scholarly journals Research Advances in Multi-Omics on the Traditional Chinese Herb Dendrobium officinale

2022 ◽  
Vol 12 ◽  
Author(s):  
Yue Wang ◽  
Yan Tong ◽  
Oluwaniyi Isaiah Adejobi ◽  
Yuhua Wang ◽  
Aizhong Liu
Keyword(s):  
Chinese Herb ◽  
Dendrobium Officinale ◽  
Active Components ◽  
Traditional Chinese Herb ◽  
Anti Cancer ◽  
Epiphytic Plant ◽  
Wild Resources ◽  
Regulation Mechanisms ◽  
Detection Technologies

Dendrobium officinale Kimura et Migo is an important epiphytic plant, belonging to the Orchidaceae family. There are various bioactive components in D. officinale plants, mainly including polysaccharides, alkaloids, and phenolic compounds. These compounds have been demonstrated to possess multiple functions, such as anti-oxidation, immune regulation, and anti-cancer. Due to serious shortages of wild resources, deterioration of cultivated germplasm and the unstable quality of D. officinale, the study has been focused on the biosynthetic pathway and regulation mechanisms of bioactive compounds. In recent years, with rapid developments in detection technologies and analysis tools, omics research including genomics, transcriptomics, proteomics and metabolomics have all been widely applied in various medicinal plants, including D. officinale. Many important advances have been achieved in D. officinale research, such as chromosome-level reference genome assembly and the identification of key genes involved in the biosynthesis of active components. In this review, we summarize the latest research advances in D. officinale based on multiple omics studies. At the same time, we discuss limitations of the current research. Finally, we put forward prospective topics in need of further study on D. officinale.

scholarly journals Acanthopanax henryi: Review of Botany, Phytochemistry and Pharmacology

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2215
Author(s):  
Xiao-Jun Li ◽  
Si-Qi Tang ◽  
Hao Huang ◽  
Jiao Luo ◽  
Xiao-Dan Zhang ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Chinese Herb ◽  
Quinic Acid ◽  
Chemical Compositions ◽  
Active Components ◽  
Triterpenoid Saponins ◽  
Traditional Chinese Herb ◽  
Anti Cancer ◽  
Pharmacological Studies

Acanthopanax henryi (Oliv.) Harms (Araliaceae), also known as Eleutherococcus henryi and Caoyewujia (Hengliwujia) in Chinese, is a widely used traditional Chinese herb with the effects of expelling wind and removing dampness, relaxing the muscles and stimulating the blood circulation, and regulating the flow of qi to alleviate pain in the theory of Traditional Chinese Medicine. Acanthopanax henryi (AH, thereafter) possesses ginseng-like activities and is known as ginseng-like herb. In the past decade, a great number of phytochemical and pharmacological studies on AH have been carried out. Several kinds of chemical compositions have been reported, including terpenoids (monoterpenoids, diterpenoids, and triterpenoid saponins), phenylpropanoids, caffeoyl quinic acid derivatives, flavonoids, lignans, sterols, fatty acids, etc., among which, triterpenoid saponins were considered to be the most active components. Considerable pharmacological experiments in vitro have demonstrated that AH possessed anti-neuroinflammatory, anti-adipogenic, anti-inflammatory, antibacterial, anti-cancer, anti-oxidation, anti-AChE, anti-BuChE, and antihyaluronidase activities. The present review is an up-to-date and comprehensive analysis of the botany, phytochemistry, and pharmacology of AH.

scholarly journals Traditional Chinese Herb Combined with Surgery versus Surgery for Varicocele Infertility: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Rong-liang Dun ◽  
Min Yao ◽  
Long Yang ◽  
Xue-jun Cui ◽  
Jian-min Mao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Chinese Herb ◽  
Chinese Herbs ◽  
Cochrane Library ◽  
Dichotomous Data ◽  
Surgery Group ◽  
Traditional Chinese Herb ◽  
The Cochrane Library

Objective. The objective of this study was to conduct a systematic review to assess the effectiveness and safety of traditional Chinese herb combined with surgery for male varicocele infertility compared to surgery.Methods. Randomized controlled trials (RCTs) data of traditional Chinese herbs combined with surgery for male varicocele fertility versus surgery were collected by searching the Cochrane Library, Embase, PubMed, and Chinese databases. The risk of bias was assessed using Cochrane Handbook. Study outcomes were presented as risk ratios (RRs) for dichotomous data.Results. Seventeen of 72 potentially relevant trials met the inclusion criteria. The methodological qualities of the RCTs were low. Compared with the surgery group, the traditional Chinese herb combined with surgery group had superiority in pregnancy rate at 3-month (RR=1.76, andP=0.008), 6-month (RR=1.58, andP=0.0005), and 2-year (RR=1.58, andP=0.0005) follow-ups. No RCT was found to describe the side effects.Conclusion. On considering the low methodological quality of RCTs, there was no enough evidence on traditional Chinese herb with surgery for male varicocele infertility, and more high-quality RCTs of large sample sizes are required.

scholarly journals Genomic Characterization and Expression Analysis of Basic Helix-Loop-Helix (bHLH) Family Genes in Traditional Chinese Herb Dendrobium officinale

Plants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1044 ◽  
Author(s):  
Yue Wang ◽  
Aizhong Liu
Keyword(s):  
Protein Interactions ◽  
Environmental Changes ◽  
Chinese Herb ◽  
Dendrobium Officinale ◽  
Functional Study ◽  
Limited Information ◽  
Basic Helix Loop Helix ◽  
Helix Loop Helix ◽  
Traditional Chinese Herb ◽  
Bhlh Genes

Dendrobium officinale Kimura et Migo is of great importance as a traditional Chinese herb due to its abundant metabolites. The family of basic helix-loop-helix (bHLH) transcription factors widely exists in plants and plays an essential role in plant growth and development, secondary metabolism as well as responses to environmental changes. However, there is limited information on bHLH genes in D. officinale. In the present study, a total of 98 putative DobHLH genes were identified at the genomic level, which could be classified into 18 clades. Gene structures and conserved motifs in DobHLH genes showed high conservation during their evolution. The conserved amino acids and DNA bindings of DobHLH proteins were predicted, both of which are pivotal for their function. Furthermore, gene expression from eight tissues showed that some DobHLH genes were ubiquitously expressed while other DobHLH genes were expressed in the specific tissues. Expressional changes of DobHLH genes under MeJA and ABA treatments were detected by qRT-PCR. The protein–protein interactions between DobHLHs were predicted and several interactions were confirmed by yeast two hybrid. Therefore, our results here contribute to the understanding of bHLH genes in D. officinale and lay a foundation for the further functional study of its biological processes.

scholarly journals Network Pharmacology Based Prediction of Active Ingredients and Targets of Chinese Herb She Xiang in Treating Facial Paralysis 

2020 ◽  
Author(s):  
Xiaoyan Li ◽  
Chuang Zhao ◽  
Jiamiao Wang ◽  
Lan Shen ◽  
Zhidan Liu
Keyword(s):  
Facial Paralysis ◽  
Critical Role ◽  
Chinese Herb ◽  
Network Pharmacology ◽  
Active Ingredients ◽  
Active Components ◽  
Protein Targets ◽  
Docking Model ◽  
Traditional Chinese Herb ◽  
Effective Component

Abstract The traditional Chinese herb, She Xiang, has been found to accelerate the recovery of facial paralysis including Bell’s palsy by acupoint application in China. However, the underlining mechanism was not well known which has become an obstacle on the way to further development. In this study, we attempted to explore the pharmacology mechanism of She Xiang on facial paralysis treatment preliminarily by bioinformatics analysis. As a result, 59 active ingredients were identified in She Xiang by Traditional Chinese Medicine Integrated Database, such as 17-Beta-Estradiol, testosterone, and 2,6-Decamethylene Pyridine. Totally 837 genes were identified to be differently expressed in the blood sample of facial paralysis patients by RNA sequencing. Finally, 33 overlapped proteins were obtained overlapped with the prediction of comparative toxicogenomics database (CTD) and BATMAN. Proteins of interest were closely related with 406 GO BP and 4 pathways. The hub protein in PPI network contained FOS, JUN, POMC, and GPER1. Pharmacology network was constructed with 15 active components of She Xiang, 33 protein targets and 4 pathways. The docking model of Androst-4-Ene-3, 17-Dione (ASD) and FUS-JUN complexes (1FOS) was predicted and constructed. In conclusion, this work indicated testosterone as the effective component of She Xiang may advance the recovery of facial paralysis by targeting FUN, MAPK and cAMP signaling pathway; docking of ASD and 1FOS might play a critical role in facial paralysis treatment by She Xiang. Further work will be carried out in human or experimental animals to test and verify the predicted results.

Resveratrol: A new potential therapeutic agent for melanoma?

2019 ◽  
Vol 26 ◽  
Author(s):  
Mohamad Hossein Pourhanifeh ◽  
Kazem Abbaszadeh-Goudarzi ◽  
Mohammad Goodarzi ◽  
Sara G.M. Piccirillo ◽  
Alimohammad Shafiee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Therapeutic Agent ◽  
Current Knowledge ◽  
Treatment Resistance ◽  
Anti Cancer ◽  
Apoptosis Inducer ◽  
Life Threatening ◽  
First Time

: Melanoma is the most life-threatening and aggressive class of skin malignancies. The incidence of melanoma has steadily increased. Metastatic melanoma is greatly resistant to standard anti-melanomatreatments such as chemotherapy, and 5-year survival rate of cases with melanoma who have metastatic form of disease is less than 10%. The contributing role of apoptosis, angiogenesis and autophagy in the pathophysiology of melanoma has been previously demonstrated. Thus, it is extremely urgent to search for complementary therapeutic approachesthat couldenhance the quality of life of subjects and reduce treatment resistance and adverse effects. Resveratrol, known as a polyphenol component present in grapes and some plants, has anti-cancer properties due to its function as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis. However, more clinical trials should be conducted to prove resveratrol efficacy. : Herein, for first time, we summarize current knowledge of anti-cancerous activities of resveratrol in melanoma.

Circadian rhythms, sleep, and anti-cancer treatments

2018 ◽  
Author(s):  
Pasquale F. Innominato ◽  
David Spiegel
Keyword(s):  
Quality Of Life ◽  
Circadian Rhythms ◽  
Biological Functions ◽  
Cancer Treatments ◽  
Anti Cancer ◽  
Timing System ◽  
Physical Wellbeing ◽  
Circadian Timing System ◽  
Chemotherapy Agents

The circadian timing system temporally regulates biological functions relevant for psycho-physical wellbeing, spanning all the systems related to health. Hence, disruption of circadian rhythms, along with sleep cycles, is associated with the development of several diseases, including cancer. Moreover, altered circadian and sleep functions negatively impact on cancer patients’ quality of life and survival, above and beyond known determinants of outcome. This alteration can occur as a consequence of cancer, but also of anti-cancer treatments. Indeed, circadian rhythms govern also the ability of detoxifying chemotherapy agents across the 24 hours. Hence, adapting chemotherapy delivery to the molecular oscillations in relevant drug pathways can decrease toxicity to healthy cells, while increasing the number of cancer cells killing. This chronomodulated chemotherapy approach, together with the maintenance of proper circadian function throughtout the whole disease challenge, would finally result in safer and more active anticancer treatments, and in patients experiencing better quality and quantity of life.

scholarly journals Commercialization of Aframomum spp. in Africa: a Systematic Review of Literature and Supporting Botanical Vouchers

2021 ◽  
Author(s):  
Ronja Hermiene Maria Knippers ◽  
Sandrine Gallois ◽  
Tinde van Andel
Keyword(s):  
Literature Review ◽  
Conservation Status ◽  
Future Research ◽  
East African ◽  
African Countries ◽  
Wild Resources ◽  
Living Material ◽  
Specific Species ◽  
Material Information

AbstractAframomum (Zingiberaceae) is a genus of plants native to tropical Africa that are sold on African markets as spices and traditional medicine. Not all species of Aframomum are equally abundant or widespread, and no overview exists of the specific species traded or the quality of the species identifications in publications referencing the sale of Aframomum. Through a systematic literature review, we show that 14 species of Aframomum are sold in 15 African countries. The majority of the studies were done in Nigeria and Cameroon and A. melegueta was the most frequently reported species in trade. A. kayserianum was the only commercialized species with confirmed conservation issues. Our literature review shows extensive knowledge gaps regarding the commercialization of Aframomum in Africa. Most studies did not include herbarium vouchers, or only used market-sourced plant material, which impedes the possibilities for species verifications. Additionally, most East African countries were devoid of relevant research. These gaps can be bridged by future research in East Africa and voucher collection from living material. Information on the conservation status of traded Aframomum species can be obtained by population studies on wild resources and documenting local domestication efforts, as the cultivation of marketed species tends to relieve the pressure from wild resources.

scholarly journals Characterization of the complete chloroplast genome of traditional Chinese herb, Solanum japonense Nakai. (Solanaceae)

2021 ◽  
Vol 6 (1) ◽  
pp. 211-213
Author(s):  
Xiaoxia Zhang ◽  
Xiaofeng Zhang ◽  
Huan Wang ◽  
Shilong Chen ◽  
Tingfeng Cheng ◽  
...  
Keyword(s):  
Chloroplast Genome ◽  
Chinese Herb ◽  
Complete Chloroplast Genome ◽  
Traditional Chinese Herb

scholarly journals The complete chloroplast genome of Isodon rubescens, a traditional Chinese herb

2021 ◽  
Vol 6 (2) ◽  
pp. 337-338
Author(s):  
Zhiyong Yue ◽  
Yan Wang ◽  
Baozhen Zhou ◽  
Hanping Wang
Keyword(s):  
Chloroplast Genome ◽  
Chinese Herb ◽  
Complete Chloroplast Genome ◽  
Traditional Chinese Herb

scholarly journals Precision Medicine: From “Omics” to Economics towards Data-Driven Healthcare - Time for European Transformation

2017 ◽  
Vol 2 (Suppl. 1) ◽  
pp. 1-10 ◽  
Author(s):  
Denis Lacombe ◽  
Lifang Liu ◽  
Françoise Meunier ◽  
Vassilis Golfinopoulos
Keyword(s):  
Drug Development ◽  
Development Process ◽  
Precision Oncology ◽  
Drug Development Process ◽  
Cancer Treatments ◽  
True Value ◽  
Efficient Access ◽  
Funding Agencies ◽  
Anti Cancer

There is room for improvement for optimally bringing the latest science to the patient while taking into account patient priorities such as quality of life. Too often, regulatory agencies, governments, and funding agencies do not stimulate the integration of research into care and vice versa. Re-engineering the drug development process is a priority, and healthcare systems are long due for transformation. On one hand, patients need efficient access to treatments, but despite precision oncology approaches, efficiently shared screening platforms for sorting patients based on the biology of their tumour for trial access are lacking and, on the other hand, the true value of cancer care is poorly addressed as central questions such as dose, scheduling, duration, and combination are not or sub-optimally addressed by registration trials. Solid evidence on those parameters could potentially lead to a rational and wiser use of anti-cancer treatments. Together, optimally targeting patient population and robust comparative effectiveness data could lead to more affordable and economically sound approaches. The drug development process and healthcare models need to be interconnected through redesigned systems taking into account the full math from drug development into affordable care.

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