scholarly journals Family Conflict Associated With Intrinsic Hippocampal-OFC Connectivity in Adolescent Depressive Disorder

2022 ◽  
Vol 12 ◽  
Author(s):  
Ruohan Feng ◽  
Weijie Bao ◽  
Lihua Zhuo ◽  
Yingxue Gao ◽  
Hongchao Yao ◽  
...  
Keyword(s):  
Depressive Disorder ◽  
Life Events ◽  
Family Environment ◽  
Family Conflict ◽  
Life Stress ◽  
Adolescent Depression ◽  
Treatment Strategies ◽  
Neural Mechanism ◽  
Stressful Events ◽  
Orbital Frontal Cortex

BackgroundFamily environment and life events have long been suggested to be associated with adolescent depression. The hippocampus plays a crucial role in the neural mechanism of major depressive disorder (MDD) through memory during stressful events. However, few studies have explored the exact neural mechanisms underlying these associations. Thus, the current study aimed to explore alterations in hippocampal functional connectivity (FC) in adolescent MDD based on resting-state functional magnetic resonance imaging and further investigate the relationship between hippocampal FC, environmental factors, and clinical symptom severity.MethodsHippocampal FC was calculated using the seed-based approach with the bilateral hippocampus as the seed for 111 adolescents with and without MDD; comparisons were made between participants with MDD and controls. We applied the Chinese version of the Family Environment Scale (FES-CV) and Adolescents Self-Rating Life Events Checklist (ASLEC) to evaluate family environment and life stress. Their relationship with hippocampal FC alterations was also investigated.ResultsWe found that compared to controls, adolescents with MDD showed decreased connectivity between the left hippocampus and bilateral orbital frontal cortex (OFC) and right inferior temporal gyrus. In addition, the hippocampal-OFC connectivity was negatively correlated with conflict scores of the FES-CV in the MDD group and mediated the association between family conflict and depressive and anxiety symptoms.ConclusionOur findings are novel in the field and demonstrate how family conflict contributes to MDD symptomatology through hippocampal-OFC connectivity; these findings may provide potential targets for personalized treatment strategies.

scholarly journals Do “Dark” Personality Features Buffer Against Adversity? The Associations Between Cumulative Life Stress, the Dark Triad, and Mental Distress

SAGE Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 215824401882238 ◽  
Author(s):  
Minna Lyons ◽  
Kate Evans ◽  
Samuli Helle
Keyword(s):  
Life Events ◽  
Life Stress ◽  
Mental Distress ◽  
Stressful Life Events ◽  
Dark Triad ◽  
Stressful Events ◽  
Stressful Life ◽  
Online Study ◽  
The Face ◽  
The Impact

Stressful life events have a major impact on adverse mental health outcomes, although not all individuals are equally affected. According to the buffering hypothesis, there may be personality traits that protect individuals against mental distress in the face of adversity, playing thus a moderating role between life stressors and mental distress. In the present online study ( N = 574), Dark Triad of personality (i.e., Machiavellianism, narcissism, and psychopathy) were investigated as moderators between cumulative stressful life events and mental distress (i.e., psychosis, anxiety, and depression). Those who experienced more stressful events during lifetime, and scored higher in Machiavellianism, had higher scores on a psychosis instrument. Narcissism buffered the impact of stressful events on psychosis and depression. The results are discussed in terms of unique profiles associated with each of the traits.

scholarly journals 2341

2017 ◽  
Vol 1 (S1) ◽  
pp. 36-36
Author(s):  
Courtney Vaughan ◽  
Bethany Stangl ◽  
Rajita Sinha ◽  
Vijay Ramchandani
Keyword(s):  
Life Events ◽  
Chronic Stress ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Stressful Events ◽  
Computer Assisted ◽  
Chronic Stressors ◽  
Stress Interview ◽  
The Impact

OBJECTIVES/SPECIFIC AIMS: The objective of this analysis was to characterize the impact of stress, both early life and chronic, on intravenous alcohol self-administration (IV-ASA) in healthy non-dependent drinkers using the Computer-Assisted Infusion System (CAIS). Personality measures also have shown to impact drinking behavior, particularly impulsivity. Few studies have assessed the impact of stress and impulsivity on drinking behaviors in a non-dependent population. METHODS/STUDY POPULATION: Healthy non-dependent drinkers (n=28) completed a CAIS session, where they push a button adlib to self-administer standardized IV alcohol infusions. Participants completed the Cumulative Chronic Stress interview and the Early Life Stress Questionnaire (ELSQ) for stress measures. The Cumulative Chronic Stress interview was broken up into 4 sections: major life events, life traumas, recent life events, and chronic stressors. The number of endorsed events was added up to create 4 separate scores. Subjective response and craving measures were collected serially using the Drug Effects Questionnaire (DEQ) and Alcohol Urge Questionnaire (AUQ). The Impaired Control Scale (ICS) assessed failed control over recent drinking in the past 6 months. Impulsivity was assessed using the NEO personality inventory, which included the N-impulsive sub-facet, as well as the UPPS-P Impulsive Behavior Scale. RESULTS/ANTICIPATED RESULTS: Results showed early life stress events (ELSQ) are related to more chronic stressors in the cumulative chronic stress interview (p=0.005). Participants with higher chronic stress scores showed lower subjective effects, as measured by the DEQ, following the priming exposure (p=0.036) but had more craving for alcohol as measured by the AUQ (p=0.009). A regression analysis showed the number of chronic stressful events predicted ICS failed attempts to control drinking (p=0.034), after covarying for sex. Participants with more chronic stressful events showed more impulsivity on the N-impulsivity measure (p=0.034) and the UPPS-P positive urgency measure (p=0.005). DISCUSSION/SIGNIFICANCE OF IMPACT: Non-dependent drinkers with more early life stress tend to have a higher number of chronic stressful events. More chronically stressful events were associated with feeling less effects of alcohol and higher craving for alcohol. Participants with more chronically stressful events also appear to have more failed attempts at controlling their drinking. Future analysis will assess for mediation and moderation of these factors. Chronically stressful events and impulsive behaviors could serve as important areas for intervention for better treatment outcomes for alcohol use disorders.

Psychopathology and early life stress in migrant youths: an analysis of the ‘Growing up in Ireland’ study

2019 ◽  
Vol 36 (3) ◽  
pp. 177-185
Author(s):  
S. Cotter ◽  
C. Healy ◽  
D. Ni Cathain ◽  
P. Williams ◽  
M. Clarke ◽  
...  
Keyword(s):  
Life Events ◽  
Life Stress ◽  
Stressful Life Events ◽  
Early Life Stress ◽  
Stressful Events ◽  
Stressful Life ◽  
Growing Up ◽  
Policy Makers ◽  
Significant Difference ◽  
The Relationship

ObjectivesMigrant youths endure many challenges. Such challenges can be stressful and lead to psychological difficulties. We investigated the relationship between migration, psychopathology and stressful events in children and adolescents. We hypothesised that migrant youths would show higher levels of psychopathology and more stressful life events than non-migrant youths.MethodUsing the Child cohort (Cohort ‘98) of the ‘Growing up in Ireland’ study we investigated psychopathology, as measured by the Strengths and Difficulties questionnaire (SDQ) at age 9 and 13 and stressful life events in migrant and non-migrant youths.ResultsThere was no significant difference between the proportion of migrant and non-migrant youths reporting psychopathology in childhood (p>0.05) or adolescence (p>0.05). Analysis of the SDQ subscales revealed that a significantly greater proportion of migrant youths had hyperactivity problems in childhood (p = 0.04) but a greater proportion of non-migrant youths had emotional problems in early adolescence (p = 0.04). We found that migrant youths experienced significantly more stressful life events than their non-migrant counterparts (p<0.01), however, once ‘Moving house/country‘ was removed as a stressor, there was no difference between the groups (p>0.27).ConclusionsContrary to our hypothesis, we observed that there were few differences between migrant and non-migrant youths in the levels of psychopathology. Migrant youths experienced a greater number of stressful life events, however, this was attributable to stressors relating to moving. An increased understanding of the factors promoting resilience, as demonstrated by the migrant youths, could aid health professionals and policy makers to effectively tailor interventions for mental health promotion.

Stress conceptions in life event research: Towards a person‐centred perspective

1987 ◽  
Vol 1 (3) ◽  
pp. 123-140 ◽  
Author(s):  
Gerhard Vossel
Keyword(s):  
Life Events ◽  
Life Stress ◽  
Stressful Events ◽  
Main Question ◽  
Time Dimension ◽  
Life Event ◽  
Critical Life Events ◽  
Dependent Variables ◽  
The Individual ◽  
Theoretical Foundations

The present article focuses on a discussion of the theoretical foundations of life event research. Since critical life events are usually regarded as stressful events, the main question is which concepts of stress are employed in different life event approaches and what is their rationale. The discussion centres on two topics that have to be treated independently: the question of specificity vs nonspecificity and the question of individualized vs normative weightings. It is shown that different life event approaches rely on different concepts of stress. Numerous objections lead to a rejection of the nonspecificity concept and a normative proceeding. However, even when a specificity view of stress is advocated and individual weights are used, life stress measures do not account for a substantial proportion of the variance in the stress‐related dependent variables. Therefore, a reorientation of life event research is required. It is proposed that future life event research should concentrate on the individual meaning of events and adequately consider the time dimension as well CIS processes of coping.

Intimate Partner Violence Perpetration Among Military Spouses

2021 ◽  
pp. 088626052110041
Author(s):  
Yangjin Park ◽  
Kathrine Sullivan ◽  
Lyndon A. Riviere ◽  
Julie C. Merrill ◽  
Kristina Clarke-Walper
Keyword(s):  
Risk Factors ◽  
Family Conflict ◽  
Partner Violence ◽  
Stressful Events ◽  
Military Spouses ◽  
Marital Discord ◽  
Direct Effects ◽  
Work Family Conflict ◽  
Ipv Perpetration ◽  
Work Family

Military spouses are an understudied population with respect to intimate partner violence (IPV) perpetration. Due to the unique demands of service members’ jobs, military couples are documented to experience particular individual, couple, and family-level risk factors that may lead to IPV perpetration. Using the frustration-aggression hypothesis and considering the possibility of mutual violence, we examined (a) the direct effects of stressful events, marital discord, and work–family conflict on IPV perpetration among military spouses and (b) the indirect effect of anger arousal between stressful events, marital discord, and work–family conflict on IPV perpetration. This study is a secondary analysis of data drawn from a survey of army spouses conducted by the Walter Reed Army Institute of Research in 2012. The sample consists of 314 female spouses of active-duty members (white 75%, enlisted 80%). After controlling for covariates (including spouse race, rank, household size, age, living distance from military installation), the direct effects of marital discord and anger on IPV perpetration were statistically significant. Also, the direct effects of marital discord and work–family conflict on anger were significant. The path model demonstrated that the indirect effects of marital discord and work–family conflict on IPV perpetration via anger were significant. Finally, most physical and verbal violence was reported to occur in the form of mutual violence with their partners. Study findings suggest that the pathway of risk factors impacting IPV might differ depending on the sources of stress. The Family Advocacy Program, military social work practitioners, and other behavioral health providers should consider domains of risk and provide support to military spouses that is specifically tailored to these risk factors. Furthermore, considering the mediating role of anger arousal in the relationship between marital discord, work–family conflict and IPV, programs to address anger might be helpful to reduce IPV among military spouse perpetrators.

scholarly journals Meaning of Aging, Gerotranscendence, and Successful Aging in Older Adults With Chronic Health Conditions

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 423-423
Author(s):  
Meredith Troutman-Jordan
Keyword(s):  
Older Adults ◽  
Problem Solving ◽  
Life Events ◽  
Successful Aging ◽  
Stressful Events ◽  
Functional Health ◽  
Major Influence ◽  
Unexpected Death ◽  
Major Life ◽  
Problem Solving Skills

Abstract Aging presents change in the form of opportunities and challenges, from common physical alterations, to major life events. Perception of such events is greatly shaped by one’s mental health, and is a major influence on gerotranscendence, a positive kind of aging involving redefinition of self, relationships, and proposed to be a precursor to successful aging. A mixed-methods cross-sectional descriptive design was used to study 50 older adults. Life Events Checklist, Gerotranscendence Scale, Herth Hope Index, and Successful Aging Inventory were administered. Mean participant age was 70.78 years; there were 9 males (18%), 41 females (82%), 13 were Black (26%), and 37 were White (74%). Participants reported a number of stressful events, most frequently transportation accidents, followed by other very stressful events or experiences, and sudden unexpected death of someone close. Gerotranscendence scores ranged from 0-10 (µ 6.88, a moderate score). Successful aging scores ranged from 40-79 (µ 62.33, a moderate score). A sub-sample of 6 participants engaged in semi-structured interviews, which were transcribed verbatim and subject to content analysis. Faith, displaced longing, temporal anticipation, proactive problem-solving/coping, and concern for future generations were emergent qualitative themes. Findings highlight opportunities for providers from multiple disciplines to target risks and possibilities for aging successfully and to promote hope, optimism, problem-solving skills, and gerotranscendence in all older adults, regardless of physical or functional health status.

scholarly journals Factors associated with the onset of major depressive disorder in adults with type 2 diabetes living in 12 different countries: results from the INTERPRET-DD prospective study

2020 ◽  
Vol 29 ◽  
Author(s):  
C. E. Lloyd ◽  
N. Sartorius ◽  
H. U. Ahmed ◽  
A. Alvarez ◽  
S. Bahendeka ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Major Depressive Disorder ◽  
Depressive Symptoms ◽  
Depressive Disorder ◽  
Life Events ◽  
Stressful Life Events ◽  
Regression Analyses ◽  
Major Depressive

Abstract Aims To examine the factors that are associated with changes in depression in people with type 2 diabetes living in 12 different countries. Methods People with type 2 diabetes treated in out-patient settings aged 18–65 years underwent a psychiatric assessment to diagnose major depressive disorder (MDD) at baseline and follow-up. At both time points, participants completed the Patient Health Questionnaire (PHQ-9), the WHO five-item Well-being scale (WHO-5) and the Problem Areas in Diabetes (PAID) scale which measures diabetes-related distress. A composite stress score (CSS) (the occurrence of stressful life events and their reported degree of ‘upset’) between baseline and follow-up was calculated. Demographic data and medical record information were collected. Separate regression analyses were conducted with MDD and PHQ-9 scores as the dependent variables. Results In total, there were 7.4% (120) incident cases of MDD with 81.5% (1317) continuing to remain free of a diagnosis of MDD. Univariate analyses demonstrated that those with MDD were more likely to be female, less likely to be physically active, more likely to have diabetes complications at baseline and have higher CSS. Mean scores for the WHO-5, PAID and PHQ-9 were poorer in those with incident MDD compared with those who had never had a diagnosis of MDD. Regression analyses demonstrated that higher PHQ-9, lower WHO-5 scores and greater CSS were significant predictors of incident MDD. Significant predictors of PHQ-9 were baseline PHQ-9 score, WHO-5, PAID and CSS. Conclusion This study demonstrates the importance of psychosocial factors in addition to physiological variables in the development of depressive symptoms and incident MDD in people with type 2 diabetes. Stressful life events, depressive symptoms and diabetes-related distress all play a significant role which has implications for practice. A more holistic approach to care, which recognises the interplay of these psychosocial factors, may help to mitigate their impact on diabetes self-management as well as MDD, thus early screening and treatment for symptoms is recommended.

Reduced latency to first antidepressant treatment in Italian patients with a more recent onset of major depressive disorder

2017 ◽  
Vol 41 (S1) ◽  
pp. S529-S529
Author(s):  
B. Grancini ◽  
B. Dell’Osso ◽  
L. Cremaschi ◽  
F. De Cagna ◽  
B. Benatti ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Antidepressant Treatment ◽  
Stressful Events ◽  
Major Depressive ◽  
Recent Onset ◽  
Valid Predictor ◽  
Before And After ◽  
Competing Interest ◽  
Year 2000

IntroductionMajor depressive disorder (MDD) is a prevalent burdensome disease, which frequently remains untreated. The duration of untreated illness (DUI) is modifiable parameter and a valid predictor of outcome. Previous investigation in patients with MDD revealed a DUI of different years, while recent reports have documented a reduction of DUI across time, in patients with different psychiatric disorders.Objectives/aimsThe present study was aimed to investigate potential differences in terms of DUI and related variables in patients with MDD across time.MethodsAn overall sample of 188 patients with MDD was divided in two subgroups on the basis of their epoch of onset (onset before and after year 2000). DUI and other onset-related variables were assessed through a specific questionnaire and compared between the two subgroups.ResultsThe whole sample showed a mean DUI of approximately 4.5 years, with a lower value in patients with more recent onset compared to the other subgroup (27.1 ± 42.6 vs. 75.8 ± 105.2 months, P < .05). Moreover, patients with onset after 2000 reported higher rates of onset-related stressful events and lower ones for benzodiazepines prescription (65% vs. 81%; P = 0.02; 47% vs. 30%; P = 0.02).ConclusionsThe comparison of groups with different epochs of onset showed a significant reduction in terms of DUI and benzodiazepines prescription, and a higher rate of onset-related stressful events in patients with a more recent onset. Reported findings are of epidemiologic and clinical relevance in order to evaluate progress and developments in the diagnostic and therapeutic pathways of MDD in Italian and other countries.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Effects of Life Stress and Dysphoria on Complex Judgments

1993 ◽  
Vol 72 (3_suppl) ◽  
pp. 1355-1363 ◽  
Author(s):  
John S. Gillis
Keyword(s):  
Life Events ◽  
Undergraduate Students ◽  
State Anxiety ◽  
Life Stress ◽  
Focus Of Attention ◽  
Judgment Task ◽  
Judgment And Decision Making ◽  
Subjective Distress ◽  
External Sources ◽  
Two Indices

A sparse literature concerning the effects of stress on judgment and decision making has produced two tentative conclusions: (1) stress impairs judgment and (2) such impairment is often the result of the narrowing of a judge's focus of attention. While evidence supportive of these propositions exists, there have also been contradictory findings. This investigation attempted to address both of these issues. 98 undergraduate students completed a complex multiple-cue judgment task and were also assessed as to (a) their exposure to two potential sources of stress (life events and irrational thinking) and (b) the amount of personal dysphoria they were experiencing. Two indices of subjective distress, depression and state anxiety, were significantly related to poor judgmental performance. None of several indices of potential stressors confirmed a relationship, which suggests that possible external sources of stress do not negatively affect judgment unless they generate subjective distress at the time judgments are made. There was no support for the “narrowing” hypothesis.

The Prognosis of Depression in Old Age

1983 ◽  
Vol 142 (2) ◽  
pp. 111-119 ◽  
Author(s):  
Elaine Murphy
Keyword(s):  
Life Events ◽  
Life Stress ◽  
Intimate Relationship ◽  
Class Differences ◽  
Poor Outcome ◽  
Physical Health Problems ◽  
The Face ◽  
One Year ◽  
Severe Life Events

SummaryThe paper describes a one year prospective study of 124 elderly depressed patients. Only one third of the group had a good outcome. Poor outcome was associated with severity of initial illness, those with depressive delusions having a particularly poor outcome. Outcome was also influenced by physical health problems and severe life events in the follow-up year. Social class differences in outcome were thought to be due to class differences in the experience of severe life events. There was no evidence that an intimate relationship protected against relapse in the face of continuing life stress.

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