scholarly journals Recent Advances in Phenolic Metabolites and Skin Cancer

2021 ◽  
Vol 22 (18) ◽  
pp. 9707
Author(s):  
Teodora Daria Pop ◽  
Zorita Diaconeasa
Keyword(s):  
Skin Cancer ◽  
Subcutaneous Tissue ◽  
Tumor Development ◽  
Skin Melanoma ◽  
Resistance Development ◽  
Chemopreventive Agents ◽  
Naturally Occurring ◽  
Positive Growth ◽  
Positive Growth Rate ◽  
Inflammatory Effect

Skin cancer represents any tumor development from the cutaneous structures within the epidermis, dermis or subcutaneous tissue, and is considered to be the most prevalent type of cancer. Compared to other types of cancer, skin cancer is proven to have a positive growth rate of prevalence and mortality. There are available various treatments, including chemotherapy, immunotherapy, radiotherapy and targeted therapy, but because of the multidrug resistance development, a low success has been registered. By this, the importance of studying naturally occurring compounds that are both safe and effective in the chemoprevention of skin cancer is emphasized. This review focuses on melanoma because it is the deadliest form of skin cancer, with a significantly increasing incidence in the last decades. As chemopreventive agents, we present polyphenols and their antioxidant activity, anti-inflammatory effect, their ability to balance the cell cycle and to induce apoptosis and their various other effects on skin melanoma. Besides chemoprevention, studies suggest that polyphenols can have treating abilities in some conditions. The limitations of using polyphenols are also pointed out, which are related to their poor bioavailability and stability, but as the technology is well developed, it is possible to augment the efficacy of polyphenols in the case of melanoma.

scholarly journals Lies, Gosh Darn Lies, and Not Enough Good Statistics: Why Epidemic Model Parameter Estimation Fails

2020 ◽  
Author(s):  
Daniel E. Platt ◽  
Laxmi Parida ◽  
Pierre Zalloua
Keyword(s):  
Genetic Association ◽  
Transmission Rate ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Personal Space ◽  
Model Parameters ◽  
Spread Model ◽  
Positive Growth ◽  
Positive Growth Rate ◽  
Rate Limiting

AbstractAn opportunity exists in exploring epidemic modeling as a novel way to determine physiological and demic parameters for genetic association studies on a population/environmental (quasi) epidemiological study level. First, the spread of SARS-COV-2 has produced population specific lineages; second, epidemic spread model parameters are tied directly to these physiological and demic rates (e. g. incubation time, recovery time, transmission rate); and third, these parameters may serve as novel phenotypes to associate with region-specific genetic mutations as well as demic characteristics (e. g. age structure, cultural observance of personal space, crowdedness). Therefore, we sought to understand whether the parameters of epidemic models could be determined from the trajectory of infections, recovery, and hospitalizations prior to peak, and also to evaluate the quality and comparability of data between jurisdictions reporting their statistics necessary for the analysis of model parameters across populations. We found that, analytically, the pre-peak growth of an epidemic is limited by a subset of the model variates, and that the rate limiting variables are dominated by the expanding eigenmode of their equations. The variates quickly converge to the ratio of eigenvector components of the positive growth rate, which determines the doubling time. There are 9 parameters and 4 independent components in the eigenmode, leaving 5 undetermined parameters. Those parameters can be strikingly population dependent, and can have significant impact on estimates of hospital loads downstream. Without a sound framework, measurements of infection rates and other parameters are highly corrupted by uneven testing rates to uneven counting and reporting of relevant values. From the standpoint of phenotype parameters, this means that structured experiments must be performed to estimate these parameters in order to perform genetic association studies, or to construct viable models that accurately predict critical quantities such as hospitalization loads.

scholarly journals Extracellular Vesicles Derived From Canine Mesenchymal Stromal Cells in Serum Free Culture Medium Have Anti-inflammatory Effect on Microglial Cells

2021 ◽  
Vol 8 ◽  
Author(s):  
Yukina Kuwahara ◽  
Karin Yoshizaki ◽  
Hidetaka Nishida ◽  
Hiroaki Kamishina ◽  
Sadatoshi Maeda ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
Stromal Cells ◽  
Culture Medium ◽  
Serum Free ◽  
Naturally Occurring ◽  
Serum Free Condition ◽  
Cell Sources ◽  
Fetal Bovine ◽  
Inflammatory Effect

Mesenchymal stem/stromal cells (MSCs) have been used as cell sources for treating dogs with naturally-occurring diseases. Extracellular vesicles (EVs) derived from MSCs are now recognized as pivotal to modulating the immune response and supporting tissue repair. Manufacture of MSC-EVs for clinical application mandates removal of the xeno-proteins, including fetal bovine serum. The objective of this study was to examine whether canine MSCs survived and secreted EVs in serum-free medium (SFM) conditions and to assess the immunomodulatory effect of EVs in vitro. Canine MSCs were found to survive and secrete EVs under SFM conditions. The surface markers of MSCs in the SFM were similar to MSCs in complete culture medium. Canine MSC-EVs had a diameter of ~300 nm and were positive for EV markers. MSC-derived EVs from the serum-free condition reduced the levels of IL-1β by BV-2 cells in response to LPS stimulation. These results warrant further studies of the use of SFM for producing EVs derived from canine MSCs.

scholarly journals The Growth Performance of Selected Spice Crops in Haryana State

2021 ◽  
Vol 14 (3) ◽  
pp. 346-357
Author(s):  
Choote Lal ◽  
Rohtas Kait
Keyword(s):  
Growth Rate ◽  
Growth Performance ◽  
Productivity Growth ◽  
Secondary Data ◽  
The State ◽  
Descriptive Statistics ◽  
Kharif Season ◽  
Significant Growth ◽  
Positive Growth ◽  
Positive Growth Rate

Abstract Subject and purpose of work: The study aims to evaluate the growth performance of spice crops in Haryana state of India. Materials and methods: The study is based on secondary data obtained over the period of 17 years i.e., from 2001-2002 to 2017-2018. Four spice crop – ginger, turmeric, garlic and fenugreek were selected from rabi and kharif season on the basis of the largest area sown. In order to analyze the data descriptive statistics (mean and C.V.) and CGR (compound growth rate) were employed. Results: T he s tudy r evealed a significant p ositive g rowth r ate o f 2.20%, 4.50% and 2.20% in the area, production and productivity of ginger in the district of Panchkula, respectively. In the district of Yamunanagar, a growth rate 13.80% and 10.20% was found in the area and production of turmeric. However, a negative productivity growth rate of -3.20% was also revealed. A positive growth rate 1.50%, 3.30% and 0.17% was found in the area, production and productivity of garlic in Karnal district. In the district of Yamunanagar, a growth rate for fenugreek of 7.30% and 7.60% and 13.90% in the area, production and productivity was found. The state of Haryana recorded a significant growth of 1.7%, 2.8% and 1.1% per annum in the area, production and productivity of spice crops respectively. Conclusions: T he s tudy r evealed a positive g rowth rate across all the selected spice crops, indicating improving prospects of spice crops in Haryana state.

scholarly journals Kelayakan Usaha Ayam Broiler (Studi pada Usaha Peternakan di Desa Cibinong)

2018 ◽  
Vol 33 (2) ◽  
pp. 96
Author(s):  
Elpawati Elpawati ◽  
Achmad Tjachja Nugraha ◽  
Ratu Shofiatina
Keyword(s):  
Small Scale ◽  
Selling Price ◽  
Poultry Production ◽  
Poultry Farm ◽  
Financial Feasibility ◽  
Positive Growth ◽  
Poultry Farms ◽  
Positive Growth Rate ◽  
Small Scale Farmers ◽  
The Many

<p>Indonesia poultry consumption has increased year by year, with the average positive growth rate of 4.6%. This situation can be a chance for both small and large scales of poultry farmers, considering that poultry consumption is increasing every year. The rate of poultry production in Gunung Sindur was correlated with the amount of the existing poultry farms. Romli Farm was a small scale poultry farm in Gunung Sindur, Bogor. This poultry farm, with no partnership, could independently survive amongst the many other existing farms. However, although the opportunities were wide open, this business was not always viable for the farmers because many of small-scale farmers could not be able either to increase the income or to carry on the business. This research aimed to study the income, financial feasibility (NPV, IRR, Net B/C Ratio, and PP), the BEP of Selling Price, and the BEP of Product in Romli Farm.</p>

Tumor targeting profiling of hyaluronan-coated lipid based-nanoparticles

Nanoscale ◽  
2014 ◽  
Vol 6 (7) ◽  
pp. 3742-3752 ◽  
Author(s):  
Shoshy Mizrahy ◽  
Meir Goldsmith ◽  
Shani Leviatan-Ben-Arye ◽  
Einat Kisin-Finfer ◽  
Orit Redy ◽  
...  
Keyword(s):  
Cell Growth ◽  
Embryonic Development ◽  
Tumor Targeting ◽  
Tumor Development ◽  
Naturally Occurring ◽  
Healing Processes

Hyaluronan (HA), a naturally occurring high Mw (HMw) glycosaminoglycan, has been shown to play crucial roles in cell growth, embryonic development, healing processes, inflammation, and tumor development and progression.

scholarly journals Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer

2019 ◽  
Vol 117 ◽  
pp. 109091 ◽  
Author(s):  
Jawun Choi ◽  
Dae-Hyo Lee ◽  
Sang-Youel Park ◽  
Jae-Won Seol
Keyword(s):  
Skin Cancer ◽  
Tumor Angiogenesis ◽  
Tumor Development

scholarly journals New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals:In VitroandIn VivoStudies and the Underlying Mechanisms

2014 ◽  
Vol 2014 ◽  
pp. 1-18 ◽  
Author(s):  
Madhulika Singh ◽  
Shankar Suman ◽  
Yogeshwer Shukla
Keyword(s):  
Skin Cancer ◽  
Cell Cycle Progression ◽  
Molecular Mechanisms ◽  
Cancer Chemoprevention ◽  
Chemopreventive Agents ◽  
Novel Approach ◽  
Comprehensive Knowledge ◽  
Underlying Mechanisms

Skin cancer is still a major cause of morbidity and mortality worldwide. Skin overexposure to ultraviolet irradiations, chemicals, and several viruses has a capability to cause severe skin-related disorders including immunosuppression and skin cancer. These factors act in sequence at various steps of skin carcinogenesis via initiation, promotion, and/or progression. These days cancer chemoprevention is recognized as the most hopeful and novel approach to prevent, inhibit, or reverse the processes of carcinogenesis by intervention with natural products. Phytochemicals have antioxidant, antimutagenic, anticarcinogenic, and carcinogen detoxification capabilities thereby considered as efficient chemopreventive agents. Considerable efforts have been done to identify the phytochemicals which may possibly act on one or several molecular targets that modulate cellular processes such as inflammation, immunity, cell cycle progression, and apoptosis. Till date several phytochemicals in the light of chemoprevention have been studied by using suitable skin carcinogenicin vitroandin vivomodels and proven as beneficial for prevention of skin cancer. This revision presents a comprehensive knowledge and the main molecular mechanisms of actions of various phytochemicals in the chemoprevention of skin cancer.

scholarly journals The PARP Inhibitors, Veliparib and Olaparib, Are Effective Chemopreventive Agents for Delaying Mammary Tumor Development in BRCA1-deficient Mice

2014 ◽  
Vol 7 (7) ◽  
pp. 698-707 ◽  
Author(s):  
Ciric To ◽  
Eun-Hee Kim ◽  
Darlene B. Royce ◽  
Charlotte R. Williams ◽  
Ryan M. Collins ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Tumor Development ◽  
Parp Inhibitors ◽  
Chemopreventive Agents ◽  
Deficient Mice

scholarly journals Multiple Roles for VEGF in Non-Melanoma Skin Cancer: Angiogenesis and Beyond

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Kelly E. Johnson ◽  
Traci A. Wilgus
Keyword(s):  
Skin Cancer ◽  
Critical Role ◽  
Tumor Development ◽  
Skin Carcinogenesis ◽  
Skin Tumors ◽  
Angiogenic Factor ◽  
Non Melanoma Skin Cancer ◽  
New Treatments ◽  
Melanoma Skin

Vascular endothelial growth factor (VEGF) is known to play a critical role in the development of non-melanoma skin cancers. VEGF is a potent pro-angiogenic factor and it is elevated in mouse and human skin tumors. The use of transgenic and knockout mice has shown that VEGF is essential for tumor development in multiple models of skin carcinogenesis and, until recently, the mechanism of action has been primarily attributed to the induction of angiogenesis. However, additional roles for VEGF have now been discovered. Keratinocytes can respond directly to VEGF, which could influence skin carcinogenesis by altering proliferation, survival, and stemness.In vivostudies have shown that loss of epidermal VEGFR-1 or neuropillin-1 inhibits carcinogenesis, indicating that VEGF can directly affect tumor cells. Additionally, VEGF has been shown to promote tumor growth by recruiting macrophages to skin tumors, which likely occurs through VEGFR-1. Overall, these new studies show that VEGF carries out functions beyond its well-established effects on angiogenesis and highlight the need to consider these alternative activities when developing new treatments for non-melanoma skin cancer.

scholarly journals The consequences of ozone layer depletion on the health of Poles – a case study of skin melanoma

2019 ◽  
Vol 14 (2) ◽  
pp. 223-236
Author(s):  
Stanisław Wieteska ◽  
Małgorzata Jabłońska
Keyword(s):  
Skin Cancer ◽  
Life Insurance ◽  
Statistical Data ◽  
Skin Neoplasms ◽  
Ozone Layer ◽  
Skin Melanoma ◽  
Ozone Layer Depletion ◽  
Skin Cancers ◽  
Raising Awareness

This article presents the results of the observation of cases of skin melanomas in Poland. Dermatologists raise the problem of increased sunlight penetration and the unreasonable use of solar radiation. This causes numerous cases of skin cancer. The aim of the article is to signal the threat posed by the depletion of the ozone layer in Poland. The article uses a research method based on an analysis of statistical data on skin cancers, supported by the available research in this area. Studies show that the incidence of skin cancer in Poland in 2007-2016 nearly doubled. Women are more prone than men to skin neoplasms. The mortality rate due to skin melanoma also increased dramatically. In the article, we point to the need of raising awareness of the hazards, and consider the coverage of treatment costs by life insurance as one of the options to protect the health of insured persons. We also raise the problem of prophylaxis on the basis of sunscreen cosmetic products.

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