scholarly journals Analysis of level of apoptosis markers in patients with coronary heart disease

2020 ◽  
Vol 4 (35) ◽  
pp. 5-8
Author(s):  
O. S. Polunina ◽  
L. P. Voronina ◽  
G. N. Mukhambetova ◽  
G. Yu. Maslyaeva ◽  
P. N. Voronina
Keyword(s):  
Heart Rate ◽  
Correlation Analysis ◽  
Ischemic Cardiomyopathy ◽  
Comparison Group ◽  
Annexin A5 ◽  
Healthy Individuals ◽  
Right Heart ◽  
Constant Form ◽  
History Of ◽  
Apoptosis Markers

Objective. To study and analyze the level of markers of apoptosis of annexin A5 (AnxA5) and Bcl‑2 in patients with past myocardial infarction (MI) and ischemic cardiomyopathy (ICMP), depending on the presence of atrial fibrillation (AF) of a constant form.Materials and methods. It were examined 43 patients with past MI and 47 patients with ICMP. All patients are divided into subgroups depending on the presence of AF of a constant form (patients with right heart rate and with AF a constant form). As a comparison group, 30 somatically healthy individuals were examined. Plasma levels of Bcl‑2 and AnxA5 in all examined individuals were determined by enzyme immunoassay.Results. Statistically significant changes in the level of AnxA5 and Bcl‑2 were revealed in all examined patients compared with somatically healthy individuals. It was found that the level of AnxA5 was statistically significantly higher in patients with AF constant form compared with patients with right heart rate and statistically significantly higher in patients with ICMP in the corresponding subgroups (patients with right heart rate and AF constant form) compared with patients with MI. The level of Bcl‑2 was statistically significantly lower in patients with AF constant form compared with patients with right heart rate and statistically significantly lower in patients with ICMP in the corresponding subgroups (patients with the correct rhythm and AF constant form) compared with patients with MI. According to the results of the correlation analysis, statistically significant positive (AnxA5) and negative (Bcl‑2) correlations between the level of apoptosis markers and the duration in the history of AF of a constant form were revealed in all examined patients.Conclusion. More pronounced changes in the level of apoptosis markers were detected in patients with ICMP, compared with patients with previous MI in both the subgroup of patients with with right heart rate and the subgroup of patients with AF with a constant form. All the examined patients in the subgroup of patients with AF have a constant form, the severity of changes in the level of studied markers of apoptosis is higher than in patients in the subgroup with right heart rate. The results of the correlation analysis indicate the presence of correlations between the level of markers of apoptosis AnxA5 and Bcl‑2 and the duration of AF of a constant form in the anamnesis in patients with past MI and ICMP.

scholarly journals Clinical significance of heart rate variability and Q-T interval duration during Holter monitoring of ECG in patients with essential hypertension

2004 ◽  
Vol 10 (1) ◽  
pp. 39-42
Author(s):  
A. V. Shabalin ◽  
Ye. N. Gulyaeva ◽  
Ye. Ye. Torochkina ◽  
E. M. Verkoshanskaya ◽  
O. V. Kovalenko ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Essential Hypertension ◽  
Clinical Significance ◽  
Comparison Group ◽  
Low Frequency ◽  
Holter Monitoring ◽  
Total Power ◽  
Interval Duration ◽  
Healthy Individuals

The clinical significance of heart rate variability and Q-T interval duration during 24-hour bifunctional monitoring of ECG and blood pressure (BP) was studied in 81 patients aged 22-58 years (mean 41,40±0,72 years) who had Stages I-III essential hypertension (EH). A comparison group included 20 healthy individuals. Temporary and spectral methods were used to assess the parameters of heart rate variability; 24-hour Q-Tand O-Tk intervals, as well as echocardiographic data were analyzed. Patients with Stages I-III EH were ascertained to have a progressive decrease in diurnal heart rate variability along with a reduction in the total power of the spectrum, in the power of low-frequency constituents, and in their ratio. EH progression was found to be associated with an increase in the duration of the Q-T interval, its corrected values during daylight hours and with the degree of heart rate variability without circadian changes. The degree of autonomous cardiac control was statistically significantly related to heart rate variability and a risk for ventricular repolarization disorders.

Relationships between values of myocardial remodeling parameters and level of apoptosis biomarkers in patients with ischemic cardiomyopathy

2021 ◽  
Vol 1 (30) ◽  
pp. 38-42
Author(s):  
G. N. Mukhambetova ◽  
O. S. Polunina ◽  
L. P. Voronina ◽  
N. B. Greenberg ◽  
E. A. Polunina ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Ischemic Cardiomyopathy ◽  
The Other ◽  
Control Group ◽  
Annexin A5 ◽  
Myocardial Remodeling ◽  
Healthy Individuals ◽  
Systolic Volume ◽  
Sphericity Index ◽  
Close Relationship

The aim of the research. To study levels of the apoptosis biomarkers annexin A5 (AnxA5) and Bcl‑2 and to identify the presence of correlations of structural and functional parameters of the myocardium with the level of the studied biomarkers in patients with ischemic cardiomyopathy (ICMP).Materials and methods. Patients with ICMP (n = 47) were examined as the main group. The control group included 30 somatically healthy individuals. Bcl‑2 and APA5 levels were determined in the blood serum by the enzyme immunoassay.Results. It was found that in the group of patients with ICMP. The level of AnxA5 was statistically significantly higher (p < 0.001), and the level of Bcl‑2 was statistically significantly lower (p < 0.001) than in the control group. Based on the results of the correlation analysis a noticeable close relationship on the Cheddock scale was revealed between levels of the studied apoptosis biomarkers and the values of the sphericity index of in diastole and systole of left ventricle (LV), final diastolic and systolic volume of LV and ejection fraction of LV. Between the other parameters of myocardial remodeling and levels of the studied biomarkers of apoptosis, the closeness of relationships on the Cheddock scale were weak and moderate.

scholarly journals Differences in Hemodynamic, Hormonal and Heart Rate Variability Parameters in Complication-Free Pregnancies Compared to Individuals with Gestational Diabetes Mellitus and Preeclampsia: An Observational Retrospective Analysis

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 626
Author(s):  
Max L. Eckstein ◽  
Othmar Moser ◽  
Andreas Rössler ◽  
Manfred G. Moertl ◽  
Andreas Jantscher ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Healthy Individuals ◽  
Stress Indicators ◽  
Hair Samples ◽  
History Of ◽  
Post Hoc

To investigate differences in hemodynamic, hormonal and heart rate variability parameters in women following complication-free pregnancies (healthy), preeclampsia and gestational diabetes mellitus (GDM) after giving childbirth. Data of 60 women (healthy: n = 29, age 32.7 ± 4.5 years, BMI 24.2 ± 4.3 kg/m2; preeclampsia: n = 16, age 35.3 ± 4.4 years, 28.5 ± 6.4 kg/m2; GDM, n = 15, age 32.3 ± 6.0 years, BMI 26.4 ± 6.2 kg/m2) were included. Two visits were conducted 16 and 48 weeks after giving childbirth. Hair samples were taken for analysis of cortisol and testosterone. ECG and blood pressure were recorded at each visit. Data were analyzed via RM-ANOVA and post-hoc testing (p ≤ 0.05). Heart rate increased from visit 1 to visit 2, whereas SDNN decreased (both p = 0.03). RMSSD showed an increased trend for groups (p = 0.06). Testosterone in the GDM group was significantly higher compared to the other groups (p = 0.002). Cortisol levels were significantly higher following post-hoc testing GDM was different compared to healthy individuals (p = 0.02). Hemodynamic changes from week 16 to week 48 did not differ between groups (p > 0.05). No differences between individuals with preeclampsia and healthy individuals were found for all hemodynamic parameters (p > 0.05). The study showed higher levels of chronic stress indicators in GDM measured via heart rate variability and cortisol compared to women with a history of preeclampsia and healthy women.

scholarly journals Cellular and humoral apoptosis markers in acute coronary syndrome combined with essential hypertension

2008 ◽  
Vol 14 (4) ◽  
pp. 332-335 ◽  
Author(s):  
L. V. Vasina
Keyword(s):  
Myocardial Infarction ◽  
Acute Coronary Syndrome ◽  
Unstable Angina ◽  
Mononuclear Cells ◽  
Control Group ◽  
Annexin A5 ◽  
Healthy Individuals ◽  
Coronary Syndrome ◽  
Early Stages ◽  
Apoptosis Markers

The aim of this work was to examine the contents of annexin A5, sApo-1/Fas and sBcl-2 and the number of circulating mononuclear cells in apoptosis in order to clarify their role in the pathogenesis of acute coronary syndrome (ACS) combined with arterial hypertension (AH). We examined 83 patients with ACS (47 patients with unstable angina and 36 with myocardial infarction) and 14 healthy individuals. AH has been identified in 15 patients with unstable angina and in 17 with myocardial infarction. The number of viable mononuclear cells was significantly decreased and the number of mononuclear cells at the early stages of apoptosis (annexin A5-positive) was significantly increased as compared to control group in patients with the ACS, especially if combined with AH. At the same time there was a significant increase of sBcl-2 and sApo-1/Fas and annexin A5 in blood of the patients with myocardial infarction compared to patients with unstable angina, especially if combined with AH. The association between the level of sAro-1/Fas, annexin A5 and the number of circulating mononuclear cells at the early stages of apoptosis was shown in the study. Thus, in ACS, especially if combined with AH, enhanced cell apoptosis resulting from hemodynamic abnormal changes leads to activation of antiapoptotic mechanisms aimed at the decrease of the thrombophilia severity by reducing thrombogenic features of endotheliocytes subjected to apoptosis.

Electrophysiological remodeling of the heart in patients with arterial hypertension

2021 ◽  
pp. 26-32
Author(s):  
M. S. Maksimova
Keyword(s):  
Heart Rate ◽  
Left Ventricle ◽  
Correlation Analysis ◽  
Arterial Hypertension ◽  
Research Methods ◽  
Qt Interval ◽  
Positive Relationship ◽  
Healthy Individuals ◽  
Myocardial Mass ◽  
Qrs Duration

Aim. Study electrocardiographic (ECG) and vectorcardiographic (VCG) indicators for various types of structural-  geometric remodeling of the left ventricle (LV) in patients with arterial hypertension (AH).Material and research methods. The analysis was performed in 336 people, including 264 patients with AH, mean age 61.02 ± 7.61 years and 72 practically healthy individuals (57.18 ± 6.47). The ECG indicators of heart rate and duration of P, QRS, RR, PQ, QT, QT corrected according to the Bazett, Friderici and Sagie formulas (QTCB, QTCF, QTCS) were assessed. Echocardiography was used to calculate myocardial mass (LVMM) and LVMM index (LVMI), relative wall thickness (RWT). In the own plane of the VCG: the area of the QRS loop (SQRS), the magnitude of the geometric vector (maxQRS) were determined.Results. Correlation analysis showed the presence of a positive relationship between LVM and LVMI with SQRS (r = 0.49 and r = 0.38), maxQRS (r = 0.28 and r=0.33) and with QRS duration (r = 0.50 and r = 0.43). The groups of patients with concentric (CG) and eccentric (EH) hypertrophy in comparison with controls and patients with AH without LVH gave significantly higher values of absolute QT, QTCF, QTCS. There was a positive correlation between QT and QTС with LVMM, LVMI and no relationship with RWT.Conclusions. In LVH, the duration of QRS and SQRS in its own plane increased. The highest SQRS values were observed in patients with CG of the left ventricle in comparison with EG. Patients with CG and EG did not differ in QRS duration. In patients with AH and LVH, the duration of absolute and corrected values of the QT interval was significantly longer than in patients without LVH. The QT interval lengthened with an increase in LVMM and LVMI. QT duration did not depend on the type of LV hypertrophy — concentric or eccentric.

Impact of childhood maltreatment and resilience on behavioral and neural patterns of inhibitory control during emotional distraction

2021 ◽  
pp. 1-12
Author(s):  
Lauren A. Demers ◽  
Ruskin H. Hunt ◽  
Dante Cicchetti ◽  
Julia E. Cohen-Gilbert ◽  
Fred A. Rogosch ◽  
...  
Keyword(s):  
Inhibitory Control ◽  
Childhood Maltreatment ◽  
Adaptive Functioning ◽  
Comparison Group ◽  
Inferior Frontal Gyrus ◽  
Neural Systems ◽  
Behavioral Regulation ◽  
Frontal Pole ◽  
History Of ◽  
Task Irrelevant

Abstract Exposure to childhood maltreatment (CM) may disrupt typical development of neural systems underlying impulse control and emotion regulation. Yet resilient outcomes are observed in some individuals exposed to CM. Individual differences in adult functioning may result from variation in inhibitory control in the context of emotional distractions, underpinned by cognitive–affective brain circuits. Thirty-eight healthy adults with a history of substantiated CM and 34 nonmaltreated adults from the same longitudinal sample performed a Go/No-Go task in which task-relevant stimuli (letters) were presented at the center of task-irrelevant, negative, or neutral images, while undergoing functional magnetic resonance imaging. The comparison group, but not the maltreated group, made increased inhibitory control errors in the context of negative, but not neutral, distractor images. In addition, the comparison group had greater right inferior frontal gyrus and bilateral frontal pole activation during inhibitory control blocks with negative compared to neutral background images relative to the CM group. Across the full sample, greater adaptive functioning in everyday contexts was associated with superior inhibitory control and greater right frontal pole activation. Results suggest that resilience following early adversity is associated with enhanced attention and behavioral regulation in the context of task-irrelevant negative emotional stimuli in a laboratory setting.

Features of the long-term dynamics of heart rate variability among workers of a potash ore processing enterprise

2021 ◽  
Vol 61 (7) ◽  
pp. 442-450
Author(s):  
Alexandr E. Nosov ◽  
Nina V. Zaitseva ◽  
Vitalii G. Kostarev ◽  
Julia A. Ivashova ◽  
Maksim A. Savinkov ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Significant Relationship ◽  
Work Experience ◽  
Fine Particles ◽  
Comparison Group ◽  
Stress Index ◽  
Observation Group ◽  
Ore Processing ◽  
Processing Enterprise

Introduction. Currently, the violation of heart rate variability as one of the main pathogenetic mechanisms of the damaging effect of pollutants, associated effects on the cardiovascular system. The study aims to explore the dynamics of the influence of the autonomic nervous system (ANS) on heart rate variability (HRV) in workers of a potassium ore processing enterprise exposed to industrial pollutants (fine fractions of potassium chloride dust, formaldehyde, hexane, heptane) with an assessment of changes in dependence from work experience, establishment of cause-and-effect relationships of violations of heart rate variability with exposure to chemical compounds. Materials and methods. The object of the study was 140 employees of a potash ore processing enterprise, assigned to the observation group, and 76 employees of the administrative and technical apparatus, who made up the comparison group. Samples were taken from the air of the working medium for the content of saturated hydrocarbons (hexane, heptane), the vapors of formhehyde were considered, and the presence of fine particles PM2.5 and PM10 was established. Investigation of biological media (blood, urine) of workers at the enterprise determination of formaldehyde in blood, hexane and heptane in urine. Evaluation of heart rate variability was carried out on a computer electrocardiograph "Poli-Spectr-8/EX" using a cardiorhythmographic program using the method of time analysis, variation pulsometry and spectral analysis. Results. The concentration of fine particles in the air at the workplaces of the observation group was 12-111 times higher for PM2.5, and 5.6-74.6 times higher for PM10 than for the work places of the comparison group. The concentration of formaldehyde, hexane and heptane in the air did not exceed hygienic standards. In the observation group relative to the comparison group, formaldehyde blood was 1.5 times (p<0.001), in the urine of hexane - 1.2 times (p=0.011), heptane - 1.3 times (p=0.046). It was found that with an experience of up to 10 years, formaldehyde in the blood of workers in the observation group was 1.4 times higher than that in the comparison group (p=0.011), with an experience of more than 10 years - 1.7 times (p=0.005). In the urine of workers in the observation group with work experience of up to 10 years, an excess of 1.3 (p=0.026) relative to the comparison group of hexane was found. HRV data analysis. With damage to the length of service in the observation group, there was a significant decrease in the temporal analysis indicators (SDNN, ms, RMSSD, ms, pNN50, %, CV, %), while in the comparison group, only the CV, % decrease was statistically significant; the values of IN conventional units, AMo, % significantly increased (p=0.03 and p=0.003, respectively). A statistically significant relationship was established between the likelihood of an increase depending on the content of heptane in urine (b0=0.22; b1=10.6; F=21.5; R2=0.09; p=0.0001) and formaldehyde in the blood (b0=0.02; b1=6.55; F=69.6; R2=0.25; p=0.0001) in the surveyed workers. Conclusions. Activation of central ergotropic and humoral-metabolic mechanisms, a tendency towards a decrease in parasympathetic influences. The method of logistic regression analysis established a statistically significant relationship between the probability of an increase in the stress index depending on the heptane content in the blood of the surveyed suppliers.

Sex Differences in Inmates: Anger, Sensitivity to Provocation and Family History of Imprisonment

2021 ◽  
pp. 0306624X2110491
Author(s):  
Marta Bodecka-Zych ◽  
Anna Zajenkowska ◽  
Mary Bower Russa
Keyword(s):  
Family History ◽  
Comparison Group ◽  
Female Inmates ◽  
Male And Female ◽  
Female Prisoners ◽  
Increased Risk ◽  
Incarcerated Populations ◽  
History Of ◽  
Male Prisoners

Little research has explored the role of aggression, anger, and family history of incarceration as they relate to female offenders. The current study aimed to address this gap in the literature by investigating these possible risk factors for incarceration among both men and women. The survey involved 123 (61 female and 62 male) prisoners convicted for violent crimes and a comparison group of 118 (60 female and 58 male) adults from the community. We found that women (convicted and non-convicted) were more sensitive to provocation than men, while community adults showed higher levels of trait anger than prisoners. Detainees were more likely than community adults to have a relative in prison. Although male and female inmates were equally likely to have a relative in prison, they differed in their relation to the imprisoned relative. Male and female prisoners showed increased risk for incarceration of same sex, first degree relatives (father and brothers for men, and mothers for women). These results may contribute to improved understanding of incarcerated populations. As such, this represents a critical first step in creating recovery programs that are more gender appropriate.

Features of the course of labor in women with a history of perinatal loss

2018 ◽  
pp. 66-68
Author(s):  
L.I. Vorobey ◽  
Keyword(s):  
Premature Birth ◽  
Soft Tissues ◽  
Comparison Group ◽  
Child Death ◽  
Randomized Study ◽  
Perinatal Loss ◽  
Early Discharge ◽  
State Of Health ◽  
Repeat Pregnancy ◽  
History Of

The objective: was to determine the features of the course of labor in women with a history of perinatal lesions. Materials and methods. A prospective, concurrent, controlled, randomized study was conducted involving 68 women aged 26.8 ±0.5 years, with a gestation period of 28.1 ±0.56 weeks, 41 of whom had perinatal history lesions (main group) and comparable for anthropodemographic indicators and terms of gestation of 27 women with a repeat pregnancy without abortion or unsuccessful childbirth (child death) in the history (comparison group). Results. In the anamnestic aspect, the characteristics of pregnant women with a history of perinatal losses are a relatively shorter interval between repeated pregnancies, a more frequent development of extragenital pathology - the respiratory, nervous, endocrine, cardiovascular and orthopedic disorders, and a higher incidence of gynecological anamnesis. In the context of complications of delivery, women with perinatal losses are characterized by premature birth, anomalies of labor, early discharge of amniotic fluid, ruptures of soft tissues. Conclusion. It is necessary to make a comparative analysis of the course of pregnancy, childbirth and the state of health of newborns in women with a history of obstetrical anamnesis in connection with violations of neurovegetative regulation. Key words: perinatal losses, anamnesis, childbirth, current.

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