword(s):  
Acute Toxicity ◽  
Ethanolic Extract ◽  
Negative Control ◽  
Male Mice ◽  
Animal Test ◽  
Group I ◽  
Liver And Kidney ◽  
Single Dosage ◽  
Histopathology Examination ◽  
Lung And Kidney

The acute toxicity of Jatropa curcas leaves on Balb/C male mice was studied in rats. This research aimed to determine acute toxicity, evaluate spectrum of toxic effect and mechanism that caused the death of animal test after administration of ethanolic extract of J. curcas leaves, single dosage orally on 24 hours observation. The research used male mice, which are divided into 5 groups. Group I was negative control with CMC-Na. Group II, III, IV, and V were given extract with dose of 1400 mg/kgBW, 2240 mg/kgBW, 3584 mg/kgBW and 5734 mg/kgBW, respectively. Evaluation of the toxic symptoms and death of animal test was done for 24 hours. If the animal test was died before 24 hours then it underwent surgery to take the heart, liver, lung, and kidney. In the end of the evaluation, all mice were killed to take the vital organs for histopathologic examination. No mortality was observed during study. The test resulted LD50 of ethanolic extract from J. curcas leaves using Balb/C male mice was 5734 mg/kg of BW. It was categorized as practically not toxic. Administration of the extract did not cause alterations of animal behaviours. Histopathology examination shows inflammation in lung, liver, and kidney after administration of the extract.

scholarly journals UJI DAYA ANTIINFLAMASI EKSTRAK ETANOLIK KULIT TERONG BELANDA (Solanum betaceum, Cav.) PADA MENCIT JANTAN YANG DIINDUKSI KARAGENIN

2020 ◽  
Vol 16 (02) ◽  
pp. 86
Author(s):  
Margareta Retno Priamsari ◽  
Rina Ayu Krismonikawati
Keyword(s):  
Diclofenac Sodium ◽  
Ethanolic Extract ◽  
Positive Control ◽  
Negative Control ◽  
Test Material ◽  
Edema Formation ◽  
Flavonoid Compounds ◽  
The One ◽  
Post Hoc ◽  
Solanum Betaceum

ABSTRACT Inflammation is a normal response to injury due to release of chemical mediators such as prostaglandins. Solanum betaceum Cav. skin contains flavonoid compounds. This study aims to determine the antiinflammatory power and the effect of variations in the dose of ethanolic extract of the skin of Solanum betaceum Cav on Swiss male strain mice caragenin-induced. The ethanolic extract of Solanum betaceum Cav skin was obtained using remaseration method with 96% ethanol solvent. Antiinflammatory power test using edema formation method with induction of caragenin 1% intraplantar 30 minutes before administration of the test material. Tests were carried out on 25 mice records which were divided into 5 groups namely negative control (0.5% CMC Na suspension), positive control (diclofenac sodium suspension in 0.5% CMC Na dose 7 mg/kgBW) and given suspension respectively. Dutch eggplant skin ethanolic extract in CMC Na 0.5% dose 70 mg/kgBW; 140 mg/kgBW; 280 mg/kgBW orally. The parameters observed were edema thickness measured using calipers at 30 minute intervals for 360 minutes. The results of edema thickness difference are used to calculate the Area Under Curve (AUC) and the percentage of antiinflammatory power (% AIP). Dat a were analyzed statistically with the One Way Anova test and continued by the Post Hoc Test with a 95% confidence level. The results showed that the ethanolic extract of Solanum betaceum Cav skin contains flavonoid compounds and has antiinflammatory power. The greater the dose of ethanolic extract of Solanum betaceum Cav skin, the greater the anti-inflammatory power. Keywords: Solanum betaceum Cav., antinflammation, caragenin

scholarly journals The Hepatoprotective Effect of Ethanol Extract of Syzygium campanulatum (Korth) and Syzygium aromaticum (L) Leaf on Male Wistar Rat (Rattus Norvegicus) was Induced by Paracetamol

2017 ◽  
Vol 15 (2) ◽  
pp. 196
Author(s):  
Much Ilham Novalisa Aji Wibowo ◽  
Nur Aeni ◽  
Zidna Mazayatul Huda ◽  
Nunuk Aries Nurulita
Keyword(s):  
Wistar Rats ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Hepatoprotective Activity ◽  
Group Iv ◽  
Control Group ◽  
Syzygium Aromaticum ◽  
Male Wistar Rats ◽  
Hepatoprotective Agent ◽  
Better Than

Syzygium campanulatum and Syzygium aromaticum contains antioxidant components suchas flavonoids, phenolic, and terpenoids. May have hepatoprotective properties in reducing SGPT and SGOT activity. This research wants to determine the potency of hepatoprotective of ethanolic extract of Syzygium campanulatum (Korth) and Syzygium aromaticum leaf compared with curcuma tablets. This research uses 24 male Wistar rats divided into 6 groups: I, II, III (as a normal, induction, and compared control), group IV, V, VI were treated 105, 210, and 420 mg/kg BW respectively. The study was conducted for 9 days. After 7 days of treatment, treated groups were exposed by hepatotoxic dose of paracetamol (2000 mg/kg BW). The SGPT and SGOT activity of all groups was measured by enzimatic assay. The result can be concluded that Syzygium campanulatum extract was found to be active as hepatoprotective agent with 210 mg/kg BW dosage (SGPT 21.76 ± 3.98 U/L and SGOT 7.32±6.74U/L) as eff ective as with the curcuma tablets (SGPT 23.91 ± 4.41 U/L and SGOT 14.12±5.37 U/L) and the hepatoprotective activity of Syzygium campanulatum extract at a dosage 420 mg/kg BW better than curcuma tablets (SGPT 12.43 ± 6.51 U/L and SGOT 6.64 ± 5.88 U/L). While the hepatoprotec Syzygium campanulatum and Syzygium aromaticum contains antioxidant components such as flavonoids, phenolic, and terpenoids.May have hepatoprotective properties in reducing SGPT and SGOT activity. This research wants to determine the potency of hepatoprotective of ethanolic extract of Syzygium campanulatum (Korth) and Syzygium aromaticum leaf compared with curcuma tablets. This research uses 24 male Wistar rats divided into 6 groups: I, II, III (as a normal, induction, and compared control), group IV, V, VI were treated 105, 210, and 420 mg/kg BW respectively. The study was conducted for 9 days. After 7 days of treatment, treated groups were exposed by hepatotoxic dose of paracetamol (2000 mg/kg BW). The SGPT and SGOT activity of all groups was measured by enzimatic assay. The result can be concluded that Syzygium campanulatum extract was found to be active as hepatoprotective agent with 210 mg/kg BW dosage (SGPT 21.76 ± 3.98 U/L and SGOT 7.32±6.74U/L) as eff ective as with the curcuma tablets (SGPT 23.91 ± 4.41 U/L and SGOT 14.12±5.37 U/L) and the hepatoprotective activity of Syzygium campanulatum extract at a dosage 420 mg/kg BW better than curcuma tablets (SGPT 12.43 ± 6.51 U/L and SGOT 6.64 ± 5.88 U/L). While the hepatoprotective activity of Syzygium aromaticum extracts eff ective as with curcuma tablets at all dosage variation.

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