scholarly journals Evolution, Interspecies Transmission, and Zoonotic Significance of Animal Coronaviruses

2021 ◽  
Vol 8 ◽  
Author(s):  
Prapti Parkhe ◽  
Subhash Verma

Coronaviruses are single-stranded RNA viruses that affect humans and a wide variety of animal species, including livestock, wild animals, birds, and pets. These viruses have an affinity for different tissues, such as those of the respiratory and gastrointestinal tract of most mammals and birds and the hepatic and nervous tissues of rodents and porcine. As coronaviruses target different host cell receptors and show divergence in the sequences and motifs of their structural and accessory proteins, they are classified into groups, which may explain the evolutionary relationship between them. The interspecies transmission, zoonotic potential, and ability to mutate at a higher rate and emerge into variants of concern highlight their importance in the medical and veterinary fields. The contribution of various factors that result in their evolution will provide better insight and may help to understand the complexity of coronaviruses in the face of pandemics. In this review, important aspects of coronaviruses infecting livestock, birds, and pets, in particular, their structure and genome organization having a bearing on evolutionary and zoonotic outcomes, have been discussed.

2007 ◽  
Vol 81 (8) ◽  
pp. 4012-4020 ◽  
Author(s):  
D. Vijaykrishna ◽  
G. J. D. Smith ◽  
J. X. Zhang ◽  
J. S. M. Peiris ◽  
H. Chen ◽  
...  

ABSTRACT Although many novel members of the Coronaviridae have recently been recognized in different species, the ecology of coronaviruses has not been established. Our study indicates that bats harbor a much wider diversity of coronaviruses than any other animal species. Dating of different coronavirus lineages suggests that bat coronaviruses are older than those recognized in other animals and that the human severe acute respiratory syndrome (SARS) coronavirus was directly derived from viruses from wild animals in wet markets of southern China. Furthermore, the most closely related bat and SARS coronaviruses diverged in 1986, an estimated divergence time of 17 years prior to the outbreak, suggesting that there may have been transmission via an unknown intermediate host. Analysis of lineage-specific selection pressure also indicated that only SARS coronaviruses in civets and humans were under significant positive selection, also demonstrating a recent interspecies transmission. Analysis of population dynamics revealed that coronavirus populations in bats have constant population growth, while viruses from all other hosts show epidemic-like increases in population. These results indicate that diverse coronaviruses are endemic in different bat species, with repeated introductions to other animals and occasional establishment in other species. Our findings suggest that bats are likely the natural hosts for all presently known coronavirus lineages and that all coronaviruses recognized in other species were derived from viruses residing in bats. Further surveillance of bat and other animal populations is needed to fully describe the ecology and evolution of this virus family.


Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1127
Author(s):  
Shanley N. Roach ◽  
Ryan A. Langlois

Astroviruses are non-enveloped, single-stranded RNA viruses that infect mammalian and avian species. In humans, astrovirus infections are one of the most common causes of gastroenteritis in children. Infection has also been linked to serious neurological complications, especially in immunocompromised individuals. More extensive disease has also been characterized in non-human mammalian and avian species. To date, astroviruses have been detected in over 80 different avian and mammalian hosts. As the number of hosts continues to rise, the need to understand how astroviruses transmit within a given species as well as to new host species becomes increasingly important. Here, we review the current understanding of astrovirus transmission, the factors that influence viral spread, and the potential for cross-species transmission. Additionally, we highlight the current gaps in knowledge and areas of future research that will be key to understanding astrovirus transmission and zoonotic potential.


2021 ◽  
Vol 12 ◽  
Author(s):  
Yu Zhao ◽  
Xueqiang Su ◽  
Xinya Wang ◽  
Mengna Wang ◽  
Xujing Chi ◽  
...  

TCP is a plant-specific transcription factor that plays an important role in flowering, leaf development and other physiological processes. In this study, we identified a total of 155 TCP genes: 34 in Pyrus bretschneideri, 19 in Fragaria vesca, 52 in Malus domestica, 19 in Prunus mume, 17 in Rubus occidentalis and 14 in Prunus avium. The evolutionary relationship of the TCP gene family was examined by constructing a phylogenetic tree, tracking gene duplication events, performing a sliding window analysis. The expression profile analysis and qRT-PCR results of different tissues showed that PbTCP10 were highly expressed in the flowers. These results indicated that PbTCP10 might participated in flowering induction in pear. Expression pattern analysis of different developmental stages showed that PbTCP14 and PbTCP15 were similar to the accumulation pattern of fruit lignin and the stone cell content. These two genes might participate in the thickening of the secondary wall during the formation of stone cells in pear. Subcellular localization showed that PbTCPs worked in the nucleus. This study explored the evolution of TCP genes in six Rosaceae species, and the expression pattern of TCP genes in different tissues of “Dangshan Su” pear. Candidate genes related to flower induction and stone cell formation were identified. In summary, our research provided an important theoretical basis for improving pear fruit quality and increasing fruit yield by molecular breeding.


2021 ◽  
Vol 8 ◽  
Author(s):  
Pavel Kvapil ◽  
Joško Račnik ◽  
Marjan Kastelic ◽  
Pavlína Pittermannová ◽  
Tatjana Avšič-Zupanc ◽  
...  

Monitoring infectious diseases is one of the most important pillars of preventative veterinary medicine in zoological collections. The zoo environment offers a great variety of different animal species living in proximity and in contact with small wild animals and vectors (e.g., ticks and mosquitos). In this context, tick-borne encephalitis virus (TBEV), Usutu virus (USUV), and West Nile virus (WNV) causing vector-borne diseases are emerging pathogens that raise concern. The aim of the study was to detect antibodies to selected flaviviruses in various animal species in the Ljubljana Zoo, Slovenia. In total, 874 sera from 96 animal species were tested for antibodies to TBEV by enzyme-linked immunosorbent assays (ELISA); positive samples were confirmed by a virus neutralization test (VNT) using TBEV, WNV, and USUV antigens. Antibodies to TBEV were detected by ELISA in 3.9% (34/874) of zoo animals, with 4% (30/753) in mammals and 5% (4/86) in birds; the sera of reptiles (n = 34) and amphibians (n = 1) were negative. Antibodies to TBEV were confirmed by VNT in 11 mammals; one bird was positive for both WNV and USUV. The mixture of exotic animal species and their contact with wild animals and vectors such as ticks and mosquitos suggest that screening of infectious diseases in zoo animals might provide good insight into the epizootological situation of the area. This is the first survey of TBEV, WNV, and USUV in a zoological collection in Slovenia.


2020 ◽  
Vol 95 (1) ◽  
Author(s):  
Li Qin ◽  
Wentao Shen ◽  
Zhongfa Tang ◽  
Weiyao Hu ◽  
Lingna Shangguan ◽  
...  

ABSTRACT Potyviridae is the largest family of plant-infecting RNA viruses and includes many agriculturally and economically important viral pathogens. The viruses in the family, known as potyvirids, possess single-stranded, positive-sense RNA genomes with polyprotein processing as a gene expression strategy. The N-terminal regions of potyvirid polyproteins vary greatly in sequence. Previously, we identified a novel virus species within the family, Areca palm necrotic spindle-spot virus (ANSSV), which was predicted to encode two cysteine proteases, HCPro1 and HCPro2, in tandem at the N-terminal region. Here, we present evidence showing self-cleavage activity of these two proteins and define their cis-cleavage sites. We demonstrate that HCPro2 is a viral suppressor of RNA silencing (VSR), and both the variable N-terminal and conserved C-terminal (protease domain) moieties have antisilencing activity. Intriguingly, the N-terminal region of HCPro1 also has RNA silencing suppression activity, which is, however, suppressed by its C-terminal protease domain, leading to the functional divergence of HCPro1 and HCPro2 in RNA silencing suppression. Moreover, the deletion of HCPro1 or HCPro2 in a newly created infectious clone abolishes viral infection, and the deletion mutants cannot be rescued by addition of corresponding counterparts of a potyvirus. Altogether, these data suggest that the two closely related leader proteases of ANSSV have evolved differential and essential functions to concertedly maintain viral viability. IMPORTANCE The Potyviridae represent the largest group of known plant RNA viruses and account for more than half of the viral crop damage worldwide. The leader proteases of viruses within the family vary greatly in size and arrangement and play key roles during the infection. Here, we experimentally demonstrate the presence of a distinct pattern of leader proteases, HCPro1 and HCPro2 in tandem, in a newly identified member within the family. Moreover, HCPro1 and HCPro2, which are closely related and typically characterized with a short size, have evolved contrasting RNA silencing suppression activity and seem to function in a coordinated manner to maintain viral infectivity. Altogether, the new knowledge fills a missing piece in the evolutionary relationship history of potyvirids and improves our understanding of the diversification of potyvirid genomes.


2020 ◽  
Vol 9 (22) ◽  
Author(s):  
Kasumi Ishida-Kuroki ◽  
Nachiko Takeshita ◽  
Yoshihiro Nitta ◽  
Takehisa Chuma ◽  
Ken Maeda ◽  
...  

ABSTRACT We report 16S rRNA amplicon sequence data from feces from 58 wild boars, 60 feral raccoons, 9 wild Japanese badgers, 21 wild masked palm civets, and 8 wild raccoon dogs in Japan. The predominant bacterial taxa in the fecal microbiota were similar in part but varied among the animal species.


2018 ◽  
Vol VIII (z. 2) ◽  
pp. 123-137
Author(s):  
Magdalena Micińska

Animal traps have always accompanied man, with whom the primary people organized the first hunts. Along with the development of hunting art, traps gradually gave way to specialized hunting weapons. However, the use of animal traps on a large scale still occurs in countries that are world exporters of fur and skins of wild animals - Canada, Russia and the USA. Driven by expressed in art. 13 TFEU with the principle of animal welfare, the European Union has introduced a number of regulations to ensure humane catches in member countries as well as in third countries exporting skin and fur. The purpose of this article is to analyze the current legal situation in Poland with regard to the implementation of EU legislation on humane trap standards, with particular regard to the obligations contained in the agreement concluded between the European Community, Canada and the Russian Federation on 22 July 1997 - on international humane trapping standards . Keywords - EU, Poland, Russia, Canada, USA, animal welfare, humane animal protection, snare, poaching, animal species protection, hunting, animal traps, hunting, trapping, hunting law.


1988 ◽  
Vol 15 (3) ◽  
pp. 239-249 ◽  
Author(s):  
Gbadebo Jonathan Osemeobo

To conserve a resource without having adequate data and finance is difficult and frustrating. The situation of wildlife in Nigeria is nevertheless different. Except in the Yankari, Upper Ogun, and Kwiabaha, Game Reserves, and the Kainji Lake National Park, little efforts have been made to protect the Nigerian animal wildlife resources from human pressure and widespread extinction. To many, what remains of the wild animals are best seen in the few state-owned zoological gardens in Nigeria. However, because most indigenous large animal species—including Elephant, Buffalo, Chimpanzee, Gorilla, Rhinoceros, Leopard, and Ostrich—have not been able to reproduce in the various zoological gardens so far, the hope to conserve these animals is brittle. The questions are, what factors are working against wildlife conservation? Indeed, what hopes exist for Nigerian animal wildlife?Animal wildlife is a declining resource in Nigeria because of unplanned land-use practices. For example, landuses in game reserves are often conflicting and contradictory. Four land-uses: timber extraction, hunting, food-crop production, and settlement, are simultaneously going on in game reserves, with little or no control measures and with no management plans. The excessive demands for land for these conflicting uses have greatly disturbed the ecosystems involved, thus making the survival of the wild animals uncertain. Specifically, the problems of wildlife conservation in Nigeria are: (a) poaching; (b) indiscriminate burning of the vegetation; (c) uncontrolled grazing activities in the reserves; (d) intensive logging for domestic and industrial uses; (e) user rights on the reserves enjoyed by the traditional owners of the land before reservation; (f) lack of adequate funds to manage the reserves; (g) ineffective legislation; (h) lack of trained manpower; (i) urban sprawl; and (j) infrastructural development of roads, electric and telegraph lines, and irrigation schemes, all within the game reserves.The future for Nigerian animal wildlife depends on the nation's ability to conserve what is left either in their natural habitat or, at least, in zoological gardens. The task is not simple under conditions of economic depression, with inadequate manpower and without effective management of game reserves. In these circumstances, the game reserves should be reduced to manageable numbers, while state governments should win public sympathy through adequate conservation publicity and the provision of sufficient vehicles and personnel to manage the game reserves.The policy of land-use in game reserves should be reviewed, while researches should be conducted on (a) the levels of land-use that could be consistent with maintaining wild animals in the reserves, (b) the number and species of animals hunted per year, (c) the population of animal species in the game reserves and their habitat suitability, (d) the endangered and extinct animal species and specific reasons for the decline in their populations, and (e) human problems peculiar to each reserve and ways of minimizing them.


2009 ◽  
Vol 83 (7) ◽  
pp. 2917-2929 ◽  
Author(s):  
Jelle Matthijnssens ◽  
Christiaan A. Potgieter ◽  
Max Ciarlet ◽  
Viviana Parreño ◽  
Vito Martella ◽  
...  

ABSTRACT A limited number of human G6P[14] rotavirus strains that cause gastroenteritis in humans have been isolated in Europe and Australia. The complete genome sequences were determined for five of these human strains—B10925-97 (isolated in Belgium in 1997), 111/05-27 (Italy, 2005), PA169 (Italy, 1987), MG6 (Australia, 1993), and Hun5 (Hungary, 1997)—and their genetic relatedness to animal rotavirus strains was evaluated by sequencing the complete genome of the sheep rotavirus OVR762 (G8P[14]; Spain, 2002), the guanaco (Lama guanicoe) rotavirus strains Arg/Chubut/99 and Arg/Río Negro/98 (G8P[14] and G8P[1], respectively; Argentina, 1999 and 1998), the sable antelope strain RC-18/08 (G6P[14]; South Africa, 2008), and the bovine rotavirus strain Arg/B383/98 (G15P[11]; Argentina, 1998). These analyses revealed an overall consensus genomic constellation (G6/G8)-P[14]-I2-(R2/R5)-C2-M2-(A3/A11)-N2-T6-(E2/E12)-H3, together with a few gene reassortments, and the phylogenetic analyses confirmed that the P[14] human strains evaluated in this study were closely related to rotavirus strains isolated from sheep, cattle, goats, guanacos, and antelopes and to rabbits (albeit to a lesser extent), suggesting that one (or more) of these animal species might be the source of the human G6P[14] strains. The main feature of the genotype and phylogenetic analyses was the close overall genomic relatedness between the five human G6P[14] rotavirus strains and the ovine and antelope rotavirus strains. Taken together, these data strongly suggest a common origin for the human P[14] strains and those of the even-toed ungulates belonging to the mammalian order Artiodactyla, with sheep probably playing a key role in the interspecies transmission responsible for the introduction of P[14] rotavirus strains into the human population.


Author(s):  
Mera Usman Muhammed ◽  
Mayaki Abubakar Musa ◽  
Gambo Abdulrahman Abdullahi

This study was carried out to compare the digital rectal (DR) thermometer with non-contact infrared thermometer (IRT) measurements at two locations on the face in some large animal species. Two hundred and forty (240) animals comprising of equal numbers of three species (cattle, camel and horses) of varying age and either sex was used. The IR temperature was taken from two sites [frontal (FIRT) and temporal (TIRT) region] on the animal face. The mean IR temperatures (FIRT and TIRT) were higher than the RT in all the animal species. The two thermometers correlate poorly in all the animal species. Bland-Altman analysis showed high biases and limits of agreement not acceptable for clinical purposes. In conclusion, IRT seems to offer a quick and easy way to determine the animal temperature but clinically it cannot be used interchangeably with DR thermometer at the moment for body temperature measurement in these animal species.


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