scholarly journals Insights Into the Regulation of Gynecological Inflammation-Mediated Malignancy by Metalloproteinases

2021 ◽  
Vol 9 ◽  
Author(s):  
Yasmin Begum ◽  
Anuradha Pandit ◽  
Snehasikta Swarnakar
Keyword(s):  
Extracellular Matrix ◽  
Tumor Cell ◽  
Low Income ◽  
Expression Patterns ◽  
Immune Surveillance ◽  
Reproductive Age ◽  
Cellular Interactions ◽  
Gynecological Disorders ◽  
Membrane Bound ◽  
A Disintegrin And Metalloproteinase

Gynecological illness accounts for around 4.5% of the global disease burden, which is higher than other key global health concerns such as malaria (1.04%), TB (1.9%), ischemic heart disease (2.2%), and maternal disorders (3.5%). Gynecological conditions in women of reproductive age are linked to both in terms of diagnosis and treatment, especially in low-income economies, which poses a serious social problem. A greater understanding of health promotion and illness management can help to prevent diseases in gynecology. Due to the lack of established biomarkers, the identification of gynecological diseases, including malignancies, has proven to be challenging in most situations, and histological exams remain the gold standard. Metalloproteinases (MMPs, ADAMs, ADAMTSs) and their endogenous inhibitors (TIMPs) modulate the protease-dependent bioavailability of local niche components (e.g., growth factors), matrix turnover, and cellular interactions to govern specific physical and biochemical characteristics of the environment. Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM), and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc-dependent endopeptidases that contribute significantly to the disintegration of extracellular matrix proteins and shedding of membrane-bound receptor molecules in several diseases, including arthritis. MMPs are noteworthy genes associated with cancer development, functional angiogenesis, invasion, metastasis, and immune surveillance evasion. These genes are often elevated in cancer and multiple benign gynecological disorders like endometriosis, according to research. Migration through the extracellular matrix, which involves proteolytic activity, is an essential step in tumor cell extravasation and metastasis. However, none of the MMPs’ expression patterns, as well as their diagnostic and prognostic potential, have been studied in a pan-cancer context. The latter plays a very important role in cell signaling and might be used as a cancer treatment target. ADAMs are implicated in tumor cell proliferation, angiogenesis, and metastasis. This review will focus on the contribution of the aforementioned metalloproteinases in regulating gynecological disorders and their subsequent manipulation for therapeutic intervention.

Differential Expression Patterns of a Disintegrin and Metalloproteinase With Thrombospondin Motifs (ADAMTS) -1, -4, -5, and -14 in Human Placenta and Gestational Trophoblastic Diseases

2014 ◽  
Vol 138 (5) ◽  
pp. 643-650 ◽  
Author(s):  
So-Young Lee ◽  
Hyang-Sin Lee ◽  
Minchan Gil ◽  
Chong Jai Kim ◽  
Yong-Hee Lee ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Human Placenta ◽  
Expression Patterns ◽  
Cell Types ◽  
First Trimester ◽  
Staining Intensity ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases ◽  
A Disintegrin And Metalloproteinase ◽  
Time Specific

Context.—The ability of intermediate trophoblasts to invade maternal tissue during placentation depends on how well they can degrade the extracellular matrix. Invasion into the extracellular matrix requires many complex proteases. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a novel family of secreted metalloproteinases. The ADAMTS-1, -4, -5, and -14 subtypes are known to be expressed in human placenta, but little is understood about their expression patterns. Objective.—To examine the expression patterns of ADAMTS-1, -4, -5, and -14 in specific human placenta cell types during gestation and in gestational trophoblastic diseases. Design.—Placental tissues were obtained from 25 pregnant women and 21 cases of gestational trophoblastic diseases (10 early complete moles, 3 placental site trophoblastic tumors, 4 invasive moles, and 4 choriocarcinomas). The expression of the 4 ADAMTS was analyzed by immunohistochemistry. Results.—ADAMTS-1, -4, -5, and -14 were differentially expressed by the human placenta throughout gestation in a time-specific and cell type–specific manner, as well as in gestational trophoblastic diseases. ADAMTS-1 showed gradually strong staining intensity in gestational trophoblastic diseases according to the invasive potential but showed consistent strong intensity throughout normal placenta. ADAMTS-4 and ADAMTS-5 exhibited higher and restricted expression in first-trimester intermediate trophoblasts. They also exhibited comparably strong expression in gestational trophoblastic diseases. However, ADAMTS-14 expression remained unchanged throughout gestation. Conclusions.—The restricted expression pattern of ADAMTS-4 and ADAMTS-5 and their increased expression in gestational trophoblastic diseases suggest that these 2 ADAMTS subtypes are associated with a biological phenotype of trophoblasts involved in human placentation and the development of gestational trophoblastic diseases.

scholarly journals Modulating Tumor Cell Functions by Tunable Nanopatterned Ligand Presentation

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 212
Author(s):  
Katharina Amschler ◽  
Michael P. Schön
Keyword(s):  
Extracellular Matrix ◽  
Tumor Cell ◽  
Cell Fate ◽  
Epithelial Mesenchymal Transition ◽  
Model Systems ◽  
Cellular Functions ◽  
Biophysical Parameters ◽  
Ligand Density ◽  
Mesenchymal Transition ◽  
Cell Functions

Cancer comprises a large group of complex diseases which arise from the misrouted interplay of mutated cells with other cells and the extracellular matrix. The extracellular matrix is a highly dynamic structure providing biochemical and biophysical cues that regulate tumor cell behavior. While the relevance of biochemical signals has been appreciated, the complex input of biophysical properties like the variation of ligand density and distribution is a relatively new field in cancer research. Nanotechnology has become a very promising tool to mimic the physiological dimension of biophysical signals and their positive (i.e., growth-promoting) and negative (i.e., anti-tumoral or cytotoxic) effects on cellular functions. Here, we review tumor-associated cellular functions such as proliferation, epithelial-mesenchymal transition (EMT), invasion, and phenotype switch that are regulated by biophysical parameters such as ligand density or substrate elasticity. We also address the question of how such factors exert inhibitory or even toxic effects upon tumor cells. We describe three principles of nanostructured model systems based on block copolymer nanolithography, electron beam lithography, and DNA origami that have contributed to our understanding of how biophysical signals direct cancer cell fate.

scholarly journals Role of miRNAs in Normal Endometrium and in Endometrial Disorders: Comprehensive Review

2021 ◽  
Vol 10 (16) ◽  
pp. 3457
Author(s):  
Kamila Kolanska ◽  
Sofiane Bendifallah ◽  
Geoffroy Canlorbe ◽  
Arsène Mekinian ◽  
Cyril Touboul ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Mirna Expression ◽  
Expression Patterns ◽  
Mirna Regulation ◽  
Rigorous Analysis ◽  
Sexual Hormones ◽  
Physiological Mechanisms ◽  
Normal Endometrium ◽  
Gynecological Disorders

The molecular responses to hormonal stimuli in the endometrium are modulated at the transcriptional and post-transcriptional stages. Any imbalance in cellular and molecular endometrial homeostasis may lead to gynecological disorders. MicroRNAs (miRNAs) are involved in a wide variety of physiological mechanisms and their expression patterns in the endometrium are currently attracting a lot of interest. miRNA regulation could be hormone dependent. Conversely, miRNAs could regulate the action of sexual hormones. Modifications to miRNA expression in pathological situations could either be a cause or a result of the existing pathology. The complexity of miRNA actions and the diversity of signaling pathways controlled by numerous miRNAs require rigorous analysis and findings need to be interpreted with caution. Alteration of miRNA expression in women with endometriosis has been reported. Thus, a potential diagnostic test supported by a specific miRNA signature could contribute to early diagnosis and a change in the therapeutic paradigm. Similarly, specific miRNA profile signatures are expected for RIF and endometrial cancer, with direct implications for associated therapies for RIF and adjuvant therapies for endometrial cancer. Advances in targeted therapies based on the regulation of miRNA expression are under evaluation.

scholarly journals Transcriptome-Based Identification and Molecular Evolution of the Cytochrome P450 Genes and Expression Profiling under Dimethoate Treatment in Amur Stickleback (Pungitius sinensis)

Animals ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 873 ◽  
Author(s):  
Jun Cao ◽  
Xiuzhu Cheng
Keyword(s):  
Expression Profiling ◽  
Transcriptome Sequencing ◽  
Cell Metabolism ◽  
Functional Divergence ◽  
Expression Patterns ◽  
Cytochrome P450s ◽  
Cytochrome P450 Genes ◽  
Membrane Bound ◽  
Functional Relevance ◽  
Functional Investigation

Cytochrome P450s (CYPs) are a family of membrane-bound mono-oxygenase proteins, which are involved in cell metabolism and detoxification of various xenobiotic substances. In this study, we identified 58 putative CYP genes in Amur stickleback (Pungitius sinensis) based on the transcriptome sequencing. Conserved motif distribution suggested their functional relevance within each group. Some present recombination events have accelerated the evolution of this gene family. Moreover, a few positive selection sites were identified, which may have accelerated the functional divergence of this family of proteins. Expression patterns of these CYP genes were investigated and indicated that most were affected by dimethoate treatment, suggesting that CYPs were involved in the detoxication of dimethoate. This study will provide a foundation for the further functional investigation of CYP genes in fishes.

scholarly journals The relationship between self-report and biomarkers of stress in low-income reproductive-age women

2010 ◽  
Vol 203 (6) ◽  
pp. 577.e1-577.e8 ◽  
Author(s):  
Ann E.B. Borders ◽  
William A. Grobman ◽  
Laura B. Amsden ◽  
Thomas W. McDade ◽  
Lisa K. Sharp ◽  
...  
Keyword(s):  
Low Income ◽  
Reproductive Age ◽  
Self Report ◽  
Reproductive Age Women ◽  
The Relationship

Unraveling the extracellular matrix-tumor cell interactions to aid better targeted therapies for neuroblastoma

2021 ◽  
Vol 608 ◽  
pp. 121058
Author(s):  
Rebeca Burgos-Panadero ◽  
Souhaila H. El Moukhtari ◽  
Inmaculada Noguera ◽  
Carlos Rodríguez-Nogales ◽  
Susana Martín-Vañó ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Tumor Cell ◽  
Targeted Therapies ◽  
Cell Interactions

scholarly journals An Intergenerational Women’s Empowerment Intervention to Mitigate Domestic Violence

2012 ◽  
Vol 18 (3) ◽  
pp. 346-370 ◽  
Author(s):  
Suneeta Krishnan ◽  
Kalyani Subbiah ◽  
Sajida Khanum ◽  
Prabha S. Chandra ◽  
Nancy S. Padian
Keyword(s):  
Domestic Violence ◽  
Health Outcomes ◽  
Low Income ◽  
Program Planning ◽  
Women's Empowerment ◽  
Reproductive Age ◽  
Women’S Empowerment ◽  
Adverse Health Outcomes ◽  
Prevention Interventions ◽  
Domestic Violence Prevention

A growing body of literature has documented the global prevalence of domestic violence against women of reproductive age as well as the association between violence and an array of adverse reproductive, psychosocial, and child health outcomes . However, there is a dearth of research on domestic violence prevention interventions in the peer-reviewed literature to guide program planning and policy-making efforts. In this article, the authors describe the development and assessment of the feasibility, acceptability, and potential effectiveness of an intergenerational women’s empowerment-based intervention to mitigate domestic violence and related adverse health outcomes in low-income urban communities in Southern India.

scholarly journals Assessment of knowledge and practices of Internally Displaced pregnant women attending to antenatal clinic center at Arbat camp in Sulaimani, Kurdistan Region of Iraq

2017 ◽  
Vol 3 (1) ◽  
pp. 52-56
Author(s):  
Layla Abdulkhalk Abass
Keyword(s):  
Antenatal Care ◽  
Pregnant Women ◽  
Low Income ◽  
Reproductive Age ◽  
Good Knowledge ◽  
Internally Displaced Persons ◽  
Islamic State ◽  
Displaced Persons ◽  
Kurdistan Region ◽  
Internally Displaced

Internally displaced persons are peoples displaced in it is own country but not crossed a border. After (Islamic State of Iraq and Syria attacked in 2014 to Iraq, millions of Iraqi people flee from their own city war zone to safe camps in Kurdistan region north of Iraq, Arbat camp is one of these camps. Iraqi civilian people constitute most new displacement persons around the world as at least 2.2 million were displaced in 2014. An important part of basic maternal health care is antenatal care that must be provided during pregnancy. Aim of this study is to provide demographic data of Internally Displaced Persons pregnant women and the effect on antenatal care knowledge and practices among of Arbat camp that visits to camp health centers on their health. Assessment of knowledge and practices of pregnant women about antennal care. A cross-sectional descriptive study has been conducted to assess the knowledge and practices of (103) women attended to antenatal care of internally displaced persons) at Arbat camps between 1 January to 30 June 2016. Data collected through the questionnaire form by face-to-face interview. Statistical analyses performed by using SPSS version 16.0, to find descriptive analysis like percentage and frequency and for relative statistical analysis. The results have revealed that most of the pregnant women were in the active reproductive age group 18-25 years old 56(54.4%) pregnant women, housewives 102(99%), illiterate 48(46.6%) pregnant women, were in families that have low income with 48(46.6%) pregnant women with significant relation to the knowledge and practices to antenatal care. In conclusion, most pregnant women have very good knowledge about antenatal care except about performing oral health hygiene during pregnancy. The majority of pregnant women in camps have very good knowledge about all practices that must be do during antenatal except taking medication without a physician prescription.

scholarly journals Stillbirth and infant death: mental health among low-income mothers in Mumbai

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lisa Roberts ◽  
Solomon J. Renati ◽  
Shreeletha Solomon ◽  
Susanne Montgomery
Keyword(s):  
Mental Health ◽  
At Risk ◽  
Low Income ◽  
Infant Death ◽  
Postnatal Depression ◽  
Perinatal Loss ◽  
Reproductive Age ◽  
Cross Sectional ◽  
History Of ◽  
Perinatal Grief

Abstract Background India has the highest number of stillbirths and the highest neonatal death rate in the world. In the context of its pronatalist society, women who experience perinatal loss often encounter significant social repercussions on top of grief. Furthermore, even when pregnancy outcomes were favorable, adverse life circumstances put some women at risk for postnatal depression. Therefore, perinatal loss and postnatal depression take a heavy toll on women’s mental health. The purpose of this study is to assess mental health among a sample of Mumbai slum-dwelling women with a history of recent childbirth, stillbirth, or infant death, who are at risk for perinatal grief, postnatal depression, or mental health sequelae. Methods We conducted a mixed method, cross-sectional study. A focus group discussion informed the development of a comprehensive survey using mainly internationally validated scales. After rigorous forward and back-translation, surveys were administered as face-to-face structured interviews due to low literacy and research naiveté among our respondents. Interviews were conducted by culturally, linguistically, gender-matched, trained research assistants. Results Of our reproductive age (N = 260) participants, 105 had experienced stillbirth, 69 had a history of infant death, and 25 had experienced both types of loss. Nearly half of the sample met criteria for postnatal depression, and 20% of these women also met criteria for perinatal grief. Anxiety and depression varied by subgroup, and was highest among women desiring an intervention. Conclusions Understanding factors contributing to women’s suffering related to reproductive challenges in this pronatalist context is critically important for women’s wellbeing.

scholarly journals Maternity incentive scheme on safe delivery services in rural area of Kavre district

2015 ◽  
Vol 5 (2) ◽  
pp. 30-35
Author(s):  
A Baniya ◽  
D Chhetri ◽  
B Pokhrel
Keyword(s):  
Rural Area ◽  
Low Income ◽  
Rural Women ◽  
Child Death ◽  
Reproductive Age ◽  
Incentive Scheme ◽  
Hospital Services ◽  
Safe Delivery ◽  
Birth Attendance ◽  
Delivery Services

Maternity incentive schemes were to encourage mothers to use skilled birth attendance for the best prevention of maternal and child death whereas the pregnant women should have access to high quality prenatal care which, they can afford and where, they are treated with respect. The objective of the study was to determine the knowledge and utilization of maternal incentives scheme on delivery services at rural area of Nepal. This study was cross-sectional descriptive in nature and Study was conducted in Panchkhal VDC, Kavre district of Nepal.The numbers of married women of reproductive age group were the study population. The sample size was taken as 96. Most of the respondent had primary education (38.5%) and illiterate (15.6%). Highest mobilization of sources which provided throughout the health institute disseminates the MIS information During the study seventy nine mothers went to hospital for treatment. Utilization of incentive helps to change the delivery behavior (practice) of women (78%) within the hospital services by the skilled birth attendants. The 54.2% were not getting money (private hospital) for delivery and 13.5% respondents used money in nutrition and transport, 11.5% used in medicine and 1.0% respondent didn’t spend money. Low income and poor women (63%) have been more benefited from the incentive scheme followed by Janajati (12.5%), Dalit (12.5%) and rural women (9.4%) respectively. Importance of maternity incentive scheme (MIS) on safe delivery services (SDS) needs to be disseminated in rural community through integrated health education program. Most of the respondents reported that only incentive is not the matter of utilization of hospital services, but the issue of mother and child health.

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