Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease

The objective of the present study was to evaluate hair toxic metal levels in patients with obesity and/or coronary heart disease (CHD). Following a 2 × 2 factorial design, subjects without CHD were grouped into normal weight control (n = 123) and obese groups (n = 140). Patients suffering from CHD were divided into normal weight (n = 180) and obese CHD subjects (n = 240). Hair Al, As, Cd, Hg, Ni, and Pb levels were evaluated using inductively-coupled plasma mass-spectrometry. The data demonstrate that hair Al and Hg levels were higher in obese subjects as compared to normal weight controls. Normal weight CHD patients were characterized by significantly higher hair Al, As, Cd, and Pb levels when compared to healthy subjects. The highest hair Al, As, and Pb levels were observed in obese CHD patients, significantly exceeding the respective values in other groups. Factorial analysis revealed significant influence of factorial interaction (CHD*obesity) only for hair Pb content. Given the role of obesity as a risk factor for CHD, it is proposed that increased toxic metal accumulation in obesity may promote further development of cardiovascular diseases.

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Surface Morphology and Histopathological Aspects of Metallic Used Cardiovascular CoCr Stents

Metals ◽

10.3390/met10091112 ◽

2020 ◽

Vol 10 (9) ◽

pp. 1112

Author(s):

George-Razvan Pandelea-Dobrovicescu ◽

Mariana Prodana ◽

Florentina Golgovici ◽

Daniela Ionita ◽

Maria Sajin ◽

...

Keyword(s):

Electron Microscopy ◽

Surface Morphology ◽

Inductively Coupled Plasma ◽

Tissue Response ◽

Histopathological Analysis ◽

Toxic Response ◽

Inductively Coupled ◽

Metal Levels ◽

Plasma Mass Spectrometry ◽

Tem Method

In this study, CoCr cardiovascular metallic stents with the same chemical composition as well as the adjacent tissues were analyzed. Recovered stents and adjacent tissues were characterized by surface morphology techniques like light microscopy (LM), scanning electron microscopy coupled with energy dispersive X-ray spectroscopy (SEM-EDS) and transmission electron microscopy (TEM). The presence of metals in the tissue from around explanted stent was also confirmed by TEM method. The released metal ions were measured using inductively coupled plasma mass spectrometry (ICP-MS). Histopathological analysis was used to highlight host tissue response to the implanted stents. EDX analysis revealed that 21 stents had the same composition. The quantities of Cr ions detected in the tissues were between 5 and 14 ppb and for Co ions were between 4 and 10 ppb. The tissue sections near the layers that generated large quantities of ions showed restenosis development and the deposits of surface calcifications were highlighted. The heavy metal levels observed in this study due to corrosion are too low to cause a systemic toxic response.

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A Review of Metal Levels in Urban Dust, Their Methods of Determination, and Risk Assessment

Atmosphere ◽

10.3390/atmos12070891 ◽

2021 ◽

Vol 12 (7) ◽

pp. 891

Author(s):

Chikumbusko Chiziwa Kaonga ◽

Ishmael Bobby Mphangwe Kosamu ◽

Wells Robert Utembe

Keyword(s):

Heavy Metals ◽

Risk Assessment ◽

Inductively Coupled Plasma ◽

Urban Dust ◽

Risk Levels ◽

Inductively Coupled ◽

Icp Ms ◽

Metal Levels ◽

Plasma Mass Spectrometry

This review gives insights into the levels of metals in urban dust, their determination methods, and risk assessment. Urban dust harbors a number of pollutants, including heavy metals. There are various methods used for the sampling of urban dust for heavy-metal analysis and source-apportionment purposes, with the predominant one being the use of plastic sampling materials to avoid prior contamination. There are also various methods for the determination of metals, which include: atomic absorption spectroscopy (AAS) and inductively coupled plasma-mass spectrometry (ICP-MS), among others. Studies have shown that pollutants in urban dust are mainly derived from industrial activities and coal combustion, whereas traffic emissions are also an important, but not a predominant source of pollution. The varying particle-size distribution of urban dust and its large surface area makes it easier for the deposition and transport of heavy metals. Risk-assessment studies have shown that metals in urban dust could cause such problems as human pulmonary toxicity and reduction of invertebrate populations. The risk levels seem to be higher in children than adults, as some studies have shown. It is therefore important that studies on metals in urban dust should always incorporate risk assessment as one of the main issues.

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Study on toxic metal levels in commercial marine organisms from Romanian market

Analele Universitatii Ovidius Constanta - Seria Chimie ◽

10.2478/auoc-2014-0011 ◽

2014 ◽

Vol 25 (2) ◽

pp. 59-64

Author(s):

Sonia Amariei ◽

Gheorghe Gutt ◽

Mircea Oroian ◽

Alexandra Bodnar

Keyword(s):

Heavy Metals ◽

Inductively Coupled Plasma ◽

Toxic Metal ◽

Marine Organisms ◽

Cadmium Content ◽

Inductively Coupled ◽

Icp Ms ◽

Metal Levels ◽

Commission Regulation ◽

Excessive Consumption

Abstract The goal of this study was to analyze the content of heavy metals in fish, shellfish, molluscs cephalopods on the Romanian market. We have analyzed heavy metals traces in sixteen marine organisms species. Analyses of heavy metal traces were done with mass spectrometer with inductively coupled plasma- ICP-MS, Agilent Technologies 7500 Series. Among the elements identified it was analyzed the content of Cd, Hg, Pb, metals with high toxicity to the human body, and the obtained values were interpreted in accordance with Commission Regulation (EC) No 1881/2006 concerning the maximum allowable quantity per kg wet product and Provisional Tolerated Weekly Intake (PTWI) established by the Joint Committee experts WHO / FAO. The risk assessment performed indicated that marine organisms were safe for the consumer except the four species that cadmium content may be exceeded for a regular or excessive consumption.

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Effects of Basicity and Mesh on Cr Leaching of EAF Carbon Steel Slag

Applied Sciences ◽

10.3390/app9010121 ◽

2018 ◽

Vol 9 (1) ◽

pp. 121 ◽

Cited By ~ 2

Author(s):

Davide Mombelli ◽

Silvia Barella ◽

Andrea Gruttadauria ◽

Carlo Mapelli ◽

Gwenn Le Saout ◽

...

Keyword(s):

Carbon Steel ◽

Inductively Coupled Plasma ◽

Steel Slag ◽

Impurity Content ◽

Toxic Metal ◽

Slag Basicity ◽

X Ray ◽

Inductively Coupled ◽

Cooling Speed ◽

Plasma Mass Spectrometry

The slag’s chromium leaching is one of the most pressing concerns in Electric Arc Furnace (EAF) carbon and stainless steels production. In recent years, many studies have aimed at understanding which properties (basicity, cooling speed) and phases (spinels, wustite, silicates) determine the Cr leaching, defining different indices (sp-factor, cs-factor) in order to forecast the slag’s behavior compared to the leaching of this toxic metal. The literature suggests that spinel formation is usually a good way to fix Cr and prevent its leaching. However, in some conditions (high basicity, low amount of spinel-forming species) soluble Cr-bearing phases can be formed, i.e., Ca-chromite or unstable spinel. In these conditions, Cr can be leached easily, even if it is bound in a spinel structure. In this paper, the effects of basicity and impurities (Ca, Si) on the instability of Cr-spinel was investigated, with respect to slag mesh. The influence of basicity was also studied on Mg-wustite stability, which might contribute to the leaching of Cr. Different samples of carbon steel slag, suspected of forming unstable spinels, belonging to different steel grade production, were also investigated. Both granulated (4 mm) and milled (<100 μm) slag were analyzed. Scanning Electron Microscopy coupled with Energy Dispersive Spectroscopy (SEM-EDS) analyses were carried out to measure the local chemical composition of Cr-bearing phases. This data was correlated with slag basicity (by X-Ray Fluorescence: XRF), spinel fraction (by X-Ray Diffraction: XRD), and Cr leaching (by Inductively Coupled Plasma Mass Spectrometry: ICP-MS). The main results indicate that the increase of the slag basicity implies an increase of the impurity content (Ca, Si) in the spinel, also over-saturated by Cr. This aspect, coupled with spinel geometrical features, seems to justify the unexpected Cr leaching of some slag samples. Basicity does not influence the chemistry of wustite, thus excluding it as an additional Cr leaching source.

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Heavy metal accumulation in Lacistorhynchus dollfusi (Trypanorhyncha: Lacistorhynchidae) infecting Citharichthys sordidus (Pleuronectiformes: Bothidae) from Santa Monica Bay, Southern California

Parasitology ◽

10.1017/s003118201600038x ◽

2016 ◽

Vol 143 (6) ◽

pp. 794-799 ◽

Cited By ~ 6

Author(s):

C. COURTNEY-HOGUE

Keyword(s):

Heavy Metal ◽

Inductively Coupled Plasma ◽

Metal Accumulation ◽

Heavy Metal Accumulation ◽

Fish Host ◽

Inductively Coupled ◽

Santa Monica Bay ◽

Metal Levels ◽

Santa Monica ◽

Plasma Mass Spectrometry

SUMMARYThe accumulation of heavy metals in macroparasites of fish has been widely studied in freshwater environments. Less is known about metal uptake in cestodes parasitizing marine fish. Lacistorhynchus dollfusi is a common larval cestode parasite of Pacific sanddab (Citharichthys sordidus), a flatfish species inhabiting Santa Monica Bay. The ability of this cestode to concentrate metals in its tissues was compared with metal levels in its sanddab host. Fish and cestode tissue were analysed for 14 elements using Inductively Coupled Plasma Mass Spectrometry. The elements analysed were silver (Ag), arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), iron (Fe), mercury (Hg), potassium (K), lead (Pb), rubidium (Rb), selenium (Se), strontium (Sr), titanium (Ti) and zinc (Zn). Three of the 14 metals (Cu, Hg and Zn) were significantly greater in concentration in L. dollfusi compared with their levels in the liver, intestine and muscle of their fish host. They ranked in concentration from highest to lowest as follows: Zn > Cu > Hg. The ability of the cestode L. dollfusi to uptake metals at higher concentrations than its host warrants its consideration as a candidate for a heavy metal accumulation indicator of pollution exposure in Pacific sanddab.

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EDTA Chelation Therapy in the Treatment of Neurodegenerative Diseases: An Update

Biomedicines ◽

10.3390/biomedicines8080269 ◽

2020 ◽

Vol 8 (8) ◽

pp. 269

Author(s):

Alessandro Fulgenzi ◽

Daniele Vietti ◽

Maria Elena Ferrero

Keyword(s):

Neurodegenerative Diseases ◽

Toxic Metals ◽

Inductively Coupled Plasma ◽

Chelation Therapy ◽

Ethylenediaminetetraacetic Acid ◽

Human Subjects ◽

Toxic Metal ◽

Chelating Agent ◽

Inductively Coupled ◽

Plasma Mass Spectrometry

We have previously described the role played by toxic-metal burdens in the etiology of neurodegenerative diseases (ND). We herein report an updated evaluation of toxic-metal burdens in human subjects affected or not affected by ND or other chronic diseases. Each subject underwent a chelation test with the chelating agent calcium disodium ethylenediaminetetraacetic acid (CaNA2EDTA or EDTA) to identify the presence of 20 toxic metals in urine samples using inductively coupled plasma mass spectrometry. Our results show the constant presence of toxic metals, such as lead, cadmium, cesium, and aluminum, in all examined subjects but the absence of beryllium and tellurium. Gadolinium was detected in patients undergoing diagnostic magnetic resonance imaging. The presence of toxic metals was always significantly more elevated in ND patients than in healthy controls. Treatment with EDTA chelation therapy removes toxic-metal burdens and improves patient symptoms.

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Occupational Exposure to Metals and Serum Adiponectin Levels Among Shipyard Workers: A Cohort Study with Weighted Quantile Sum Regression Analyses

10.21203/rs.3.rs-1150249/v1 ◽

2021 ◽

Author(s):

Chen-Jung Wu ◽

A-Chuan Ho ◽

Shih-Ya Chen ◽

Chih-Hong Pan ◽

Hsiao-Chi Chuang ◽

...

Keyword(s):

Repeated Measures ◽

Inductively Coupled Plasma ◽

Joint Effect ◽

Serum Adiponectin ◽

Metal Exposure ◽

Enzyme Linked Immunosorbent Assay ◽

Inductively Coupled ◽

Increased Risk ◽

Metal Levels ◽

Plasma Mass Spectrometry

Abstract Background: The influence of welding-associated air pollutants on workers’ health is mainly regarded as a core issue in public health and occupational medicine. Previous studies have indicated that workers exposed to metal fumes had an increased risk of metabolic syndrome, which was correlated with decreased serum adiponectin levels. This study aimed to explore whether heavy metal exposure affects the concentration of adiponectin among welding workers. Methods: The study participants were recruited from a shipyard with 31 office workers and 100 welding workers in 2015. Urinary metal concentrations were measured by inductively coupled plasma–mass spectrometry. Serum adiponectin was measured by enzyme-linked immunosorbent assay. Inferential statistics on repeated measures were performed using generalized estimating equations (GEEs). A weighted quantile sum (WQS) regression model was conducted to examine the joint effect of the association of multimetal exposure with serum adiponectin. Results: After adjustment for all confounding variables through a GEE analysis, significantly negative associations of numerous urinary metals with serum adiponectin were detected in the welding workers, including Cr (β = -0.088; 95% CI: -0.148, -0.027), Mn (β = -0.174; 95% CI: -0.267, -0.081), Co (β = -0.094; 95% CI: -0.158, -0.029), Ni (β = -0.108; 95% CI: -0.208, -0.008), Cd (β = -0.067; 95% CI: -0.115, -0.018), and Pb (β = -0.089; 95% CI: -0.163, -0.015). The contributions of multiple urinary metal levels to serum adiponectin levels, determined individually by WQS regression, suggested that Pb was the greatest contributor. Conclusions: Welding workers exposed to heavy metals such as Pb, Cr, Co, Mn, Ni, and Cd might have reduced serum adiponectin levels and an increased risk of cardiovascular disease.

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Does metal porosity affect metal ion release in blood and urine following total hip arthroplasty? A short term study

Hip International ◽

10.1177/1120700018762167 ◽

2018 ◽

Vol 28 (5) ◽

pp. 522-530 ◽

Cited By ~ 6

Author(s):

Alessandro Bistolfi ◽

Andrea Cimino ◽

Gwo-Chin Lee ◽

Riccardo Ferracini ◽

Giovanni Maina ◽

...

Keyword(s):

Surface Area ◽

Acetabular Component ◽

Inductively Coupled Plasma ◽

Metal Ion ◽

Titanium Implants ◽

Ion Release ◽

Inductively Coupled ◽

Metal Ion Release ◽

Metal Levels ◽

Plasma Mass Spectrometry

Introduction: The surface area of exposed metal in a trabecular-titanium acetabular component is wider compared to traditional-titanium implants. The purpose of this study is to establish if this increase in surface area can lead to a significant increase in systemic metal levels. Methods: 19 patients with conventional acetabular component and 19 with trabecular-titanium cup were compared. Aluminum, Vanadium and Titanium in blood and urine were assessed before surgery and at intervals for 2 years. The samples were analysed using an inductively coupled plasma mass spectrometry. Results: Patients with trabecular-titanium did not have significantly higher metal ion levels compared to patients with conventional cups up to 2 years. A trend over time was statistically significant in both blood and urine for aluminum and titanium concentrations. Conclusions: The three-dimensionality and the wide surface of the trabecular-titanium acetabular component did not affect metal ion release compared to traditional implants after 2 years.

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