scholarly journals Brain, Depression, Epigenetics: New Data

2020 ◽  
Vol 6 (5) ◽  
pp. 163-183 ◽  
Author(s):  
N. Romanchuk ◽  
V. Pyatin ◽  
A. Volobuev ◽  
S. Bulgakova ◽  
E. Treneva ◽  
...  
Keyword(s):  
Hybrid Methods ◽  
The Body ◽  
Energy Regulation ◽  
Healthy Life ◽  
The World ◽  
Multimodal Methods ◽  
The Brain ◽  
Brain Connections ◽  
Pituitary Adrenal Axis

Abstract. Depression is a destructive syndrome, with allostatic overload and transient dysregulation of neurological, metabolic and immunological status functions, as well as reprogramming in the hypothalamic-pituitary-adrenal axis. Depression causes pathological changes in the secretion and motility of the digestive system, and failure of bidirectional intestinal-brain connections modify the intestinal microbiota. Chronic depression destabilizes the “cognitive and visceral brain”. The neuroendocrine component of the new neural network brain models and controls molecular, functional, behavioral and Autonomous responses in response to the formation (creation, cultivation) of a new healthy biomicrobiota. Constant self-organization of functional systems of the body is provided by homeostatic regulation in the framework of deterministic and stochastic science. The architecture and functions of the brain support efficient energy regulation. The internal model of the brain negatively affects the development and maintenance of depression. For example, mood, motor, autonomic, immune, metabolic, and circadian dysregulations indicate a Central problem with ineffective energy regulation. Depression is an internal pattern associated with distress, mental withdrawal from the world, and physical withdrawal from the world. Allostasis and depression, allostatic dysregulation and instantaneous distress are based on the fundamental multidisciplinary role of metabolism. The author's work in the creation of a new protective functional and epigenetic nutrition, the clinical application of strategic combined and hybrid methods and tools in the neurorehabilitation of the circadian system, the use of artificial intelligence in the functioning of the “cognitive brain” and “visceral brain” and the “brain-microbiota” neural networks are promising applications in personalized medicine. Psychoneuroimmunological communications and neuroendocrinological multimodal methods can significantly increase the duration of an active and high-quality healthy life.

scholarly journals A Review on Neuronutrition

2019 ◽  
Author(s):  
Aruthra Devi ◽  
Rita Narayanan
Keyword(s):  
Cognitive Abilities ◽  
Neurological Disorders ◽  
Growth And Development ◽  
The Body ◽  
Brain Health ◽  
Healthy Life ◽  
Memory Problems ◽  
The World ◽  
Human Need ◽  
The Brain

Nutrition is a basic human need and a prerequisite to a healthy life. Since it is bonded with food, it is essential to advocate nutrition in terms of food. A proper diet is important from the very early stages (gestation period) of life for proper growth and development. Neuronutrition portrays how food affects the brain and its function. Brain is where the performances begin and end. It monitors and controls all the energy metabolism of the body and it never stops working. Neuronutrition is the nutrition needed to achieve healthy brain and good neurocognitive function. Dietary manipulations are a viable strategy for enhancing cognitive abilities and protecting the brain from damage. No single food is key to good brain health but rather a combination of food. Neurological disorders such as Alzheimer's disease, mental fatigue, and memory problems are prevalent across the world, and this opens the door to provide tailormade products which cater to consumer's desire for better neuronutrition.

Play’s Nature

2017 ◽  
Author(s):  
Thomas S. Henricks
Keyword(s):  
Human Body ◽  
Brain Activity ◽  
The Body ◽  
Physical Processes ◽  
Bodily Movement ◽  
Physical Play ◽  
The World ◽  
The Brain

This chapter examines the link between play and nature, or more specifically, the human body. Our feats of thinking, feeling, and acting depend profoundly on structures of the body and the brain. Decisions to play are conditioned by our physical forms. Feelings about what we are doing—registered as sensations and emotions—arise from long-established physical processes. And we move through the world only as our bodies permit. Understanding play means understanding these physical processes. In that context, the chapter focuses on the consequences of play for physiology. It reviews studies of bodily movement, brain activity, consciousness, and affect in both humans and animals. It also explores animal play, classic theories of physical play, the role of the organism in play, play as an expression of surplus resources, and the role of brain in play.

scholarly journals BRAIN CONNECTIONS ANALYSIS USING GRAPH THEORY MEASURES

2019 ◽  
Vol 2 ◽  
pp. 94
Author(s):  
Oļesja Minejeva ◽  
Zigurds Markovics ◽  
Nauris Zdanovskis
Keyword(s):  
Complex Structure ◽  
Brain Regions ◽  
The Body ◽  
Virtual Space ◽  
General Idea ◽  
Node Degree ◽  
Structural Description ◽  
The Brain ◽  
Brain Connections

Brain is a part of the organism’s complex structure that performs many functions, which are responsible for the main human abilities: to talk, to hear, to move, to see, etc. The brain consists of several areas that are not only directly connected with the different body systems, but also depend and may affect each other. Researchers and doctors are trying to summarize and visualize these relationships for an important purpose – to get the information about possible reactions of the body in case of various diseases, possibilities of recovery, risks, etc. important issues. Neurologists are looking for ways to "move" through the brain in virtual space for viewing the synapses between different areas. It might be useful to get a general idea of how brain regions are interrelated. The term "connectome", which is the complete structural description of the brain connections, or the map of connections, is used for the common perception of brain relationships. Connectome is a network of thousands of nerve fibres that transmits signals between the special regions responsible for functions such as vision, hearing, movement and memory, and combines these functions in a system that perceives, decides and acts as a whole. So, the relationships of brain neural regions can be represented as a graph with vertices corresponding to specific areas, but edges are links between these areas. This graph can be analysed using quantitative measures, like node degree, centrality, modularity etc. This article discusses the different network measures for the connections between brain's regions. The purpose is to determine the most important areas and the role of individual connections in the general functional brain model.

Role of Rasayana in Prevention of COVID-19 - A Review

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 716-722
Author(s):  
Sneha Dhakite ◽  
Sadhana Misar Wajpeyi
Keyword(s):  
Immune System ◽  
Respiratory System ◽  
Viral Infections ◽  
Cost Effective ◽  
The Body ◽  
Healthy Life ◽  
Vital Functions ◽  
Healthy Life Style ◽  
And Control

The “Coronavirus disease 19 (COVID-19)” is caused by “Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)”, a newly discovered member of the Coronaviridae family of viruses which is a highly communicable. There is no effective medical treatment till date for Coronavirus disease hence prevention is the best way to keep disease away. Rasayana proved to be highly efficacious and cost effective for the Prevention and Control of viral infections when vaccines and standard therapies are lacking. Rasayana Chikitsa is one of the eight branches of Ashtanga Ayurveda which helps to maintain healthy life style. Rasayana improves immunity and performs many vital functions of human body. Vyadhikshamatva that is immune mechanism of the body is involved in Prevention of the occurrence of a new disease and it also decreases the virulence and progression of an existing disease. In COVID-19 the Respiratory system mainly get affected which is evident from its symptoms like cold, cough and breathlessness. Here the drugs help in enhancing immune system and strengthening functions of Respiratory system can be useful. For this purpose, the Rasayana like Chyavanprasha, Agastya Haritaki, Pippali Rasayana, Guduchi, Yashtimadhu, Haridra, Ashwagandha, Tulsi are used. Rasayana working on Respiratory system are best for Prevention of Coronavirus and boosting immune system. Rasayana Chikitsa can be effective in the Prevention as well as reducing symptoms of COVID-19.

Myriad Aspects of Secular Thinking on Malayali Cuisine

GIS Business ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. 202-206
Author(s):  
SAJITHA M
Keyword(s):  
Social Status ◽  
Daily Life ◽  
Social Indicators ◽  
The Body ◽  
Human Being ◽  
Healthy Life ◽  
The Social ◽  
The World ◽  
History Of ◽  
Civilized Society

Food is one of the main requirements of human being. It is flattering for the preservation of wellbeing and nourishment of the body.  The food of a society exposes its custom, prosperity, status, habits as well as it help to develop a culture. Food is one of the most important social indicators of a society. History of food carries a dynamic character in the socio- economic, political, and cultural realm of a society. The food is one of the obligatory components in our daily life. It occupied an obvious atmosphere for the augmentation of healthy life and anticipation against the diseases.  The food also shows a significant character in establishing cultural distinctiveness, and it reflects who we are. Food also reflected as the symbol of individuality, generosity, social status and religious believes etc in a civilized society. Food is not a discriminating aspect. It is the part of a culture, habits, addiction, and identity of a civilization.Food plays a symbolic role in the social activities the world over. It’s a universal sign of hospitality.[1]

scholarly journals Millimeter (MM) wave and microwave frequency radiation produce deeply penetrating effects: the biology and the physics

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Martin L. Pall
Keyword(s):  
Magnetic Fields ◽  
Electric Fields ◽  
Cardiac Activity ◽  
Maximum Level ◽  
Voltage Sensor ◽  
The Body ◽  
Time Varying ◽  
The Brain ◽  
Mm Waves

Abstract Millimeter wave (MM-wave) electromagnetic fields (EMFs) are predicted to not produce penetrating effects in the body. The electric but not magnetic part of MM-EMFs are almost completely absorbed within the outer 1 mm of the body. Rodents are reported to have penetrating MM-wave impacts on the brain, the myocardium, liver, kidney and bone marrow. MM-waves produce electromagnetic sensitivity-like changes in rodent, frog and skate tissues. In humans, MM-waves have penetrating effects including impacts on the brain, producing EEG changes and other neurological/neuropsychiatric changes, increases in apparent electromagnetic hypersensitivity and produce changes on ulcers and cardiac activity. This review focuses on several issues required to understand penetrating effects of MM-waves and microwaves: 1. Electronically generated EMFs are coherent, producing much higher electrical and magnetic forces then do natural incoherent EMFs. 2. The fixed relationship between electrical and magnetic fields found in EMFs in a vacuum or highly permeable medium such as air, predicted by Maxwell’s equations, breaks down in other materials. Specifically, MM-wave electrical fields are almost completely absorbed in the outer 1 mm of the body due to the high dielectric constant of biological aqueous phases. However, the magnetic fields are very highly penetrating. 3. Time-varying magnetic fields have central roles in producing highly penetrating effects. The primary mechanism of EMF action is voltage-gated calcium channel (VGCC) activation with the EMFs acting via their forces on the voltage sensor, rather than by depolarization of the plasma membrane. Two distinct mechanisms, an indirect and a direct mechanism, are consistent with and predicted by the physics, to explain penetrating MM-wave VGCC activation via the voltage sensor. Time-varying coherent magnetic fields, as predicted by the Maxwell–Faraday version of Faraday’s law of induction, can put forces on ions dissolved in aqueous phases deep within the body, regenerating coherent electric fields which activate the VGCC voltage sensor. In addition, time-varying magnetic fields can directly put forces on the 20 charges in the VGCC voltage sensor. There are three very important findings here which are rarely recognized in the EMF scientific literature: coherence of electronically generated EMFs; the key role of time-varying magnetic fields in generating highly penetrating effects; the key role of both modulating and pure EMF pulses in greatly increasing very short term high level time-variation of magnetic and electric fields. It is probable that genuine safety guidelines must keep nanosecond timescale-variation of coherent electric and magnetic fields below some maximum level in order to produce genuine safety. These findings have important implications with regard to 5G radiation.

CCM3 Loss-Induced Lymphatic Defect Is Mediated by the Augmented VEGFR3-ERK1/2 Signaling

2021 ◽  
Author(s):  
Lingfeng Qin ◽  
Haifeng Zhang ◽  
Busu Li ◽  
Quan Jiang ◽  
Francesc Lopez ◽  
...  
Keyword(s):  
Nuclear Translocation ◽  
Fluorescein Isothiocyanate ◽  
The Body ◽  
Blue Dye ◽  
Transcriptional Level ◽  
Dependent Manner ◽  
Cavernous Malformations ◽  
Morphological Alterations ◽  
The Brain

Objective: Cerebral cavernous malformations (CCMs) can happen anywhere in the body, although they most commonly produce symptoms in the brain. The role of CCM genes in other vascular beds outside the brain and retina is not well-examined, although the 3 CCM-associated genes ( CCM1 , CCM2 , and CCM3 ) are ubiquitously expressed in all tissues. We aimed to determine the role of CCM gene in lymphatics. Approach and Results: Mice with an inducible pan–endothelial cell (EC) or lymphatic EC deletion of Ccm3 ( Pdcd10 ECKO or Pdcd10 LECKO ) exhibit dilated lymphatic capillaries and collecting vessels with abnormal valve structure. Morphological alterations were correlated with lymphatic dysfunction in Pdcd10 LECKO mice as determined by Evans blue dye and fluorescein isothiocyanate(FITC)-dextran transport assays. Pdcd10 LECKO lymphatics had increased VEGFR3 (vascular endothelial growth factor receptor-3)-ERK1/2 signaling with lymphatic hyperplasia. Mechanistic studies suggested that VEGFR3 is primarily regulated at a transcriptional level in Ccm3-deficient lymphatic ECs, in an NF-κB (nuclear factor κB)–dependent manner. CCM3 binds to importin alpha 2/KPNA2 (karyopherin subunit alpha 2), and a CCM3 deletion releases KPNA2 to activate NF-κB P65 by facilitating its nuclear translocation and P65-dependent VEGFR3 transcription. Moreover, increased VEGFR3 in lymphatic EC preferentially activates ERK1/2 signaling, which is critical for lymphatic EC proliferation. Importantly, inhibition of VEGFR3 or ERK1/2 rescued the lymphatic defects in structure and function. Conclusions: Our data demonstrate that CCM3 deletion augments the VEGFR3-ERK1/2 signaling in lymphatic EC that drives lymphatic hyperplasia and malformation and warrant further investigation on the potential clinical relevance of lymphatic dysfunction in patients with CCM.

scholarly journals The Relationship between Dramatic Text and Performance with the Centrality of the Body with a Look at Anne Bogart’s Rendition of The Persians

1970 ◽  
Vol 2 (2) ◽  
pp. 25-31
Author(s):  
Samin Gheitasy ◽  
Leila Montazeri ◽  
Simin Dolatkhah
Keyword(s):  
The Body ◽  
Physical Approach ◽  
The World ◽  
Dramatic Text ◽  
And Performance ◽  
Anne Bogart ◽  
The Relationship ◽  
Sociological View

The dramatic text defines, to some extent, the structure of the work but the type of performance and the physical approach to the text can represent different meanings. The body of the actor, as a means of conveying concepts from the text to the audience, can be effective in creating different interpretations and meanings of the text. Since eons ago, directors have used the body of the actor with different approaches, and the application of body on the stage has always been underdoing changes. Anne Bogart is one of the few directors who is less known in the Iranian theater despite possessing the most updated and well-known methods of practice and performance in the world. Using her viewpoint method, she brings live and dynamic bodies to the stage; bodies that are able to convey the hidden meanings of the text to the audience in the most suitable way. The overall purpose of this research is to find the relationship between the dramatic text and the performance with the centrality of the body with a sociological view toward the body. To this end, by presenting Foucault's theories, the researchers defines the role of the body in the society and its extent of effectivity and impressibility. Finally, this study explores the implications of this role in each element of Aeschylus’s The Persians, and it shall show how Bogart beautifully represents them using the bodies of her actors during performance.

The World-Relatedness of Affectivity: Heidegger and Richir

2021 ◽  
Vol 66 (2 supplement) ◽  
pp. 55-77
Author(s):  
Dominic Nnaemeka Ekweariri
Keyword(s):  
The Body ◽  
Phenomenal Experience ◽  
Affective States ◽  
Personal Experiences ◽  
The World

" My investigation reveals that Heidegger’s account of affectivity – though his programmatical determination included an ontical dimension or otherwise lived, personal experiences – is overshadowed by a dense ontology that cannot enable real phenomenal experience. This is why he could not account for other affective states such as emotions, feel-ings and the role of the body in affectivity. Besides, in that account we are lost when we seek to answer the question of whether moods are “one” or “many”. My aim is to point out how these deficiencies in Heidegger’s account of mood could be overcome in Richir’s account of affectivity, where indeterminate background feelings (affections) could give rise to a deter-minate and occurent emotion (affects). The advantage of this move is a rich ontic account of affectivity where not only the body but also sense/meaning of affective episodes play a robust role in an encounter of world events. If Richir reproached Heidegger for existential solipsism, one could now reproach the former for existentiell/phenomenal solipsism. In the end I suggest that these two core but opposite aspects of affectivity (the ontological and the ontic) belong to the same reality: Dasein is not just in the world (ontology), but also the world is in Dasein (ontic/phenomenological). Keywords: mood, affection, affect, Heidegger’s ontology, Richir’s Leib and sense. "

Becoming Gypsy: Tell Me What the Body Knows in Flamenco Dance

2015 ◽  
Vol 6 (1) ◽  
pp. 22-35
Author(s):  
Diane Oatley
Keyword(s):  
Knowledge Acquisition ◽  
The Body ◽  
Physical Interaction ◽  
Embodied Knowledge ◽  
Physical Processes ◽  
The Unconscious ◽  
The World ◽  
Language And Cognition ◽  
Experiences Of Women

Abstract In The Meaning of the Body, philosopher Mark Johnson makes a case for the significance of movement in terms of the body processes he holds as essential to the generation of meaning and knowledge acquisition in physical interaction with the world–equally essential as language and cognition. The article employs this theory in interpreting the experiences of women learning flamenco dance in Spain. The investigation of the perceptions of women studying flamenco dance, a dance tradition often defined as “gypsy,” indicates that exposure to flamenco dance and culture leads to revision of stereotypes regarding embodiment and difference, but respondents did not relate this revision to bodily engagement, or physical processes particular to dancing flamenco. Although Johnson’s failure to properly account for the role of the unconscious proved to be a serious shortcoming in the theory, and one which had implications for the findings, application of the theory disclosed the parameters of a discourse on the body in flamenco. The theory thus represents a radical gesture in redefining embodiment in its own right in a manner that precludes dualism with the consequent opening of a range of alternative perspectives on the articulation of embodied knowledge.

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