scholarly journals A Two-Stage Mutation Stochastic Model of Carcinogenesis Driven by a Three Level Environmental Process

2020 ◽  
Vol 5 (6) ◽  
pp. 1468-1487
Author(s):  
V. S. S. Yadavalli ◽  
S. Udayabaskaran ◽  
C. T. Dora Pravina ◽  
S. Sreelakshmi
Keyword(s):  
Random Environment ◽  
Normal Cell ◽  
Malignant Cell ◽  
Intermediate Cell ◽  
Malignant Cells ◽  
Level 3 ◽  
Environmental Process ◽  
The Mean ◽  
Intermediate Cells ◽  
Level 2

A two-mutation model of carcinogenesis which evolves under the influence of three level random environment on the production process is formulated and analyzed. A random environment occupies one of the levels 1, 2 and 3 at any time t according to a Markov process. When the environment is in level 1, a normal cell either divides into two normal cells or dies; and an intermediate cell divides into two intermediate cells or dies. When the environment is in level 2, a normal cell either divides into one normal cell and one intermediate cell or dies and an intermediate cell either divides into one intermediate cell and one malignant cell or dies. When the environment is in level 3, a normal cell either divides into two intermediate cells or dies and an intermediate cell either divides into two malignant cells or dies. It is assumed that, once a malignant cell is produced, it generates a malignant tumor with probability 1. We obtain the mean numbers of normal, intermediate and malignant cells at any time t.

scholarly journals A Two-Stage Mutation Stochastic Model of Carcinogenesis Driven by a Two Level Random Environment

2020 ◽  
Vol 5 (6) ◽  
pp. 1392-1408 ◽  
Author(s):  
V. S. S. Yadavalli ◽  
S. Udayabaskaran ◽  
C. T. Dora Pravina ◽  
S. Sreelakshmi
Keyword(s):  
Stochastic Model ◽  
Random Environment ◽  
Normal Cell ◽  
Malignant Cell ◽  
Intermediate Cell ◽  
Malignant Cells ◽  
Two Stage ◽  
Normal Cells ◽  
The Mean ◽  
Intermediate Cells

In this paper, we present a two-stage stochastic model of carcinogenesis in a two level random environment. The random environment switches between two levels, say, 1 and 2 alternately. When the environment is in level 1, a normal cell either divides into two normal cells or dies; and an intermediate cell divides into two intermediate cells or dies. When the environment is in level 2, a normal cell either divides into two intermediate cells or divides into one normal cell and one intermediate cell or divides into two normal cells or dies; and an intermediate cell either divides into two malignant cells or divides into one intermediate cell and one malignant cell or divides into two intermediate cells or dies. It is assumed that, once a malignant cell is produced, it generates a malignant tumor with probability 1. We obtain the mean numbers of normal, intermediate and malignant cells.

Unification of the "Burst" and "Linear" Theories of Periodontal Disease Progression: A Multilevel Manifestation of the Same Phenomenon

2003 ◽  
Vol 82 (3) ◽  
pp. 200-205 ◽  
Author(s):  
M.S. Gilthorpe ◽  
A.T. Zamzuri ◽  
G.S. Griffiths ◽  
I.H. Maddick ◽  
K.A. Eaton ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Disease Progression ◽  
Repeated Measures ◽  
Regression To The Mean ◽  
Random Coefficient Models ◽  
Linear Change ◽  
New Approach ◽  
Level 3 ◽  
The Mean ◽  
Level 2

Previously, burst and linear theories for periodontal disease progression were proposed based on different but limited statistical methods of analysis. Multilevel modeling provides a new approach, yielding a more comprehensive model. Random coefficient models were used to analyze longitudinal periodontal data consisting of repeated measures (level 1), sites (level 2), teeth (level 3), and subjects (level 4). Large negative and highly significant correlations between random linear and quadratic time coefficients indicated that subjects and teeth with greater-than-average linear change experienced decelerated variation. Conversely, subjects and teeth with less-than-average linear change experienced accelerated variation. Change therefore exhibited a dynamic regression to the mean at the tooth and subject levels. Since no equilibrium was attained throughout the study, changes were cyclical. When considered as a multilevel system, the "linear" and "burst" theories of periodontal disease progression are a manifestation of the same phenomenon: Some sites improve while others progress, in a cyclical manner.

scholarly journals Assessment of the Level-3 MODIS daily aerosol optical depth in the context of surface solar radiation and numerical weather modeling

2013 ◽  
Vol 13 (2) ◽  
pp. 675-692 ◽  
Author(s):  
J. A. Ruiz-Arias ◽  
J. Dudhia ◽  
C. A. Gueymard ◽  
D. Pozo-Vázquez
Keyword(s):  
Solar Radiation ◽  
Aerosol Optical Depth ◽  
Optical Depth ◽  
Surface Solar Radiation ◽  
Numerical Weather ◽  
Modis Aod ◽  
Level 3 ◽  
Weather Modeling ◽  
The Mean ◽  
Level 2

Abstract. The daily Level-3 MODIS aerosol optical depth (AOD) product is a global daily spatial aggregation of the Level-2 MODIS AOD (10-km spatial resolution) into a regular grid with a resolution of 1° × 1°. It offers interesting characteristics for surface solar radiation and numerical weather modeling applications. However, most of the validation efforts so far have focused on Level-2 products and only rarely on Level 3. In this contribution, we compare the Level-3 Collection 5.1 MODIS AOD dataset from the Terra satellite available since 2000 against observed daily AOD values at 550 nm from more than 500 AERONET ground stations around the globe. Overall, the mean error of the dataset is 0.03 (17%, relative to the mean ground-observed AOD), with a root mean square error of 0.14 (73%, relative to the same), but these errors are also found highly dependent on geographical region. We propose new functions for the expected error of the Level-3 AOD, as well as for both its mean error and its standard deviation. Additionally, we investigate the role of pixel count vis-à-vis the reliability of the AOD estimates, and also explore to what extent the spatial aggregation from Level 2 to Level 3 influences the total uncertainty in the Level-3 AOD. Finally, we use a radiative transfer model to investigate how the Level-3 AOD uncertainty propagates into the calculated direct normal and global horizontal irradiances.

scholarly journals The anticancer agent PB-100, selectively active on malignant cells, inhibits multiplication of sixteen malignant cell lines, even multidrug resistant

2000 ◽  
Vol 23 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Mirko Beljanski
Keyword(s):  
Cancer Cells ◽  
Tumor Cells ◽  
Cell Lines ◽  
Plant Extract ◽  
Normal Cell ◽  
Anticancer Agent ◽  
Malignant Cell ◽  
Multidrug Resistant ◽  
Cell Multiplication ◽  
Malignant Cells

The plant-derived anticancer agent PB-100 selectively destroys cancer cells, even when multidrug resistant; yet, it does not inhibit normal (non-malignant) cell multiplication. Testing of PB-100 on sixteen malignant cell lines, several multidrug resistant, as well as on five normal cell lines, confirmed our previous results. Flavopereirine and dihydroflavopereirine, the active principles of PB-100, were chemically synthesized and displayed the same selectivity for tumor cells as the purified plant extract, being active at even lower concentrations.

scholarly journals Evaluation of acceptability of the use of internal and external condoms in couples: a cross-over study

2020 ◽  
Vol 9 (9) ◽  
pp. e846997942
Author(s):  
Tatiana Moreira Afonso ◽  
Taciana Silveira Passos ◽  
Marcos Antonio Almeida-Santos
Keyword(s):  
Repeated Measures ◽  
Analogue Scale ◽  
Ease Of Use ◽  
Wave Type ◽  
Four Dimensions ◽  
Level 3 ◽  
The Mean ◽  
Level 1 ◽  
Level 2 ◽  
Better Than

Objective: To evaluate the acceptability (comfort, ease of use, lubrication, and pleasure) of internal and external condom use in stable couples. Metodology: This randomized cross-over trial included 54 couples (108 adult individuals). Participants were asked to evaluate acceptability measures of both types of condoms using the Visual Analogue Scale.  We developed a three-level hierarchical model [level 1= three repeated measures (wave, type of condom); level 2= individual (gender, age); level 3= couple (sequence of presentation of female versus external condom)]. Results: The "ease of use" dimension represented the biggest difference between the types of condoms for men (Hedges 'g = 0.96; p <0.0001) and women (Hedges' g = 1.62; p <0.0001). Regardless of gender, external condoms performed better (1.61; 95% HPD = 1.41 – 1.81). Men gave lower scores in general (-0.62; 95% HPD = -1.16 − -0.10). Conclusion: The external condom scored better than the internal condom for women and their male partners. The scores tended to improve with the repetitive use of the condom. There is no evidence of the influence of the age of the individuals or the randomly selected sequence of use of condoms with regards to the mean score of the four dimensions.

scholarly journals Assessment of the Level-3 MODIS daily aerosol optical depth in the context of surface solar radiation and numerical weather modeling

2012 ◽  
Vol 12 (9) ◽  
pp. 23219-23260 ◽  
Author(s):  
J. A. Ruiz-Arias ◽  
J. Dudhia ◽  
C. A. Gueymard ◽  
D. Pozo-Vázquez
Keyword(s):  
Solar Radiation ◽  
Aerosol Optical Depth ◽  
Optical Depth ◽  
Spatial Resolution ◽  
Surface Solar Radiation ◽  
Numerical Weather ◽  
Level 3 ◽  
Weather Modeling ◽  
The Mean ◽  
Level 2

Abstract. The Level-3 MODIS aerosol optical depth (AOD) product offers interesting features for surface solar radiation and numerical weather modeling applications. Remarkably, the Collection 5.1 dataset extends over more than a decade, and provides daily values of AOD over a global regular grid of 1°×1° spatial resolution. However, most of the validation efforts so far have focused on Level-2 products (10-km, at original resolution) and only rarely on Level-3 (at aggregated spatial resolution of 1°×1°). In this contribution, we compare the Level-3 Collection 5.1 MODIS AOD dataset available since 2000 against observed daily AOD values at 550 nm from more than 500 AERONET ground stations around the globe. One aim of this study is to check the advisability of this MODIS dataset for surface shortwave solar radiation calculations using numerical weather models. Overall, the mean error of the dataset is 0.03 (17%, relative to the mean ground-observed AOD), with a root mean square error of 0.14 (73%, relative to the same), albeit these values are found highly dependent on geographical region. For AOD values below about 0.3 the expected error is found very similar to that of the Level-2 product. However, for larger AOD values, higher errors are found. Consequently, we propose new functions for the expected error of the Level-3 AOD, as well as for both its mean error and its standard deviation. Additionally, we investigate the role of pixel count vis-à-vis the reliability of the AOD estimates. Our results show that a higher pixel count does not necessarily turn into a more reliable AOD estimate. Therefore, we recommend to verify this assumption in the dataset at hand if the pixel count is meant to be used. We also explore to what extent the spatial aggregation from Level-2 to Level-3 influences the total uncertainty in the Level-3 AOD. In particular, we found that, roughly, half of the error might be attributable to Level-3 AOD sub-pixel variability. Finally, we use a~radiative transfer model to investigate how the Level-3 AOD uncertainty propagates into the calculated direct normal (DNI) and global horizontal (GHI) irradiances. Overall, results indicate that, for Level-3 AODs smaller than 0.5, the induced uncertainty in DNI due to the AOD uncertainty alone is below 15% on average, and below 5% for GHI (for a solar zenith angle of 30°. However, the uncertainty in AOD is highly spatially variable, and so is that in irradiance.

STUDY OF SOUND LEVELS IN NICU: DESCRIPTIVE STUDY

2021 ◽  
pp. 16-17
Author(s):  
Dilip Kumar ◽  
V Shankar Vengalapudi ◽  
Maneesha Panduranga Halkar ◽  
Ranjan Kumar Pejaver
Keyword(s):  
American Academy ◽  
Physical Factor ◽  
Descriptive Study ◽  
Night Time ◽  
Sound Exposure ◽  
American Academy Of Pediatrics ◽  
Sound Levels ◽  
Level 3 ◽  
The Mean ◽  
Level 2

Introduction: The American Academy of Pediatrics (AAP) and the Joint Committee on Infant Hearing (JCIH) have introduced noise as a major physical factor causing pollution in NICUs. The American Academy of Paediatrics recommends that sound levels be lower than 45 dBA in the NICU. They thus suggested that the admittance of infants to these wards might be associated with deafness This project included conducting sound surveys of naturall Methodology: y occurring noise in the NICU environments. There was no direct neonate involvement. Each part has two sections A and B, the section A is from more sick babies requiring Level 3 NICU care, whereas the section B is for babies requiring Level 2 NICU care. The mean num Results: bers of staff present in NICU during Day and Night time is 9 and 6 respectively. For all the infants in section A and section B, monitors were used, infusion pumps were used for all babies in section A and as required in section B. Average ventilated babies/day was 1. Conclusion: The sound levels measured in NICU environment and inside incubator in section A and section B, the results show there is no signicant difference the level of sound exposure to the babies in each section.

scholarly journals 925 Maintenance of Elective Surgical Care During Covid-19 Pandemic

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
H Digne-Malcolm ◽  
A Kanwal ◽  
P Puventhiranathan ◽  
L Phelan ◽  
M Hamid ◽  
...  
Keyword(s):  
Length Of Stay ◽  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Elective Surgery ◽  
Surgical Care ◽  
Patient Transfers ◽  
Level 3 ◽  
The Mean ◽  
Further Development ◽  
Level 2

Abstract Introduction Recent publications demonstrate significant morbidity in surgical patients with concurrent COVID-19 infection. This, combined with the redistribution of resources to support the pandemic, led to abrupt cessation in planned operating. COVID-19-free ‘cold’ sites were established to enable elective surgery to resume with reduced risk. We evaluate the outcomes and limitations of a newly established cold site. Method Data were collected retrospectively for all patients operated between June and September 2020 by either General Surgery or Urology. Primary outcomes were 30-day COVID-19 infection and 30-day mortality. Secondary outcomes included length of stay, 30-day complications, and need for transfer to ‘hot’ hospital sites. Results 881 patients were included. No patients had a positive COVID-19 test within 30 days of their operation. 30-day mortality was 0.01% (n = 1). The mean (+/-SD) length of stay was 1.69+/-3.42 days. 12.15% (n = 107) of patients experienced a complication within 30 days and 11.7% (n = 103) were readmitted within 30 day of discharge. 3.3% (n = 29) of patients required transfer to a ‘hot’ hospital site. 44.8% of these were admitted to level 2 or level 3 care, 17.2% required total parenteral nutrition, and 20.7% returned to theatre. Conclusions ‘Cold’ surgical sites are effective in preventing peri-operative COVID-19 infection. Elective surgery can therefore continue safely through the pandemic with such precautions. Further development of on-site resources, including provision for total parenteral nutrition and access to higher level care, will help to minimise the need for patient transfers to COVID-19 exposed sites.

Historical text archives and prosopography: the COEL database system

1998 ◽  
Vol 10 (1-3) ◽  
pp. 57-72 ◽  
Author(s):  
K. S. B. Keats-Rohan
Keyword(s):  
Research Tool ◽  
Direct Access ◽  
Specific Situation ◽  
Core Data ◽  
Secondary Sources ◽  
The Core ◽  
Level 3 ◽  
Full Discussion ◽  
Available Information ◽  
Level 2

The COEL database and database software, a combined reference and research tool created by historians for historians, is presented here through Screenshots illustrating the underlying theoretical model and the specific situation to which that has been applied. The key emphases are upon data integrity, and the historian's role in interpreting and manipulating what is often contentious data. From a corpus of sources (Level 1) certain core data are extracted for separate treatment at an interpretive level (Level 3), based upon a master list of the core data (Level 2). The core data are interdependent: each record in Level 2 is of interest in itself; and it either could or should be associated with an(other) record(s) as a specific entity. Sometimes the sources are ambiguous and the association is contentious, necessitating a probabilty-coding approach. The entities created by the association process can then be treated at a commentary level, introducing material external to the database, whether primary or secondary sources. A full discussion of the difficulties is provided within a synthesis of available information on the core data. Direct access to the source texts is only ever a mouse click away. Fully query able, COEL is formidable look-up and research tool for users of all levels, who remain free to exercise an alternative judgement on the associations of the core data. In principle, there is no limit on the type of text or core data that could be handled in such a system.

POTRET PERILAKU RELIGIUS MAHASISWA UIN SAYARIF HIDAYATULLAH JAKARTA

Al-Risalah ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. 126-148
Author(s):  
Ay Maryani
Keyword(s):  
Religious Behavior ◽  
Male And Female ◽  
Mean Values ◽  
Significance Level ◽  
Average Value ◽  
Environment Variable ◽  
Independent Variable ◽  
The Mean ◽  
Gender Factor ◽  
Level 2

This study describes the religious behavior of UIN Syarif Hidayatullah Jakarta students. The variables used are internal and external environment as independent variable and religious behavior as dependent variable. The internal environment variable consists of gender factor, (male and female). The external environmental variables comprise the faculty environment, the present resident and the place to grow. The present resident consist of dormitories, boarding houses and parents' homes and the place to grow consist of urban and rural environment. Religious behavior variables consist of habluminallah behavior and habluminannas behavior. Habluminallah's behavior measured by (1) knowledge of faith and worship, (2) attitudes toward faith and worship, and (3) practice of faith and worship. The habluminannas variable measured by (1) Islamic behavior for them self, like honest, discipline and good work / studyethics, trust and concern on legality, (2) Islamic behavior with others, like generous, cooperation, caring, respect to the people's rights and tolerance and (3) Islamic behavior for the natural surroundings, like love of nature and nature conservation efforts. The methodology used was (1) Statistical descriptive, (2) MANOVA (Multivariate Analysis of Variance) and (3) Independent sample t-test. The results showed the religious behavior UIN Syarif Hidayatullah Jakarta students has a very good category. This is indicated by the mean values for the behavior of haluminallah and habluminannas of 158.85 and 178.76,  espectively. The average value of habluminallah behaviour in the range of values "145-180" with the category of "very good" and habluminannas behavior in the range value "165-205" with the category "very good. Habluminallah and habluminannas behavior are different for each faculty. This is indicated by the significance level of Pillai Trace, Wilk Lambda, Hotelling Trace, Roy's Largest Root of 0.00 (<0.05). Habluminallah and habluminannas behavior are the same for respondents who live in dormitories, boarding houses, and parents' homes. This is indicated by the value of F test and significance at Wilk's Lambda respectively for 2.055 and 0.085 (>0.05). Habluminallah and habluminannas behaviors are similar for urban and rural respondents. This is known from the sig level. (2-tailed) for habluminallah and habluminannas behavior of 0.317 and 0.245 (> 0.05), respectively. Habluminallah and habluminannas behaviors are similar for male and female. This is known from the sig level. (2-tailed) for habluminallah and habluminannas behavior of 0.950 and 0.307 (> 0.05),respectively. The results of this study are expected to be used to develop university policies that can enhance the Islamic values of UIN Syarif Hidayatullah Jakarta.

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