scholarly journals Vitamin A Levels Among Pre-School Children of Central and Western China

2021 ◽  
Vol 9 ◽  
Author(s):  
Qian Chen ◽  
Yongfang Liu ◽  
Li Chen ◽  
Jie Chen ◽  
Ting Yang ◽  
...  
Keyword(s):  
Vitamin A ◽  
School Children ◽  
Vitamin A Deficiency ◽  
Western China ◽  
Healthy Children ◽  
Serum Retinol ◽  
Developing Regions ◽  
Children's Caregivers ◽  
Social Demographic ◽  
And Control

Objective: To investigate vitamin A deficiency of pre-school children in central and western China for developing strategies to prevent and control vitamin A deficiency (VAD) among children.Design: From November 2018 to September 2019, a total of 2,194 healthy children aged 2–6 years were enrolled. Serum retinol levels in the children were detected by liquid-phase tandem mass spectrometry. In addition, social demographic and dietary questionnaires were collected through interviews with children's caregivers.Setting: The participants were enrolled in 12 cities or their subordinate jurisdictions in the central and western regions of China.Participants: Two thousand one hundred and ninety four healthy children aged 2–6 years old.Results: Overall, 35.51% (779/2,194) of the children were found to be vitamin A insufficient (VAI, serum retinol < 1.05 μmol/L). Elder children had a higher risk to suffer from VAI, with proportions of 25.00% (87/348), 28.92% (142/491), 38.38% (256/667), and 42.73% (294/688) among children aged 2, 3, 4, and 5 years, respectively. Vitamin A levels were also positively correlated with per capita income (AOR = 1.18) and regional economic level (0.71), and the frequency of milk intake (0.91).Conclusions: The incidence of VAI was higher among children aged 2–6 years, and the incidence of VAI increases with age. VA levels were positively correlated with levels of economic development in the family and region. So prevention strategies for VAD need to focus on pre-school children, especially dairy intake and developing regions.

scholarly journals Isolated and combined prevalence of anemia, vitamin A deficiency and zinc deficiency in preschool children 12-72 months for the government of Paraíba

2014 ◽  
Vol 27 (3) ◽  
pp. 301-310 ◽  
Author(s):  
Dixis Figueroa Pedraza ◽  
Márcia Cristina Sales
Keyword(s):  
Vitamin A ◽  
Zinc Deficiency ◽  
School Children ◽  
Vitamin A Deficiency ◽  
Serum Zinc ◽  
Nutritional Deficiencies ◽  
Simultaneous Occurrence ◽  
Micronutrient Deficiencies ◽  
Serum Retinol ◽  
Prevalence Of Anemia

OBJECTIVE: To estimate the isolated and combined prevalence of anemia, vitamin A deficiency and zinc deficiency in pre-school children, as well as the distribution of isolated deficiencies according to gender, age and prior supplementation with vitamin A. METHODS: Cross-sectional study with pre-school children in the state of Paraíba, Brazil. Analysis of the average concentrations of hemoglobin, serum retinol and serum zinc, according to gender, age and previous vitamin A supplementation of children were carried out as well as the risk of simultaneous occurrence of micronutrient deficiencies in the presence of these deficiencies. RESULTS: The prevalence of anemia, vitamin A deficiency and zinc deficiency were 15.4%, 23.3% and 13.8%, respectively. The anemia was significantly associated with age (p<0.01). Children previously supplemented by vitamin A had higher serum retinol concentrations than children without supplements, an effect that was not observed for concentrations of hemoglobin or serum zinc. The prevalence of anemia associated with vitamin A deficiency was 5.8%, with the chance of vitamin A deficiency and anemia coexist 2.21 times (95%CI=1.03-4.84) higher in the case of vitamin A deficiency or anemia rather than in the absence of these conditions. CONCLUSION: The high prevalence of micronutrient deficiencies which are important in child growth, as well as the coexistence of nutritional deficiencies, point out the need to strengthen nutrition intervention strategies that consider this issue.

scholarly journals Efektivitas Program Fortifikasi Minyak Goreng dengan Vitamin A terhadap Status Gizi Anak Sekolah di Kota Makasar

2010 ◽  
Vol 4 (6) ◽  
pp. 255 ◽  
Author(s):  
Endang Achadi ◽  
Siti Arifah ◽  
Siti Muslimatun ◽  
Trisari Anggondowati ◽  
Asih Setiarini
Keyword(s):  
Vitamin A ◽  
School Children ◽  
Vitamin A Deficiency ◽  
Urban Slum ◽  
The Body ◽  
Slum Area ◽  
Serum Retinol ◽  
Significant Public Health ◽  
The Impact ◽  
Prevalence Of Anemia

Di Indonesia, kekurangan Vitamin A masih menjadi masalah kesehatan masyarakat yang penting seperti terlihat pada balita penderita vitamin A defisiensi subklinis yang tinggi (50%). Hal tersebut akan berpengaruh terhadap berbagai fungsi tubuh yang antara lain meliputi sistem imun, penglihatan, sistem reproduksi dan diferensiasi sel. Tujuan dari penelitian ini adalah untuk mengetahui kontribusi konsumsi minyak yang diperkaya vitamin A dalam memperbaiki status vitamin A dan hemoglobin balita. Penelitian dengan disain studi intervensi Before-After ini dilaksanakan pada anak sehat berusia 7-10 tahun yang diberi obat cacing sebelum intervensi dilakukan. Pengukuran serum retinol dan hemoglobin dilakukan sebelum dan 3 bulan setelah intervensi . Minyak yang difortifikasi vitamin A telah disediakan di warung/ toko di sekitar tempat tinggal responden. Untuk meningkatkan demand, penelitian ini dilengkapi dengan pendekatan pemasaran sosial yang dilakukan pihak lain. Secara umum tidak terlihat perubahan status gizi, tetapi prevalensi anemia turun dari 21,8% menjadi 11,6%. Sementara, prevalens vitamin A defisiensi ditemukan lebih rendah pada anak yang mengkonsumsi ³12 minggu (26,6%) daripada yang mengkonsumsi < 12 minggu (42%) . Hasil tersebut dapat dijadikan pertimbangan untuk merekomendasikan agar minyak difortifikasi vitamin A.Kata kunci: Defisiensi vitamin A, anak sekolah, minyak fortifikasiAbstractVitamin A deficiency (VAD) remains as one of significant public health problems in Indonesia. Around 50% of under five children are suffering from subclinical VAD. Deficiency of vitamin A will affect several important role in the body, such as immune system, vision, reproductive system and cell differentiation. Therefore, guarding Indonesian children to be free from VAD is crucial for their quality as Human Resources. We assessed the impact of the consumption of vitamin A fortified cooking oil on the improvement of vitamin A and hemoglobin status among school children in urban slum area in Makassar City. The study was an intervention design Before-After. Healthy school children 7-10 years were selected from schools and de-wormed before the intervention. Serum retinol and hemoglobin was measured at baseline and at 3 months after. Fortified oil was made available through distribution at shops and accompanied with social marketing. Eventhough overall there was no change in VAD prevalence, the VAD prevalence is lower among children who consumedfortified oil ³12 weeks (26.6%) compared to those who consumed <12 weeks (42%). Prevalence of anemia decreased from 21.8% to 11.6%. We recommended that fortified oil is made mandatory.Key words: Vitamin A deficiency, school children, fortified oil

scholarly journals Prevalence of ocular signs and subclinical vitamin A deficiency and its determinants among rural pre-school children in India

2011 ◽  
Vol 15 (4) ◽  
pp. 568-577 ◽  
Author(s):  
Avula Laxmaiah ◽  
Madhavan K Nair ◽  
Nimmathota Arlappa ◽  
Pullakhandam Raghu ◽  
Nagalla Balakrishna ◽  
...  
Keyword(s):  
Vitamin A ◽  
School Children ◽  
Rural Areas ◽  
Vitamin A Deficiency ◽  
Economic Status ◽  
Dried Blood Spots ◽  
Sampling Procedure ◽  
Serum Retinol ◽  
Cross Sectional ◽  
Ocular Signs

AbstractObjectiveTo assess the magnitude and determinants of vitamin A deficiency (VAD) and coverage of vitamin A supplementation (VAS) among pre-school children.DesignA community-based cross-sectional study was carried out by adopting a multistage, stratified, random sampling procedure.SettingRural areas of eight states in India.SubjectsPre-school children and their mothers were covered.ResultsA total of 71 591 pre-school children were clinically examined for ocular signs of VAD. Serum retinol concentrations in dried blood spots were assessed in a sub-sample of 3954 children using HPLC. The prevalence of Bitot spots was 0·8 %. The total ocular signs were significantly higher (P < 0·001) among boys (2·6 %) compared with girls (1·9 %) and in older children (3–4 years) compared (P < 0·001) with younger (1–2 years), and were also high in children of labourers, scheduled castes and illiterate mothers. The odds of having Bitot spots was highest in children of scheduled caste (OR = 3·8; 95 % CI 2·9, 5·0), labourers (OR = 2·9; 95 % CI 2·1, 3·9), illiterate mothers (OR = 2·7; 95 % CI 2·2, 2·3) and households without a sanitary latrine (OR = 5·9; 95 % CI 4·0, 8·7). Subclinical VAD (serum retinol level <20 μg/dl) was observed in 62 % of children. This was also relatively high among scheduled caste and scheduled tribe children. The rate of coverage of VAS was 58 %.ConclusionsThe study revealed that VAD is a major nutritional problem and coverage of VAS was poor. The important determinants of VAD were illiteracy, low socio-economic status, occupation and poor sanitation. Strengthening the existing VAS programme and focused attention on dietary diversification are essential for prevention of VAD.

scholarly journals Albendazole increases serum retinol concentration in primary schoolchildren with low serum retinol

2015 ◽  
Vol 34 (2) ◽  
pp. 121
Author(s):  
Jane Florida Kalumpiu ◽  
Yenny Djuardi ◽  
Taniawati Supali
Keyword(s):  
Vitamin A ◽  
Primary School ◽  
School Children ◽  
High Performance ◽  
Vitamin A Deficiency ◽  
Primary School Children ◽  
Serum Retinol ◽  
Serum Retinol Concentration ◽  
Retinol Concentration ◽  
Low Serum

Background<br />Soil-transmitted helminth (STH) infection is still a health problem in Indonesia. Vitamin A deficiency (VAD) is often found together with STH. The effect of the deworming program on the vitamin A status of primary school children is unknown. The objective of this study was to evaluate the effect of albendazole on serum retinol concentrations in primary school children.<br /><br />Methods<br />An experimental study of pre-post test design without control was carried out on 118 children from grades 3-5 at one primary school in North Jakarta, from July to September 2014. Flotac examination was used to determine STH infections and high performance liquid chromatography was performed to measure serum retinol concentration. Stool and blood samples were taken twice: before and three weeks after treatment with albendazole 400 mg single dose for three consecutive days given to all children either infected or uninfected. Paired t-test was used to analyze the data. <br /><br />Results<br />Of the 118 children, the prevalence of STH was 71.2%. The prevalence of low retinol serum (&lt;1.05 mmol/L) was 17 (17.2%) and of mild VAD was 2 (2.0%). Albendazole given in 3 consecutive days could not increase serum retinol concentrations (p=0.055). Serum retinol concentration significantly increased after albendazole treatment in children with low retinol serum at baseline (p=0.001). <br /><br />Conclusions<br />In children with low serum retinol concentration, treatment with albendazole increased retinol concentration. Integrated deworming and vitamin A supplementation strategies should be evaluated in this population.

scholarly journals Effect of single-dose albendazole and vitamin A supplementation on the iron status of pre-school children in Sichuan, China

2016 ◽  
Vol 115 (8) ◽  
pp. 1415-1423 ◽  
Author(s):  
Ke Chen ◽  
Hu Mina Xie ◽  
Weizheng Tian ◽  
Xiaoling Zheng ◽  
Alice C. Jiang
Keyword(s):  
Single Dose ◽  
Vitamin A ◽  
School Children ◽  
Vitamin A Deficiency ◽  
Iron Status ◽  
Control Group ◽  
Serum Retinol ◽  
Group 3 ◽  
Group 2

AbstractThe aim of this study was to explore the effect of single-dose albendazole and vitamin A intervention on the anaemic status and Fe metabolism of pre-school children. This study was a randomised, placebo-controlled and double-blinded intervention trial. All eligible anaemic pre-school children were randomly divided into three groups: group 1 received no intervention, which served as the control group, group 2 received 400 mg single-dose albendazole administration and group 3 received a 60000 μg vitamin A capsule combined with 400 mg single-dose albendazole at the beginning of the study. The follow-up period was for 6 months. Anthropometry and biochemical index about Fe metabolism were measured before and after intervention. A total of 209 pre-school anaemic children were randomly divided into three intervention groups (sixty-four, sixty-two and sixty for groups 1, 2 and 3, respectively). The mean age of the children in the study was 4·4 (sd 0·7) years and 50·5 % of the children were female (94/186). After a follow-up period of 6 months, the levels of serum retinol, ferritin, transferrin receptor-ferritin index and body total Fe content of children in group 3 were significantly higher compared with children in groups 1 and 2 (P<0·05). Moreover, the proportion of vitamin A deficiency, marginal vitamin A deficiency and Fe deficiency among children in group 3 were markedly lower compared with children in groups 1 and 2 (P<0·05). Albendazole plus vitamin A administration showed more efficacy on the improvement of serum retinol and Fe metabolic status.

scholarly journals Re-Defining the Population-Specific Cut-Off Mark for Vitamin A Deficiency in Pre-School Children of Malawi

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 849
Author(s):  
Blessings H. Likoswe ◽  
Edward J. M. Joy ◽  
Fanny Sandalinas ◽  
Suzanne Filteau ◽  
Kenneth Maleta ◽  
...  
Keyword(s):  
Vitamin A ◽  
School Children ◽  
Vitamin A Deficiency ◽  
Threshold Concentration ◽  
The Body ◽  
Retinol Binding Protein ◽  
World Health ◽  
Target Tissue ◽  
Serum Retinol ◽  
Health Organization

Retinol Binding Protein (RBP) is responsible for the transport of serum retinol (SR) to target tissue in the body. Since RBP is relatively easy and cheap to measure, it is widely used in national Micronutrient Surveys (MNS) as a proxy for SR to determine vitamin A status. By regressing RBP concentration against SR concentration measured in a subset of the survey population, one can define a population-specific threshold concentration of RBP that indicates vitamin A deficiency (VAD). However, the relationship between RBP and SR concentrations is affected by various factors including inflammation. This study, therefore, aimed to re-define the population-specific cut-off for VAD by examining the influence of inflammation on RBP and SR, among pre-school children (PSC) from the 2015–16 Malawi MNS. The initial association between RBP and SR concentrations was poor, and this remained the case despite applying various methods to correct for inflammation. The World Health Organization (WHO) recommends the threshold of 0.7 µmol/L to define VAD for SR concentrations. Applying this threshold to the RBP concentrations gave a VAD prevalence of 24%, which reduced to 10% after inflammation adjustments following methods developed by the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA). Further research is required to identify why SR and RBP were poorly associated in this population. Future MNS will need to account for the effect of inflammation on RBP to measure the prevalence of VAD in Malawi.

scholarly journals Relationship of serum carotenoids and retinol with anaemia among pre-school children in the northern mountainous region of Vietnam

2010 ◽  
Vol 13 (11) ◽  
pp. 1863-1869 ◽  
Author(s):  
Nguyen Cong Khan ◽  
Phan Van Huan ◽  
Nguyen Van Nhien ◽  
Le Danh Tuyen ◽  
Saskia de Pee ◽  
...  
Keyword(s):  
Vitamin A ◽  
School Children ◽  
Vitamin A Deficiency ◽  
Geometric Mean ◽  
Provitamin A ◽  
Mountainous Region ◽  
Serum Retinol ◽  
Provitamin A Carotenoids ◽  
Serum Carotenoids ◽  
Β Carotene

AbstractObjectiveTo characterize the relationship between serum carotenoids, retinol and anaemia among pre-school children.DesignA cross-sectional study was conducted in two groups: anaemic and non-anaemic. Serum levels of retinol, α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein and zeaxanthin were measured in the study subjects.SettingSix rural communes of Dinh Hoa, a rural and mountainous district in Thai Nguyen Province, in the northern mountainous region of Vietnam.SubjectsA total of 682 pre-school children, aged 12–72 months, were recruited.ResultsGeometric mean serum concentrations of carotenoids (μmol/l) were 0·056 for α-carotene, 0·161 for β-carotene, 0·145 for β-cryptoxanthin, 0·078 for lycopene, 0·388 for lutein and 0·075 for zeaxanthin. The mean levels of Hb and serum retinol were 108·8 g/l and 1·02 μmol/l, respectively. The prevalence of anaemia and vitamin A deficiency was 53·7 % and 7·8 %, respectively. After adjusting for sex and stunting, serum retinol concentrations (μmol/l; OR = 2·06, 95 % CI 1·10, 3·86, P = 0·024) and total provitamin A carotenoids (μmol/l; OR = 1·52, 95 % CI 1·01, 2·28, P = 0·046) were independently associated with anaemia, but non-provitamin A carotenoids (μmol/l; OR = 0·93, 95 % CI 0·63, 1·37, P = 0·710) were not associated with anaemia.ConclusionsAmong pre-school children in the northern mountainous region of Vietnam, the prevalences of vitamin A deficiency and anaemia are high, and serum retinol and provitamin A carotenoids are independently associated with anaemia. Further studies are needed to determine if increased consumption of provitamin A carotenoids will reduce anaemia among pre-school children.

scholarly journals Serum Vitamin A Content among Malnourished and Healthy Children in Kisangani City, DRC

2019 ◽  
pp. 269-276
Author(s):  
F. Lusamaki Mukunda ◽  
E. Solomo ◽  
Mosisi Moleka ◽  
Omekomba Konde ◽  
L. E. Likaka ◽  
...  
Keyword(s):  
Vitamin A ◽  
Nutritional Status ◽  
Vitamin A Deficiency ◽  
Serum Vitamin ◽  
The Body ◽  
Healthy Children ◽  
Serum Retinol ◽  
Cross Sectional ◽  
Major Health Problem ◽  
Malnourished Children

Summary: Vitamin A is an essential micronutrient needed by the body for various physiological functions. Its deficiency is associated with several functional disorders. The objective of this study is to determine blood vitamin A levels in malnourished and healthy children. Methods: It is a cross-sectional analytical study, consisting of determining the vitamin A content in the blood of children suffering from malnutrition and those in good nutritional status. Our sampling was casual and 59 children aged 6 to 59 months were retained. Among them 30 healthy children chosen from those attending preschool consultation at U HC and 29 malnourished children from those followed at M TNU for the management of malnutrition. The serum vitamin A assay was performed according to the method described by Tietz. Children with serum vitamin A level below 30 μg / 100 ml had vitamin A deficiency and those with a serum level greater than or equal to 30 μg / 100 ml had good vitamin A status. Percent, average and standard deviation calculations were performed. The Chi square statistical test was used to compare serum vitamin A content in healthy and malnourished children, as well as other maternal parameters for a significance level of 0.05.  Results: from 59 children examined, 30 or 50.8% were 6-17 months old, the average age was 21.9 ± 13 months. 45.7% had a serum retinol level between 50-59 μg/100 ml; the average value was 46.84 μg ± 14.27.  The prevalence of VAD was 20.3% and this deficit was more marked in children aged 6-17 months that is 50% (P<0.014). Among 12 children with VAD, 10 or 83.3% were the wealthy and two were the malnourished, the difference was statically significant (P< 0.011). Conclusion: Vitamin A deficiency remains a major health problem in the DRC. This affect all children regardless of their current nutritional status. Supplementation with this vitamin remains one of the palliative solutions.

Research Recommendations for Applying Vitamin A-Labelled Isotope Dilution Techniques to Improve Human Vitamin A Nutrition

2014 ◽  
Vol 84 (Supplement 1) ◽  
pp. 52-59 ◽  
Author(s):  
Sherry A. Tanumihardjo ◽  
Anura V. Kurpad ◽  
Janet R. Hunt
Keyword(s):  
Public Health ◽  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Human Subjects ◽  
The Body ◽  
Pool Size ◽  
Serum Retinol ◽  
Vitamin A Status ◽  
Status Assessment ◽  
Total Body

The current use of serum retinol concentrations as a measurement of subclinical vitamin A deficiency is unsatisfactory for many reasons. The best technique available for vitamin A status assessment in humans is the measurement of total body pool size. Pool size is measured by the administration of retinol labelled with stable isotopes of carbon or hydrogen that are safe for human subjects, with subsequent measurement of the dilution of the labelled retinol within the body pool. However, the isotope techniques are time-consuming, technically challenging, and relatively expensive. There is also a need to assess different types of tracers and doses, and to establish clear guidelines for the use and interpretation of this method in different populations. Field-friendly improvements are desirable to encourage the application of this technique in developing countries where the need is greatest for monitoring the risk of vitamin A deficiency, the effectiveness of public health interventions, and the potential of hypervitaminosis due to combined supplement and fortification programs. These techniques should be applied to validate other less technical methods of assessing vitamin A deficiency. Another area of public health relevance for this technique is to understand the bioconversion of β-carotene to vitamin A, and its relation to existing vitamin A status, for future dietary diversification programs.

Vitamin A Supplementation and Measles

1995 ◽  
Vol 16 (9) ◽  
pp. 358-359
Author(s):  
Glenn J. Fennelly
Keyword(s):  
Vitamin A ◽  
Acute Phase ◽  
Vitamin A Deficiency ◽  
Serum Levels ◽  
Morbidity And Mortality ◽  
Serum Retinol ◽  
Vitamin A Supplementation

Vitamin A deficiency resulting from inadequate intake or induced by infection is associated with increased morbidity and mortality. Measles, the major single infectious cause of mortality in children worldwide, is more severe in children who have preexisting vitamin A deficiency. Several recent studies suggest that: 1) measles is associated with depressed serum levels of vitamin A; 2) hyporetinemia, defined as a serum retinol of less than 0.7 µmol/L, is associated with increased mortality from measles, especially in children younger than 2 years of age; and 3) vitamin A will decrease the risk of complications and death when administered during the acute phase of illness (within 5 days of the onset of rash).

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