scholarly journals Progress of Home-Based Food Allergy Treatment during the Coronavirus Disease Pandemic in Japan: A Cross-Sectional Multicenter Survey

Children ◽  
2021 ◽  
Vol 8 (10) ◽  
pp. 919
Author(s):  
Akihiro Maeta ◽  
Yuri Takaoka ◽  
Atsuko Nakano ◽  
Yukiko Hiraguchi ◽  
Masaaki Hamada ◽  
...  
Keyword(s):  
Food Allergy ◽  
Allergic Diseases ◽  
Oral Immunotherapy ◽  
Medical Care System ◽  
Cross Sectional ◽  
State Of Emergency ◽  
Emergency Visits ◽  
Home Based ◽  
Multicenter Survey ◽  
Allergy Treatment

The coronavirus disease 2019 (COVID-19) pandemic’s impact on food allergy treatment such as home-based oral immunotherapy (OIT) is not known. This cross-sectional, questionnaire-based anonymized survey screened 2500 parents of children with allergic diseases and was conducted in the pediatric outpatient clinics of 24 hospitals. Basic clinical data of the children were collected along with the degree of allergy control, parental anxiety about emergency visits, and the risk of COVID-19 in the first state of emergency. A total of 2439 (97.6%) questionnaires were collected, and 1315 parents who were instructed to initiate home-based OIT for their children were enrolled (OIT group). Subjective OIT progress compared to before the COVID-19 pandemic was ascertained as “Full”, “Middle”, “Low”, “Little”, and “Stop” in 264 (20.1%), 408 (31.0%), 384 (29.2%), 203 (15.4%), and 56 (4.3%) participants, respectively. Anxiety about emergency visits and the risk of COVID-19 were negatively associated with the subjective OIT progress. In Japan, approximately half of the children continued smoothly the home-based OIT during the COVID-19 pandemic. Parents with high levels of anxiety about the disruption of the medical care system due to COVID-19 and the risk of COVID-19 did not experience a smooth continuation of home-based OIT.

scholarly journals Perception of food allergy among mothers of allergic children in Southwestern Saudi Arabia

2021 ◽  
Vol 19 (2) ◽  
Author(s):  
Youssef A. Alqahtani ◽  
Ayed A. Shati ◽  
Ahmad A. Alhanshani ◽  
Bayan M. Hanif ◽  
Eman S. Salem ◽  
...  
Keyword(s):  
Food Allergy ◽  
Hospital Admissions ◽  
Unmet Need ◽  
Allergic Diseases ◽  
The United States ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Food Allergies ◽  
Geographic Variations ◽  
Cross Sectional

Background: Food allergy (FA) is increasingly recognized with the highest prevalence in preschool children; there has been a significant increase in hospital admissions for systemic allergic diseases with anaphylaxis and food allergies. Hospital admissions for food allergy were noticed to rise from 6 to 41 per million between 1990 and 2000 worldwide . The prevalence of food allergy is increasing over time with significant geographic variations. It is estimated to affect 6% of children in the United States (USA); according to a study conducted in Makkah, by AL Mokarmah, the prevalence of FA among children attending the well-baby clinic was 22.5% and in Riyadh is 6% among children who visit the allergy clinic at King Khalid University Hospital. FA in children is usually caused by milk (2.5%), egg (1.3%), peanut (0.8%), tree nuts (0.2%), fish (0.1%), as well as shellfish (0.1%), with an overall prevalence of 6%. Methods: In this cross-sectional study, a self-administered questionnaire was used in the data collection. After data were collected, they were entered in the Statistical Software IBM SPSS version 22. Descriptive and inferential statistics were obtained. Results: Out of 980 mothers, 49% were suffering from food allergy, while 28.6% of their children were suffering from food allergy. Shellfish was the most common cause of food allergy (38%). Conclusion: The management of FA in children is improving through the acquisition of new knowledge in diagnosis and treatment. Education of physicians and food-allergic patients about FA and its treatment is becoming recognized as an unmet need. Key words: Food allergy, mother, children, knowledge, prevalence, factors

scholarly journals Impact of COVID-19 on Stroke Admissions and the Medical Care System in the Tokyo Metropolitan Area

2020 ◽  
Vol 11 ◽  
Author(s):  
Takahiro Ota ◽  
Yoshiaki Shiokawa ◽  
Teruyuki Hirano
Keyword(s):  
Medical Care ◽  
Acute Stroke ◽  
Metropolitan Area ◽  
The State ◽  
Medical Care System ◽  
State Of Emergency ◽  
Tokyo Metropolitan ◽  
Tokyo Metropolitan Area ◽  
Multicenter Survey ◽  
Care System

Aims: This study aimed to assess the number of patients with acute stroke seeking medical emergency care since the declaration of the state of emergency in the COVID-19 pandemic in the Tokyo metropolitan area of Japan.Methods: In this combined retrospective and prospective multicenter survey, data on the numbers of hospital admissions due to acute ischemic stroke, of large vessel occlusion (LVO) cases, and of reperfusion therapies performed from February to July 2020, restrictions of the medical care system, and comprehensive stroke center (CSC) scale scores were collected in 19 stroke centers in Tokyo.Results: In the survey period, 3,456 patients were admitted with acute stroke. There was a decrease in the number of admissions (−22%), LVO (−22%), thrombolysis (−6%), and thrombectomy (−23%) during the state of emergency, but the ratio of thrombectomy to LVO cases was not different. The acceptance of acute stroke cases by emergency transport and emergent operations in the central eastern area of Tokyo, was also significantly decreased to <50% and remains <60%. According to CSC scores, each hospital restricted their infrastructure or educational activities according to their medical resources. There was only one stroke case with COVID-19 (thrombectomy case) in all 3,456 patients in this study.Conclusion: The COVID-19 pandemic had a major impact on stroke care in Tokyo, including stroke admissions and medical care systems, resulting in a significant reduction in thrombolysis and thrombectomy. The extent of the drop may be the result of the number of COVID-19 patients.

scholarly journals Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy

2020 ◽  
Author(s):  
Yoshihiro Takasato ◽  
Yosuke Kurashima ◽  
Masahiro Kiuchi ◽  
Kiyoshi Hirahara ◽  
Sayuri Murasaki ◽  
...  
Keyword(s):  
Food Allergy ◽  
T Cell ◽  
Mast Cells ◽  
Regulatory T Cell ◽  
Regulatory Network ◽  
Allergic Diseases ◽  
Treg Cells ◽  
Oral Immunotherapy ◽  
Cellular Mechanisms ◽  
Novel Strategy

AbstractOral immunotherapy (OIT) is an effective approach to controlling food allergy. Although the detailed molecular and cellular mechanisms of OIT are unknown currently, they must be understood to advance the treatment of allergic diseases in general. To elucidate the mechanisms of OIT, especially during the immunological transition from desensitization to allergy regulation, we generated a clinical OIT murine model and used it to examine immunological events of OIT. We found that in mice that completed OIT successfully, desensitized mast cells (MCs) showed functionally beneficial alterations, such as increased induction of regulatory cytokines and enhanced expansion of regulatory T cells. Importantly, these regulatory-T-cell-mediated inhibitions of allergic responses were dramatically decreased in mice lacking OIT-induced desensitized MC. Collectively, these findings show that the desensitization process modulates the activation of MCs, leading directly to enhanced induction of regulatory-T-cell expansion and promotion of clinical allergic unresponsiveness. Our results suggest that efficiently inducing regulatory MCs is a novel strategy for the treatment of allergic disease.

scholarly journals Peran Imunoterapi pada Tatalaksana Alergi Makanan (The Role of Immunotherapy in Food Allergy)

2020 ◽  
Vol 6 (2) ◽  
pp. 19-28
Author(s):  
Hendra Hendra Hendra
Keyword(s):  
Food Allergy ◽  
Immune System ◽  
Oral Immunotherapy ◽  
World Allergy Organization ◽  
New Paradigm ◽  
Allergy Immunotherapy ◽  
Immunologic Reaction ◽  
Allergy Treatment

AbstrakAlergi makanan merupakan reaksi  imun yang terjadi setelah paparan terhadap makanan tertentu. World Allergy Organization (WAO) melaporkan 22% penduduk dunia menderita alergi dan terus meningkat setiap tahun.  Data tahun 2014, diperkirakan kasus alergi makanan terjadi pada 5% dewasa dan 8% pada anak-anak. Alergi makanan adalah bagian dari reaksi hipersensitivitas, yakni hiperesponsivitas imunologik terhadap antigen spesifik, dapat berasal dari makanan atau mikroorganisme patogen maupun  produknya. Alergi  makanan menunjukkan gejala klinis lokal ataupun sistemik. Perkembangan ilmu pengetahuan mengarahkan perubahan paradigma dari pencegahan alergi yang berupa tindakan  menghindari alergen  ke arah desensitisasi dan induksi aktif toleransi imunologik. Imunoterapi dibuat berdasarkan hubungan dengan alergen spesifik. Sebagai dasar teori yaitu dengan  melakukan  peningkatan  paparan secara bertahap seorang penderita dengan alergen yang spesifik, maka diharapkan akan terjadi suatu  proses desensitisasi atau peningkatan toleransi terhadap alergen tersebut. Oral imunoterapi melibatkan makanan yang merupakan alergen dan dikonsumsi bertahap dengan peningkatan dosis. Sebagian besar protokol oral imunoterapi meliputi fase eskalasi, diikuti dengan peningkatan dosis dan dosis maintenance. Optimasi imunoterapi dapat dilakukan dengan modifikasi protokol seperti dosis, durasi, probiotik dengan imunoterapi, ataupun modifikasi dengan alergen multipel.Kata kunci: alergi makanan, imunoterapi AbstractFood allergy is immunologic reaction after food exposures. World Allergy Organization (WAO) reported 22% worldwide have allergy and keep increasing. In 2014, food allergy been speculated 5% in adult and 8% in child. Food allergy is a part of hypersensitivity, as hyperresponsiveness in immune system with spesific antigen from food. Food allergy can manifest as local or systemic. New paradigm in food allergy treatment, shifted from avoid the allergen to desensitization and tolerance. In patient with gradual exposure with spesific allergen, desensitization and tolerance been expected. Oral immunotherapy involve food consuming and increased the doses. It consist of escalation, increasing doses and maintenance. For optimizing immunotherapy, it can been modified with dosage, duration, combined with probiotic or with multiple ellergen.       Keywords: food allergy, immunotherapy

Postbiotics: A novel strategy in food allergy treatment

2020 ◽  
Vol 61 (3) ◽  
pp. 492-499 ◽  
Author(s):  
Aziz Homayouni Rad ◽  
Leili Aghebati Maleki ◽  
Hossein Samadi Kafil ◽  
Amin Abbasi
Keyword(s):  
Food Allergy ◽  
Allergy Treatment ◽  
Novel Strategy

scholarly journals Addressing Common Misconceptions in Food Allergy: A Review

Children ◽  
2021 ◽  
Vol 8 (6) ◽  
pp. 497
Author(s):  
Aikaterini Anagnostou
Keyword(s):  
Food Allergy ◽  
The United States ◽  
Specific Ige ◽  
Oral Immunotherapy ◽  
Food Allergies ◽  
Allergy Prevention ◽  
Diagnosis And Management ◽  
Skin Prick Tests ◽  
Food Specific Ige ◽  
Common Misconceptions

Background: Food allergies are common, affecting 1 in 13 school children in the United States and their prevalence is increasing. Many misconceptions exist with regards to food allergy prevention, diagnosis and management. Objective: The main objective of this review is to address misconceptions with regards to food allergies and discuss the optimal, evidence-based approach for patients who carry this diagnosis. Observations: Common misconceptions in terms of food allergy prevention include beliefs that breastfeeding and delayed introduction of allergenic foods prevent the development of food allergies. In terms of diagnosis, statements such as ‘larger skin prick tests or/and higher levels of food-specific IgE can predict the severity of food-induced allergic reactions’, or ‘Tryptase is always elevated in food-induced anaphylaxis’ are inaccurate. Additionally, egg allergy is not a contraindication for receiving the influenza vaccine, food-allergy related fatalities are rare and peanut oral immunotherapy, despite reported benefits, is not a cure for food allergies. Finally, not all infants with eczema will develop food allergies and epinephrine auto-injectors may unfortunately be both unavailable and underused in food-triggered anaphylaxis. Conclusions and relevance: Healthcare professionals must be familiar with recent evidence in the food allergy field and avoid common misunderstandings that may negatively affect prevention, diagnosis and management of this chronic disease.

scholarly journals Food Allergy Treatment Value: Child Caregiver and Patient Perspectives

2021 ◽  
Author(s):  
Moaz Abdelwadoud ◽  
Sanaz Eftekhari ◽  
Hannah Jaffee ◽  
Melanie Carver ◽  
T. Joseph Mattingly
Keyword(s):  
Food Allergy ◽  
Patient Perspectives ◽  
Allergy Treatment ◽  
Child Caregiver

Effect of an interval rehabilitation program with home-based, vibration-assisted training on the development of muscle and bone in children with cerebral palsy – an observational study

2020 ◽  
Vol 33 (8) ◽  
pp. 1083-1092 ◽  
Author(s):  
Ibrahim Duran ◽  
Kyriakos Martakis ◽  
Christina Stark ◽  
Leonie Schafmeyer ◽  
Mirko Rehberg ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Bone Growth ◽  
Muscle Growth ◽  
Rehabilitation Program ◽  
Whole Body ◽  
Cross Sectional ◽  
Home Based ◽  
Children With Cerebral Palsy ◽  
One Year ◽  
Intensive Rehabilitation

AbstractObjectivesIn children with cerebral palsy (CP), the most common cause of physical impairment in childhood, less muscle and bone growth has been reported, when compared with typically developing children. The aim of this study was to evaluate the effect of an intensive rehabilitation program including physiotherapy in combination with 6 months of home-based, vibration-assisted training on muscle and bone growth in children with CP.MethodsWe included children with CP, who participated in a rehabilitation program utilizing whole-body vibration (WBV). Muscle mass was quantified by appendicular lean mass index (App-LMI) and bone mass by total-body-less-head bone mineral content (TBLH-BMC) assessed by Dual-energy X-ray absorptiometry (DXA) at the beginning of rehabilitation and one year later. To assess the functional muscle-bone unit, the relation of TBLH-BMC to TBLH lean body mass (TBLH-LBM) was used.ResultsThe study population included 128 children (52 females, mean age 11.9 ± 2.7). App-LMI assessed in kg/m2 increased significantly after rehabilitation. The age-adjusted Z-score for App-LMI showed no significant change. TBLH-BMC assessed in gram increased significantly. The Z-scores for TBLH-BMC decreased lesser than expected by the evaluation of the cross-sectional data at the beginning of rehabilitation. The parameter $\frac{TBLH-BMC}{TBLH-LBM}$ did not change relevantly after 12 months.ConclusionsMuscle growth and to a lesser extent bone growth could be increased in children with CP. The intensive rehabilitation program including WBV seemed to have no direct effect on the bone, but the observed anabolic effect on the bone, may only been mediated through the muscle.

scholarly journals Association of Health Literacy with the Implementation of Exercise during the Declaration of COVID-19 State of Emergency among Japanese Community-Dwelling Old-Old Adults

2021 ◽  
Vol 18 (4) ◽  
pp. 2100
Author(s):  
Daijo Shiratsuchi ◽  
Hyuma Makizako ◽  
Yuki Nakai ◽  
Yoshiaki Taniguchi ◽  
Tomomi Akanuma ◽  
...  
Keyword(s):  
Health Literacy ◽  
Mail Survey ◽  
Good Health ◽  
Cross Sectional Study ◽  
Exercise Group ◽  
Community Dwelling ◽  
Multivariate Logistic Regression Model ◽  
Cross Sectional ◽  
State Of Emergency ◽  
Old Adults

Health literacy is important for promoting and maintaining good health in old-old adults. It may influence the implementation of exercise in the coronavirus disease epidemic. The present cross-sectional study investigated the association of each dimension of health literacy with the implementation of exercise during the declaration of a state of emergency due to coronavirus disease in community-dwelling old-old adults. We collected data from 483 community-dwelling old-old adults (52.8% women) aged between 77 and 99 years who participated in a mail survey. Participants were divided into exercise or nonexercise groups based on the implementation of exercise during the declaration of a state of emergency. Health literacy was assessed using a 14-item health literacy scale. There were 327 (67.7%) participants in the exercise group and 156 (32.3%) in the nonexercise group. A significantly higher score of health literacy was observed in the exercise group than in the nonexercise group (communicative health literacy score = 14.0 ± 3.6 vs. 12.7 ± 3.8, p = 0.001). In a multivariate logistic regression model adjusted for potential confounders, high communicative health literacy scores were significantly associated with the implementation of exercise during the declaration of a state of emergency (odds ratio = 1.88, 95% confidence interval = 1.20–2.93). Approximately two-thirds of community-dwelling old-old adults implement exercise during the declaration of a state of emergency. High communicative health literacy was associated with the implementation of exercise during this period.

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