scholarly journals Association between Physical Activity and Seasonal Variations in Metabolic and Vascular Function in Adults

Endocrines ◽  
2021 ◽  
Vol 2 (2) ◽  
pp. 150-159
Author(s):  
Hiroto Honda ◽  
Makoto Igaki ◽  
Motoaki Komatsu ◽  
Shin-ichiro Tanaka
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Seasonal Variations ◽  
Vascular Function ◽  
Blood Lipid ◽  
Climate Conditions ◽  
Important Method ◽  
Increased Risk ◽  
Seasonal Impact ◽  
All Cause Mortality

This article highlights the association between physical activity (PA) and seasonal variations in metabolic and vascular function in adults. Increasing PA is an important method for preventing cardiovascular disease (CVD) and all-cause mortality by improving blood glucose, blood pressure, blood lipid profiles, body fat, insulin resistance, and vascular function, such as endothelial function. Conversely, various factors, such as seasonal climate conditions, may affect the amount of PA that individuals undertake. Changes in PA often induce seasonal variations in metabolic and vascular function; the deterioration of such functions in winter is the most prominent, and there is clear evidence of an increased risk of CVD in this season. Understanding the influence of PA on seasonal variations observed in metabolic and vascular function is necessary for the management of these physiological functions. In this article summary, few studies have proven that maintaining PA can suppress the variations, and it remains unclear what types, intensities, and durations of regular PA are effective for circumventing seasonal impact. In addition to further studies, there is a need to educate individuals about the strategies to manage PA and other aspects of their lifestyles throughout the year, particularly in winter.

scholarly journals Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats

2009 ◽  
Vol 117 (3) ◽  
pp. 129-138 ◽  
Author(s):  
Emily M. Segar ◽  
Andrew W. Norris ◽  
Jian-Rong Yao ◽  
Shanming Hu ◽  
Stacia L. Koppenhafer ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vascular Function ◽  
Vascular Dysfunction ◽  
Diabetic Rats ◽  
Late Gestation ◽  
Group Differences ◽  
Pregnant Rats ◽  
Increased Risk ◽  
Specific Insulin ◽  
Diabetic Mothers

ODM (offspring of diabetic mothers) have an increased risk of developing metabolic and cardiovascular dysfunction; however, few studies have focused on the susceptibility to disease in offspring of mothers developing diabetes during pregnancy. We developed an animal model of late gestation diabetic pregnancy and characterized metabolic and vascular function in the offspring. Diabetes was induced by streptozotocin (50 mg/kg of body weight, intraperitoneally) in pregnant rats on gestational day 13 and was partially controlled by twice-daily injections of insulin. At 2 months of age, ODM had slightly better glucose tolerance than controls (P<0.05); however, by 6 months of age this trend had reversed. A euglycaemic–hyperinsulinamic clamp revealed insulin resistance in male ODM (P<0.05). In 6–8-month-old female ODM, aortas had significantly enhanced contractility in response to KCl, ET-1 (endothelin-1) and NA (noradrenaline). No differences in responses to ET-1 and NA were apparent with co-administration of L-NNA (NG-nitro-L-arginine). Relaxation in response to ACh (acetylcholine), but not SNP (sodium nitroprusside), was significantly impaired in female ODM. In contrast, males had no between-group differences in response to vasoconstrictors, whereas relaxation to SNP and ACh was greater in ODM compared with control animals. Thus the development of diabetes during pregnancy programmes gender-specific insulin resistance and vascular dysfunction in adult offspring.

Multimorbidity, mortality, and physical activity

2016 ◽  
Vol 12 (4) ◽  
pp. 272-280 ◽  
Author(s):  
Paul D Loprinzi ◽  
Ovuokerie Addoh ◽  
Chelsea Joyner
Keyword(s):  
Physical Activity ◽  
Mortality Risk ◽  
Physical Inactivity ◽  
Self Report ◽  
Minimal Effect ◽  
Increased Risk ◽  
All Cause Mortality ◽  
The Government ◽  
Physician Diagnosis

Objectives Multimorbidity and physical inactivity are individually associated with increased mortality risk, but the possibility for physical activity to moderate the multimorbidity–mortality relationship has yet to be investigated. Methods Data from the 1999–2006 NHANES were employed, with 16,091 participants constituting the analytic sample. Participants were followed through 2011, including a median follow-up of 99 months. Physical activity was assessed via self-report with multimorbidity assessed from physician diagnosis. Results After adjustment, for every 1 morbidity increase, participants had a 23% increased risk of all-cause mortality (HR = 1.23; 95% CI: 1.19–1.28; p < 0.001). Multimorbidity mostly remained associated with all-cause mortality across all levels of physical activity, with the exception of those achieving four times the dose of the government guidelines. Discussion With the exception of those who engaged in high levels of self-reported physical activity, physical activity had a minimal effect on the multimorbidity–mortality relationship.

scholarly journals Metabolic syndrome identifies normal weight insulin-resistant stroke patients at risk for recurrent vascular disease

2018 ◽  
Vol 14 (6) ◽  
pp. 639-645 ◽  
Author(s):  
Jennifer L Dearborn ◽  
Catherine M Viscoli ◽  
Silvio E Inzucchi ◽  
Lawrence H Young ◽  
Walter N Kernan
Keyword(s):  
Myocardial Infarction ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Obesity Paradox ◽  
Normal Weight ◽  
Diabetic Patients ◽  
Insulin Resistant ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Patients At Risk

Background The obesity paradox refers to the finding in observational studies that patients with obesity have a better prognosis after stroke than normal weight patients. Aim To test the hypothesis that there might be important heterogeneity within the obese stroke population, such that those with metabolic syndrome would be at higher risk for stroke or myocardial infarction and all-cause mortality compared to patients without metabolic syndrome. Methods The Insulin Resistance Intervention after Stroke trial enrolled non-diabetic patients with a recent ischemic stroke or transient ischemic attack and insulin resistance. We examined the association between metabolic syndrome and outcome risk in patients with normal weight at entry (body mass index (BMI) = 18.5–24.9 kg/m2), overweight (BMI = 25–29.9 kg/m2), or obesity (BMI ≥ 30 kg/m2). Analyses were adjusted for demographic features, treatment assignment, smoking, and major comorbid conditions. Results Metabolic syndrome was not associated with greater risk for stroke or myocardial infarction among 1536 patients who were overweight (adjusted hazard ratio (HR), 0.95; 95% confidence interval (CI): 0.69–1.31) or 1626 obese patients (adjusted HR, 1.00; 95% CI: 0.70–1.41). However, among 567 patients with a normal BMI, metabolic syndrome was associated with increased risk for stroke or myocardial infarction (adjusted HR, 2.05; 95% CI: 1.25–3.37), and all-cause mortality (adjusted HR, 1.70; 95% CI: 1.03–2.81) compared to patients without metabolic syndrome. Conclusions The presence of metabolic syndrome identified normal weight patients with insulin resistance but no diabetes who have a higher risk of adverse cardiovascular outcomes, compared with patients without metabolic syndrome.

Vascular Dysfunction and Insulin Resistance in Aging

2019 ◽  
Vol 17 (5) ◽  
pp. 465-475 ◽  
Author(s):  
Agnieszka Baranowska-Bik ◽  
Wojciech Bik
Keyword(s):  
Insulin Resistance ◽  
Vascular Function ◽  
Vascular Dysfunction ◽  
Pathological Condition ◽  
Normal Serum ◽  
Metabolic Effects ◽  
Low Grade ◽  
Physiological Concentration ◽  
Repair Capacity ◽  
Increased Risk

: Insulin was discovered in 1922 by Banting and Best. Since that time, extensive research on the mechanisms of insulin activity and action has continued. Currently, it is known that the role of insulin is much greater than simply regulating carbohydrate metabolism. Insulin in physiological concentration is also necessary to maintain normal vascular function. : Insulin resistance is defined as a pathological condition characterized by reduced sensitivity of skeletal muscles, liver, and adipose tissue, to insulin and its downstream metabolic effects under normal serum glucose concentrations. There are also selective forms of insulin resistance with unique features, including vascular insulin resistance. Insulin resistance, both classical and vascular, contributes to vascular impairment resulting in increased risk of cardiovascular disease. Furthermore, in the elderly population, additional factors including redistribution of fat concentrations, low-grade inflammation, and decreased self-repair capacity [or cell senescence] amplify the vascular abnormalities related to insulin resistance.

Relationship Between Employment Status, Reported Physical Activity, and Sitting Time During COVID-19 Pandemic

2020 ◽  
pp. 1-4
Author(s):  
Bryndan W. Lindsey ◽  
Ali Boolani ◽  
Justin J. Merrigan ◽  
Nelson Cortes ◽  
Shane V. Caswell ◽  
...  
Keyword(s):  
Physical Activity ◽  
Employment Status ◽  
Working Environment ◽  
Sitting Time ◽  
Full Time ◽  
Multiple Linear Regressions ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Linear Regressions ◽  
Daily Total

Background: The COVID-19 pandemic has changed our working environment and divided workers into essential or nonessential statuses. Employment status is a major factor determining the amount of physical activity performed. Our purpose was to understand how employment status affects physical activity and sitting time. Methods: Between April 13 and May 4, 2020, 735 full-time employed individuals responded to a survey investigating daily life and overall health during the COVID-19 pandemic. Participants reported how much physical activity they had performed in the last 7 days. Multiple linear regressions were performed for physical activity and sitting time. Results: Physical activity was not associated with employment status. An interaction effect between hours worked and employment status was found for sitting time. Conclusions: Employment status was not related to physical activity; however, it did affect the amount of time spent sitting, with nonessential employees sitting more and working more hours than essential employees. Because greater amounts of daily total sitting time have been associated with increased risk of all-cause mortality, it is important that increased sitting time be attenuated by greater physical activity.

scholarly journals Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity

2010 ◽  
Vol 4 (1) ◽  
pp. 89-96 ◽  
Author(s):  
George S. Metsios ◽  
Antonios Stavropoulos Kalinoglou ◽  
Aamer Sandoo ◽  
Jet J.C.S. Veldhuijzen van Zanten ◽  
Tracey E. Toms ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Physical Activity ◽  
Endothelial Dysfunction ◽  
Vascular Function ◽  
Necrosis Factor Alpha ◽  
Reactive Protein ◽  
Non Invasive ◽  
Increased Risk ◽  
Invasive Techniques

Inflammation disturbs biochemical pathways involved in homeostasis of the endothelium. Research has established clear links between inflammatory mediators, particularly C-reactive protein and tumour necrosis factor alpha, endothelial dysfunction, and atherosclerosis. Endothelial dysfunction and atherosclerosis may be subclinical at early stages, and thus the ability to detect them with non-invasive techniques is crucially important, particularly in populations at increased risk for cardiovascular disease, such as those with rheumatoid arthritis. This may allow the identification of interventions that may reverse these processes early on. One of the best non-pharmacological interventions that may achieve this is physical activity. This review explores the associations between inflammation, endothelial dysfunction, and atherosclerosis and discusses the role of exercise in blocking specific pathways in the inflammation, endothelial dysfunction - atherosclerosis network.

Abstract 14662: Relationships Between Physical Activity, Coronary Artery Calcium, and Cardiovascular Outcomes in the Multi-Ethnic Study of Atherosclerosis: MESA

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Charles A German ◽  
Jason Fanning ◽  
Matthew J Singleton ◽  
Michael D Shapiro ◽  
Peter H Brubaker ◽  
...  
Keyword(s):  
Physical Activity ◽  
Coronary Artery ◽  
Coronary Artery Calcium ◽  
Adverse Outcomes ◽  
Atherosclerotic Cardiovascular Disease ◽  
Ethnic Study ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Cox Proportional Hazard Regression ◽  
Reduced Risk

Introduction: Physical activity is associated with decreased rates of atherosclerotic cardiovascular disease (ASCVD) and mortality. However, high levels of physical activity (PA) have paradoxically been linked with elevated levels of coronary artery calcium (CAC). It remains unclear whether high levels of physical activity in the presence of high CAC are associated with adverse outcomes in a diverse, multi-ethnic population. Hypothesis: We hypothesized that high compared to low levels of PA are associated with a reduction in incident ASCVD and all-cause mortality, even in the presence of high CAC. Methods: Baseline total PA (MET-min/week) in the Multi-Ethnic Study of Atherosclerosis (MESA), obtained via questionnaire, was divided into quartiles. CAC was dichotomized into low (CAC <100 Agatston Units (AU)) and high (CAC ≥100 AU) categories. Outcomes of interest included ASCVD and all-cause mortality. Cox proportional hazard regression analysis was used to assess associations between PA, ASCVD, and all-cause mortality among low and high CAC groups. Results: Among the 6,814 participants included in this study, the average age was 62 years, 53% were female, and 38% were non-Hispanic white. In participants with CAC <100 AU and PA in the highest quartile, we observed a significant reduction in ASCVD and all-cause mortality compared with participants in the lowest PA quartile (Table1). In participants with CAC ≥100 AU and PA in the highest quartile, we observed a significant reduction in all-cause mortality, but no difference in the risk of ASCVD compared with participants in the lowest PA quartile. Conclusions: Our study suggests that high levels of PA are associated with a reduced risk of ASCVD and all-cause mortality among individuals with low CAC, and a reduced risk of all-cause mortality among individuals with high CAC. There was no evidence to suggest an increased risk of ASCVD from high levels of PA in individuals with high CAC.

scholarly journals Physical Activity in the Japan Population: Association with Blood Lipid Levels and Effects in Reducing Cardiovascular and All-Cause Mortality

2011 ◽  
Vol 18 (12) ◽  
pp. 1129-1130
Author(s):  
Shinji Koba ◽  
Hiroaki Tanaka ◽  
Chizuko Maruyama ◽  
Norio Tada ◽  
Sadatoshi Birou ◽  
...  
Keyword(s):  
Physical Activity ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Population Association ◽  
All Cause Mortality ◽  
Blood Lipid Levels

P627Patterns of physical activity over 22 years and mortality: the HUNT Study, Norway

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
T Moholdt ◽  
B Moe ◽  
T I L Nilsen
Keyword(s):  
Physical Activity ◽  
Mortality Risk ◽  
Cox Regression ◽  
Baseline Measure ◽  
Physically Active ◽  
Reference Category ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Hunt Study ◽  
Cvd Mortality

Abstract Background The majority of studies relating physical activity (PA) to mortality have assessed PA using one baseline measure. Important questions in a preventive perspective are whether you can compensate for prior physical inactivity by taking up PA at a later stage in life and whether being physically active earlier in life can confer benefits even if you become inactive later. We investigated how patterns of PA over 22 years associated with all-cause and cardiovascular disease (CVD) mortality. Methods We used data from the prospective population-based HUNT Study in Norway, including 10,491 men and 12,655 women aged ≥20 years who participated at HUNT in 1984–86 and 2006–08. PA was categorised into inactive, <2 h/week or ≥2 h/week, making nine categories of patterns of PA over 22 years. All-cause and CVD mortality were assessed from the national Cause of Death Registry, with follow-up until the end of 2013. We used Cox regression to estimate adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for all-cause and CVD mortality within categories of PA patterns, compared to the reference category of individuals who reported ≥2 h/week at both examinations. Estimates were adjusted for baseline age, sex, body mass index, smoking, education level and blood pressure. Results Individuals who were inactive in both 1984–86 and in 2006–08 had increased risk of all-cause mortality (HR 1.99, 95% CI 1.48–2.67) and CVD mortality (HR 2.68, 95% 1.47–4.86) compared to those who were physically active ≥2 h/week at both examination. The HRs for all-cause and CVD mortality were 1.60 (1.22–2.15) and 1.90 (1.06–3.42), respectively, for those who reported PA of <2h/week at both examinations. Individuals who went from being physically active in 1984–86 to inactive in 2006–08, had a comparable risk of all-cause and CVD mortality as those who were inactive at both examinations. Overall, the mortality risk was still increased in those who took up PA between the two examinations, compared to the reference category. Physical activity & all-cause mortality. Discussion Individuals who remained physically inactive or who decreased their PA over 22 years had substantially increased all-cause and CVD mortality risk. Taking up PA only attenuated the risk but a high level of sustained PA was associated with the lowest risk. Acknowledgement/Funding Funded by the Norwegian Health Association

scholarly journals Association between changes in lifestyle and all-cause mortality: the Health and Lifestyle Survey

2018 ◽  
Vol 72 (8) ◽  
pp. 711-714 ◽  
Author(s):  
James White ◽  
Giles Greene ◽  
Mika Kivimaki ◽  
G David Batty
Keyword(s):  
Physical Activity ◽  
Fruits And Vegetables ◽  
Population Sample ◽  
Health Behaviours ◽  
Unhealthy Lifestyle ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Modal Change ◽  
The Uk

BackgroundTo examine the combined influence of changes in physical activity, diet, smoking and alcohol consumption on all-cause mortality.MethodsHealth behaviours were assessed in 1984/1985 and 1991/1992 in 8123 adults from the UK (4666 women, median age 41.0 years). An unhealthy lifestyle score was calculated, allocating one point for smoking, fruits and vegetables <3 times a day, physical activity <2 hours a week and >14 units (women) or >21 units of alcohol (men) per week.ResultsThere were 2003 deaths over a median follow-up of 6.6 years (IQR 5.9–7.2) following the resurvey. The modal change in the unhealthy lifestyle score was zero, 41.8% had the same score, 35.5% decreased and 22.7% increased score between surveys. A one unit decrease in the unhealthy lifestyle score was not associated with a beneficial effect on mortality (HR 0.93; 95% CI 0.83 to 1.04). A one unit increase in the unhealthy lifestyle score increased the risk of mortality (adjusted HR 1.09; 95% CI 1.01 to 1.18).ConclusionsIn this general population sample, the adoption of an unhealthy lifestyle was associated with an increased risk of mortality.

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