scholarly journals Methylene Blue Application to Lessen Pain: Its Analgesic Effect and Mechanism

2021 ◽  
Vol 15 ◽  
Author(s):  
Seung Won Lee ◽  
Hee Chul Han
Keyword(s):  
Methylene Blue ◽  
Pain Relief ◽  
Sodium Current ◽  
Public Attention ◽  
Analgesic Effects ◽  
Relieve Pain ◽  
Discogenic Low Back Pain ◽  
Current Reduction ◽  
Insight Into ◽  
Anti Inflammation

Methylene blue (MB) is a cationic thiazine dye, widely used as a biological stain and chemical indicator. Growing evidence have revealed that MB functions to restore abnormal vasodilation and notably it is implicated even in pain relief. Physicians began to inject MB into degenerated disks to relieve pain in patients with chronic discogenic low back pain (CDLBP), and some of them achieved remarkable outcomes. For osteoarthritis and colitis, MB abates inflammation by suppressing nitric oxide production, and ultimately relieves pain. However, despite this clinical efficacy, MB has not attracted much public attention in terms of pain relief. Accordingly, this review focuses on how MB lessens pain, noting three major actions of this dye: anti-inflammation, sodium current reduction, and denervation. Moreover, we showed controversies over the efficacy of MB on CDLBP and raised also toxicity issues to look into the limitation of MB application. This analysis is the first attempt to illustrate its analgesic effects, which may offer a novel insight into MB as a pain-relief dye.

scholarly journals Local Anesthetic Lidocaine and Cancer: Insight Into Tumor Progression and Recurrence

2021 ◽  
Vol 11 ◽  
Author(s):  
Caihui Zhang ◽  
Cuiyu Xie ◽  
Yao Lu
Keyword(s):  
Pain Relief ◽  
Signaling Pathways ◽  
Local Anesthetic ◽  
Immune Regulation ◽  
Molecular Mechanisms ◽  
Primary Treatment ◽  
Akt Signaling ◽  
Clinical Benefits ◽  
Insight Into ◽  
Anti Inflammation

Cancer is a leading contributor to deaths worldwide. Surgery is the primary treatment for resectable cancers. Nonetheless, it also results in inflammatory response, angiogenesis, and stimulated metastasis. Local anesthetic lidocaine can directly and indirectly effect different cancers. The direct mechanisms are inhibiting proliferation and inducing apoptosis via regulating PI3K/AKT/mTOR and caspase-dependent Bax/Bcl2 signaling pathways or repressing cytoskeleton formation. Repression invasion, migration, and angiogenesis through influencing the activation of TNFα-dependent, Src-induced AKT/NO/ICAM and VEGF/PI3K/AKT signaling pathways. Moreover, the indirect influences are immune regulation, anti-inflammation, and postoperative pain relief. This review summarizes the latest evidence that revealed potential clinical benefits of lidocaine in cancer treatment to explore the probable molecular mechanisms and the appropriate dose.

scholarly journals The Psychoprophylactic Method of Painless Childbirth in Socialist Czechoslovakia: from State Propaganda to Activism of Enthusiasts

2016 ◽  
Vol 60 (4) ◽  
pp. 534-556 ◽  
Author(s):  
Ema Hrešanová
Keyword(s):  
Pain Relief ◽  
Scientific Method ◽  
Communist Regime ◽  
The West ◽  
Medical Journals ◽  
History Of ◽  
English Speaking ◽  
The 1960S ◽  
Pharmacological Method ◽  
Insight Into

This paper explores the history of the ‘psychoprophylactic method of painless childbirth’ in socialist Czechoslovakia, in particular, in the Czech and Moravian regions of the country, showing that it substantially differs from the course that the method took in other countries. This non-pharmacological method of pain relief originated in the USSR and became well known as the Lamaze method in western English-speaking countries. Use of the method in Czechoslovakia, however, followed a very different path from both the West, where its use was refined mainly outside the biomedical frame, and the USSR, where it ceased to be pursued as a scientific method in the 1950s after Stalin’s death. The method was imported to Czechoslovakia in the early 1950s and it was politically promoted as Soviet science’s gift to women. In the 1960s the method became widespread in practice but research on it diminished and, in the 1970s, its use declined too. However, in the 1980s, in the last decade of the Communist regime, the method resurfaced in the pages of Czechoslovak medical journals and underwent an exciting renaissance, having been reintroduced by a few enthusiastic individuals, most of them women. This article explores the background to the renewed interest in the method while providing insight into the wider social and political context that shaped socialist maternity and birth care in different periods.

New insight into the microstructure of natural calcined laterites and their performance as heterogeneous Fenton catalyst for methylene blue degradation

2018 ◽  
Vol 124 (2) ◽  
pp. 931-956 ◽  
Author(s):  
Gloria Murielle Rostandi Kpinsoton ◽  
Héla Karoui ◽  
Yohan Richardson ◽  
Blédja N’dri Stéphanie Koffi ◽  
Hamma Yacouba ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Heterogeneous Fenton ◽  
Methylene Blue Degradation ◽  
Fenton Catalyst ◽  
Heterogeneous Fenton Catalyst ◽  
Insight Into

scholarly journals Management of Oral Pain

2012 ◽  
Vol 3 (2) ◽  
pp. 207-212
Author(s):  
Frieda A Pickett
Keyword(s):  
Pain Relief ◽  
Scientific Evidence ◽  
Dental Pain ◽  
Pain Response ◽  
Dental Services ◽  
Over The Counter ◽  
Oral Pain ◽  
Pain Pathways ◽  
Relieve Pain ◽  
Tooth Preparation

ABSTRACT Pain is the leading reason for individuals to seek dental care and understanding factors in pain response assists in pain management. Some dental services, including those involving tooth preparation, can result in postprocedure discomfort leading to a recommendation for analgesic therapy following treatment. Analgesia is defined as pain relief by inhibiting specific pain pathways and drugs to relieve pain are analgesics. Over the counter agents are efficacious agents for most dental pain with ibuprofen and acetaminophen commonly recommended. Considerations for analgesic recommendations, based on the medical history, scientific evidence of efficacy, and patient preferences are discussed. How to cite this article Pickett FA. Management of Oral Pain. World J Dent 2012;3(2):207-212.

scholarly journals CONTROL OF POST-SURGICAL PAIN

2010 ◽  
Vol 17 (03) ◽  
pp. 400-404
Author(s):  
ALI MIR MANSOURI ◽  
FARNOUSH FARZI ◽  
SHIRIN KHALKHALIRAD ◽  
Katayoon Haryalchi ◽  
Abas Sediginejad
Keyword(s):  
Pain Relief ◽  
Cesarean Section ◽  
Pain Control ◽  
Nausea And Vomiting ◽  
Chi Square ◽  
Double Blind ◽  
Analgesic Effects ◽  
Emergency Cesarean ◽  
Surgical Pain ◽  
Chi Square Test

Introduction: There are many complications for patients with post cesarean section relative pain. So it delays in discharging or increasing in hospital stay. The objective of this study was a comparison between Tramadol and Meperidine according to pain relief or other possible complications in post cesarean section pain control. Materials and Methods: This study was a double blind clinical trial. It arranged for 240 parturients who scheduled for emergency cesarean section with pain after surgery in spite of spinal anesthesia. All patients were in ASA class I. They were divided randomly in two groups .Meperidine (M) and Tramadol (T) groups with 120 patients in each group. After beginning of pain in post anesthesia care unit (VAS> or = 4), in group (T) tramadol 1.5 mg/kg and in group (M) meperidine  .5 mg/kg were injected intravenously. Apart from pain, other drug complications such as shivering, blood pressure changes, itching, nausea and vomiting, drowsiness were recorded one and two hours after injection. Data were analyzed by chi-square test. Results: Relative frequency rate (RFR) of 50% decrease in pain score one hour after intravenous injection was 56.7% in group (T) and 69.2% in group (M) ( P = 0.054). RFR for respiratory depression after one hour was 5.8% in (M) group and 0 in (T) group (P = 0.007). RFR for nausea after one hour was 39.2% in (T) group and 23.3% in (M) group (P = 0.008). RFR for vomiting after one hour was 23.3% in (T) group and 13.3% in (M) group (P= 0.045). RFR for drowsiness after one hour was 25% in (M) group and 3.3% in (T) group (P=0.007). There was no statistically significant relationship after 2nd hour for pain relief, nausea, vomiting and drowsiness between two groups. There was no difference between two groups in RFR for shivering, blood pressurechanges and itching in both two groups. Conclusion: This study illustrates both remedies Meperidine and Tramadol which were effective for pain relief and shivering after cesarean section. But according to high incidence of nausea and vomiting with Tramadol and more analgesic effects of Meperidine than Tramadol, administration of Meperidine is better than Tramadol after cesarean section for pain control.

scholarly journals Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1–mediated immunoescape via STING-IFN signaling and extracellular vesicles

2020 ◽  
Vol 8 (2) ◽  
pp. e001372
Author(s):  
An Ning Cheng ◽  
Li-Chun Cheng ◽  
Cheng-Liang Kuo ◽  
Yu Kang Lo ◽  
Han-Yu Chou ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Protein Quality ◽  
Innate Immune ◽  
Oxygen Species ◽  
Diagnostic Biomarker ◽  
Cell Immunity ◽  
Insight Into ◽  
Anti Inflammation

BackgroundMitochondrial Lon is a chaperone and DNA-binding protein that functions in protein quality control and stress response pathways. The level of Lon regulates mitochondrial DNA (mtDNA) metabolism and the production of mitochondrial reactive oxygen species (ROS). However, there is little information in detail on how mitochondrial Lon regulates ROS-dependent cancer immunoescape through mtDNA metabolism in the tumor microenvironment (TME).MethodsWe explored the understanding of the intricate interplay between mitochondria and the innate immune response in the inflammatory TME.ResultsWe found that oxidized mtDNA is released into the cytosol when Lon is overexpressed and then it induces interferon (IFN) signaling via cGAS-STING-TBK1, which upregulates PD-L1 and IDO-1 expression to inhibit T-cell activation. Unexpectedly, upregulation of Lon also induces the secretion of extracellular vehicles (EVs), which carry mtDNA and PD-L1. Lon-induced EVs further induce the production of IFN and IL-6 from macrophages, which attenuates T-cell immunity in the TME.ConclusionsThe levels of mtDNA and PD-L1 in EVs in patients with oral cancer function as a potential diagnostic biomarker for anti-PD-L1 immunotherapy. Our studies provide an insight into the immunosuppression on mitochondrial stress and suggest a therapeutic synergy between anti-inflammation therapy and immunotherapy in cancer.

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