scholarly journals Management of Geographic Tongue, Fissure Tongue, and Oral Candidiasis on Dorsum of an Elderly Smoking Patient’s Tongue

2019 ◽  
Vol 3 (4) ◽  
pp. 182-186
Author(s):  
Sri Hernawati
Keyword(s):  
Fungal Infections ◽  
Oral Candidiasis ◽  
Healing Process ◽  
Aloe Vera ◽  
Inflammatory Lesion ◽  
Oral Solution ◽  
Predisposing Factors ◽  
Nutritional Deficiencies ◽  
Clinical Appearance ◽  
Filiform Papillae

Background: A geographic tongue is an inflammatory lesion of the tongue accompanied with atrophy formation of papilla or depapilation of the filiform papillae. The geographic tongue usually appears together with the appearance of the fissure tongue, a midline, multiple, fissure on the surface of the tongue that expands from front to back and has various patterns. Predisposing factors of geographic tongue and fissure tongue are nutritional deficiencies and stress. Oral candidiasis is one of the fungal infections that affect the oral mucosa caused by the fungus Candida albicans. Predisposing factors of oral candidiasis e.g. stress, and smoking habits. Case: 64-year-old male patient with a clinical appearance on the dorsum of the tongue in a bracelet-like form with depapilation, vertical fissure 3 mm deep and thick white plaque which could be scraped and felt painful. Diagnosis: geographic tongue, fissure tongue and oral candidiasis. Therapy: aloe vera in oral solution as antiinflammatory and analgesic, Nystatin oral suspension functions as a topical antifungal medicine, multivitamin Becomzet (Vitamin B complex, A, C, E, and Zinc) as a multivitamin. Conclusion: after therapy using aloe vera solution, nystantin becomzet controls both patients had undergone a healing process in both the case of geographic tongue, fissure tongue and oral candidiasis. Keywords: Geographic tongue, Candidasis

scholarly journals Management of Geographic Tongue in a Patient with Mango Alergy Accompanied with Fissure Tongue, Oral Candidiasis and Cheilitis

2019 ◽  
Vol 3 (12) ◽  
pp. 503-508
Author(s):  
Sri Hernawati
Keyword(s):  
Oral Candidiasis ◽  
Healing Process ◽  
Final Diagnosis ◽  
Vitamin B ◽  
Solid Organ ◽  
Trigger Factors ◽  
Clinical Appearance ◽  
Physiological Conditions ◽  
Pathological Conditions ◽  
Fissured Tongue

The tongue is a solid organ formed by skeletal muscles that has an important function as the sense of taste, mastication, swallowing, and speaking. There are several physiological conditions on the tongue which can be pathological conditions e.g. Geographic tongue and Fissured tongue. This situation may occur due to trigger factors e.g. allergic reactions. Allergies of certain fruits e.g. mangoes are very rare. However, in some patients those cases may cause immediate or delayed hypersensitivity reactions. A 40-year-old male patient complained that his tongue felt sore after eating a lot of mango salad, after clinical examination the results showed clinical appearance were: 1) island-shaped atrophy, surrounded by white edges, pain; 2) fissure, multiple, redness, pain; 3) yellowish white plaque, can be scraped, no clear boundary, no pain in the dorsum of the tongue. In addition to the extraoral examination there were abnormalities in the upper and lower lips of the patient in the form of fissure, vertical, multiple, accompanied by desquamation. The final diagnosis the patient was geographic tongue with fissured tongue, oral candidiasis in the dorsum of the tongue, and cheilitis on the upper and lower lips. Therapy provided to patient was topical benzidamine HCl oral oral anti-inflammatory medicine, oral suspension topical nystatin antifungal, OM ointment, Becomzet multivitamin (Vitamin B complex, A, C, E, and Zinc) as multivitamin and tongue cleaner. Two weeks after treatment with benzydamine HCL which acts to inhibit TNFα and prostaglandin, administration of ointments that are analgesic and help the healing process (for geographic tongue and fissure tongue), and administration of nystatin for oral candidiasis, nystatin a macrolide polyene whose toxicity low and specific for candida albicans, accompanied by multivitamins that help the healing process, tongue geography, tongue fissure and oral candidiasis heal. Keywords: fissure tongue; oral candidiasis; cheilitis; mango

scholarly journals Management of Hairy Tongue With Oral Candidiasis In Active Smokers

2020 ◽  
Vol 4 (2) ◽  
pp. 33
Author(s):  
Sri Hernawati
Keyword(s):  
Oral Cavity ◽  
Oral Candidiasis ◽  
Final Diagnosis ◽  
Predisposing Factors ◽  
Vitamin B ◽  
Poor Oral Hygiene ◽  
Oral Health Education ◽  
Dental Hospital ◽  
Filiform Papillae ◽  
Yellowish White

Hairy tongue is an abnormal lengthening of the filiform papillae of the tongue, clinically the dorsum of the tongue looks hair-coated. The etiology of hairy tongue is idiopathic. Predisposing factors for hairy tongue are poor oral hygiene, antibiotics, excessive smoking, oral candidiasis, alcohol consumption, radiation therapy. Candidiasis is an opportunistic infection of the oral cavity caused by Candida albicans (C. albicans). This fungus can cause a pathogenic condition, and is the most common fungal infection found in the human oral cavity. Predisposing factors for oral candidiasis are the use of dentures, xerostomia, stress, and smoking habits. Objective: To demonstrate the management of a case of hairy tongue with oral candidiasis on the dorsum of the tongue. Case: A 54-year-old male patient came to the Dental Hospital of Jember University for treatment with a complaint of feeling thick and yellowish-brown color on the back of the tongue with clinical features of an extension of the papillae filiformis in the posterior third of the dorsum of the tongue, and a white-yellowish white plaque, could be scraped, but not sick. The patient had complained it since ± 3 years ago. The patient claimed to have never had his tongue scraped off and never treated it. In addition, he smoked a pack of cigarette a day and consumed coffee every morning and evening. Conclusion: The final diagnosis in the patient was hairy tongue with oral candidiasis on the dorsum of the tongue. Therapy provided to the patient i.e. Nystatin oral suspension functions as a topical antifungal medication, Becomzet multivitamin (Vitamin B complex, A, C, E, and Zinc) as a multivitamin and Tongue cleaner as a tongue cleaner. Dental and oral health education was conducted for preventing hairy tongue. Keywords: hairy tongue; oral candidiasis; active smokers

scholarly journals Clinical Characteristics and Relevance of Oral Candida Biofilm in Tongue Smears

2021 ◽  
Vol 7 (2) ◽  
pp. 77
Author(s):  
Eunae Cho ◽  
YounJung Park ◽  
Ki-Yeol Kim ◽  
Dawool Han ◽  
Hyun Sil Kim ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Oral Candidiasis ◽  
Salivary Flow ◽  
Nutritional Deficiencies ◽  
Low Grade ◽  
High Grade ◽  
Novel Method ◽  
Oral Candida ◽  
Antifungal Use ◽  
Candida Biofilm

Dimorphic Candida exist as commensal yeast carriages or infiltrate hyphae in the oral cavity. Here, we investigated the clinical relevance of Candida hyphae in non-pseudomembranous oral candidiasis (OC) by smears of tongue biofilms. We conducted a retrospective study of 2829 patients who had had tongue smears regardless of OC suspicion. Clinical characteristics were evaluated using a novel method of assessing hyphae. Clinical factors (moderate/severe stimulated pain, pain aggravated by stimulation, tongue dorsum appearance and initial topical antifungal use) were highly significant in the high-grade hyphae group but were statistically similar in the low-grade hyphae and non-observed hyphae group, suggesting low-grade hyphae infection as a subclinical OC state. In addition to erythematous candidiasis (EC), a new subtype named “morphologically normal symptomatic candidiasis” (MNSC) with specific pain patterns and normal tongue morphology was identified. MNSC had a significantly higher proportion of moderate and severe stimulated pain cases than EC. Low unstimulated salivary flow rate (<0.1 mL/min) was found to be a common risk factor in MNSC and EC. In non-pseudomembranous OC, pain patterns were dependent on Candida hyphae degree regardless of tongue dorsum morphology. Morphologic differences seen in high-grade hyphae infection were not associated with systemic diseases or nutritional deficiencies.

scholarly journals Polymer-Based Scaffolds Loaded with Aloe vera Extract for the Treatment of Wounds

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 961
Author(s):  
Sibusiso Alven ◽  
Vuyolwethu Khwaza ◽  
Opeoluwa O. Oyedeji ◽  
Blessing A. Aderibigbe
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Mechanical Performance ◽  
Healing Process ◽  
Aloe Vera ◽  
Antimicrobial Properties ◽  
Biological Properties ◽  
Wound Management ◽  
Wound Healing Process ◽  
Treatment Of Wounds

The treatment of wounds is one challenging biomedical field due to delayed wound healing common in chronic wounds. Several factors delay wound healing, including microbial infections, malnutrition, underlying physiological conditions, etc. Most of the currently used wound dressing materials suffer from poor antimicrobial properties, poor biodegradability and biocompatibility, and weak mechanical performance. Plant extracts, such as Aloe vera, have attracted significant attention in wound management because of their interesting biological properties. Aloe vera is composed of essential constituents beneficial for the wound healing process, such as amino acids, vitamins C and E, and zinc. Aloe vera influences numerous factors that are involved in wound healing and stimulates accelerated healing. This review reports the therapeutic outcomes of aloe vera extract-loaded polymer-based scaffolds in wound management.

scholarly journals PENGARUH PEMBERIAN GEL KOMBINASI EKSTRAK GETAH PEPAYA (Carica papaya L) DAN EKSTRAK DAGING LIDAH BUAYA (Aloe vera) TERHADAP PROSES PENYEMBUHAN ULKUS TRAUMATIKUS PADA MALE WISTAR RATS YANG MENDERITA DIABETES MELITUS

2015 ◽  
Vol 2 (1) ◽  
pp. 41
Author(s):  
Umi Kulsum ◽  
Ratnawati Hendari ◽  
Siti Chumaeroh
Keyword(s):  
Wound Healing ◽  
Ulcer Healing ◽  
Wistar Rats ◽  
Povidone Iodine ◽  
Healing Process ◽  
Aloe Vera ◽  
Control Group ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Papaya Latex

Introduction: Research on the use of papaya and aloevera sap on wound healing each been done, but effects the combination of the two extracts on wound healing in diabetes mellitus condition has not been done.Purpose: This study aims to determine the effect of a gel combination of papaya latex and aloevera flesh extracts on the traumatics ulcer healing process in diabetic rats.Methods: True experimental laboratory research with the post-test-only control group design that performed on 28 male wistar rats which were divided intofour groups: DM and non-DM rat that treatment with povidone iodine and gel combination of papaya latex and aloevera flesh extract. The treatment was done for 7 days with smearing that was given 2x/day. Traumatics ulcer healing seen from the number of fibroblasts that then were analyzed by One WayAnova and post hoc LSD test.Results: The results showed the number of fibroblasts in DM and non-DM rat with povidone iodine were 44.6 and 42.73; in the DM and non-DM rat with a gel combination of papaya latex and aloe vera flesh extracts were 61.10 and 77.03. One Way Anova test resulted p-value = 0.000, it was mean that there were at least a significant difference on the number of fibroblasts in the two groups. Differences of the number fibroblasts was shown in all groups, except in the group DM and non-DM rats with povidone iodine (p = 0.764).Conclusion: Conclusion of the study was the provision of a gel combination of papaya latex and aloevera flesh extracts effect on the traumatics ulcer healing process in diabetic rats.

scholarly journals PENGARUH EKSTRAK DAGING LIDAH BUAYA (Aloe Vera) TERHADAP PENYEMBUHAN ULSERASI MUKOSA MULUT PADA MALE WISTAR RATS

2015 ◽  
Vol 1 (1) ◽  
pp. 25
Author(s):  
Laila Fitrotuz Zahroh ◽  
Rahmawati Sri Praptiningsih ◽  
Moh. Baehaqi
Keyword(s):  
Oral Mucosa ◽  
Wistar Rats ◽  
Healing Process ◽  
Research Result ◽  
Aloe Vera ◽  
Control Group ◽  
Control Group Design ◽  
Significant Difference ◽  
Male Wistar Rats

Background: Oral mucosa ulceration which often occurs usually in the form of white-yellowish spot with concave surface, reddish edge and pain. Based on previous research, Aloe vera process anti-inflammation substance that could help quickening ulceration healing process. This research aims to know the effect of Aloe vera flesh extract on Male wistar rats oral mucosa ulceration in-vivo. Method: this research was quasi experimental research with the post-test only control group design using Male wistar rats as the testing animal. In the research, there were three treatment groups: The first groups which was given aquadest treatment, second groups with Aloe vera flesh extract, and third groups which was given chlorhexidine gluconate 0,2% treatment. The data collecting was based on histopathology observation concerning the increase of fibroblast quantity. Result: The research result based on comparison test among the three groups with One Way Anova showed that on Day 3th, the average quantity of fibroblast didn't have significant difference between the treatment group and control group positive that was p>0,05, meanwhile on Day 7th every group showed significant difference p<0,05. Conclusion: It concluded that Aloe vera flesh extract has influence on the healing of Male wistar rats oral mucosa ulceration as shown by fibroblast increasing quantity.

scholarly journals Silk derived formulations for accelerated wound healing in diabetic mice

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10232
Author(s):  
Muniba Tariq ◽  
Hafiz Muhammad Tahir ◽  
Samima Asad Butt ◽  
Shaukat Ali ◽  
Asma Bashir Ahmad ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silk Fibroin ◽  
Chronic Wounds ◽  
Histological Analysis ◽  
Healing Process ◽  
Aloe Vera ◽  
Wound Contraction ◽  
Wound Dressings ◽  
Control Group ◽  
Diabetic Mice

Background The present study aimed to prepare effective silk derived formulations in combination with plant extract (Aloe vera gel) to speed up the wound healing process in diabetic mice. Methods Diabetes was induced in albino mice by using alloxan monohydrate. After successful induction of diabetes in mice, excision wounds were created via biopsy puncture (6 mm). Wound healing effect of silk sericin (5%) and silk fibroin (5%) individually and in combination with 5% Aloe vera gel was evaluated by determining the percent wound contraction, healing time and histological analysis. Results The results indicated that the best biocompatible silk combination was of 5% silk fibroin and 5% Aloe vera gel in which wounds were healed in 13 days with wound contraction: 98.33 ± 0.80%. In contrast, the wound of the control group (polyfax) healed in 19 day shaving 98.5 ± 0.67% contraction. Histological analysis revealed that the wounds which were treated with silk formulations exhibited an increased growth of blood vessels, collagen fibers, and much reduced inflammation. Conclusion It can be concluded that a combination of Bombyx mori silk and Aloe vera gel is a natural biomaterial that can be utilized in wound dressings and to prepare more innovative silk based formulations for speedy recovery of chronic wounds.

scholarly journals Denture Stomatitis: Report of a Case with Rarely Used Treatment Modality and Review of Literature

2020 ◽  
Vol 4 (5) ◽  
pp. 116-119
Author(s):  
Parul Uppal Malhotra ◽  
Neera Ohri ◽  
Yagyeshwar Malhotra ◽  
Anindita Mallik
Keyword(s):  
Candida Albicans ◽  
Candida Species ◽  
Fungal Infections ◽  
Bacterial Colonization ◽  
Oral Candidiasis ◽  
Clinical Signs ◽  
Fungal Growth ◽  
Dimorphic Fungus ◽  
Denture Stomatitis ◽  
Microbial Invasion

Candida albicans is the most common Candida species isolated from the oral cavity both in healthy and diseased. Candida albicans is a dimorphic fungus existing both in blastopore phase (yeast phase) and the hyphal or mycelial phase. Although these organisms typically colonize mucocutaneous surfaces, the latter can be portals of entry into deeper tissues when host defences are compromised. Denture stomatitis is a common form of oral candidiasis that manifests as a diffuse inflammation of the maxillary denture bearing areas & is associated with angular cheilitis. At least 70% of individuals with clinical signs of denture stomatitis exhibit fungal growth & these conditions most likely result from yeast colonization of the oral mucosa combined with Bacterial colonization. Candida species act as an endogenous infecting agent on tissue predisposed by chronic trauma to microbial invasion. At one time, oral fungal infections were rare findings in general dentist's office. They were more commonly seen in hospitalized and severely debilitated patients. However with enhanced medical and pharmaceutical technology, increasing numbers of ambulatory immunosuppressed individuals with oral fungal infections are seeking out general dentists for diagnosis and treatment of these lesions.

scholarly journals Itraconazole Oral Solution for Primary Prophylaxis of Fungal Infections in Patients with Hematological Malignancy and Profound Neutropenia: a Randomized, Double-Blind, Double-Placebo, Multicenter Trial Comparing Itraconazole and Amphotericin B

2000 ◽  
Vol 44 (7) ◽  
pp. 1887-1893 ◽  
Author(s):  
J. L. Harousseau ◽  
A. W. Dekker ◽  
A. Stamatoullas-Bastard ◽  
A. Fassas ◽  
W. Linkesch ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Invasive Aspergillosis ◽  
Amphotericin B ◽  
Hematological Malignancy ◽  
Fungal Infections ◽  
Treated Group ◽  
Multicenter Trial ◽  
Oral Solution ◽  
Double Blind ◽  
Systemic Fungal Infection

ABSTRACT Systemic and superficial fungal infections are a major problem among immunocompromised patients with hematological malignancy. A double-blind, double-placebo, randomized, multicenter trial was performed to compare the efficacy and safety of itraconazole oral solution (2.5 mg/kg of body weight twice a day) with amphotericin B capsules (500 mg orally four times a day) for prophylaxis of systemic and superficial fungal infection. Prophylactic treatment was initiated on the first day of chemotherapy and was continued until the end of the neutropenic period (>0.5 × 109 neutrophils/liter) or up to a maximum of 3 days following the end of neutropenia, unless a systemic fungal infection was documented or suspected. The maximum treatment duration was 56 days. In the intent-to-treat population, invasive aspergillosis was noted in 5 (1.8%) of the 281 patients assigned to itraconazole oral solution and in 9 (3.3%) of the 276 patients assigned to oral amphotericin B; of these, 1 and 4 patients died, respectively. Proven systemic fungal infection (including invasive aspergillosis) occurred in 8 patients (2.8%) who received itraconazole, compared with 13 (4.7%) who received oral amphotericin B. Itraconazole significantly reduced the incidence of superficial fungal infections as compared to oral amphotericin B (2 [1%] versus 13 [5%]; P = 0.004). Although the incidences of suspected fungal infection (including fever of unknown origin) were not different between the groups, fewer patients were administered intravenous systemic antifungals (mainly intravenous amphotericin B) in the group receiving itraconazole than in the group receiving oral amphotericin B (114 [41%] versus 132 [48%];P = 0.066). Adequate plasma itraconazole levels were achieved in about 80% of the patients from 1 week after the start of treatment. In both groups, the trial medication was safe and well tolerated. Prophylactic administration of itraconazole oral solution significantly reduces superficial fungal infection in patients with hematological malignancies and neutropenia. The incidence of proven systemic fungal infections, the number of deaths due to deep fungal infections, and the use of systemic antifungals tended to be lower in the itraconazole-treated group than in the amphotericin B-treated group, without statistical significance. Itraconazole oral solution is a broad-spectrum systemic antifungal agent with prophylactic activity in neutropenic patients, especially for those at high risk of prolonged neutropenia.

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