scholarly journals Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy

2019 ◽  
Vol 20 (12) ◽  
pp. 2940 ◽  
Author(s):  
Yin-Hwa Shih ◽  
Tong-Hong Wang ◽  
Tzong-Ming Shieh ◽  
Yu-Hsin Tseng
Keyword(s):  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Burning Sensation ◽  
Therapeutic Interventions ◽  
Future Research ◽  
Oral Health Literacy ◽  
Diagnostic Biomarkers ◽  
Submucous Fibrosis ◽  
Underlying Mechanisms

Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5–15% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, diagnostic biomarkers, and therapeutic interventions. In addition to the aggressive treatment of OSF, its prevention is also important. Future research should, therefore, focus on improving the oral health literacy of the patients susceptible to OSF.

Comparison Of Collagen-Curcumin Blend (Collaper Rtu)With Intralesional Steroid Injections in Oral Submucous Fibrosis a Randomized, Open-Label Interventional Study.

2021 ◽  
Author(s):  
Bharat Kwatra ◽  
Manya Pahwa
Keyword(s):  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Burning Sensation ◽  
Current Therapy ◽  
Intralesional Injection ◽  
Complete Regression ◽  
Open Label ◽  
Tongue Protrusion ◽  
Interincisal Distance ◽  
Submucous Fibrosis

Abstract Introduction: Oral Submucous Fibrosis (OSMF) is a precancerous condition characterized by limited mouth opening, burning sensation, stiffness, and blanching of the oral mucosa induced by areca nut eating. With any of the current therapy regimens, complete regression of the illness has not been accomplished in all patients. Curcumin is a yellow pigment found in curry powder that has antioxidant, anti-inflammatory, and pro-apoptotic properties. As a result, interventional research was conducted to determine the efficacy of Collaper RTu a proprietary collagen-curcumin based product in patients with OSMF.Setting and design: Forty patients with clinically and histologically confirmed Oral Submucous Fibrosis participated in a randomized open label interventional research. Method & materials: For the research, forty patients with clinically and histologically verified Oral Submucous Fibrosis were randomly assigned to one of two groups. The first group was given a weekly intralesional injection of 4 mg Dexamethasone and 1500 I.U Hyaluronidase, whereas the second was given two Collagen-Curcumin pills (Collaper Rtu 60mg Collagen with 100 mg Curcumin) every day for three months. On a weekly basis, the improvement of burning sensation, interincisal distance, and tongue protrusion was assessed.Results: From early to late stages, the burning feeling improved in both groups. Collaper Rtu was found to eliminate the burning feeling. In groups 1 and 2, the mean increase in interincisal distance was 3.13 mm and 1.25 mm, respectively. The interincisal distance improved significantly in both groups by the end of the first month. When compared to group 2, group 1's tongue protrusion recovered faster at the conclusion of the first month. Conclusion: Collaper RTu is useful and effective in lowering the burning feeling in people with early OSMF.

scholarly journals Hearing Efficiency in Oral Submucous Fibrosis: A Clinical Study

2020 ◽  
Author(s):  
J. S. Shah ◽  
Nutan Lunagariya
Keyword(s):  
Oral Mucosa ◽  
Conductive Hearing Loss ◽  
Oral Submucous Fibrosis ◽  
Hearing Threshold ◽  
Mouth Opening ◽  
Burning Sensation ◽  
Areca Nut ◽  
Gradual Reduction ◽  
Submucous Fibrosis ◽  
Conductive Hearing

Abstract Oral Submucous fibrosis (OSMF) is a chronic insidious disease of oral mucosa that occurs due to areca-nut chewing, consumption of chillies, autoimmunity and genetic predisposition. The disease starts with burning sensation and inability to tolerate spicy foods with gradual reduction in mouth opening due to fibrosis of the oral mucosa. The extension of fibrosis into the naso pharynx leads to reduction in hearing efficiency. As very few studies had been done to evaluate the hearing disability in OSMF patients, this study had been undertaken to prove the same. To evaluate hearing efficiency in patients with Oral Submucous Fibrosis of various grades of severity. Presentation includes 30 patients of osmf with various grades and evaluated for hearing efficacy by audiometry. Hearing threshold was compared in different grades of osmf. The present study revealed a significant association between OSMF and hearing deficit. Involvement of the palatal muscles with OSMF may decrease the patency of the Eustachian tube, leading to conductive hearing loss. Therefore, the protocol for managing OSMF patients should include ENT consultation and treatment for hearing deficit in order to increase the success rate of treatment.

scholarly journals EFFICACY OF ANTIOXIDANT WITH ALOE VERA GEL VERSUS INTRA-LESIONAL STEROIDS IN THE MANAGEMENT OF ORAL SUBMUCOUS FIBROSIS - A PROSPECTIVE COMPARATIVE STUDY

2021 ◽  
Vol 71 (Suppl-3) ◽  
pp. S526-29
Author(s):  
Muhammad Tahir ◽  
Asim Abbas ◽  
Faiz Ul Hassan Nawaz ◽  
Mohsin Raza ◽  
Atif Rafique ◽  
...  
Keyword(s):  
Comparative Study ◽  
Lipoic Acid ◽  
Oral Submucous Fibrosis ◽  
Aloe Vera ◽  
Mouth Opening ◽  
Burning Sensation ◽  
Alpha Lipoic Acid ◽  
Aloe Vera Gel ◽  
Prospective Comparative Study ◽  
Submucous Fibrosis

Objective: To compared efficacy of alpha lipoic acid (antioxidant medication) and aloe vera gel together versus intralesional steroids (hydrocortisone) in management of oral submucous fibrosis by evaluating post treatment clinical features of mouth opening and burning sensation. Study Design: A prospective comparative study. Place and Duration of Study: Department of ENT, Combined Military Hospital, Malir Karachi, from Jul 2018 to Mar 2020. Methodology: Twenty-eight patients were involved in the research and were distributed into two groups, I and II. Alpha lipoid acid with aloe vera gel was given in group I and hydrocortisone was given in group II. Burning sensation and mouth opening were recorded both at start and at monthly interval later on for three consecutive months. The data collected were statistically analyzed by using SPSS-22. Results: A significant lessening in burning sensation (p<0.001) and improvement in mouth opening were noticed in both groups. However, comparison between alpha lipoic acid with aloe vera gel group versus hydrocortisone group showed almost similar results. Conclusion: Alpha lipoic acid and aloe vera gel can significantly improve oral submucous fibrosis clinically. So, these can be utilized as an alternative option in cases where intralesional steroid is poorly tolerated or is contraindicated.

scholarly journals Effectiveness of Pentoxifylline Therapy for Management of Oral Submucous Fibrosis

2022 ◽  
Vol 19 (1) ◽  
pp. 51-54
Author(s):  
Dwarika Prasad Bajgai ◽  
Bela Agrawal ◽  
Abadhesh Yadav
Keyword(s):  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Burning Sensation ◽  
Oral Disease ◽  
Medical College ◽  
Adjacent Structures ◽  
Group A ◽  
Submucous Fibrosis ◽  
Group B

Introduction: Oral submucous fibrosis is a chronic oral disease characterized by progressive buildup of constricting collagen bands in the cheeks and adjacent structures of the mouth due to chewing of areca nut. This can severely restrict mouth opening and tongue movement causing pain and burning sensation in the mouth. Aims: This study evaluates the efficacy of pentoxifylline in the management of oral submucous fibrosis. Methods: A hospital-based study, conducted in the dental outpatient department of Nepalgunj Medical College from October 2019 to September 2020. Forty-nine patients who were diagnosed histopathologically with oral submucous fibrosis were included. The patients were divided into two groups. In group A, patients were given, 200 mg thrice daily for first 30 days, then dose hiked to 400 mg thrice daily for two more months. Group B patients received treatment with multi-vitamin capsules (B-complex one capsule before sleep daily) for three months. All patients were followed up for six months and were assessed for maximum inter-incisor opening, pain on opening of mouth and burning sensation. Results: There was no statistical difference in mouth opening at baseline and first follow up. The mouth opening was significantly more in group A compared to group B from second follow up which persisted till third follow up (p <0.05). Pain and burning sensation significantly reduced in group A compared to group B from 2nd follow up which persisted till 3rd follow up (p <0.05). Few patients had nausea, dyspepsia and vomiting during treatment in group A which resolved within a few days without the need for cessation of the drug. Conclusion: Pentoxifylline can bring about significant clinical improvements in the symptoms of oral submucous fibrosis like mouth opening, pain and burning sensation, thereby improving the quality of life of the affected individuals.

scholarly journals Quality of Life in Oral Submucous Fibrosis- A Case Report with a Literature Review

2021 ◽  
Vol 15 (1) ◽  
pp. 4-10
Author(s):  
Shishir Ram Shetty ◽  
Sesha Reddy ◽  
Pooja Narain Adtani ◽  
Raghavendra Shetty ◽  
Ashwin Lakshminarayanan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Case Report ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Specific Questionnaire ◽  
Spicy Food ◽  
Potentially Malignant ◽  
Submucous Fibrosis ◽  
Published Research

Introduction: Oral Submucous Fibrosis (OSMF) is a potentially malignant disorder commonly found in the Southeast Asian region, classically characterized through restricted mouth opening and burning sensation in the mouth on consuming spicy food. The etiopathogenesis and treatment aspects of OSMF have been extensively researched and reviewed. However, the effect of this condition on the Quality of Life (QoL) of patients has not gained much consideration. The aim of our case report is to highlight the importance of evaluating the QoL in an OSMF patient by using discipline-specific questionnaire and also to present to the readers a review of the recently published research articles on the application of QoL questionnaires in OSMF patients. Results: It was observed that most of the researchers used generic and discipline-specific questionnaire for evaluating the quality of life in OSMF patients. Conclusion: Evaluation of QoL is recommended during the treatment of OSMF patients. There is a need to develop and employ more of disease-specific QoL instruments for OSMF patients.

scholarly journals Management of Histologically Proven Oral Submucous Fibrosis with Intralesional Steroids and Hyaluronidase- A Report of Two Cases

2021 ◽  
Author(s):  
R Preethi ◽  
S Aravind Warrier ◽  
CV Divyambika
Keyword(s):  
Clinical Symptoms ◽  
Oral Submucous Fibrosis ◽  
Burning Sensation ◽  
Treatment Modalities ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Submucous Fibrosis ◽  
Randomised Controlled ◽  
Patients Experience

Oral Submucous Fibrosis (OSMF) is a chronic debilitating disease characterised by progressive fibrosis. The disease is predominantly seen in South East Asia and mainly attributed to areca nut chewing habit. The classical presentation includes generalised blanching with palpable fibrotic bands in the oral mucosa. Patients experience severe burning sensation, trismus and difficulty in gustatory functions, thus resulting in compromised nutritional status. The OSMF has been grouped under Oral Potentially Malignant Disorders (OPMD) and has high rates of malignant transformation. Although randomised controlled trials on different treatment modalities have been conducted, currently there is no effective medical management. This paper highlights two cases of OSMF presenting with severe burning sensation and trismus, who underwent incisional biopsy for histopathological confirmation and to rule out dysplasia. Both the patients were treated with dexamethasone and hyaluronidase, biweekly for four weeks. Post-treatment there was significant improvement in the clinical symptoms, thus providing the patients with better quality of life.

scholarly journals A Clinico-Demographic Evaluation of Patients with Oral Submucous Fibrosis: a Cross Sectional Study

2021 ◽  
pp. 22-29
Author(s):  
Abdul Bari Memon ◽  
Aneela Atta Ur Rahman ◽  
Kashif Ali Channar ◽  
Naresh Kumar
Keyword(s):  
Significant Relationship ◽  
Oral Submucous Fibrosis ◽  
Maxillofacial Surgery ◽  
Mouth Opening ◽  
Burning Sensation ◽  
University Hospital ◽  
Oral And Maxillofacial Surgery ◽  
Aged Patients ◽  
Cross Sectional ◽  
Submucous Fibrosis

Aim: To evaluate the Clinico-Demographic variables in patients of Oral Submucous Fibrosis Study Design:  Descriptive Cross Sectional Place and Duration of Study: Department of Oral and Maxillofacial Surgery, Liaquat Medical University Hospital from December 2017 to February 2019. Methodology: The recruitment of patients was done after the clinical diagnosis of oral sub mucous fibrosis (OSMF) patients. The demographic information and associated factors were recorded on the proforma. Mouth opening (MO) was measured between upper and lower central incisors with vernier caliper. Burning sensation (BS) and pain were measured using Visual Analog Scale (VAS). The data were analyzed by SPSS Version-16. Results: Male and female were (66%) and (34%) respectively. The mean age was 41.04±11.24. The frequency of gutka usage was 44% and 43% followed by betel nut as 21% and 23% in functional stages as per Inter Incisal Mouth Opening (IIMO-2) and (IIMO-3) respectively. The BS was shown as severe 49% and 40% followed by moderate as 32% and 37% in functional stages IIMO-2 and IIMO-3 respectively whereas pain was shown as severe 82% and 18% and as moderate 63% and 37% in functional stage M2 and M3 respectively showed statistically significant relationship (p=0.041). Conclusion: Males were more affected and middle aged patients were more involved. Majority of patients were using gutka and had 3rd functional stage of mouth opening. The burning sensation and pain were the most common clinical complains. There was significant relationship of functional stages with pain.

scholarly journals Tulasi a magical herb and a boon for management of oral submucous fibrosis: a clinical study

2017 ◽  
Vol 5 (11) ◽  
pp. 4719 ◽  
Author(s):  
G. Madhulatha ◽  
N. Vijayalaxmi ◽  
T. Harshavardhan
Keyword(s):  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Modern Medicine ◽  
Burning Sensation ◽  
Rank Test ◽  
P Value ◽  
Signed Rank ◽  
Signed Rank Test ◽  
Submucous Fibrosis

Background: Plants are a good source of drugs in traditional and modern medicine. One among these plants is “tulasi” The queen of herbs” which is used in ayurveda for its diverse properties like antioxidant, analgesic, anti-inflammatory, antidiabetic, and others. It belongs to labiate family and is the most sacred and valued in traditional culture of India. AIMS of the study was to evaluate the efficacy of Tulasi in the treatment of OSMF.Methods: The study included 20 individuals, females and males of age group 20-50yrs who visited the outpatient department who were diagnosed clinically as having OSMF, categorized according to pindborg’s classification. Patients were asked to apply 500mg of Tulasi medicine paste (Tulasi powder mixed with glycerine) twice daily for 1month and were recalled for follow up every week for 1month. All the clinical parameters - mouth opening, burning sensation, pain with the lesion and others were evaluated and recorded in specially designed proforma.Results: Friedman test and wilcoxon signed rank test was used for statistical evaluation. Significant improvement with P value <0.05 was noticed in burning sensation, mouth opening and pain associated with the lesion.Conclusions: The study concludes that Tulasi can be used as a main treatment modality in the management of patients with OSMF.

scholarly journals Oral Submucous Fibrosis: A Review on Biomarkers, Pathogenic Mechanisms, and Treatments

2020 ◽  
Vol 21 (19) ◽  
pp. 7231
Author(s):  
Yen-Wen Shen ◽  
Yin-Hwa Shih ◽  
Lih-Jyh Fuh ◽  
Tzong-Ming Shieh
Keyword(s):  
Quality Of Life ◽  
Treatment Guidelines ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Molecular Evidence ◽  
Pathogenic Mechanisms ◽  
Standard Treatment Guidelines ◽  
Submucous Fibrosis ◽  
Betel Nut Chewing

Oral submucous fibrosis (OSF) is a collagen deposition disorder that affects a patient’s oral function and quality of life. It may also potentially transform into malignancy. This review summarizes the risk factors, pathogenic mechanisms, and treatments of OSF based on clinical and bio-molecular evidence. Betel nut chewing is a major risk factor that causes OSF in Asia. However, no direct evidence of arecoline-induced carcinogenesis has been found in animal models. Despite identification of numerous biomarkers of OSF lesions and conducting trials with different drug combinations, clinicians still adopt conservative treatments that primarily focus on relieving the symptoms of OSF. Treatments focus on reducing inflammation and improving mouth opening to improve a patient’s quality of life. In conclusion, high-quality clinical studies are needed to aid clinicians in developing and applying molecular biomarkers as well as standard treatment guidelines.

scholarly journals Evaluating the Quality of Life in Oral Sub Mucous Fibrosis Patients by WHOQLF-Brief Questionnaire: A Study Protocol

2021 ◽  
pp. 171-175
Author(s):  
Dhiran Talatule ◽  
Ramhari Sathawane ◽  
Romita Gaikwad ◽  
Rakhi Chandak ◽  
Ayesha Sayyad ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Data Collection ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Well Being ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Submucous Fibrosis

Background: - Oral Submucous fibrosis (OSMF) is a chronic insidious inflammatory disease which presents with the clinical presentation of burning sensation, fibrosis which ultimately leads to reduced mouth opening. The quality of life is the perception of an individual on their oral health as well as their well-being. The assessment of quality of life in the patients with OSMF plays an important role in the cessation of the habit. Aim: - To analyse the quality of life in patients diagnosed with Oral Submucous Fibrosis (OSMF). Study Design: - Cross-Sectional Study Methodology: This is a cross-sectional study will be conducted on 300 diagnosed patients of OSMF. Selection of patients will be done as per the inclusion criteria. The nature and Purpose of the study will be explained to the patients before the data collection. Results: The results will be evaluated by the statistician after the data collection and the results will be published in the peer reviewed journals. Improvement in the quality of life in OSMF patients. Knowledge and awareness regarding the consequences of betelnut in the population of Central India.

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