scholarly journals A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems

2021 ◽  
Vol 8 ◽  
Author(s):  
Hongyun Lu ◽  
Shengliang Zhang ◽  
Jinling Wang ◽  
Qihe Chen
Keyword(s):  
Controlled Release ◽  
Safety Concern ◽  
Food Delivery ◽  
Cutting Edge ◽  
Bioactive Molecules ◽  
Recent Advancement ◽  
Alternative Drug ◽  
Delivery Strategies

Recently, owing to well-controlled release, enhanced distribution and increased permeability, nanocarriers used for alternative drug and food-delivery strategies have received increasingly attentions. Nanocarriers have attracted a large amount of interest as potential carriers of various bioactive molecules for multiple applications. Drug and food-based delivery via polymeric-based nanocarriers and lipid-based nanocarriers has been widely investigated. Nanocarriers, especially liposomes, are more and more widely used in the area of novel nano-pharmaceutical or food-based design. Herein, we aimed to discuss the recent advancement of different surface-engineered nanocarriers type, along with cutting-edge applications for food and nanomedicine and highlight the alternative of phytochemical as nanocarrier. Additionally, safety concern of nanocarriers was also highlighted.

Antibiotic-anionic Clay Matrix Used for Drug Controlled Release

2018 ◽  
Vol 69 (2) ◽  
pp. 321-323
Author(s):  
Georgeta Zegan ◽  
Elena Mihaela Carausu ◽  
Loredana Golovcencu ◽  
Alina Sodor Botezatu ◽  
Eduard Radu Cernei ◽  
...  
Keyword(s):  
Controlled Release ◽  
Layered Double Hydroxides ◽  
Bioactive Molecules ◽  
Drug Controlled Release ◽  
Anionic Clays ◽  
Anionic Clay ◽  
Toxicological Studies ◽  
High Efficient ◽  
Clay Matrix ◽  
Double Hydroxides

Anionic clay matrix acting as drug controlled release system have shown in last years a great potential for delivery of bioactive molecules and chemical therapeutics. This organic-inorganic nanohybrid system is high efficient offering an excellent protection of intercalated compounds from degradation. Compared to other nanoparticles used in medical area, anionic clays type layered double hydroxides have found to be biocompatible according to toxicological studies. Ampicillin containing MgAlLDHs and ZnAlLDH samples have been prepared following two routes: anion-exchange procedure and reconstruction from calcined layered double hydroxides. Solid samples have been characterized by FTIR and SEM-EDX highlighting the alteration of pristine LDHs structure when the antibiotic is introduced in the interlayer gallery.

scholarly journals Recent Advancement in Controlling Industrial Pollutions

2019 ◽  
Vol 8 (6S2) ◽  
pp. 788-789
Keyword(s):  
Plastic Waste ◽  
Cutting Edge ◽  
Warm Temperature ◽  
Recent Advancement

Contaminants convey contamination into the regular habitat that makes unfriendly alternate. contamination can appear as artificial substances or power, for example, commotion, warm temperature or light pollutants. Wind-blown residue and flotsam and jetsam, along with plastic sacks, are blown offshore from landfills and specific zones. Plastic sacks and one-of-a-kind varieties of plastic waste that have been disposed of which exhausted inside the sea, gift dangers to untamed existence and fisheries. finally this paper learns about infection manage in cutting-edge circumstance. [1],[ 3],[5]

Influence of Nano Formulation on Augmenting the Seed Quality in Groundnut (Arachis hypogaea L.)

2020 ◽  
Author(s):  
C. Tamilarasan ◽  
K. Raja
Keyword(s):  
Controlled Release ◽  
Seed Quality ◽  
Germination Percentage ◽  
Bioactive Molecules ◽  
Seed Coating ◽  
Crop Failure ◽  
Seedling Length ◽  
Vigour Index ◽  
Moisture Conditions ◽  
Nano Formulation

Background: Groundnut were mainly cultivated under rain fed condition, lack of initial seedling quality due to lower moisture conditions, it causes reduced crop yield and in sometimes it leads to crop failure. In order to overcome this problems, effective seed enhancement techniques as seed coating plays major role in maintaining the seed quality. Methods: The controlled release of bioactive molecules namely hormones gibberellic acid (GA3) as a smart delivery system can be achieved through seed coating in groundnut by exploiting advanced nanotechnology. Infusion of active ingredients as hormones (GA3) through the seed coating formulation by nano formulation methods. At nano level it influences the effects at higher level and gives best results through controlled release of hormones without any loss. Result: Due to nano formulation coating in groundnut, seeds had an effective results in all the parameters viz., imbibition rate (48%), speed of germination (5.5), germination percentage (87%), seedling length (24.7 cm), vigour index (2142), hydrolysing enzymes (α-amylase14.83 and lipase 1.481), which significantly differs from untreated seeds. Hence, it was concluded that the GA3 infused nano formulation coating at 15 ml per kilogram of seed can be used for seed quality improvement in groundnut for better seedling establishment.

Controlled release behavior of bioactive molecules from photo-reactive hyaluronic acid-alginate scaffolds

2006 ◽  
Vol 14 (5) ◽  
pp. 530-538 ◽  
Author(s):  
Hye Sung Nam ◽  
Jeongho An ◽  
Dong June Chung ◽  
Ji-Heung Kim ◽  
Chong-Pyoung Chung
Keyword(s):  
Hyaluronic Acid ◽  
Controlled Release ◽  
Bioactive Molecules ◽  
Release Behavior

scholarly journals Quercetin Impact in Pancreatic Cancer: An Overview on Its Therapeutic Effects

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Parina Asgharian ◽  
Abbas Pirpour Tazehkand ◽  
Saiedeh Razi Soofiyani ◽  
Kamran Hosseini ◽  
Miquel Martorell ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Bioactive Molecules ◽  
High Rate ◽  
Therapeutic Effects ◽  
Molecular Signaling ◽  
Anticancer Compounds ◽  
Beneficial Effects ◽  
Cancerous Cell ◽  
Alternative Drug ◽  
Advanced Stages

Pancreatic cancer (PC) is a lethal malignancy cancer, and its mortality rates have been increasing worldwide. Diagnosis of this cancer is complicated, as it does not often present symptoms, and most patients present an irremediable tumor having a 5-year survival rate after diagnosis. Regarding treatment, many concerns have also been raised, as most tumors are found at advanced stages. At present, anticancer compounds-rich foods have been utilized to control PC. Among such bioactive molecules, flavonoid compounds have shown excellent anticancer abilities, such as quercetin, which has been used as an adjunctive or alternative drug to PC treatment by inhibitory or stimulatory biological mechanisms including autophagy, apoptosis, cell growth reduction or inhibition, EMT, oxidative stress, and enhancing sensitivity to chemotherapy agents. The recognition that this natural product has beneficial effects on cancer treatment has boosted the researchers’ interest towards more extensive studies to use herbal medicine for anticancer purposes. In addition, due to the expensive cost and high rate of side effects of anticancer drugs, attempts have been made to use quercetin but also other flavonoids for preventing and treating PC. Based on related studies, it has been found that the quercetin compound has significant effect on cancerous cell lines as well as animal models. Therefore, it can be used as a supplementary drug to treat a variety of cancers, particularly pancreatic cancer. This review is aimed at discussing the therapeutic effects of quercetin by targeting the molecular signaling pathway and identifying antigrowth, cell proliferation, antioxidative stress, EMT, induction of apoptotic, and autophagic features.

scholarly journals Development of Gelatin-Coated Microspheres for Novel Bioink Design

Polymers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 3339
Author(s):  
Muskan Kanungo ◽  
Yale Wang ◽  
Noah Hutchinson ◽  
Emma Kroll ◽  
Anna DeBruine ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Controlled Release ◽  
Flow Rate ◽  
Bioactive Molecules ◽  
Great Promise ◽  
Charged Surface ◽  
Design Expert ◽  
Gelatin Concentration ◽  
Gelatin Coating ◽  
Positively Charged

A major challenge in tissue engineering is the formation of vasculature in tissue and organs. Recent studies have shown that positively charged microspheres promote vascularization, while also supporting the controlled release of bioactive molecules. This study investigated the development of gelatin-coated pectin microspheres for incorporation into a novel bioink. Electrospray was used to produce the microspheres. The process was optimized using Design-Expert® software. Microspheres underwent gelatin coating and EDC catalysis modifications. The results showed that the concentration of pectin solution impacted roundness and uniformity primarily, while flow rate affected size most significantly. The optimal gelatin concentration for microsphere coating was determined to be 0.75%, and gelatin coating led to a positively charged surface. When incorporated into bioink, the microspheres did not significantly alter viscosity, and they distributed evenly in bioink. These microspheres show great promise for incorporation into bioink for tissue engineering applications.

scholarly journals Applications of mesoporous silica materials in food – a review

2013 ◽  
Vol 31 (No. 2) ◽  
pp. 99-107 ◽  
Author(s):  
A. Bernardos ◽  
L. Kouřimská
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Digestive System ◽  
Functional Foods ◽  
Bioactive Molecules ◽  
Silica Supports ◽  
Silica Materials ◽  
Mesoporous Silica Materials ◽  
Health Field

Mesoporous silica materials have been developed for some applications in the health field. These solids are used for the controlled release of bioactive molecules, as catalysts in the synthesis of essential nutrients, as sensors to detect unhealthy products etc., with many applications in food technologies. By combining mesoporous silica materials with food, we can create healthier products, the products that improve our quality of life. The development of mesoporous materials applied to food could result in protecting bioactive molecules during their passage though the digestive system. For this reason, the controlled release of bioactive molecules is a very interesting topic for the discipline of food technology. The use of mesoporous silica supports as catalysts in the synthesis of nutrients and as sensors for the detection of unhealthy products, essential in food, is in great demand industrially for the manufacture of functional foods and films for food and industrial packaging. This review shows some examples of silica materials and their applications in food.  

scholarly journals Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1939
Author(s):  
Jessica Hoff ◽  
Berit Karl ◽  
Jana Gerstmeier ◽  
Uwe Beekmann ◽  
Lisa Schmölz ◽  
...  
Keyword(s):  
Wound Healing ◽  
Controlled Release ◽  
Wound Dressing ◽  
Pharmaceutical Formulations ◽  
Bioactive Molecules ◽  
Bacterial Nanocellulose ◽  
Cellular Effects ◽  
Persistent Inflammation ◽  
Advanced Therapy ◽  
Anti Inflammatory

Inflammation is a hallmark of tissue remodeling during wound healing. The inflammatory response to wounds is tightly controlled and well-coordinated; dysregulation compromises wound healing and causes persistent inflammation. Topical application of natural anti-inflammatory products may improve wound healing, in particular under chronic pathological conditions. The long-chain metabolites of vitamin E (LCM) are bioactive molecules that mediate cellular effects via oxidative stress signaling as well as anti-inflammatory pathways. However, the effect of LCM on wound healing has not been investigated. We administered the α-tocopherol-derived LCMs α-13′-hydroxychromanol (α-13′-OH) and α-13′-carboxychromanol (α-13′-COOH) as well as the natural product garcinoic acid, a δ-tocotrienol derivative, in different pharmaceutical formulations directly to wounds using a splinted wound mouse model to investigate their effects on the wounds’ proinflammatory microenvironment and wound healing. Garcinoic acid and, in particular, α-13′-COOH accelerated wound healing and quality of the newly formed tissue. We next loaded bacterial nanocellulose (BNC), a valuable nanomaterial used as a wound dressing with high potential for drug delivery, with α-13′-COOH. The controlled release of α-13′-COOH using BNC promoted wound healing and wound closure, mainly when a diabetic condition was induced before the injury. This study highlights the potential of α-13′-COOH combined with BNC as a potential active wound dressing for the advanced therapy of skin injuries.

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