Burden of COVID-19 and Vaccination Coverage in the Italian Population as of October 2021

Following the pandemic scenario, researchers from all over the world, including Italians, have undertaken fervent research activity using the epidemiological data available on the sites of government and national and international research institutes. The objectives of our study were: (1) to analyze the load and trend of the COVID-19 pandemic in Italy, from the beginning to October 2021; (2) to analyze vaccination coverage by age groups and types of vaccines administered and check how the vaccination campaign has influenced the course of the disease and deaths; (3) to evaluate the Italian situation in the European context, comparing the incidence and mortality of Italy with respect to European countries; (4) finally, to evaluate how much vaccination coverage may have had an effect on mortality in the various European countries. Databases were structured to archive Italian and European COVID-19 data provided by Our World in Data, and data came from the Ministry of Health, to evaluate percentage of vaccines administered. The monthly trend of the cumulative incidence per 100,000 inhabitants in the period January 2020–October 2021 was evaluated. It is important to underline 3 peaks of incidence and mortality rates that occurred during the three waves of COVID-19: March–April–May 2020, October–November–December 2020, and March–April–May 2021. There is a slight increase in incidence in August 2021 and in mortality in September 2021. The three mortality rate peaks, related to the three waves of COVID-19, are always higher in Italy than in Europe, particularly in April 2020, December 2020, and March 2021. From May 2021 to October 2021, the mortality trend reversed, and it turned out to be higher in Europe than in Italy. Regarding vaccination, Italy currently has an important coverage, not only in the most fragile population, where it exceeds 90%, but also in the 12–19 age group, with percentages above 65%. The Pfizer/BioNTech vaccine was used widely in all age groups (first and second dose), with highest administration in 12–19 age groups and 80+, while the lowest was recorded in the 70–79 age group. In conclusion, these data confirm the importance of vaccination in the management of the COVID-19 pandemic.

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Vaccination Prioritization Strategies for COVID-19 in Korea: A Mathematical Modeling Approach

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18084240 ◽

2021 ◽

Vol 18 (8) ◽

pp. 4240

Author(s):

Yongin Choi ◽

James Slghee Kim ◽

Jung Eun Kim ◽

Heejin Choi ◽

Chang Hyeong Lee

Keyword(s):

Age Groups ◽

Epidemiological Data ◽

The Elderly ◽

Age Group ◽

Elderly Age ◽

Social Distancing ◽

Vaccination Strategies ◽

Effective Age ◽

Incidence And Mortality ◽

Age Dependent

Coronavirus disease 2019 (COVID-19) vaccination has recently started worldwide. As the vaccine supply will be limited for a considerable period of time in many countries, it is important to devise the effective vaccination strategies that reduce the number of deaths and incidence of infection. One of the characteristics of COVID-19 is that the symptom, severity, and mortality of the disease differ by age. Thus, when the vaccination supply is limited, age-dependent vaccination priority strategy should be implemented to minimize the incidences and mortalities. In this study, we developed an age-structured model for describing the transmission dynamics of COVID-19, including vaccination. Using the model and actual epidemiological data in Korea, we estimated the infection probability for each age group under different levels of social distancing implemented in Korea and investigated the effective age-dependent vaccination strategies to reduce the confirmed cases and fatalities of COVID-19. We found that, in a lower level of social distancing, vaccination priority for the age groups with the highest transmission rates will reduce the incidence mostly, but, in higher levels of social distancing, prioritizing vaccination for the elderly age group reduces the infection incidences more effectively. To reduce mortalities, vaccination priority for the elderly age group is the best strategy in all scenarios of levels of social distancing. Furthermore, we investigated the effect of vaccine supply and efficacy on the reduction in incidence and mortality.

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Trends of Stomach Cancer in Central Serbia

Medicina ◽

10.3390/medicina57070665 ◽

2021 ◽

Vol 57 (7) ◽

pp. 665

Author(s):

Miodrag M. Stojanovic ◽

Natasa K. Rancic ◽

Marija R. Andjelkovic Apostolovic ◽

Aleksandra M. Ignjatovic ◽

Mirko V. Ilic

Keyword(s):

Stomach Cancer ◽

Preventive Measures ◽

Age Groups ◽

Optimal Number ◽

P Value ◽

Age Group ◽

Joinpoint Regression ◽

Mortality Trends ◽

Incidence Trend ◽

Incidence And Mortality

Somach cancer is the third most common cause of cancer-related deaths worldwide. The objective of the paper was to analyze the incidence and mortality trends of stomach cancer in Central Serbia in the period between 1999–2017. Materials and Methods: trends and annual percentage change (APC) of the incidence and mortality rate with corresponding 95% confidence intervals (CI) were calculated by joinpoint regression analyses. The optimal number of Joinpoints was identified using the Monte Carlo permutation method. The trend was considered to be significantly increasing (positive change) or decreasing (negative change) when the p-value was below 0.05 (p < 0.05). Results: the total number of new cases was 16,914 (10,873 males and 6041 females) and the total number of mortality cases was 14,790 (9348 in and 5442 in females). Almost one third (30.8%) of new cases were registered in the 60–69-year age group, and new cases were significantly more frequent in males than in females (30.8% vs. 29.02%, p < 0.001). Joinpoint regression analysis showed a significant decrease of incidence trend in females during the 2000–2015 period with APC of −2.13% (95% CI: −3.8 to −0.5, p < 0.001). An insignificant decrease in incidence trend was in males with APC of −0.72% (95% CI: −2.3 to 0.9, p = 0.30). According to the joinpoint analysis, a significant decrease of mortality trends both in males during 2000–2015 with APC of −2.21% (95% CI: −1.6 to −7.5, p ≤ 0.001 and in females, during the same period, with APC of −1.75% (95% CI: −2.9 to −0.6, p < 0.001) was registered. From 2015 to 2017, a significant increase of mortality was registered with APC of 44.5% (95% CI: from 24.2 to −68.1, p ≤ 0.001) in females and in males with APC of 53.15% (95% CI: 13.5 to −106.6, p ≤ 0.001). Conclusion: a significant decrease of stomach cancer incidence trend in females and insignificant decrease of incidence trend in males were determined in Central Serbia. Based on presented results, the mortality trend decreased significantly both in males and in females during 2000–2015, and from 2015 to 2017 we recorded a significant increase in mortality in both sexes. We found significantly more new cases in women than in men in the age group of 40–49, and the mortality of stomach cancer was significantly more frequent among females compared to males in the age groups 30–39, as well as in the 50–59 age group. There is a need for improving recording and registration of new cases of stomach cancer, especially in females. Urgent primary and secondary preventive measures are needed—introducing stomach cancer screening and early detection of premalignant changes. Urgent primary and secondary preventive measures are needed.

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THE CHANGING TREND OF MORTALITY CAUSED BY GASTROINTESTINAL CANCERS IN IRAN DURING THE YEARS 2006-2010

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.201800000-60 ◽

2018 ◽

Vol 55 (3) ◽

pp. 237-241 ◽

Cited By ~ 1

Author(s):

Fatemeh SALEHI ◽

Ali AHMADI ◽

Seyede Soghra AHMADI SOODEJANI ◽

Milad SHAHINI SHAMS ABADI

Keyword(s):

Causes Of Death ◽

Age Groups ◽

Mortality Data ◽

Gastrointestinal Cancers ◽

Mortality Trend ◽

Pancreatic Cancers ◽

Incidence And Mortality ◽

High Incidence ◽

Increasing Trend ◽

Changing Trend

ABSTRACT BACKGROUND: Cancers are one of the most important causes of death in the world. According to their high incidence and mortality, gastrointestinal cancers have particular importance among other cancers. OBJECTIVE: Therefore, this study was conducted to investigate the mortality change trends of gastrointestinal cancers in Iran. METHODS: This study was performed by analyzing the reported mortality data in 29 provinces of Iran in 2006-2010. Mortality trend of gastrointestinal cancers was drawn for both sexes in the study years and disaggregated by age groups and their frequency distribution. The WinPepi software was used for analysis. RESULTS: In the years 2006-2010, the mortality rate of, gastric, colorectal, liver and pancreatic cancers, has significantly increased. Totally, gastrointestinal mortality is higher in men than women. Also, the results showed that by increasing age, death from these cancers also increased. CONCLUSION: The most important causes of death from gastrointestinal cancers were gastric, liver and colorectal cancers in Iran and because of their increasing trend in the country, performing preventive interventions for the cancers’ risk factors is necessary.

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Epidemiology of Childhood Hyperthyroidism in France: A Nationwide Population-Based Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2018-00273 ◽

2018 ◽

Vol 103 (8) ◽

pp. 2980-2987 ◽

Cited By ~ 3

Author(s):

Marie Simon ◽

Annabel Rigou ◽

Joëlle Le Moal ◽

Abdelkrim Zeghnoun ◽

Alain Le Tertre ◽

...

Keyword(s):

Age Groups ◽

Poisson Model ◽

Epidemiological Data ◽

Epidemiological Survey ◽

Population Based ◽

Antithyroid Drugs ◽

Childhood And Adolescence ◽

Age Group ◽

Cross Sectional ◽

The Impact

Abstract Context Hyperthyroidism affects all age groups, but epidemiological data for children are scarce. Objective To perform a nationwide epidemiological survey of hyperthyroidism in children and adolescents. Design A cross-sectional descriptive study. Setting Identification of entries corresponding to reimbursements for antithyroid drugs in the French national insurance database. Participants All cases of childhood hyperthyroidism (6 months to 17 years of age) in 2015. Main Outcome Measures National incidence rate estimated with a nonlinear Poisson model and spatial distribution of cases. Results A total of 670 cases of childhood hyperthyroidism were identified. Twenty patients (3%) had associated autoimmune or genetic disease, with type 1 diabetes and Down syndrome the most frequent. The annual incidence for 2015 was 4.58/100,000 person-years (95% CI 3.00 to 6.99/100,000). Incidence increased with age, in both sexes. This increase accelerated after the age of 8 in girls and 10 in boys and was stronger in girls. About 10% of patients were affected before the age of 5 years (sex ratio 1.43). There was an interaction between age and sex, the effect of being female increasing with age: girls were 3.2 times more likely to be affected than boys in the 10 to 14 years age group and 5.7 times more likely to be affected in the 15 to 17 years age group. No conclusions about spatial pattern emerged. Conclusion These findings shed light on the incidence of hyperthyroidism and the impact of sex on this incidence during childhood and adolescence. The observed incidence was higher than expected from the results published for earlier studies in Northern European countries.

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Covid-19 Incidence and Mortality by Age Strata and Comorbidities in Mexico City: A Focus in the Pediatric Population

Frontiers in Public Health ◽

10.3389/fpubh.2021.738423 ◽

2021 ◽

Vol 9 ◽

Author(s):

Nadia González-García ◽

María F. Castilla-Peón ◽

Fortino Solórzano Santos ◽

Rodolfo Norberto Jiménez-Juárez ◽

Maria Elena Martínez Bustamante ◽

...

Keyword(s):

Pediatric Population ◽

Age Groups ◽

Population Data ◽

Older Age ◽

Age Group ◽

Education Policies ◽

Infected People ◽

Risk Of Death ◽

Incidence And Mortality ◽

Pediatric Populations

Background: SARS-COV2 appears less frequently and less severely in the pediatric population than in the older age groups. There is a need to precisely estimate the specific risks for each age group to design health and education policies suitable for each population.Objective: This study aimed to describe the risk of death in SARS-COV2 infected subjects by age group and according to the presence of comorbidities.Methods: We analyzed data of confirmed SARS-COV2 infection cases where symptoms began between February 22th, 2020, and April 18th, 2021, as published by the General Epidemiology Direction (DGE) of the Mexican Ministry of Health. We calculated COVID-19 incidence and mortality by age group using population data from the Statistics and Population National Institute (INEGI), and estimated the association between risk of death and the presence of comorbidities.Results: Mortality in SARS-COV2 infected people varied considerably, between 7 and 155 deaths per million per year in the under-20 age groups compared to 441 to 15,929 in the older age groups. Mortality in pediatric populations is strongly associated with comorbidities (OR: 4.6-47.9) compared to the milder association for older age groups (OR: 3.16–1.23).Conclusion: The risk of death from SARS-COV2 infection in children is low and is strongly associated with comorbidities.

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Covid-19 Incidence And Mortality By Age Strata And Comorbidities In Mexico City: A Focus In The Pediatric Population

10.1101/2021.06.21.21259282 ◽

2021 ◽

Author(s):

MARIA FERNANDA CASTILLA PEON ◽

Nadia Gonzalez-Garcia ◽

Fortino Solorzano-Santos ◽

Rodolfo Jimenez Juarez ◽

Maria Elena Martinez Bustamante ◽

...

Keyword(s):

Pediatric Population ◽

Age Groups ◽

Population Data ◽

Older Age ◽

Age Group ◽

Infected People ◽

Risk Of Death ◽

Incidence And Mortality ◽

The Face ◽

Pediatric Populations

Introduction: SARS-COV2 appears less frequently and less severely in the pediatric population than in older age groups. In the face of the urgent need to reactivate activities suspended during the lockdown, mainly those essential for child development, this study aims to describe the risks of death of persons infected with SARS-COV2 by age group and according to the presence of comorbidities. Methodology: We analyzed data of confirmed SARS-COV2 infection cases where symptoms began between February 22th, 2020, and March 31, 2021, as published by the General Epidemiology Direction (DGE) of the Mexican Ministry of Health. We calculated COVID-19 incidence and mortality by age group with population data from the Statistics and Population National Institute (INEGI), estimating the correlation between risk of death and the presence of comorbidities. Results: Mortality in SARS-COV2 infected people varied considerably, between 7 to 155 deaths per million per year in the under-20 age groups compared to 441 to 15929 in the older age groups. Mortality in pediatric populations is strongly associated with comorbidities (OR: 4.6- 47.9) compared to the milder association for older age groups (OR: 3.16-1.23). Conclusions: The risk of death from SARS-COV2 infection in children is low and strongly associated with comorbidities.

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Age and Gender Specific Lung Cancer Incidence and Mortality in Hungary: Trends from 2011 Through 2016

Pathology & Oncology Research ◽

10.3389/pore.2021.598862 ◽

2021 ◽

Vol 27 ◽

Author(s):

Lilla Tamási ◽

Krisztián Horváth ◽

Zoltán Kiss ◽

Krisztina Bogos ◽

Gyula Ostoros ◽

...

Keyword(s):

Lung Cancer ◽

Age Groups ◽

Age Group ◽

Lung Cancer Incidence ◽

Age And Gender ◽

Female Population ◽

Incidence And Mortality ◽

Icd 10 ◽

And Gender ◽

Gender Specific

Objective: No assessment was conducted describing the age and gender specific epidemiology of lung cancer (LC) prior to 2018 in Hungary, thus the objective of this study was to appraise the detailed epidemiology of lung cancer (ICD-10 C34) in Hungary based on a retrospective analysis of the National Health Insurance Fund database.Methods: This longitudinal study included patients aged ≥20 years with LC diagnosis (ICD-10 C34) between January 1, 2011 and December 31, 2016. Patients with different cancer-related codes 6 months before or 12 months after LC diagnosis or having any cancer treatment other than lung cancer protocols were excluded.Results: Lung cancer incidence and mortality increased with age, peaking in the 70–79 age group (375.0/100,000 person-years) among males, while at 60–69 age group for females (148.1/100,000 person-years). The male-to-female incidence rate ratio reached 2.46–3.01 (p < 0.0001) among the 70–79 age group. We found 2–11% decrease in male incidence rate at most age groups, while a significant 1–3% increase was observed in older females (>60) annually during the study period.Conclusion: This nationwide epidemiology study demonstrated that LC incidence and mortality in Hungary decreased in younger male and female population, however we found significant increase of incidence in older female population, similar to international trends. Incidence rates peaked in younger age-groups compared to Western countries, most likely due to higher smoking prevalence in these cohorts, while lower age LC incidence could be attributed to higher competing cardiovascular risk resulting in earlier mortality in smoking population.

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Epidemiological aspects of Meningites in Brazil: a comparison between regions

10.5327/1516-3180.214 ◽

2021 ◽

Author(s):

Andrea Alexandra Narro Ayin ◽

Rafaela Seixas Pinho ◽

Aline Cristine Passos de Souza ◽

Viviane Nazaré Lopes de Souza

Keyword(s):

Ecological Study ◽

Age Groups ◽

Sao Paulo ◽

Age Group ◽

The South ◽

White Race ◽

Southeast Region ◽

The North ◽

Incidence And Mortality ◽

Analyze Data

Background: Meningites are an inflammation of the meninges, more caused by virus, however, they are severe when caused by bacterias Objectives: Analyze data regarding the epidemiology of meningites in Brazil. Methods: Ecological study based on data of incidence and mortality by brazilian regions, sex and age affected by meningitis, between the year 2015 to 2020, available on Datasus. Results: In the north were reported 1.027 cases, Pará the winner; in the southeast were found 10.882 cases, and São Paulo was the most responsible; in the northeast, 12.435 cases were recorded, with the largest number in Bahia; in the South, 19.299 cases were observed, Paraná with the greatest number; finally, the midwest with 916 cases, Goiás was the winner. 8.056 deaths were reported, with the record in the southeast region, with 51,7% of total deaths, followed by the northeast (17,3%), South 16,9%), north (7,9%) and the midwest (5,9%). There was a predominance of the diasease in males (87.189 cases) over females (51.858 cases). The age groups most affected were between 20-39 years old, followed by 1-4 years old. The most affected race were whites, with 49.648 cases, followed by browns with 26.235 cases. Conclusion: The southestern region has higher mortality from meningitis and the South a higher incidence. The white race was the most affected and the age group between 20-39 years old.

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Monitoring sociodemographic inequality in COVID-19 vaccination coverage in England: a national linked data study

10.1101/2021.10.07.21264681 ◽

2021 ◽

Author(s):

Ted Dolby ◽

Katie Finning ◽

Allan Baker ◽

Leigh Dowd ◽

Kamlesh Khunti ◽

...

Keyword(s):

Language Proficiency ◽

Vaccination Coverage ◽

English Language ◽

Age Groups ◽

Population Level ◽

Lower Percentage ◽

Area Deprivation ◽

Sociodemographic Characteristics ◽

Age Group ◽

Vaccination Rates

Background: The UK began an ambitious COVID-19 vaccination programme on 8th December 2020. This study describes variation in vaccination coverage by sociodemographic characteristics between December 2020 and August 2021. Methods: Using population-level administrative records linked to the 2011 Census, we estimated monthly first dose vaccination rates by age group and sociodemographic characteristics amongst adults aged 18 years or over in England. We also present a tool to display the results interactively. Findings: Our study population included 35,223,466 adults. A lower percentage of males than females were vaccinated in the young and middle age groups (18-59 years) but not in the older age groups. Vaccination rates were highest among individuals of White British and Indian ethnic backgrounds and lowest among Black Africans (aged ≥80 years) and Black Caribbeans (18-79 years). Differences by ethnic group emerged as soon as vaccination roll-out commenced and widened over time. Vaccination rates were also lower among individuals who identified as Muslim, lived in more deprived areas, reported having a disability, did not speak English as their main language, lived in rented housing, belonged to a lower socio-economic group, and had fewer qualifications. Interpretation: We found inequalities in COVID-19 vaccination rates by sex, ethnicity, religion, area deprivation, disability status, English language proficiency, socio-economic position, and educational attainment, but some of these differences varied by age group. Research is urgently needed to understand why these inequalities exist and how they can be addressed.

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Patterns of Dermatological manifestation in patients attending Pediatric outpatient department

Journal of Gandaki Medical College-Nepal ◽

10.3126/jgmcn.v13i2.30960 ◽

2020 ◽

Vol 13 (2) ◽

pp. 160-163

Author(s):

Arjun Bhattarai ◽

Bandana Shrestha ◽

Ravi Raj Timasina ◽

Nawaraj KC ◽

Shankar Poudel ◽

...

Keyword(s):

Demographic Data ◽

Age Groups ◽

Epidemiological Data ◽

Outpatient Department ◽

Personal Hygiene ◽

Age Group ◽

Health And Wellness ◽

Pediatric Age Group ◽

Common Category ◽

Children Health

Background: Dermatological manifestations in children contribute to significant morbidity and psychological distress. Children with dermatological problems constitute a major bulk of the patients presenting to the Outpatient department. The study was conducted with an objective to find out the pattern of skin disease among the various pediatric age group. Method: We analyzed epidemiological data of 612 patients, aged 1 months to 15 years, who were referred to the Dermatology outpatient from the Pediatric outpatient between 2nd Baisakh 2075 to 31 Chaitra 2076. Demographic data and the frequency of the various diagnoses in various age groups were studied. Result: The most common category of diagnosis was infection in 35.78%, followed by allergic reaction in 33.50% and infestations in 14.22%, other dermatosis in 13.07%, while multiple diagnosis was found in 3.43%. Among all diagnostic groups, Scabies was the most common (14.22%) followed by Urticaria (11.92%). Conclusion: Comparison of the common dermatosis with the age group showed a strongly significant effect on occurrence of common dermatosis. Their incidence can be brought down by improving nutrition and personal hygiene of children. Health and wellness of school going children reflects the health status of a community. Our study provides a preliminary baseline data for future epidemiological and clinical research.

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