scholarly journals Prophylactic Use of Meloxicam and Paracetamol in Peripartal Sows Suffering From Postpartum Dysgalactia Syndrome

2020 ◽  
Vol 7 ◽  
Author(s):  
Alexandra Schoos ◽  
Ilias Chantziaras ◽  
Jordy Vandenabeele ◽  
Evelien Biebaut ◽  
Evelyne Meyer ◽  
...  

Postpartum dysgalactia syndrome (PPDS) is a major economic problem in modern sow farms. General treatment of PPDS consists of the use of oxytocin to promote milk ejection and non-steroidal anti-inflammatory drugs (NSAIDs) to alleviate inflammatory processes. So far, studies investigated the use of a single administration of NSAIDs after parturition in healthy and non-healthy sows. The current study investigated whether administration of meloxicam or paracetamol in sows prior to parturition improves sow and piglet health as well as performance in a farm with PPDS problems in sows. Sixty sows and 978 piglets from a Belgian farrow-to-finish farm were enrolled. Sows were randomly divided into three groups: a non-treated control group, a meloxicam-treated group and a paracetamol-treated group. Treatment was administered orally for 7 days from gestation day 113 onwards. Performance and health parameters investigated in sows were gestation length, farrowing duration, litter characteristics, colostrum yield and quality (Immunoglobulin G), litter weight gain, weaning-to-estrus interval, pregnancy rate, rectal temperature, acute phase proteins and inflammatory markers serum amyloid A, haptoglobin, interferon γ, interleukin 1β and 6 backfat, constipation and feed refusal. Performance and health parameters in piglets were birthweight, average daily weight gain, colostrum intake and mortality. Paracetamol-treated sows showed a significantly (P = 0.04) lower rectal temperature (mean ± SD: 38.09 ± 0.18°C) than the meloxicam-treated sows (38.24 ± 0.18°C), but not than the control group (38.22 ± 0.18°C). Sows of the paracetamol-treated group had a significantly (P = 0.001) longer gestation length (116.3 ± 0.9 days) than sows of the control group (115.3 ± 0.6 days), but not than meloxicam-treated sows (115.9 ± 0.9 days). No significant differences between the three groups were found for all the other parameters. In conclusion, the prophylactic oral administration of either meloxicam or paracetamol for 7 days starting 2 days prior to farrowing did not show beneficial effects on both health and performance parameters of sows and piglets.

Author(s):  
Abbas Bakhteyari ◽  
Yasaman Zarrin ◽  
Parvaneh Nikpour ◽  
Zeinab Sadat Hosseiny ◽  
Zeinab Sadat Hosseiny ◽  
...  

Background: Diabetes mellitus deeply changes the genes expression of integrin (Itg) subunits in several cells and tissues such as monocytes, arterial endothelium, kidney glomerular cells, retina. Furthermore, hyperglycemia could impress and reduce the rate of successful assisted as well as non-assisted pregnancy. Endometrium undergoes thorough changes in normal menstrual cycle and the question is: What happens in the endometrium under diabetic condition? Objective: The aim of the current study was to investigate the endometrial gene expression of α3, α4, αv, Itg β1 and β3 subunits in diabetic rat models at the time of embryo implantation. Materials and Methods: Twenty-eight rats were randomly divided into 4 groups: control group, diabetic group, pioglitazone-treated group, and metformin-treated group. Real-time PCR was performed to determine changes in the expression of Itg α3, α4, αv, β1, and β3 genes in rat’s endometrium. Results: The expression of all Itg subunits increased significantly in diabetic rats’ endometrium compared with control group. Treatment with pioglitazone significantly reduced the level of Itg subunits gene expression compared with diabetic rats. While metformin had a different effect on α3 and α4 and elevated these two subunits gene expression. Conclusion: Diabetes mellitus significantly increased the expression of studied Itg subunits, therefore untreated diabetes could be potentially assumed as one of the preliminary elements in embryo implantation failure.


2016 ◽  
Vol 68 (6) ◽  
pp. 1487-1496 ◽  
Author(s):  
D.S. Lucas ◽  
E.T.F. Siqueira ◽  
M.M.H. Haguiwara ◽  
S.S. Azevedo ◽  
S.E. Yotsuyanagi ◽  
...  

ABSTRACT A non-surgical sterilant (NSS) was used with the objective of assessing the zootechnical performance, carcass and meat quality, and hormone levels. 90 male piglets were selected with birthweights varying between 1.5kg to 2.0kg. The control group was constituted of 45 males castrated by the conventional surgical method, at the seventh day of age, and the treated group was constituted of 45 males castrated with NSS (active principle of zinc gluconate in the concentration of 26.2mg/mL associated to the dimethyl sulfoxide at 0.5%), with the application of the first dose on the seventh day of age and the second dose on the fourteenth day of age. The zootechnical assessments were carried out on the farm and consisted: weight gain in the periods per animal and feed conversion. The slaughter of the animals and the assessment of the carcass and meat quality and hormone levels were carried out in a slaughterhouse and the municipality of Campinas (SP). The study demonstrated that the use of NSS was a viable alternative in relation to the zootechnical performance and the carcass quality. In relation to the meat quality there was no significant difference in the majority of the assessed parameters.


2017 ◽  
Vol 57 (8) ◽  
pp. 1731 ◽  
Author(s):  
Milan Ž. Baltić ◽  
Marija Dokmanović Starčević ◽  
Meho Bašić ◽  
Amir Zenunović ◽  
Jelena Ivanović ◽  
...  

The aim of the present study was to assess effects of selenium (Se)-yeast diet supplementation on performance and carcass composition in ducks. The study was performed on 240 1-day old ducklings of the same origin (Cherry Valley hybrid), during a 49-day period, which were fed diets supplemented with the following four different levels of Se yeast (ALKOSEL® R397): groups with Se at 0 mg/kg of the diet as-fed, 0.2 mg/kg, 0.4 mg/kg and 0.6 mg/kg. Growth performance (bodyweight, daily weight gain, daily feed intake, feed-conversion ratio) and carcass characteristics (hot and cold carcass weight, chilling losses, dressing percentage, carcass cut yields, and percentage of tissues in breast and thighs with drumsticks) of the ducks were determined. Animals fed high-Se diets (0.4 mg/kg) had higher (P < 0.05) final bodyweight and daily weight gain (from 15 to 49 days) compared with those fed diets with inadequate (0 mg/kg) or with supranutritional (0.6 mg/kg) Se levels. Ducks fed only with basal diet showed a higher (P < 0.05) feed-conversion ratio (from 15 to 49 days) compared with those supplemented with Se at 0.4 mg/kg and 0.6 mg/kg. Dressing percentage was higher (P < 0.01) in the control group (69.50%) than in the group with Se added at 0.6 mg/kg (66.85%). The weights of basic cuts from the duck carcasses did not significantly differ among compared groups. Moreover, the percentage of skin with subcutaneous fat in breast and thighs with drumsticks increased in Se-supplemented groups compared with the control group, while the opposite was determined with the percentage of muscle. It was concluded that a diet containing 0.4 mg of added Se per kilogram produced the greatest growth-performance results in ducks.


Animals ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1925
Author(s):  
José Espinosa ◽  
Rubén de la Morena ◽  
Julio Benavides ◽  
Carlos García-Pariente ◽  
Miguel Fernández ◽  
...  

In this study, the concentrations of two acute-phase proteins (APPs), haptoglobin (Hp) and serum amyloid A (SAA), were quantitatively assessed in serum samples from cattle naturally infected with paratuberculosis (PTB). APP profiles were compared across 190 animals classified according to the different pathological forms associated with infection: uninfected (n = 59), with focal lesions (n = 73), multifocal lesions (n = 19), and diffuse paucibacillary (n = 11) and diffuse multibacillary lesions (n = 28). Our results showed a significant increase in both APPs in infected animals compared to the control group, with differences depending on the type of lesion. Hp and SAA levels were increased significantly in all infected animals, except in cows with diffuse multibacillary lesions that showed similar values to non-infected animals. The expression pattern of both APPs was similar and negatively correlated with the antibody levels against PTB. These results indicate that the release of Hp and SAA is related to the presence of PTB lesions associated with a high cell-mediated immune response and a lower bacterial load, suggesting that the pro-inflammatory cytokines that are associated with these forms are the main stimulus for their synthesis. These molecules could show some potential to be used as putative biomarkers of PTB infection, particularly for the identification of subclinical animals showing pathological forms related to latency or resistance to the development of advanced lesions.


2017 ◽  
Vol 37 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Pedro Malafaia ◽  
Yury T.G. Salcedo ◽  
Ricardo A.R. Uscategui ◽  
Vinícius C. Souza ◽  
Diogo Fleury A. Costa ◽  
...  

ABSTRACT: We developed and evaluated a fast and simple method to obtain suitable bone samples for densitometry and chemical analysis through biopsies of the 12th rib of cattle. The postoperative recovery, dry matter intake (DMI) and average daily weight gain (ADG) was evaluated in 36 Nellore steers, nine of which were randomly selected for the control group and 27 others were rib biopsied. Every 30 days, rib biopsy was performed in nine steers, using a corded-electric pistol-grip drill coupled with a hole saw of a 3mm diameter pilot drill bit. This rib biopsy technique provided a suitable sample obtained in a fast way and allowed the surgeon to work alone with the animal slightly sedated and restrained in the crush. Dry matter intake (DMI) was not affected in biopsied animals. At the end of the experimental period (116 days) the average daily weight gain (ADG) was similar in the steers biopsied or not. The described method provided rib samples from cattle suitable for densitometry and chemical analysis of bone tissue without effects on health and performance. This information could greatly increase the accuracy for the diagnosis of phosphorus deficiency in cattle raised on pasture and allow the evaluation of bone metabolism in experimental animals.


2017 ◽  
Vol 22 (4) ◽  
pp. 703-706 ◽  
Author(s):  
Nematollah Asadi ◽  
Seyed Davood Husseini ◽  
Mohammad-Taghi Tohidian ◽  
Nargess Abdali ◽  
Amir Mimandipoure ◽  
...  

This study was conducted to determine the effects of dietary supplementation of peppermint ( Mentha piperita L.) on the performance of broiler chicks. 500 Ross broiler chicks were divided into 5 treatment groups of 4 replications in a completely randomized design format. The diets were ISO-caloric and ISO-nitrogenous ones and contained 1.5, 3, 4.5, and 6 g/kg of peppermint powder. At start, growing, and end periods, the effects of peppermint powder on average daily weight gain, feed conversation ratio, and mortality rate were studied. The results of the present study showed that over a production period of 42 days peppermint had a significant effect on average daily weight gain and feed conversation ratio when compared with the control group ( P < .05). The level of 4.5 g/kg had the highest average daily weight gain (52.78 g), and control treatment with 46.98 g had the least average daily weight gain among different levels of peppermint. The level of 4.5 g/kg and 6 g/kg of peppermint had the least mortality compared to control treatment during training period ( P < .05). From this experiment, we can conclude that treatment with 4.5 g/kg peppermint powder has better performance and carcass characteristics in broilers.


1988 ◽  
Vol 68 (1) ◽  
pp. 112-116 ◽  
Author(s):  
Robert K. Erickson ◽  
Frederick D. Brown ◽  
Keith L. Schaible ◽  
Robert L. Wollmann

✓ Bilateral ventromedial hypothalamic lesions in female adult rats which resulted in hyperphagia and rapid weight gain were followed by placement of fetal brain tissue in the anterior third ventricle. The treatment group received fetal hypothalamus grafts, and fetal cortical tissue of identical age was grafted into the control group. A significant reduction in average daily weight gain was noted from 4 to 12 weeks following transplantation in the treatment group. At 12 weeks posttransplantation, the animals were sacrificed for histological analysis. Examination of the hypothalamus grafts revealed neurons, ependymal clusters, and axonal processes which appeared to infiltrate the surrounding hypothalamic parenchyma.


2021 ◽  
Vol 6 (1) ◽  
pp. 57-63
Author(s):  
Galina Molyanova ◽  
Maksim Nogotkov

The purpose of the research is increasing the average daily gain of animals due to the use of the Bisolbi drug. The effect of Bisolbi preparation based on Bacillus subtilis H-13 1.5×108 (LLC «Bisolbi-Inter») on the biochemical and productive life of calves was studied. The scientific and production experiment was carried out on the basis of a dairy farm of the State «Kupinskoe» Unitary Enterprise of the Samara region involving 30 Holstein-Friesian calves. The biological effect of the drug is provided due to its adsorption properties, the ability to enhance the activity of a number of enzyme systems and increase the digestive and systemic immunity of the body. The drug use increases the integration intensity of animals: the amount of total protein in the blood serum of calves of the experimental group at 120 days of age was higher by 8.9% (p<0.05), albumin – by 9.2% (p<0.01), compared with the animal data of con-trolled group. The Bisolbi indication contributed to an increase in the intensity of carbohydrate-lipoid metabolism: the cholesterol amount was higher by 23% (p<0.01), the glucose content – by 0.4 mmol/l (p<0.05) in the blood of 120 day old calves of the experimental group, compared with the data of controlled animals. It was found that the body weight of calves in the control group of 100 days age was 105.23±2.11 kg, in the experimental group – 108.6±2.19 kg, which is 3.37 kg higher. The average daily weight gain of animals in experimental group was signif-icantly higher by 0.075 kg (p<0.01). At 120 days of age, the body weight of the experimental calves was higher by 4.19 kg (p<0.05), the average daily weight gain by 0.080 kg (p<0.05), compared with the data of the controlled ani-mals. The indication of Bisolbi 5-10 ml (LLC «Bisolbi-Inter») to calves daily for 2 months resulted in an additional profit constructively of 137 rubles from each head.


Author(s):  
N. Torres-Salado ◽  
Oscar D. García-Raymundo ◽  
María A. Maldonado-Peralta ◽  
Adelaido R. Rojas-García ◽  
Marco A. Ayala-Monter ◽  
...  

Objective: To evaluate the productive behavior of Creole sheep in the tropics fed a whole food diet that includes soybean (FS, Glycine max) fodder at different phenological stages. Methodology: The treatments T1: control, T2: 30% (SF-56 d), T3: 30% (SF-68 d), T4: 30% (SF-85 d), T5: 30% (SF-110 d) were assigned randomly to 30 male Creole sheep (15.51±1.6 kg LW). The experiment lasted 56 d. The variables evaluated were: dry matter consumption (DMC), daily weight gain (DWG) and feed conversion (FC). The experimental design wascompletely randomized and the averages of the treatments were compared using the Tukey test. Results: Differences (p<0.05) were found in DMC, DWG and FC. The DMC was lower (p<0.05) in the control group. The DWG was higher in the animals that consumed soybean fodder compared to the control group (0.205 vs 0.121 kg d-1). The FC decreased (p<0.05) 51% in T3 (SF 68 d), with respect to the control group. Study Limitations: The nutrient contribution of soybean fodder is based on the phenological stage of the plant. Likewise, producers in the tropical region have scarce knowledge about how to incorporate it in the feeding of small ruminants. Conclusions: The inclusion of 30% of soybean fodder at 68 d of age in a whole food diet improves the productive performance of the lambs because it increases daily weight gain and decreases feed conversion.


2020 ◽  
Vol 21 (3) ◽  
pp. 117
Author(s):  
Mas Yedi Sumaryadi ◽  
Dadang Mulyadi Saleh ◽  
Aras Prasetiyo Nugroho ◽  
Nu'man Hidayat ◽  
Chomsiatun Nurul Hidayah

The application of oxytocin induction to milk production in relation to the performance of kids in dairy goats had been carried out in the "PEGUMAS" dairy goat farmer group Gumelar District, Banyumas. This activity aimed to increase milk production and kid performance through the induction of the hormone oxytocin in dairy goats. The approach method was designed in two stages: the first stage carried out the socialization activities and demonstration of techniques for applying IPTEKS, and the second stage applied hormonal technology in the form of oxytocin hormone induction in dairy goats. The material used was dairy goat parity I aged 1.5 - 2 years allocated into 2 groups of 10 individuals each. Group I was dairy goat experiment not induced with the oxytocin hormone as the control. Group II was dairy goat experiment induced with the oxytocin hormone at a dose of 1 ml (10 IU) intramuscularly before milking. Milk production was measured morning and evening as daily milk production in milliliters (ml). Milk was given to the kid of each parent. The kid's performance was measured based on the daily weight gain of the kid during the study. Overall, the application of science and technology could be adopted by farmers, and oxytocin-induced dairy goat milk production (503.2 ml) was significantly higher (P<0.05) than control (305.4 ml) with an increase of 64.77%, with a positive level of correlation (r = 0.45) and contributed 19.83% to the kids daily body weight gain.


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