scholarly journals Isoliensinine: A Natural Compound with “Drug-Like” Potential

2021 ◽  
Vol 12 ◽  
Author(s):  
Yan Cheng ◽  
Hong-Li Li ◽  
Zi-Wei Zhou ◽  
Hui-Zhi Long ◽  
Hong-Yu Luo ◽  
...  
Keyword(s):  
Natural Compound ◽  
Web Of Science ◽  
Recent Literature ◽  
Aqueous Media ◽  
Future Prospects ◽  
Research Directions ◽  
Beneficial Effects ◽  
Bisbenzylisoquinoline Alkaloid ◽  
Low Toxicity ◽  
Anti Hiv

Isoliensinine, a bisbenzylisoquinoline alkaloid isolated from Nelumbo nucifera Gaertn, exerts a variety of beneficial effects, such as antitumor, cardioprotective, antioxidant, antidepressant, and anti-HIV effects, and ameliorates T2DM with hyperlipidemia and Alzheimer’s disease. In this article, the recent literature on isoliensinine, including its pharmacology, pharmacokinetics, and synthesis and extraction, is summarized. Moreover, possible future prospects and research directions are also discussed. Studies on isoliensinine were found by searching a combination of keywords including “pharmacology,” “pharmacokinetics,” and “synthesis and extraction” in the main databases, including PubMed, Google Scholar, Web of Science, NCBI, and Wan Fang. Many studies have pointed out that a major limitation of isoliensinine is its poor solubility in aqueous media. Considering its advantages and limitations, isoliensinine can be used as a lead compound to develop novel efficient and low-toxicity derivatives. The available literature indicates that isoliensinine displays “drug-like” potential. Additionally, there are many related issues and novel mechanisms that need to be explored.

Thymol Chemistry: A Medicinal Toolbox

2019 ◽  
Vol 15 (5) ◽  
pp. 454-474 ◽  
Author(s):  
Jyoti ◽  
Divya Dheer ◽  
Davinder Singh ◽  
Gulshan Kumar ◽  
Manvika Karnatak ◽  
...  
Keyword(s):  
Web Of Science ◽  
Biological Activities ◽  
Controlled Clinical Trials ◽  
Food Preservative ◽  
Beneficial Effects ◽  
Therapeutic Benefits ◽  
Trachyspermum Ammi ◽  
Randomised Controlled ◽  
Human Infections ◽  
Potential Use

Background: Thymol is a natural phenolic monoterpenoid widely used in pharmaceutical and food preservative applications. Thymol isomeric with carvacrol, extracted primarily from Thymus species (Trachyspermum ammi) and other plants sources such as Baccharisgrise bachii and Centipeda minima, has ethnopharmacological characteristics. <p></p> Methods: This review was prepared by analyzing articles published on thymol moiety in last decade and selected from Science Direct, Scopus, Pub Med, Web of Science and SciFinder. The selected articles are classified and gives brief introduction about thymol and its isolation, illustrates its natural as well as synthetic sources, and also therapeutic benefits of thymol worldwide <p></p> Results: Thymol has been covering different endeavors such as antimicrobial, antioxidant, antiinflammatory, antibacterial, antifungal, antidiarrhoeal, anthelmintic, analgesic, digestive, abortifacient, antihypertensive, spermicidal, depigmenting, antileishmanial, anticholinesterase, insecticidal and many others. This phenolic compound is among the essential scaffolds for medicinal chemists to synthesize more bio-active molecules by further derivatization of the thymol moiety. <p></p> Conclusion: Thymol is an interesting scaffold due to its different activities and derivatization of thymol is proved to enhance its biological activities. However, more robust, randomised, controlled clinical trials would be desirable with well-characterised thymol preparations to corroborate its beneficial effects in diseased patients. Moreover, in view of the potential use of thymol and thymol-rich essential oils in the treatment of human infections, comprehensive studies on chronic and acute toxicity and also teratogenicity are to be recommended.

scholarly journals Anti-Inflammatory and Immunomodulatory Effects of the Grifola frondosa Natural Compound o-Orsellinaldehyde on LPS-Challenged Murine Primary Glial Cells. Roles of NF-κβ and MAPK

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 806
Author(s):  
Sarah Tomas-Hernandez ◽  
Jordi Blanco ◽  
Santiago Garcia-Vallvé ◽  
Gerard Pujadas ◽  
María José Ojeda-Montes ◽  
...  
Keyword(s):  
Natural Compound ◽  
Underlying Disease ◽  
Grifola Frondosa ◽  
Beneficial Effects ◽  
Inflammatory Conditions ◽  
Inflammatory Mechanism ◽  
Inflammatory Phenotype ◽  
Mice Brain ◽  
Anti Inflammatory

In response to foreign or endogenous stimuli, both microglia and astrocytes adopt an activated phenotype that promotes the release of pro-inflammatory mediators. This inflammatory mechanism, known as neuroinflammation, is essential in the defense against foreign invasion and in normal tissue repair; nevertheless, when constantly activated, this process can become detrimental through the release of neurotoxic factors that amplify underlying disease. In consequence, this study presents the anti-inflammatory and immunomodulatory properties of o-orsellinaldehyde, a natural compound found by an in silico approach in the Grifola frondosa mushroom, in astrocytes and microglia cells. For this purpose, primary microglia and astrocytes were isolated from mice brain and cultured in vitro. Subsequently, cells were exposed to LPS in the absence or presence of increasing concentrations of this natural compound. Specifically, the results shown that o-orsellinaldehyde strongly inhibits the LPS-induced inflammatory response in astrocytes and microglia by decreasing nitrite formation and downregulating iNOS and HO-1 expression. Furthermore, in microglia cells o-orsellinaldehyde inhibits NF-κB activation; and potently counteracts LPS-mediated p38 kinase and JNK phosphorylation (MAPK). In this regard, o-orsellinaldehyde treatment also induces a significant cell immunomodulation by repolarizing microglia toward the M2 anti-inflammatory phenotype. Altogether, these results could partially explain the reported beneficial effects of G. frondosa extracts on inflammatory conditions.

scholarly journals An Overview of Flood Risk Analysis Methods

Water ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 474
Author(s):  
Daniel Constantin Diaconu ◽  
Romulus Costache ◽  
Mihnea Cristian Popa
Keyword(s):  
Core Collection ◽  
Web Of Science ◽  
Research Directions ◽  
Economic Implications ◽  
Forecasting Methods ◽  
Wide Range ◽  
Scientific Papers ◽  
Recent Developments ◽  
Flood Analysis ◽  
Temporal And Spatial

Scientific papers present a wide range of methods of flood analysis and forecasting. Floods are a phenomenon with significant socio-economic implications, for which many researchers try to identify the most appropriate methodologies to analyze their temporal and spatial development. This research aims to create an overview of flood analysis and forecasting methods. The study is based on the need to select and group papers into well-defined methodological categories. The article provides an overview of recent developments in the analysis of flood methodologies and shows current research directions based on this overview. The study was performed taking into account the information included in the Web of Science Core Collection, which brought together 1326 articles. The research concludes with a discussion on the relevance, ease of application, and usefulness of the methodologies.

Social media and consumer engagement: a review and research agenda

2016 ◽  
Vol 10 (4) ◽  
pp. 268-287 ◽  
Author(s):  
Victor Barger ◽  
James W. Peltier ◽  
Don E. Schultz
Keyword(s):  
Social Media ◽  
Recent Literature ◽  
Future Research ◽  
Consumer Engagement ◽  
Research Directions ◽  
Content Type ◽  
Future Research Directions ◽  
Antecedents And Consequences ◽  
Area Of Concern ◽  
Definition Of

Purpose In “Social media’s slippery slope: challenges, opportunities and future research directions”, Schultz and Peltier (2013) asked “whether or how social media can be used to leverage consumer engagement into highly profitable relationships for both parties”. The purpose of this article is to continue this discussion by reviewing recent literature on consumer engagement and proposing a framework for future research. Design/methodology/approach The paper reviews the marketing literature on social media, paying particular attention to consumer engagement, which was identified as a primary area of concern in Schultz and Peltier (2013). Findings A significant amount of research has been conducted on consumer engagement since 2010. Lack of consensus on the definition of the construct has led to fragmentation in the discipline, however. As a result, research related to consumer engagement is often not identified as such, making it difficult for academics and practitioners to stay abreast of developments in this area. Originality/value This critical review provides marketing academics and practitioners insights into the antecedents and consequences of consumer engagement and offers a conceptual framework for future research.

Evaluation effects of Quercetin on streptozotocin-treated RINm5F pancreatic β-cells in vitro

2021 ◽  
Vol 16 ◽  
Author(s):  
Maryam Mazraesefidi ◽  
Maryam Mohammad Sadeghipour ◽  
Hossein Khorramdelazad ◽  
Mahdi Mahmoodi ◽  
Alireza Khoshdel ◽  
...  
Keyword(s):  
Cell Viability ◽  
Insulin Content ◽  
Β Cells ◽  
Simultaneous Treatment ◽  
Beneficial Effects ◽  
Naturally Occurring ◽  
Low Toxicity ◽  
Pre Treatment ◽  
Glucose Stimulated Insulin Secretion

Background and objectives: Quercetin is a naturally occurring phenolic compound abundantly present in plants as a secondary metabolite. The purpose of this study was to investigate the effect of quercetin on improving RINm5F β-insulinemia cell viability, glucose-stimulated insulin secretion (GSIS), and cell insulin content in the presence or absence of streptozotocin (STZ). Methods: This experimental study was conducted on RINm5F β-insulinemia cell line. The cell viability was evaluated by MTT assay. The necrosis was confirmed by flowcytometry and insulin ELISA kit was used to measure the GSIS level and cell insulin content. It should be noted that for testing of cells by 50μM of quercetin, simultaneous treatment and pre-treatment of quercetin were performed in the presence of STZ (20mM). Results: The quercetin was able to improve the viability of RINm5F cells in the presence of STZ and to increase the GSIS level and cell insulin content under STZ and glucotoxic conditions Conclusion: The quercetin seems to have beneficial effects on β-cells, especially the synthesis and secretion of insulin. In addition to the therapeutic effect, given the low toxicity of this flavonoid and the results of this study, the quercetin as a preventive agent may play an important role in maintaining the health of β-cells in people at risk of diabetes.

scholarly journals A global bibliometric analysis of research on microplastics from 2004 to 2020

2021 ◽  
Author(s):  
Ming Li ◽  
Binshuo Liu ◽  
Lei Wu ◽  
Shuang Zhong ◽  
Chunqing Wang ◽  
...  
Keyword(s):  
Core Collection ◽  
Environmental Science ◽  
Web Of Science ◽  
Environmental Problem ◽  
Research Trends ◽  
Research Directions ◽  
Bibliographic Records ◽  
Significant Interest ◽  
The Usa ◽  
The Web

Abstract Microplastics (MPs) pollution has garnered significant interest as a serious environmental problem. To date, a large amount of research has been published on this topic. We analyzed the related studies to assess the global developments of MPs regarding the evolution, research trends, and hotspots by bibliometric. A total of 2,872 bibliographic records were retrieved from the Web of Science Core Collection, and CiteSpace 5.4 was used for bibliometrics. The results visually displayed the contributing countries, institutions, authors, keywords, and potential research directions in the MPs fields. The scientific developments in this field began in 2004 and have accelerated considerably since 2012. China and the USA are the leading countries in MPs research. The research on MPs is multidisciplinary and involves Ecology, Chemistry, Molecular Biology, Environmental Science, and Oceanography. Among these, Oceanography was the most connected with MPs and was the most well-developed. Overall, we mapped the development of MPs research and attempted a comprehensive discussion and understanding of scientific advances, as well as the progress made.

scholarly journals Scientometrics analysis of recent trends in Global Corona virus Research

2020 ◽  
Author(s):  
Krishnamurthy M ◽  
Bhalachandra S Deshpande ◽  
Sajana C
Keyword(s):  
Web Of Science ◽  
Recent Literature ◽  
High Rate ◽  
Research Progress ◽  
Research Papers ◽  
Medical Virology ◽  
Before And After ◽  
Virus Research ◽  
Recent Trends ◽  
Prolific Authors

Abstract Background: The worldwide pandemic COVID-19 has produced a wealth of research more rapidly after the outbreak. In just a couple of months, there is a rise in several studies on Coronavirus, adding up to the scholarly literature.Method: The current study attempts to Scientometric analyze very recent literature on Coronaviruses just before and after the outbreak. Besides, the objective of this exploration was to assess the global research progress on Coronavirus in recent times. The current research is an analytical descriptive study using Scientometrics. The study sample includes research papers about the Coronavirus indexed in Web of Science (WoS) database from January 1, 2019 to May 14, 2020. The records with topic search (includes Title, Abstract, Keywords and Keywords Plus) “coronavirus” were extracted. These data were analyzed by MS Excel and the visualizations were created using TableauResult: The results showed that 2551 scientific literature about the Coronavirus was indexed in WoS. A considerable number of these articles were published in journals such as the Journal of Medical Virology, Viruses, Nature, and Lancet. Authors from China, USA and Italy were the most prolific authors. About 47.51% articles received total of 11435 citations with an average of 9 citations, which indicates that nearly half articles were cited in another publication. The highest and lowest citations for these articles were 737 and 1, respectively.Conclusion: These results show a high rate of research on Coronavirus.

scholarly journals Use of heparin in patients with severe COVID-19: What is the evidence?

2021 ◽  
Vol 10 (6) ◽  
pp. e28910615820
Author(s):  
Vitória Ribeiro Dantas Marinho ◽  
Camila Vilar Oliveira Villarim ◽  
Laura Cristina Costa e Silva ◽  
André Luiz Costa e Silva ◽  
Irami Araújo-Neto ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Web Of Science ◽  
Pulmonary Thromboembolism ◽  
Cytokine Release ◽  
Beneficial Effects ◽  
Heparin Administration ◽  
Rapid Spread ◽  
New Research ◽  
D Dimer

The rapid spread of coronavirus disease (COVID-19) worldwide urges the need for studies on the illness and its management. The COVID-19 infection leads to hypercoagulation due to inflammatory cytokine release and D-dimer increase in critically ill patients, resulting in pulmonary thromboembolism (PE) and venous thromboembolism (VTE) evolving to sepsis and death. The study evaluated the currently existing evidence on heparin administration in patients with severe COVID-19. An integrative literature review was done by searching for scientific studies in the PubMed, Scopus, Embase, and Web of Science databases. The analyzed studies showed that heparin use in critically ill patients could efficiently prevent thrombotic events and reduce the exacerbated inflammatory process. However, further investigation on the effect on patients is still needed. The use of heparin in critically ill COVID-19 patients has been prescribed increasingly by doctors. But its use has not yet had its outcomes well established in the literature. Therefore, deeper investigations and new research development are needed to clarify potential beneficial effects.

scholarly journals Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 256
Author(s):  
Amir Vahedian-Azimi ◽  
Mitra Abbasifard ◽  
Farshid Rahimi-Bashar ◽  
Paul C. Guest ◽  
Muhammed Majeed ◽  
...  
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Clinical Settings ◽  
Curcumin Treatment ◽  
Partial Restoration ◽  
Beneficial Effects ◽  
Disease Outcomes ◽  
Duration Of Hospitalization ◽  
Anti Inflammatory ◽  
Related Compounds

Despite the ongoing vaccination efforts, there is still an urgent need for safe and effective treatments to help curb the debilitating effects of COVID-19 disease. This systematic review aimed to investigate the efficacy of supplemental curcumin treatment on clinical outcomes and inflammation-related biomarker profiles in COVID-19 patients. We searched PubMed, Scopus, Web of Science, EMBASE, ProQuest, and Ovid databases up to 30 June 2021 to find studies that assessed the effects of curcumin-related compounds in mild to severe COVID-19 patients. Six studies were identified which showed that curcumin supplementation led to a significant decrease in common symptoms, duration of hospitalization and deaths. In addition, all of these studies showed that the intervention led to amelioration of cytokine storm effects thought to be a driving force in severe COVID-19 cases. This was seen as a significant (p < 0.05) decrease in proinflammatory cytokines such as IL1β and IL6, with a concomitant significant (p < 0.05) increase in anti-inflammatory cytokines, including IL-10, IL-35 and TGF-α. Taken together, these findings suggested that curcumin exerts its beneficial effects through at least partial restoration of pro-inflammatory/anti-inflammatory balance. In conclusion, curcumin supplementation may offer an efficacious and safe option for improving COVID-19 disease outcomes. We highlight the point that future clinical studies of COVID-19 disease should employ larger cohorts of patients in different clinical settings with standardized preparations of curcumin-related compounds.

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