Localized Amyloidosis of the Nasal Mucosa: A Case Report and Review of the Literature

Amyloidosis is a disorder of protein folding in which various proteins automatically aggregate into a highly abnormal fibrillar conformation. Amyloidosis is classified into systemic and localized forms depending on whether the abnormal proteins deposited in several different organs or only a single organ. In localized amyloidosis of the head and neck regions, laryngeal amyloidosis is common; however, localized amyloidosis of the nose is extremely rare. We herein report a case of localized amyloidosis of the nose and review the relevant literature on localized sinonasal amyloidosis. A 41-year-old man presented with a history of severe nasal obstruction, which had persisted for two decades. Nasal endoscopy and imaging studies showed extensive thickening of the bilateral nasal mucosa and diffuse submucosal deposition of calcification. After histopathological and systemic examinations, he was diagnosed with localized amyloidosis of the nasal mucosa. Septoplasty and bilateral inferior turbinoplasty, which consisted of mucosal resection using an ultrasonic bone curette, was performed and his symptoms markedly improved. Localized sinonasal amyloidosis has a good prognosis and surgical resection should be selected as a first-line treatment; however, clinicians should recognize the high probability of recurrence.

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Dieulafoy’s lesion of the rectum: a case report and review of the literature

Endoscopy International Open ◽

10.1055/s-0043-114661 ◽

2017 ◽

Vol 05 (09) ◽

pp. E939-E942 ◽

Cited By ~ 2

Author(s):

Mo Wang ◽

Xiang Bu ◽

Jing Zhang ◽

Shanshan Zhu ◽

Ying Zheng ◽

...

Keyword(s):

Case Report ◽

Clinical Practice ◽

Gastrointestinal Bleeding ◽

Gastrointestinal Disease ◽

Relevant Literature ◽

Clinical Manifestations ◽

Review Of The Literature ◽

Dieulafoy’S Lesion ◽

Surgical Interventions ◽

History Of

AbstractOne patient with Dieulafoy’s lesion (DL) of the rectum who had a history of anal receptive intercourse is described and the relevant literature reviewed. DL is rare in clinical practice and is extremely rare in the rectum. It often affects patients with no history of cirrhosis or gastrointestinal disease and occurs with abrupt or recurrent gastrointestinal bleeding. Visible vessels can usually be found by endoscopy and coinstantaneous treatments are essential while surgical interventions can occur when necessary. The diagnosis of DL is mainly based on clinical manifestations and endoscopic features, and endoscopic treatment is the first option for hemostasis.

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A Rare Case of Giant Mesenteric Lipoblastoma in a 6-Year-Old Child and Review of the Literature

Case Reports in Surgery ◽

10.1155/2020/3018065 ◽

2020 ◽

Vol 2020 ◽

pp. 1-5

Author(s):

Maria Enrica Miscia ◽

Gabriele Lisi ◽

Giuseppe Lauriti ◽

Angela Riccio ◽

Dacia Di Renzo ◽

...

Keyword(s):

Benign Tumor ◽

Malignant Tumors ◽

Surgical Excision ◽

Review Of The Literature ◽

Imaging Studies ◽

Long Term Follow Up ◽

Rare Benign Tumor ◽

History Of

Giant mesenteric lipoblastoma is a rare benign tumor arising from the adipocytes. It can mimic malignant tumors, and its diagnosis is difficult before surgery. Imaging studies could lead the diagnosis but not confirm it. Those tumors arising in the abdomen are usually larger and can cause symptoms of compression. Surgical excision is the treatment of choice, and a long-term follow-up is necessary to detect local recurrences. Only a few cases of lipoblastomas arising from the mesentery are reported in literature. We present a case of a rare giant lipoblastoma arising from the mesentery of a 6-year-old girl, with a history of postprandial abdominal pain.

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Social Representations and Commitment

European Psychologist ◽

10.1027/1016-9040/a000317 ◽

2018 ◽

Vol 23 (3) ◽

pp. 233-249 ◽

Cited By ~ 4

Author(s):

Eric Bonetto ◽

Fabien Girandola ◽

Grégory Lo Monaco

Keyword(s):

Social Representations ◽

Social Representation ◽

Second Line ◽

Review Of The Literature ◽

First Line ◽

Research Perspectives ◽

The Social ◽

Bibliographic Search ◽

English Articles

Abstract. This contribution consists of a critical review of the literature about the articulation of two traditionally separated theoretical fields: social representations and commitment. Besides consulting various works and communications, a bibliographic search was carried out (between February and December, 2016) on various databases using the keywords “commitment” and “social representation,” in the singular and in the plural, in French and in English. Articles published in English or in French, that explicitly made reference to both terms, were included. The relations between commitment and social representations are approached according to two approaches or complementary lines. The first line follows the role of commitment in the representational dynamics: how can commitment transform the representations? This articulation gathers most of the work on the topic. The second line envisages the social representations as determinants of commitment procedures: how can these representations influence the effects of commitment procedures? This literature review will identify unexploited tracks, as well as research perspectives for both areas of research.

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Pneumomediastinum: A Rare Presentation of Inflicted Injuries in Infants

Journal of Pediatric Intensive Care ◽

10.1055/s-0040-1716857 ◽

2020 ◽

Author(s):

Adam Lee ◽

Adam Bajinting ◽

Abby Lunneen ◽

Colleen M. Fitzpatrick ◽

Gustavo A. Villalona

Keyword(s):

Literature Review ◽

Retrospective Review ◽

Review Of The Literature ◽

Rare Presentation ◽

Spontaneous Pneumomediastinum ◽

Nonaccidental Trauma ◽

Comprehensive Literature Review ◽

Healthy Infants ◽

History Of

AbstractReports of incidental pneumomediastinum in infants secondary to inflicted trauma are limited. A retrospective review of infants with pneumomediastinum and history of inflicted trauma was performed. A comprehensive literature review was performed. Three infants presented with pneumomediastinum associated with inflicted trauma. Mean age was 4.6 weeks. All patients underwent diagnostic studies, as well as a standardized evaluation for nonaccidental trauma. All patients with pneumomediastinum were resolved at follow-up. Review of the literature identified other cases with similar presentations with related oropharyngeal injuries. Spontaneous pneumomediastinum in previously healthy infants may be associated with inflicted injuries. Clinicians should be aware of the possibility of an oropharyngeal perforation related to this presentation.

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Isotretinoin induced nail fold pyogenic granuloma resolution with combination therapy: A case report and review of the literature

SKIN The Journal of Cutaneous Medicine ◽

10.25251/skin.3.4.8 ◽

2019 ◽

Vol 3 (4) ◽

pp. 275-278

Author(s):

Jonathan Bellew ◽

Chad Taylor ◽

Jaldeep Daulat ◽

Vernon Mackey

Keyword(s):

Pyogenic Granuloma ◽

Causative Factor ◽

Adolescent Male ◽

Review Of The Literature ◽

First Line ◽

Healthy Adolescent ◽

Therapeutic Modalities ◽

Children And Young Adults ◽

Intralesional Steroids ◽

Isotretinoin Therapy

Pyogenic granulomas are vascular hyperplasias presenting as red papules, polyps, or nodules on the gingiva, fingers, lips, face and tongue of children and young adults. Most commonly they are associated with trauma, but systemic retinoids have rarely been implicated as a causative factor in their appearance. We present a case of spontaneous eruption of multiple pyogenic granulomas of the bilateral periungal fingers in an otherwise healthy adolescent male undergoing isotretinoin therapy for severe nodulocystic acne. These pyogenic granulomas did not resolve spontaneously with discontinuation of isotretinoin, or first line therapeutic modalities. Their resolution did occur with administration of intralesional steroids and ablation with silver nitrate.

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History of Extensive Disease Small Cell Lung Cancer Treatment: Time to Raise the Bar? A Review of the Literature

Cancers ◽

10.3390/cancers13050998 ◽

2021 ◽

Vol 13 (5) ◽

pp. 998

Author(s):

Chiara Lazzari ◽

Aurora Mirabile ◽

Alessandra Bulotta ◽

Maria Grazia Viganó ◽

Francesca Rita Ogliari ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Treatment Time ◽

Small Cell ◽

Review Of The Literature ◽

Small Cell Lung ◽

Extensive Disease ◽

History Of ◽

Line Standard

Several trials have tried for decades to improve the outcome of extensive disease small cell lung cancer (ED-SCLC) through attempts to modify the standard treatments. Nevertheless, platinum/etoposide combination and topotecan have remained respectively the first and the second line standard treatments for the last 40 years. With the advent of immunotherapy, this scenario has finally changed. Our review aims to provide an overview of the primary studies on the actual therapeutic strategies available for ED-SCLC patients, and to highlight emerging evidence supporting the use of immunotherapy in SCLC patients.

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A Review of the Major Prosthetic Factors Influencing the Prognosis of Implant Prosthodontics

Journal of Clinical Medicine ◽

10.3390/jcm10040816 ◽

2021 ◽

Vol 10 (4) ◽

pp. 816

Author(s):

Javier Montero

Keyword(s):

Animal Studies ◽

Treatment Approach ◽

Treatment Plan ◽

Meta Analysis ◽

Good Prognosis ◽

Cochrane Library ◽

Review Of The Literature ◽

Hand Search ◽

Related Risk

Background: The treatment plan of prosthetic restorations supported by dental implants requires comprehensive scientific knowledge to deliver prostheses with good prognosis, even before the implant insertion. This review aims to analyze the main prosthetic determinants of the prognosis of implant-supported prostheses. Methods: A comprehensive review of the literature was conducted with a PICO (Patient Intervention Comparison Outcomes) question: “For partially or complete edentulous subjects treated with implant-supported prostheses, which prosthetic factors could affect clinical outcomes?”. A literature search was performed electronically in PubMed (MEDLINE), Scopus and Cochrane Library with the following equation [PROGNOS * OR RISK] FACTOR IMPLANT DENTAL, and by hand search in relevant journals and throughout the selected papers. Results: This revision was carried out based on 50 papers focused on several prosthodontics-related risk factors that were grouped as follows: implant-connection, loading protocol, transmucosal abutments, prosthetic fit, provisionalization, type of retention, impression technique, fabrication technique, and occlusion. More than a half of the studies were systematic reviews (30%), meta-analysis (16%), or prospective evaluations of prosthesis with various kinds of events (18%). However, narrative reviews of literature (14%) and in vitro/animal studies (16%) were also found. Conclusions: The current literature provides insufficient evidence for most of the investigated topics. However, based on the accumulated data, it seems reasonable to defend that the best treatment approach is the use of morse taper implants with transmucosal abutments, recorded by means of rigidly splinted copings through the pick-up technique, and screwed by milled prosthesis occlusally adjusted to minimize functional overloading.

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Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies

Materials ◽

10.3390/ma14092135 ◽

2021 ◽

Vol 14 (9) ◽

pp. 2135

Author(s):

Kamila Butowska ◽

Anna Woziwodzka ◽

Agnieszka Borowik ◽

Jacek Piosik

Keyword(s):

Drug Delivery ◽

Wide Spectrum ◽

Stimuli Responsive ◽

First Line ◽

Medical Expenses ◽

Polymeric Nanocarriers ◽

Essential Properties ◽

Life Threatening ◽

History Of ◽

Cancerous Cells

Doxorubicin, a member of the anthracycline family, is a common anticancer agent often used as a first line treatment for the wide spectrum of cancers. Doxorubicin-based chemotherapy, although effective, is associated with serious side effects, such as irreversible cardiotoxicity or nephrotoxicity. Those often life-threatening adverse risks, responsible for the elongation of the patients’ recuperation period and increasing medical expenses, have prompted the need for creating novel and safer drug delivery systems. Among many proposed concepts, polymeric nanocarriers are shown to be a promising approach, allowing for controlled and selective drug delivery, simultaneously enhancing its activity towards cancerous cells and reducing toxic effects on healthy tissues. This article is a chronological examination of the history of the work progress on polymeric nanostructures, designed as efficient doxorubicin nanocarriers, with the emphasis on the main achievements of 2010–2020. Numerous publications have been reviewed to provide an essential summation of the nanopolymer types and their essential properties, mechanisms towards efficient drug delivery, as well as active targeting stimuli-responsive strategies that are currently utilized in the doxorubicin transportation field.

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A Brief History of Psoriasis Management in Canada

Journal of Cutaneous Medicine and Surgery ◽

10.1177/1203475420903682 ◽

2020 ◽

Vol 24 (3) ◽

pp. 273-277

Author(s):

Khalad Maliyar ◽

Patrick Fleming ◽

Boluwaji Ogunyemi ◽

Charles Lynde

Keyword(s):

20Th Century ◽

Coal Tar ◽

Historical Review ◽

Chronic Inflammatory Disease ◽

Biologic Therapies ◽

First Line ◽

Revolutionary Change ◽

Clinical Presentations ◽

History Of ◽

The 19Th Century

Psoriasis is a chronic, inflammatory disease with a varying degree of clinical presentations. Managing psoriasis has always been arduous due to its chronicity and its propensity to relapse. Prior to the development of targeted biologic therapies, there were few effective treatments for psoriasis. Ancient psoriasis therapies included pinetar, plant extracts, psychotherapy, arsenic, and ammoniated mercury. In the 19th century, chrysarobin was developed. Then, in the early half of the 20th century, anthralin and coal tar were in widespread use. In the latter half of the 20th century, treatments were limited to topical first-line therapies, systemic drugs, and phototherapy. However, as the treatment of psoriasis has undergone a revolutionary change with the development of novel biologic therapies, patients with moderate to severe psoriasis have been able to avail therapies with high efficacy and durability along with an acceptable safety profile. This article is a brief historical review of the management of psoriasis prior to the inception of biologics and with the development of novel biologic therapies.

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Delayed leukoencephalopathy from suspected polymer embolism after neuroendovascular procedures

The Neuroradiology Journal ◽

10.1177/19714009211029172 ◽

2021 ◽

pp. 197140092110291

Author(s):

Thomas Mellemkjær ◽

Ronil V Chandra ◽

Lasse Speiser ◽

Benedicte P Ulhøi ◽

Claus Z Simonsen

Keyword(s):

Polymer Material ◽

Endovascular Procedures ◽

Rare Complication ◽

Diagnostic Process ◽

Line Treatment ◽

Review Of The Literature ◽

First Line ◽

Stroke Treatment ◽

Oral Glucocorticoids ◽

First Line Treatment

As the neurointervention field grows, a new side effect emerges. Delayed leukoencephalopathy (DL) is believed to be an inflammatory or allergic reaction to polymer material that is shed from catheters during endovascular procedures. We present four cases of DL after aneurysm treatment in two patients, endovascular stroke treatment and diagnostic arteriography. We present our diagnostic process, including biopsy results in two patients, our anti-inflammatory treatment and outcomes together with a review of the literature. In our series, prognosis was variable with ongoing seizures in two patients. Our literature review reveals that asymptomatic shedding of polymer material is common, occurring in a third of endovascular stroke procedures, whereas symptomatic DL occurs in <0.5% of therapeutic neuroendovascular procedures. Clinicians should be aware of this rare complication, and oral glucocorticoids seem to be a reasonable first-line treatment strategy.

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