scholarly journals Montmorillonite K10: An Efficient Organo-Heterogeneous Catalyst for Synthesis of Benzimidazole Derivatives

Catalysts ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 845
Author(s):  
Sonia Bonacci ◽  
Giuseppe Iriti ◽  
Stefano Mancuso ◽  
Paolo Novelli ◽  
Rosina Paonessa ◽  
...  
Keyword(s):  
Heterogeneous Catalysis ◽  
Focal Point ◽  
High Energy ◽  
Benzimidazole Derivatives ◽  
Chemical Structures ◽  
Montmorillonite K10 ◽  
Solvent Free Conditions ◽  
Starting Point ◽  
Work Up ◽  
High Energy Consumption

The use of toxic solvents, high energy consumption, the production of waste and the application of traditional processes that do not follow the principles of green chemistry are problems for the pharmaceutical industry. The organic synthesis of chemical structures that represent the starting point for obtaining active pharmacological compounds, such as benzimidazole derivatives, has become a focal point in chemistry. Benzimidazole derivatives have found very strong applications in medicine. Their synthesis is often based on methods that are not convenient and not very respectful of the environment. A simple montmorillonite K10 (MK10) catalyzed method for the synthesis of benzimidazole derivatives has been developed. The use of MK10 for heterogeneous catalysis provides various advantages: the reaction yields are decidedly high, the work-up procedures of the reaction are easy and suitable, there is an increase in selectivity and the possibility of recycling the catalyst without waste formation is demonstrated. The reactions were carried out in solvent-free conditions and in a short reaction time using inexpensive and environmentally friendly heterogeneous catalysis. It has been shown that the reaction process is applicable in the industrial field.

scholarly journals Montmorillonite K10: An Efficient Organo- Heterogeneous Catalyst for Synthesis of Benzimidazole Derivatives

2020 ◽  
Author(s):  
Sonia Bonacci ◽  
Giuseppe Iriti ◽  
Stefano Mancuso ◽  
Paolo Novelli ◽  
Rosina Paonessa ◽  
...  
Keyword(s):  
Heterogeneous Catalysis ◽  
Building Blocks ◽  
Synthetic Methods ◽  
Benzimidazole Derivatives ◽  
Free Condition ◽  
Short Reaction Time ◽  
Montmorillonite K10 ◽  
Solvent Free Condition ◽  
The Face ◽  
Work Up

The use of alternative synthetic methods, in the face of traditional processes that do not conform to the principles of Green Chemistry, represent a problem in the pharmaceutical industry. The procedures for the synthesis of benzimidazole derivatives have become a focus in synthetic organic chemistry, as they are building blocks of strong interest for the synthesis of compounds with pharmacological activity. Various benzimidazole derivatives have found very strong application in medicine and their synthesis is reported in the literature. A simple and environmental Montmorillonite K10 (MK10) catalyzed method for the synthesis of benzimidazole derivatives has been developed. The use of MK10 as heterogeneous catalysis provides various advantages in terms of yields, in the work up procedure of the reaction, selectivity and the possible recycle of catalyst without waste formation. The reactions were carried out in solvent free condition and in short reaction time using an inexpensive and environmentally friendly heterogeneous catalysis and it has been shown that the reaction process is applicable in the industrial field.

scholarly journals Montmorillonite K10-Catalyzed Solvent-Free Conversion of Furfural into Cyclopentenones

Catalysts ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 301 ◽  
Author(s):  
Sonia Bonacci ◽  
Monica Nardi ◽  
Paola Costanzo ◽  
Antonio De Nino ◽  
Maria Di Gioia ◽  
...  
Keyword(s):  
Reaction Time ◽  
Heterogeneous Catalysis ◽  
Heterogeneous Catalyst ◽  
Environmentally Friendly ◽  
Solvent Free ◽  
Short Reaction Time ◽  
Montmorillonite K10 ◽  
Solvent Free Conditions

A simple and eco-friendly montmorillonite K10 (MK10)-catalyzed method for the synthesis of cyclopentenone derivatives from biomass-produced furfural has been developed. The versatility of this protocol is that the reactions were performed under solvent-free conditions and in a short reaction time under heterogeneous catalysis. Montmorillonite K10 is mostly explored as a heterogeneous catalyst since it is inexpensive and environmentally friendly.

scholarly journals Improving Centrifugal Compressor Performance by Optimizing the Design of Impellers Using Genetic Algorithm and Computational Fluid Dynamics Methods

2019 ◽  
Vol 11 (19) ◽  
pp. 5409 ◽  
Author(s):  
Mohammad Omidi ◽  
Shu-Jie Liu ◽  
Soheil Mohtaram ◽  
Hui-Tian Lu ◽  
Hong-Chao Zhang
Keyword(s):  
High Energy ◽  
Subject Area ◽  
Hybrid Optimization ◽  
Blade Angle ◽  
Starting Point ◽  
Trailing Edges ◽  
Novel Method ◽  
Compressor Performance ◽  
Hybrid Optimization Model ◽  
High Energy Consumption

It has always been important to study the development and improvement of the design of turbomachines, owing to the numerous uses of turbomachines and their high energy consumption. Accordingly, optimizing turbomachine performance is crucial for sustainable development. The design of impellers significantly affects the performance of centrifugal compressors. Numerous models and design methods proposed for this subject area, however, old and based on the 1D scheme. The present article developed a hybrid optimization model based on genetic algorithms (GA) and a 3D simulation of compressors to examine the certain parameters such as blade angle at leading and trailing edges and the starting point of splitter blades. New impeller design is proposed to optimize the base compressor. The contribution of this paper includes the automatic creation of generations for achieving the optimal design and designing splitter blades using a novel method. The present study concludes with presenting a new, more efficient, and stable design.

Synthesis and Antimicrobial activities of Some Polyphenol compounds by Nano ZnO-TBAB as a Heterogeneous Catalytic Media

2020 ◽  
Vol 17 ◽  
Author(s):  
Rahele Bargebid ◽  
Ali Khalafi-Nezhad ◽  
Kamiar Zomorodian ◽  
Leila Zamani ◽  
Ali Ahmadinejad ◽  
...  
Keyword(s):  
Antibacterial Activities ◽  
Antimicrobial Activities ◽  
Reusable Catalyst ◽  
Nano Zno ◽  
Antifungal Activities ◽  
Chemical Structures ◽  
Heterogeneous Catalytic ◽  
Solvent Free Conditions ◽  
New Compounds ◽  
Derivatives Of

Introduction: Mannich reaction is a typical example of a three-component condensation reaction and the chemistry of Mannich bases has been the matter of search by researchers. Here an efficient procedure for the synthesis of some new Mannich derivatives of simple phenols is described. Methods: In this procedure a microwave-assisted and solvent less condensation were done between different phenols, secondary amines and paraformaldehyde. The reactions proceed in the presence of catalytic amount of nano ZnO and tetrabutylammonium bromide (TBAB) in excellent yields. 10 new compounds were synthesized (A1-A10). Chemical structures of all new compounds were confirmed by different spectroscopic methods. We optimized the chemical reactions in different conditions. Optimization reactions were done in the presence of different mineral oxides, different amount of TBAB and also different solvents. Nano ZnO and TBAB in catalytic amounts and solvent free conditions were the best conditions. All the synthesized compounds were screened for their antimicrobial activities. Antifungal and antibacterial activities of the synthesized compounds were evaluated against some Candida, filaments fungi, gram positive and gram negative bacteria by broth micro dilution method as recommended by CLSI. Results: The result showed that compounds A2, A3 and A4 against most of the tested Candida species and compounds A5 and A7 against C. parapsilosis and C. tropicalis, exhibited considerable antifungal activities. Also Compounds A8 and A10 showed desirable antifungal activities against C. neoformance and C. parapsilosis, respectively. The antibacterial activities of the synthesized compounds were also evaluated. Compounds A6 - A10 against E. Fecalis and compounds A5, A7, A9 and A10 against P. aeruginosa showed desirable antibacterial activities. Discussion: We have synthesized some new Mannich adducts of poly-hydroxyl phenols in the presence of nano-ZnO as a reusable catalyst, with the hope of discovering new lead compounds serving as potent antimicrobial agents. The advantages of this method are generality, high yields with short reaction times, simplicity, low cost and matching with green chemistry protocols. The antimicriobial studies of Mannich derivatives of phenols showed desirable results in vitro.

scholarly journals Searching for elusive dark sectors with terrestrial and celestial observations

2021 ◽  
Vol 2021 (6) ◽  
Author(s):  
Roberto Contino ◽  
Kevin Max ◽  
Rashmish K. Mishra
Keyword(s):  
Field Theory ◽  
Broad Class ◽  
High Energy ◽  
Effective Field ◽  
Dark Sector ◽  
Minimum Requirement ◽  
Conformal Field ◽  
Starting Point ◽  
The Standard Model ◽  
Visible Sector

Abstract We consider the possible existence of a SM-neutral and light dark sector coupled to the visible sector through irrelevant portal interactions. Scenarios of this kind are motivated by dark matter and arise in various extensions of the Standard Model. We characterize the dark dynamics in terms of one ultraviolet scale Λuv, at which the exchange of heavy mediator fields generates the portal operators, and by one infrared scale ΛIR, setting the mass gap. At energies ΛIR « E « Λuv the dark sector behaves like a conformal field theory and its phenomenology can be studied model independently. We derive the constraints set on this scenario by high- and low-energy laboratory experiments and by astrophysical observations. Our results are conservative and serve as a minimum requirement that must be fulfilled by the broad class of models satisfying our assumptions, of which we give several examples. The experimental constraints are derived in a manner consistent with the validity of the effective field theory used to define the portal interactions. We find that high-energy colliders give the strongest bounds and exclude UV scales up to a few TeV, but only in specific ranges of the IR scale. The picture emerging from current searches can be taken as a starting point to design a future experimental strategy with broader sensitivity.

scholarly journals Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
L. Whitmore ◽  
R. I. Mackay ◽  
M. van Herk ◽  
J. K. Jones ◽  
R. M. Jones
Keyword(s):  
Electron Beams ◽  
Focal Point ◽  
External Beam Radiotherapy ◽  
High Energy ◽  
Energy Electron ◽  
High Energy Electron ◽  
Dose Delivery ◽  
Entrance Dose ◽  
Very High Energy ◽  
Very High

AbstractThis paper presents the first demonstration of deeply penetrating dose delivery using focused very high energy electron (VHEE) beams using quadrupole magnets in Monte Carlo simulations. We show that the focal point is readily modified by linearly changing the quadrupole magnet strength only. We also present a weighted sum of focused electron beams to form a spread-out electron peak (SOEP) over a target region. This has a significantly reduced entrance dose compared to a proton-based spread-out Bragg peak (SOBP). Very high energy electron (VHEE) beams are an exciting prospect in external beam radiotherapy. VHEEs are less sensitive to inhomogeneities than proton and photon beams, have a deep dose reach and could potentially be used to deliver FLASH radiotherapy. The dose distributions of unfocused VHEE produce high entrance and exit doses compared to other radiotherapy modalities unless focusing is employed, and in this case the entrance dose is considerably improved over existing radiations. We have investigated both symmetric and asymmetric focusing as well as focusing with a range of beam energies.

scholarly journals Rapid four-component synthesis of dihydropyrano[2,3-c]pyrazoles using nano-eggshell/Ti(IV) as a highly compatible natural based catalyst

BMC Chemistry ◽  
2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Arefeh Dehghani Tafti ◽  
Bi Bi Fatemeh Mirjalili ◽  
Abdolhamid Bamoniri ◽  
Naeimeh Salehi
Keyword(s):  
Thermo Gravimetric Analysis ◽  
Reaction Times ◽  
Diffraction Field ◽  
Gravimetric Analysis ◽  
X Ray Diffraction ◽  
X Ray ◽  
Solvent Free Conditions ◽  
High Yields ◽  
Work Up

AbstractNano-eggshell/Ti(IV) as a novel naturally based catalyst was prepared, characterized and applied for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives. The characterization of nano-eggshell/Ti(IV) was performed using Fourier Transform Infrared spectroscopy, X-ray Diffraction, Field Emission Scanning Electron Microscopy, Energy-Dispersive X-ray Spectroscopy, and Thermo Gravimetric Analysis. Dihydropyrano[2,3-c]pyrazoles were synthesized in the presence of nano-eggshell/Ti(IV) via a four component reaction of aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate at room temperature under solvent free conditions. The principal affairs of this procedure are mild condition, short reaction times, easy work-up, high yields, reusability of the catalyst and the absence of toxic organic solvents.

scholarly journals Multiwavelength Observations of Fast Radio Bursts

Universe ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 76
Author(s):  
Luciano Nicastro ◽  
Cristiano Guidorzi ◽  
Eliana Palazzi ◽  
Luca Zampieri ◽  
Massimo Turatto ◽  
...  
Keyword(s):  
Radio Burst ◽  
High Energy ◽  
Medium Size ◽  
Radio Bursts ◽  
Starting Point ◽  
Key Points ◽  
Fast Radio Burst ◽  
Theoretical Results ◽  
Observational Strategy ◽  
Shed Light

The origin and phenomenology of the Fast Radio Burst (FRB) remains unknown despite more than a decade of efforts. Though several models have been proposed to explain the observed data, none is able to explain alone the variety of events so far recorded. The leading models consider magnetars as potential FRB sources. The recent detection of FRBs from the galactic magnetar SGR J1935+2154 seems to support them. Still, emission duration and energetic budget challenge all these models. Like for other classes of objects initially detected in a single band, it appeared clear that any solution to the FRB enigma could only come from a coordinated observational and theoretical effort in an as wide as possible energy band. In particular, the detection and localisation of optical/NIR or/and high-energy counterparts seemed an unavoidable starting point that could shed light on the FRB physics. Multiwavelength (MWL) search campaigns were conducted for several FRBs, in particular for repeaters. Here we summarize the observational and theoretical results and the perspectives in view of the several new sources accurately localised that will likely be identified by various radio facilities worldwide. We conclude that more dedicated MWL campaigns sensitive to the millisecond–minute timescale transients are needed to address the various aspects involved in the identification of FRB counterparts. Dedicated instrumentation could be one of the key points in this respect. In the optical/NIR band, fast photometry looks to be the only viable strategy. Additionally, small/medium size radiotelescopes co-pointing higher energies telescopes look a very interesting and cheap complementary observational strategy.

scholarly journals The Assessment of Carbon Dioxide Dissociation Using a Single-Mode Microwave Plasma Generator

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1558 ◽  
Author(s):  
George Mogildea ◽  
Marian Mogildea ◽  
Cristina Popa ◽  
Gabriel Chiritoi
Keyword(s):  
Carbon Dioxide ◽  
Microwave Plasma ◽  
Focal Point ◽  
Single Mode ◽  
Plasma Generator ◽  
High Energy ◽  
High Electron ◽  
Space Applications ◽  
Plasma Characterization ◽  
Co2 Atmosphere

This paper focuses on the dissociation of carbon dioxide (CO2) following the absorption processes of microwave radiation by noncontact metal wire (tungsten). Using a microwave plasma generator (MPG) with a single-mode cavity, we conducted an interaction of microwaves with a noncontact electrode in a CO2 atmosphere. High energy levels of electromagnetic radiation are generated in the focal point of the MPG’s cylindrical cavity. The metal wires are vaporized and ionized from this area, subsequently affecting the dissociation of CO2. The CO2 dissociation is highlighted through plasma characterization and carbon monoxide (CO) quantity determination. For plasma characterization, we used an optical emission spectroscopy method (OES), and for CO quantity determination, we used a gas analyzer instrument. Using an MPG in the CO2 atmosphere, we obtained a high electron temperature of the plasma and a strong dissociation of CO2. After 20 s of the interaction between microwaves and noncontact electrodes, the quantity of CO increased from 3 ppm to 1377 ppm (0.13% CO). This method can be used in space applications to dissociate CO2 and refresh the atmosphere of closed spaces.

Oxygen Supply Method Using Gas-Permeable Film for Wastewater Treatment

1993 ◽  
Vol 28 (7) ◽  
pp. 243-250 ◽  
Author(s):  
Y. Suzuki ◽  
S. Miyahara ◽  
K. Takeishi
Keyword(s):  
Wastewater Treatment ◽  
Energy Consumption ◽  
Oxygen Transfer ◽  
Transfer Rate ◽  
Oxygen Supply ◽  
Oxygen Transfer Rate ◽  
High Energy ◽  
High Rate ◽  
N Removal ◽  
High Energy Consumption

Gas-permeable film can separate air and water, and at the same time, let oxygen diffuse from the air to the water through the film. An oxygen supply method using this film was investigated for the purpose of reducing energy consumption for wastewater treatment. The oxygen transfer rate was measured for the cases with or without biofilm, which proved the high rate of oxygen transfer in the case with nitrifying biofilm which performed nitrification. When the Gas-permeable film with nitrifying biofilm was applied to the treatment of wastewater, denitrifying biofilm formed on the nitrifying biofilm, and simultaneous nitrification and denitrification occurred, resulting in the high rate of organic matter and T-N removal (7 gTOC/m2/d and 4 gT-N/m2/d, respectively). However, periodic sloughing of the denitrifying biofilm was needed to keep the oxygen transfer rate high. Energy consumption of the process using the film in the form of tubes was estimated to be less than 40% of that of the activated sludge process.

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