scholarly journals The Role of Yeasts as Biocontrol Agents for Pathogenic Fungi on Postharvest Grapes: A Review

Foods ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1650
Author(s):  
Alessandra Di Canito ◽  
María Alejandra Mateo-Vargas ◽  
Monica Mazzieri ◽  
Jesús Cantoral ◽  
Roberto Foschino ◽  
...  
Keyword(s):  
Human Health ◽  
Fungal Pathogens ◽  
Pathogenic Fungi ◽  
Phytopathogenic Fungi ◽  
Wine Grapes ◽  
Table Grapes ◽  
Chemical Pesticide ◽  
The Impact ◽  
Saccharomyces Yeasts

In view of the growing concern about the impact of synthetic fungicides on human health and the environment, several government bodies have decided to ban them. As a result, a great number of studies have been carried out in recent decades with the aim of finding a biological alternative to inhibit the growth of fungal pathogens. In order to avoid the large losses of fruit and vegetables that these pathogens cause every year, the biological alternative’s efficacy should be the same as that of a chemical pesticide. In this review, the main studies discussed concern Saccharomyces and non-Saccharomyces yeasts as potential antagonists against phytopathogenic fungi of the genera Penicillium and Aspergillus and the species Botrytis cinerea on table grapes, wine grapes, and raisins.

Role of Nutraceuticals in Health Promotion and Disease Prevention: A Review in the Indian Context

2020 ◽  
Vol 19 (2) ◽  
pp. 139-145
Author(s):  
Sheena Chhabra ◽  
Apurva Bakshi ◽  
Ravineet Kaur
Keyword(s):  
Health Promotion ◽  
Disease Prevention ◽  
Human Health ◽  
Health Issues ◽  
Scholarly Literature ◽  
Indian Context ◽  
The Impact ◽  
Immense Potential ◽  
Specific Health

Nutraceuticals have been around for quite some time. As the nomenclature suggests, they are placed somewhere between food (nutra-) and medicine (-ceuticals) in terms of their impact on human health. Researches have focused on the impact of various types of nutraceuticals on health, their efficacy in health promotion and disease prevention, and often on suitable uses of certain categories of nutraceuticals for specific health issues. However, we are still far from utilizing the immense potential of nutraceuticals for benefiting human health in a substantial manner. We review the available scholarly literature regarding the role of nutraceuticals in health promotion, their efficacy in disease prevention and the perception of nutraceuticals' health benefits by consumers. Thereafter we analyze the need for regulation of nutraceuticals and various provisions regarding the same.

scholarly journals Перспективы применения гуминового комплекса на виноградниках Крыма

2019 ◽  
pp. 122-127
Author(s):  
Magometsaigit Beibulatov ◽  
Nadezhda Tikhomirova ◽  
Natalia Urdenko ◽  
Roman Buival ◽  
Yana Radionovskaya
Keyword(s):  
Positive Impact ◽  
Cabernet Sauvignon ◽  
Wine Grapes ◽  
Total Sugars ◽  
Table Grapes ◽  
New Generation ◽  
The Impact ◽  
Positive Effect ◽  
Average Cluster

В статье представлены результаты двухлетних исследований по изучению влияния внекорневых подкормок гуминовым препаратом нового поколения GSN-2004 HUMILIFEтм (ОСН-2004) на урожай и качество винограда столового сорта Мускат янтарный и технического сорта Каберне-Совиньон в условиях Южного берега Крыма. По результатам исследований 2017-2018 гг. установлено, что внекорневые подкормки изучаемым препаратом разработанной нормой 4 л/га, способствуют увеличению урожайности винограда сорта Мускат янтарный в среднем на 23,9%, при этом повышение урожайности составляет 2,7 т/га. Урожайность винограда сорта Каберне-Совиньон увеличивается на 26,5%, при этом повышение урожайности составляет 2,2 т/га. Подтверждено положительное влияние внекорневых подкормок на показатели качества винограда сорта Мускат янтарный, которое выразилось в увеличении средней массы грозди у изучаемого сорта на 40,3%, увеличении массовой концентрации сахаров в соке ягод на 5,4% и увеличении значений глюкоацидометрического показателя (ГАП) на 15,6%. Положительное влияние внекорневых подкормок на показатели качества винограда сорта Каберне-Совиньон выразилось в увеличении средней массы грозди на 23,0% и увеличении массовой концентрации сахаров в соке ягод на 7,1%.The paper summarizes findings of a two-year study on the impact of foliar fertilizing with a new generation humic preparation GSN-2004 HUMILIFEтм (ОСН-2004) on the harvest and quality of ‘Muscat Yantarniy’ table grapes and ‘Cabernet Sauvignon’ wine grapes in the conditions of the southern coast of Crimea. The data of the 2017-2018 study established that foliar dressing with the preparation under study in the ratio of 4 l/ha increases the harvest of ‘Muscat Yantarniy’ grapes on average by 23.9%, or by 2 t/ha. The yield of ‘Cabernet Sauvignon’ grapes was increased by 26.5%, thus increasing the harvest by 2.2 t/ha. The positive impact of foliar dressing on quality indicators of ‘Muscat Yantarniy’ grapes was confirmed. Thus, the average cluster weight increased by 40.3%, total sugars in the berry juice increased by 5.4 %, and gluco-acidometric index increased by 158.06 %. The study confirmed the positive effect of foliar dressing on quality characteristics of ‘Cabernet Sauvignon’ grapes, as demonstrated by a 23% increase in the average cluster weight and a 7.1 % increase in the total sugars in the berry juice.

scholarly journals Influence of microbiota on immunity and immunotherapy for gastric and esophageal cancers

2020 ◽  
Vol 8 (3) ◽  
pp. 206-214
Author(s):  
Xiaoli Zhang ◽  
Zui Pan
Keyword(s):  
Gut Microbiota ◽  
Human Health ◽  
Potential Role ◽  
Systemic Immunity ◽  
Esophageal Cancers ◽  
The Impact

Abstract Gastric and esophageal cancers are multifactorial and multistage-involved malignancy. While the impact of gut microbiota on overall human health and diseases has been well documented, the influence of gastric and esophageal microbiota on gastric and esophageal cancers remains unclear. This review will discuss the reported alteration in the composition of gastric and esophageal microbiota in normal and disease conditions, and the potential role of dysbiosis in carcinogenesis and tumorigenesis. This review will also discuss how dysbiosis stimulates local and systemic immunity, which may impact on the immunotherapy for cancer.

scholarly journals The Mechanisms of Mating in Pathogenic Fungi—A Plastic Trait

Genes ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 831
Author(s):  
Jane Usher
Keyword(s):  
Fungal Pathogens ◽  
Crop Yields ◽  
Fungal Infections ◽  
Pathogenic Fungi ◽  
Yeast Saccharomyces Cerevisiae ◽  
Closely Related Species ◽  
Sexual And Asexual Reproduction ◽  
Target Dna ◽  
High Degree ◽  
The Impact

The impact of fungi on human and plant health is an ever-increasing issue. Recent studies have estimated that human fungal infections result in an excess of one million deaths per year and plant fungal infections resulting in the loss of crop yields worth approximately 200 million per annum. Sexual reproduction in these economically important fungi has evolved in response to the environmental stresses encountered by the pathogens as a method to target DNA damage. Meiosis is integral to this process, through increasing diversity through recombination. Mating and meiosis have been extensively studied in the model yeast Saccharomyces cerevisiae, highlighting that these mechanisms have diverged even between apparently closely related species. To further examine this, this review will inspect these mechanisms in emerging important fungal pathogens, such as Candida, Aspergillus, and Cryptococcus. It shows that both sexual and asexual reproduction in these fungi demonstrate a high degree of plasticity.

scholarly journals Transcriptome Analysis of the Barley–Deoxynivalenol Interaction: Evidence for a Role of Glutathione in Deoxynivalenol Detoxification

2010 ◽  
Vol 23 (7) ◽  
pp. 962-976 ◽  
Author(s):  
Stephanie A. Gardiner ◽  
Jayanand Boddu ◽  
Franz Berthiller ◽  
Christian Hametner ◽  
Robert M. Stupar ◽  
...  
Keyword(s):  
Defense Mechanisms ◽  
Phytopathogenic Fungi ◽  
Glutathione Depletion ◽  
Host Responses ◽  
Application Site ◽  
Nuclear Magnetic Resonance Analysis ◽  
The Impact

Trichothecenes are a major group of toxins produced by phytopathogenic fungi, including Fusarium graminearum. Trichothecenes inhibit protein synthesis in eukaryotic cells and are toxicologically relevant mycotoxins for humans and animals. Because they promote plant disease, the role of host responses to trichothecene accumulation is considered to be an important aspect of plant defense and resistance to fungal infection. Our overall objective was to examine the barley response to application of the type B trichothecene deoxynivalenol (DON). We found that DON is diluted by movement from the application site to acropetal and basipetal florets. A susceptible barley genotype converted DON to DON-3-O-glucoside, indicating that UDP-glucosyltransferases capable of detoxifying DON must exist in barley. RNA profiling of DON-treated barley spikes revealed strong upregulation of gene transcripts encoding ABC transporters, UDP-glucosyltransferases, cytochrome P450s, and glutathione-S-transferases. We noted that transcripts encoding cysteine synthases were dramatically induced by DON, and that toxin-sensitive yeast on glutathione- or cysteine-supplemented media or carrying a gene that encodes a cysteine biosynthetic enzyme exhibit DON resistance, suggesting that preventing glutathione depletion by increasing cysteine supply could play a role in ameliorating the impact of DON. Evidence for nonenzymatic formation of DON-glutathione adducts in vitro was found using both liquid chromatography–mass spectrometry and nuclear magnetic resonance analysis, indicating that the formation of DON-glutathione conjugates in vivo may reduce the impact of trichothecenes. Our results indicate that barley exhibits multiple defense mechanisms against trichothecenes.

scholarly journals Differential Role of MyD88 in Macrophage-Mediated Responses to Opportunistic Fungal Pathogens

2003 ◽  
Vol 71 (9) ◽  
pp. 5280-5286 ◽  
Author(s):  
Kieren A. Marr ◽  
S. Arunmozhi Balajee ◽  
Thomas R. Hawn ◽  
Adrian Ozinsky ◽  
Uyenvy Pham ◽  
...  
Keyword(s):  
Fungal Pathogens ◽  
Cytokine Production ◽  
Pathogenic Fungi ◽  
Adapter Protein ◽  
Wild Type ◽  
Intracellular Killing ◽  
Pathogenic Yeast ◽  
Myd88 Signaling ◽  
Deficient Mice

ABSTRACT Toll-like receptors mediate macrophage recognition of microbial ligands, inducing expression of microbicidal molecules and cytokines via the adapter protein MyD88. We investigated the role of MyD88 in regulating murine macrophage responses to a pathogenic yeast (Candida albicans) and mold (Aspergillus fumigatus). Macrophages derived from bone marrow of MyD88-deficient mice (MyD88−/−) demonstrated impaired phagocytosis and intracellular killing of C. albicans compared to wild-type (MyD88+/+) macrophages. In contrast, ingestion and killing of A. fumigatus conidia was MyD88 independent. Cytokine production by MyD88−/− macrophages in response to C. albicans yeasts and hyphae was substantially decreased, but responses to A. fumigatus hyphae were preserved. These results provide evidence that MyD88 signaling is involved in phagocytosis and killing of live C. albicans, but not A. fumigatus. The differential role of MyD88 may represent one mechanism by which macrophages regulate innate responses specific to different pathogenic fungi.

scholarly journals The Role of IL-33 in Host Response toCandida albicans

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
C. Rodríguez-Cerdeira ◽  
A. Lopez-Bárcenas ◽  
B. Sánchez-Blanco ◽  
R. Arenas
Keyword(s):  
Defense Mechanisms ◽  
Fungal Pathogens ◽  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Case Reports ◽  
Pathogenic Fungi ◽  
Cell Types ◽  
Immune Defense ◽  
Beneficial Role

Background. Interleukin (IL) 33 is a recently identified pleiotropic cytokine that influences the activity of multiple cell types and orchestrates complex innate and adaptive immune responses.Methods. We performed an extensive review of the literature published between 2005 and 2013 on IL-33 and related cytokines, their functions, and their regulation of the immune system followingCandida albicanscolonization. Our literature review included cross-references from retrieved articles and specific data from our own studies.Results. IL-33 (IL-1F11) is a recently identified member of the IL-1 family of cytokines. Accumulating evidence suggests a pivotal role of the IL-33/ST2 axis in host immune defense against fungal pathogens, includingC. albicans. IL-33 induces a Th2-type inflammatory response and activates both innate and adaptive immunity. Studies in animal models have shown that Th2 inflammatory responses have a beneficial role in immunity against gastrointestinal and systemic infections byCandidaspp.Conclusions. This review summarizes the most important clinical studies and case reports describing the beneficial role of IL-33 in immunity and host defense mechanisms against pathogenic fungi. The finding that the IL-33/ST2 axis is involved in therapeutic target has implications for the prevention and treatment of inflammatory diseases, including acute or chronic candidiasis.

scholarly journals The Impact of Mouthwash on the Oropharyngeal Microbiota of Men Who Have Sex with Men: a Substudy of the OMEGA Trial

2022 ◽  
Author(s):  
Erica L. Plummer ◽  
Kate Maddaford ◽  
Gerald L. Murray ◽  
Christopher K. Fairley ◽  
Shivani Pasricha ◽  
...  
Keyword(s):  
Human Health ◽  
External Factors ◽  
Oral Microbiota ◽  
Health It ◽  
Alternative Intervention ◽  
Sex With Men ◽  
The Impact

Given the role of the oral microbiota in human health, it is important to understand if and how external factors influence its composition. Mouthwash use is common in some populations, and the use of antiseptic mouthwash has been proposed as an alternative intervention to prevent gonorrhea transmission.

The role of the main ingredients of chocolate in the formation of its beneficial properties for the consumer

2021 ◽  
pp. 582-587
Author(s):  
I.V. Goloviznin ◽  
A.V. Ryzhakova
Keyword(s):  
Human Health ◽  
Complete Information ◽  
The Body ◽  
Specific Product ◽  
Regular Process ◽  
The World ◽  
The Impact ◽  
Confectionery Product

Chocolate is the most staple and consumed confectionery product in Russia and the world. The determination of the beneficial properties of such a product as chocolate is an important and regular process of food institutions in every country, since new lines of already well-known manufacturers and new manufacturers with an innovative assortment are added to the retail assortment. Today, it is very relevant and important to understand the impact of new products on human health. In this regard, in order to provide complete information on a specific product, it is necessary to know its composition, ingredients and their effect on the body separately and within the framework of a specific product. Along with its beneficial properties, chocolate can also affect health negatively. It is necessary to understand the mechanism of the effect of chocolate on human health when consumed and to assess the risks that may arise subsequently after its active consumption.

scholarly journals The Role of Heavy Metals in Plant Response to Biotic Stress

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2320 ◽  
Author(s):  
Iwona Morkunas ◽  
Agnieszka Woźniak ◽  
Van Mai ◽  
Renata Rucińska-Sobkowiak ◽  
Philippe Jeandet
Keyword(s):  
Heavy Metals ◽  
Metal Ion ◽  
Ion Homeostasis ◽  
Pathogenic Fungi ◽  
Growth Stimulation ◽  
Stress Factors ◽  
Ecological Communities ◽  
The Impact ◽  
The Relationship

The present review discusses the impact of heavy metals on the growth of plants at different concentrations, paying particular attention to the hormesis effect. Within the past decade, study of the hormesis phenomenon has generated considerable interest because it was considered not only in the framework of plant growth stimulation but also as an adaptive response of plants to a low level of stress which in turn can play an important role in their responses to other stress factors. In this review, we focused on the defence mechanisms of plants as a response to different metal ion doses and during the crosstalk between metal ions and biotic stressors such as insects and pathogenic fungi. Issues relating to metal ion acquisition and ion homeostasis that may be essential for the survival of plants, pathogens and herbivores competing in the same environment were highlighted. Besides, the influence of heavy metals on insects, especially aphids and pathogenic fungi, was shown. Our intention was also to shed light on the relationship between heavy metals deposition in the environment and ecological communities formed under a strong selective pressure.

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