scholarly journals Delayed Dopamine Dysfunction and Motor Deficits in Female Parkinson Model Mice

2019 ◽  
Vol 20 (24) ◽  
pp. 6251 ◽  
Author(s):  
Yuan-Hao Chen ◽  
Vicki Wang ◽  
Eagle Yi-Kung Huang ◽  
Yu-Ching Chou ◽  
Tung-Tai Kuo ◽  
...  
Keyword(s):  
Gender Differences ◽  
Mouse Model ◽  
Motor Behavior ◽  
Epidemiological Data ◽  
Behavioral Changes ◽  
Motor Deficits ◽  
Female Mice ◽  
Progressive Loss ◽  
Symptom Progression ◽  
Da Release

This study analyzed gender differences in the progressive dopamine (DA) deficiency phenotype in the MitoPark (MP) mouse model of Parkinson’s disease (PD) with progressive loss of DA release and reuptake in midbrain DA pathways. We found that the progressive loss of these DA presynaptic parameters begins significantly earlier in male than female MP mice. This was correlated with behavioral gender differences of both forced and spontaneous motor behavior. The degeneration of the nigrostriatal DA system in MP mice is earlier and more marked than that of the mesolimbic DA system, with male MP mice again being more strongly affected than female MP mice. After ovariectomy, DA presynaptic and behavioral changes in female mice become very similar to those of male animals. Our results suggest that estrogen, either directly or indirectly, is neuroprotective in the midbrain DA system. Our results are compatible with epidemiological data on incidence and symptom progression in PD, showing that men are more strongly affected than women at early ages.

scholarly journals Gender Related Changes in Gene Expression Induced by Valproic Acid in A Mouse Model of Autism and the Correction by S-adenosyl Methionine. Does It Explain the Gender Differences in Autistic Like Behavior?

2019 ◽  
Vol 20 (21) ◽  
pp. 5278 ◽  
Author(s):  
Liza Weinstein-Fudim ◽  
Zivanit Ergaz ◽  
Gadi Turgeman ◽  
Joseph Yanai ◽  
Moshe Szyf ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gender Differences ◽  
Valproic Acid ◽  
Prefrontal Cortex ◽  
Mouse Model ◽  
Behavioral Changes ◽  
Male And Female ◽  
Female Mice ◽  
Adenosyl Methionine ◽  
Males And Females

In previous studies we produced autism like behavioral changes in mice by Valproic acid (VPA) with significant differences between genders. S-adenosine methionine (SAM) prevented the autism like behavior in both genders. The expression of 770 genes of pathways involved in neurophysiology and neuropathology was studied in the prefrontal cortex of 60 days old male and female mice using the NanoString nCounter. In females, VPA induced statistically significant changes in the expression of 146 genes; 71 genes were upregulated and 75 downregulated. In males, VPA changed the expression of only 19 genes, 16 were upregulated and 3 downregulated. Eight genes were similarly changed in both genders. When considering only the genes that were changed by at least 50%, VPA changed the expression of 15 genes in females and 3 in males. Only Nts was similarly downregulated in both genders. SAM normalized the expression of most changed genes in both genders. We presume that genes that are involved in autism like behavior in our model were similarly changed in both genders and corrected by SAM. The behavioral and other differences between genders may be related to genes that were differently affected by VPA in males and females and/or differently affected by SAM.

scholarly journals Sex-Related Motor Deficits in the Tau-P301L Mouse Model

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1160
Author(s):  
Luana Cristina Camargo ◽  
Dominik Honold ◽  
Robert Bauer ◽  
N. Jon Shah ◽  
Karl-Josef Langen ◽  
...  
Keyword(s):  
Mouse Model ◽  
Mouse Models ◽  
Behavioral Changes ◽  
Motor Deficits ◽  
The Novel ◽  
Behavioral Alterations ◽  
Object Recognition Test ◽  
Histological Changes ◽  
Female Mice

The contribution of mouse models for basic and translational research at different levels is important to understand neurodegenerative diseases, including tauopathies, by studying the alterations in the corresponding mouse models in detail. Moreover, several studies demonstrated that pathological as well as behavioral changes are influenced by the sex. For this purpose, we performed an in-depth characterization of the behavioral alterations in the transgenic Tau-P301L mouse model. Sex-matched wild type and homozygous Tau-P301L mice were tested in a battery of behavioral tests at different ages. Tau-P301L male mice showed olfactory and motor deficits as well as increased Tau pathology, which was not observed in Tau-P301L female mice. Both Tau-P301L male and female mice had phenotypic alterations in the SHIRPA test battery and cognitive deficits in the novel object recognition test. This study demonstrated that Tau-P301L mice have phenotypic alterations, which are in line with the histological changes and with a sex-dependent performance in those tests. Summarized, the Tau-P301L mouse model shows phenotypic alterations due to the presence of neurofibrillary tangles in the brain.

scholarly journals Developmental and behavioral phenotypes in a new mouse model of DDX3X syndrome

2021 ◽  
Author(s):  
Andrea Boitnott ◽  
Dévina C Ung ◽  
Marta Garcia-Forn ◽  
Kristi Niblo ◽  
Danielle Mendonca ◽  
...  
Keyword(s):  
Mouse Model ◽  
Behavioral Problems ◽  
Behavioral Changes ◽  
Face Validity ◽  
Motor Deficits ◽  
Projection Neurons ◽  
Loss Of Function ◽  
Cortical Projection ◽  
Glutamatergic Neurons ◽  
Brain Malformations

ABSTRACTBackgroundMutations in the X-linked gene DDX3X account for ~2% of intellectual disability in females, often co-morbid with behavioral problems, motor deficits, and brain malformations. DDX3X encodes an RNA helicase with emerging functions in corticogenesis and synaptogenesis.MethodsWe generated a Ddx3x haploinsufficient mouse (Ddx3x+/−) with construct validity for DDX3X loss-of-function mutations. We used standardized batteries to assess developmental milestones and adult behaviors, as well as magnetic resonance imaging and immunostaining of cortical projection neurons to capture early postnatal changes in brain development.ResultsDdx3x+/− mice show physical, sensory, and motor delays that evolve into behavioral anomalies in adulthood, including hyperactivity, anxiety-like behaviors, cognitive impairments, and motor deficits. Motor function further declines with age. These behavioral changes are associated with a reduction in brain volume, with some regions (e.g., cortex and amygdala) disproportionally affected. Cortical thinning is accompanied by defective cortical lamination, indicating that Ddx3x regulates the balance of glutamatergic neurons in the developing cortex.ConclusionsThese data shed new light on the developmental mechanisms driving DDX3X syndrome and support face validity of this novel pre-clinical mouse model.

scholarly journals Changes in motor behavior, neuropathology, and gut microbiota of a Batten disease mouse model following administration of acidified drinking water

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Tyler B. Johnson ◽  
Logan M. Langin ◽  
Jing Zhao ◽  
Jill M. Weimer ◽  
David A. Pearce ◽  
...  
Keyword(s):  
Drinking Water ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Motor Behavior ◽  
Neurodegenerative Disorder ◽  
Tap Water ◽  
Batten Disease ◽  
Motor Deficits ◽  
Therapeutic Benefits ◽  
Water Ph

Abstract CLN3 mutations cause the fatal neurodegenerative disorder, CLN3 Batten disease. The Cln3−/− mouse model displays characteristic features of the human disease including motor deficits. When mice received acidified drinking water (pH 2.5–2.9) instead of normal tap water (pH 8.4) for several generations, the motor skills of Cln3−/− mice normalized to control levels, indicating a disease-modifying effect of acidified water. Here we investigated if acidified water administered from postnatal day 21 has therapeutic benefits in Cln3−/− mice. Indeed, acidified water temporarily attenuated the motor deficits, had beneficial effects on behavioral parameters and prevented microglial activation in the brain of Cln3−/− mice. Interestingly, in control mice, acidified drinking water caused brain region-specific glial activation and significant changes in motor performance. Since the gut microbiota can influence neurological functions, we examined it in our disease model and found that the gut microbiota of Cln3−/− mice was markedly different from control mice, and acidified water differentially changed the gut microbiota composition in these mice. These results indicate that acidified water may provide therapeutic benefit to CLN3 Batten disease patients, and that the pH of drinking water is a major environmental factor that strongly influences the results of murine behavioral and pathological studies.

scholarly journals Are there mortality differences between men and women in all types of intracranial hemorrhages: subarachnoid, intraparenchymal and subdural? An analysis of the Spanish population

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
J Fernandez De Bobadilla Osorio ◽  
J.R Rey-Blas ◽  
N Gonzalez-Aguado ◽  
B Fuentes ◽  
P Masedo ◽  
...  
Keyword(s):  
Gender Differences ◽  
Subarachnoid Hemorrhage ◽  
Intracranial Hemorrhage ◽  
Epidemiological Data ◽  
Spanish Population ◽  
Subdural Hemorrhage ◽  
Men And Women ◽  
Mediterranean Countries ◽  
Gender And Age ◽  
Relationship Of

Abstract Objectives There are 3 types of intracranial hemorrhage (ICH): 1) subarachnoid hemorrhage (SAH), CIE10:I60; 2) intraparenchymal hemorrhage (IPH), I61 and 3) subdural hemorrhage (SDH) I62. Epidemiological data on this field are scarce in Mediterranean countries. Our goal was to determine whether the relationship of ICH mortality with gender and age was different for the 3 types of HIC. Methods Data were retrospectively obtained from the Spanish National Institute of Statistics. Deaths/100.000 population of SAH, IPH and SDH were assessed for the entire Spanish population since 2008 to 2017 (n=46,527,039). Year 2017 was the last available for analysis. Incidence was analyzed for men and women and for age strata (<1 years of age, 2–10, 11–20, 21–30, 31–40, 41–50, 51–60, 61–70, 71–80; >80). Results In order to fit in the abstract space, only data of 2017 are presented, although years 2008 to 2017 were also analyzed and results were similar. Mortality/100,000 of IPH stayed very low under 40 years of age and then grew exponentially in both, men and women, and was significantly higher for men for all age strata. Mortality of SDH was much lower but behaved in a similar way: exponential growth since 40s and lower incidence in women. SAH behaved differently: it started to be significant since 20 years of age and there were no gender differences. Conclusion Mortality of intraparenchymal and subdural hemorrhage increases exponentially since 40 years of age and is lower in women. On the contrary, mortality of subarachnoid hemorrhage increases earlier and there are no gender differences. Death/100.000 intracranial hemorrhage Funding Acknowledgement Type of funding source: None

scholarly journals Region‐specific preservation of Purkinje cell morphology and motor behavior in the ATXN1[82Q] mouse model of spinocerebellar ataxia 1

2021 ◽  
Author(s):  
Joshua J. White ◽  
Laurens W. J. Bosman ◽  
Francois G. C. Blot ◽  
Catarina Osório ◽  
Bram W. Kuppens ◽  
...  
Keyword(s):  
Mouse Model ◽  
Purkinje Cell ◽  
Spinocerebellar Ataxia ◽  
Cell Morphology ◽  
Motor Behavior ◽  
Spinocerebellar Ataxia 1

scholarly journals Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I

2006 ◽  
Vol 189 (2) ◽  
pp. 279-287 ◽  
Author(s):  
Yongmei Wang ◽  
Takeshi Sakata ◽  
Hashem Z Elalieh ◽  
Scott J Munson ◽  
Andrew Burghardt ◽  
...  
Keyword(s):  
Gender Differences ◽  
Parathyroid Hormone ◽  
Cortical Bone ◽  
Mineral Apposition Rate ◽  
Mrna Levels ◽  
Male Mice ◽  
Bone Formation Rate ◽  
Male And Female ◽  
Female Mice ◽  
Igf I

Parathyroid hormone (PTH) exerts both catabolic and anabolic actions on bone. Studies on the skeletal effects of PTH have seldom considered the effects of gender. Our study was designed to determine whether the response of mouse bone to PTH differed according to sex. As a first step, we analyzed gender differences with respect to bone mass and structural properties of 4 month old PTH treated (80 μg/kg per day for 2 weeks) male and female CD-1 mice. PTH significantly increased fat free weight/body weight, periosteal bone formation rate, mineral apposition rate, and endosteal single labeling surface, while significantly decreasing medullary area in male mice compared with vehicle treated controls, but induced no significant changes in female mice. We then analyzed the gender differences in bone marrow stromal cells (BMSC) isolated from 4 month old male and female CD-1 mice following treatment with PTH (80 μg/kg per day for 2 weeks). PTH significantly increased the osteogenic colony number and the alkaline phosphatase (ALP) activity (ALP/cell) by day 14 in cultures of BMSCs from male and female mice. PTH also increased the mRNA level of receptor activator of nuclear factor κB ligand in the bone tissue (marrow removed) of both females and males. However, PTH increased the mRNA levels of IGF-I and IGF-IR only in the bones of male mice. Our results indicate that on balance a 2-weeks course of PTH is anabolic on cortical bone in this mouse strain. These effects are more evident in the male mouse. These differences between male and female mice may reflect the greater response to PTH of IGF-I and IGF-IR gene expression in males enhancing the anabolic effect on cortical bone.

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