Relationship between the Severity of Inflammatory Changes in Chronic Sinusitis and the Level of Vitamin D before and after the FESS Procedure

There have been a few reports confirming that vitamin D (VD3) deficiency increases inflammation in the paranasal sinuses. The work brings new information that, despite the presence of inflammation before surgery, patients with higher vitamin D levels had less inflammation, and this has been proven on three levels. We show that vitamin D levels clearly correlate with the severity of the disease in chronic sinusitis. These results have been confirmed in imaging studies (Lund MacKay scale), endoscopy (Lund-Kennedy scale) and in the SNOT 20 questionnaire. 40 patients suffering from chronic sinusitis were divided into two equal groups: group 1: with less severe radiological changes (10 or less points on the Lund-Mackay scale), group 2: with a more advanced form (>10 points). The relationship between VD3 and the severity of the disease (clinical and nasal endoscopy) was assessed. The mean VD3 level in patients in group 2 before surgery was lower (23.01 ng/mL) than in group 1 (28.02 ng/mL) (p < 0.05). They presented a higher degree of advanced changes in all the above scales, i.e., before the SNOT 20 procedure, the mean was: group 1: 30.33, group 2: 31.80 (p < NS); Lund-Kennedy: group 1: 3.21, group 2: 6.30 (p < 0.05). After surgery an increase in VD3 levels was observed in both study groups: in group 1 to the value of 37.98 ng/mL (p < 0.002) and in group 2 to 27.67 ng/mL (p < 0.004). Lower VD3 levels were found in patients with a higher stage of the disease. Reduction of inflammation increases the level of VD3 and reduces subjective and objective symptoms of chronic inflammation.

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The Impact of COVID-19 Pandemic during 2020–2021 on the Vitamin D Serum Levels in the Paediatric Population in Warsaw, Poland

Nutrients ◽

10.3390/nu13061990 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1990

Author(s):

Agnieszka Rustecka ◽

Justyna Maret ◽

Ada Drab ◽

Michalina Leszczyńska ◽

Agata Tomaszewska ◽

...

Keyword(s):

Vitamin D ◽

Seasonal Variability ◽

Serum Levels ◽

Paediatric Population ◽

Sunlight Exposure ◽

Vitamin D Levels ◽

The Mean ◽

Group 2 ◽

The Impact ◽

Group 1

Background: The main source of vitamin D is skin synthesis, which depends on sunlight exposure. During the pandemic, COVID-19 children were obliged to home confinement, which potentially limiting sunlight exposure. The aim of this study was to evaluate whether home confinement led to decreased vitamin D serum levels in children in Warsaw, Poland. Methods: The study included 1472 children who were divided into two groups, based on the date of 25(OH)D level blood sampling: before and during the pandemic. Children under 1 year of age (infants) were analysed separately. Results: A statistically significant decrease in the average level of vitamin D was observed between groups of children over 1 year of age (35 ng/mL ± 18 vs. 31 ng/mL ± 14). In infants from both groups, the mean vitamin D levels were within the normal range (Group 1 inf 54 ng/mL ± 21 vs. Group 2 inf 47 ng/mL ± 15). The characteristic seasonal variability was observed before the pandemic, with maximal vitamin D levels in summer (40 ng/mL ± 17) and minimal levels in winter (30 ng/mL ± 14). During the pandemic, no seasonal variability was observed (summer 30 ng/mL ± 11 vs. winter 30 ng/mL ± 19). Conclusions: The COVID-19 pandemic restrictions led to a significant decrease in vitamin D serum levels in children.

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Orthosiphon versus Placebo in Nephrolithiasis with Multiple Chronic Complaints: A Randomized Control Trial

Evidence-based Complementary and Alternative Medicine ◽

10.1093/ecam/nem141 ◽

2009 ◽

Vol 6 (4) ◽

pp. 495-501 ◽

Cited By ~ 7

Author(s):

Amorn Premgamone ◽

Pote Sriboonlue ◽

Srinoi Maskasem ◽

Wattana Ditsataporncharoen ◽

Bungornsri Jindawong

Keyword(s):

Myofascial Pain ◽

White Blood Cells ◽

Analog Scale ◽

Significant Difference ◽

Before And After ◽

The Mean ◽

Randomized Control ◽

Group 2 ◽

Primary Measure ◽

Group 1

Nephrolithiasis in the communities of Northeast Thailand frequently presents with multiple chronic health complaints, i.e. myofascial pain, back pain, dyspepsia, arthralgia, headache, fatigue, frank paresthesia, dysuria and any of these aggravated by purine-rich food (PRF). We assessed the efficacy of Orthosiphon in treating subjects with at least two active symptoms and negative for urine white blood cells. Subjects were randomly allocated to two groups. Crude extract of Orthosiphon given in a capsule (equivalent to 1.6–1.8 g of dried leaves of Orthosiphon) two times a day to Group 1 (n= 36) and a placebo to Group 2 (n= 40) for 14 days. The medication for each subject was packed and its code kept secret until the data analysis. Both groups were asked not to consume any of 25 purine-rich foods (PRFs) during treatment. The primary measure was the reduced sum of active severity symptoms as recorded using the visual analog scale before and after therapy (i.e. on day 7 and 14). The data on 76 subjects were processed. The mean of the total scores (95% CI) of the symptoms in each group were decreased significantly (P< 0.001); 185.6 (153.3, 218.0) to 94.7 (58.2, 131.2) in the Orthosiphon group and 196.1 (164.4, 227.8) to 89.6 (62.8, 116.5) in the placebo group. When comparing between groups, no statistically significant difference was found. The mean consumption in PRFs was significantly decreased (P< 0.001) in both groups; however, Orthosiphon did not have additional benefit over placebo at 7 and 14 days of treatment during which they reduced these foods.

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Training Badminton Footwork Ten Repetitions Two Sets Better Than Five Repetitions Four Sets for The Improvement of Leg Muscle Strength

Physical Therapy Journal of Indonesia ◽

10.51559/ptji.v2i1.18 ◽

2021 ◽

Vol 2 (1) ◽

pp. 10-15

Author(s):

I Putu Astrawan ◽

I Putu Prisa Jaya

Keyword(s):

Muscle Strength ◽

T Test ◽

Control Group ◽

Control Group Design ◽

Before And After ◽

The Mean ◽

Leg Muscle ◽

Group 2 ◽

Better Than ◽

Group 1

Background: Footwork training is important in coaching basic movements in badminton. This research aims to learn about the influence of footwork training on improving leg muscles strength. Methods: The study used a randomized pretest-posttest control group design. The participants consisted of 42 male badminton players of Universitas Pendidikan Ganesha, Bali, Indonesia, who split into two groups of footwork training (ten repetitions two sets (group 1) and five repetitions with four sets (group 2)). The coach gave the footwork exercise three times per week for 6 weeks to each group and measured the leg muscle strength using the dynamometer test. Results: The result of the within-group paired T-test before and after the training shows group 1 and group 2 (p<0.05). For group 1, the mean of leg muscle strength was 114.19±33.13 kg before the training and 183.19±33.56 kg after the training, with an increase of 60% (69 kg). On the other hand, for group 2, the mean score of leg muscle strength before the training was 113.05±31.30 kg and after the training was 141.10±34.91, with an increase of 25% (28 kg). The leg muscle strength difference between the groups before and after the training was tested using the independent T-test with a significant α=0.05. Comparing the differences of leg muscle strength for both the groups before the training was p= 0.90, and after the training was p=0.00. Conclusion: The conclusion is training badminton footwork ten repetition two sets better than five repetitions four sets to improve leg muscle strength.

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The effect of pharmacological correction with vitamin D on the cytokine response in children with atopic bronchial asthma

Kazan medical journal ◽

10.17816/kmj2019-135 ◽

2019 ◽

Vol 100 (1) ◽

pp. 135-139

Author(s):

L I Allakhverdiyeva ◽

N G Sultanova ◽

A O Dzhafarova

Keyword(s):

Vitamin D ◽

Bronchial Asthma ◽

Interleukin 2 ◽

Interleukin 13 ◽

Atopic Bronchial Asthma ◽

The Mean ◽

Pharmacological Correction ◽

Anti Inflammatory ◽

Group 2 ◽

Group 1

Aim. To study the state of the cytokine response in children with atopic bronchial asthma during pharmacological correction with vitamin D. Methods. 63 children aged 3-17 years with atopic bronchial asthma of varying severity were examined. As a control group, 10 practically healthy children of the same age who had no history of allergic manifestations and no hereditary complications, were examined. The patients were divided into two groups matched by age: group 1 included 33 patients with mild (n=20) and moderate (n=13) bronchial asthma who received only basic anti-inflammatory therapy according to the severity of asthma; group 2 included 30 children with mild (n=18) and moderate (n=12) bronchial asthma who received basic anti-inflammatory therapy with vitamin D containing Tridrop [3 drops (1500 IU) per day for 1 month]. Patients were assessed for interleukin-2, -13 and -17 in the blood serum using a solid-phase enzyme-linked immunosorbent assay before and after treatment. Results. The results obtained made it possible to clarify the changes in the cytokine spectrum in patients with atopic bronchial asthma in the course of the disease and the effect of pharmacological correction with vitamin D on it. The mean level of interleukin-2 in group 1 remained practically unchanged, the value of this cytokine was 2.77±1.51 pg/ml (p >0.05). In group 2, the mean interleukin-2 level increased to 5.07±1.02 pg/ml (p <0.01). The mean level of interleukin-13 in group 1 patients increased but not significantly, but in group 2 a decrease of interleukin-13 to 11.3±3.8 pg/ml (p <0.05) was registered. Interleukin-17 decreased by 2.6 times in group 2 (4.8±1.6 pg/ml, p <0.01). In group 1 there was no significant change in the level of interleukin-17, in all children it remained elevated (p >0.05). Conclusion. Pharmacological correction with vitamin D on the background of basic anti-inflammatory therapy promotes the positive dynamics of the level of cytokines during the treatment of atopic bronchial asthma, which is related to the ability of vitamin D to regulate the function of Th2 and, as a result, to reduce the synthesis of interleukin-13 and -17, which participate in the pathogenesis of allergies and play an important protective role in bronchial asthma.

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Immersion in Water During Active Labor Decreases Postpartum Hematocrit Fall Following Vaginal Delivery

Gynecology Obstetrics and Reproductive Medicine ◽

10.21613/gorm.2018.824 ◽

2018 ◽

pp. 1

Author(s):

Gul Nihal Buyuk ◽

Serkan Kahyaoglu ◽

Ezgi Turgut ◽

Omer Hamid Yumuşak ◽

Caner Kose ◽

...

Keyword(s):

Vaginal Delivery ◽

Postpartum Hemorrhage ◽

Study Groups ◽

Normal Vaginal Delivery ◽

Control Group ◽

The Mean ◽

Group 2 ◽

Water Birth ◽

Control Group Group ◽

Group 1

OBJECTIVE: The objective of the study was to investigate the effect of immersion in water strategy during labor on postpartum bleeding by calculating the postpartum reduction rates of the hematocrit values of the patients.STUDY DESIGN: The study groups consisted of 84 women undergoing vaginal delivery with immersion in water during labor (group 1) and the control group (group 2) of 84 women undergoing normal vaginal delivery. Patients who have received additional medical and surgical interventions for alleviation of postpartum hemorrhage, patients who have undergone an episiotomy and/or perineal trauma were not included in the study. All data were taken from patients who have delivered with spontaneous vaginal delivery. Postpartum hematocrit fall rates of the groups have been compared and the effect of immersion in water on postpartum hemorrhage has been evaluated.RESULTS: The study groups consisted of 84 women undergoing vaginal delivery with immersion in water during labor (Group 1) and the control group (Group 2) of 84 women undergoing vaginal delivery at the hospital. The women in the two groups were matched with respect to age, parity, birth weight and gestational age. The mean age of the women was 29.8±4.8 and 30.5±4.9 respectively. The mean hematocrit difference in the first group was 2.08 ± 1.88 and in the second group was 3.81 ± 1.55. The mean percentage of hematocrit reduction in the first group was 5.71% and in the second group 10.23%.CONCLUSION: Our data showed that mean hematocrit level decreases among women following vaginal delivery more than women who give birth vaginally within immersion in water during labor. The percentage of hematocrit reduction in the water birth group was lower than in the control group. Water birth seems to facilitate uterine contractions more efficiently following vaginal delivery.

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Association of changes in lipid levels with changes in vitamin D levels in a real-world setting

Scientific Reports ◽

10.1038/s41598-021-01064-1 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yonghong Li ◽

Carmen H. Tong ◽

Charles M. Rowland ◽

Jeff Radcliff ◽

Lance A. Bare ◽

...

Keyword(s):

Vitamin D ◽

Real World ◽

Smoking Status ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Lipid Levels ◽

Real World Setting ◽

Vitamin D Levels ◽

Group 2 ◽

Group 1

AbstractIn clinical trials, vitamin D supplementation has been reported to reduce serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) but not high-density lipoprotein cholesterol (HDL-C). In this cohort study we evaluated the association between changes in vitamin D (25-hydroxyvitamin D) and changes in lipid levels in a real-world setting. Changes in lipid levels over a 1-year period were evaluated among individuals whose vitamin D levels increased (group 1) or decreased (group 2) by ≥ 10 ng/mL in year 2018 versus 2017 (cohort 1; n = 5580), in 2019 versus 2018 (cohort 2, n = 6057), or in 2020 versus 2019 (cohort 3, n = 7249). In each cohort, levels of TC, LDL-C, and TG decreased in group 1 and increased in group 2. Between-group differences in average changes in the 3 cohorts ranged from 10.71 to 12.02 mg/dL for TC, from 7.42 to 8.95 mg/dL for LDL-C, and from 21.59 to 28.09 mg/dL for TG. These differences were significant after adjusting for age, sex, race, education, body mass index, blood pressure, smoking status, geographical location, and baseline levels of vitamin D and lipids (P < 0.001). Changes in vitamin D levels were not significantly associated with changes in HDL-C levels.

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Response to short course androgenisation in late reported cases with micropenis

IMC Journal of Medical Science ◽

10.3329/imcjms.v14i1.47381 ◽

2020 ◽

Vol 14 (1) ◽

pp. 1-4

Author(s):

Mahmudul Huque ◽

Tania Tofail ◽

Tofail Ahmed

Keyword(s):

Penile Length ◽

Short Term ◽

Testosterone Therapy ◽

Testosterone Treatment ◽

Short Course ◽

Before And After ◽

The Mean ◽

Pre Treatment ◽

Group 2 ◽

Group 1

Background and objectives: Micropenis is an abnormally short penis and its treatment should begin in infancy or in very early childhood. The present study investigated the response of short term testosterone therapy in late reported cases of micropenis. Methods: A total of 17 cases of micropenis between the age of 8 and 15 years were included in the study. Standard criteria for the diagnosis of micropenis were followed. All cases were treated with intramuscular testosterone 50 to 75 mg once every 21 days. Response to testosterone treatment was measured by the absolute and percent increment in stretched penile length (SPL). Response was considered adequate if final SPL crosses the average SPL for age. We also compared the response of treatment of cases reported before and after 11 years of age. Result: A total of 17 micropenis cases were included in the study. Out of total 17 boys, 10 were between 8 to 11 years (Group 1) and 7 were between 12 to 15 years (Group 2) of age. The mean pre-treatment SPL of 17 micropenis cases was 3.1±0.2 cm (CI: 2.83, 3.43 cm). The mean initial SPL of Gr1 and Gr2 was not significantly different (3.2±0.3 cm vs 3.0±0.1 cm; p>0.248). The mean post treatment SPL of 17 cases increased significantly (p<0.001) compared to their initial SPL. The range of percentage increment in SPL was 100%-400%. Higher testosterone doses were required in Gr2 cases compared to Gr1 (360±20.8 mg vs 260.7±38.5 mg). Conclusion: Micropenis in boys with palpable gonads responded to short term testosterone treatment in late reported cases and we termed these cases as simple micropenis. Ibrahim Med. Coll. J. 2020; 14(1): 1-4

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Can YKL-40 be an Inflammatory Biomarker in Vitamin D Deficiency?

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000545 ◽

2019 ◽

Vol 89 (5-6) ◽

pp. 309-313

Author(s):

Ummugulsum Can ◽

Saliha Uysal ◽

Ayse Ruveyda Ugur ◽

Aysun Toker ◽

Uysaler Aslan ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Levels ◽

Normal Serum ◽

Plasma Vitamin ◽

Inflammatory Biomarker ◽

Vitamin D Levels ◽

Group 2 ◽

Hs Crp ◽

Group 1

Abstract. Vitamin D deficiency is associated with several non-homeostatic conditions and/or diseases like inflammation, atherosclerosis, cardiovascular disease and mortality. YKL-40 is a glycoprotein, secreted by macrophages, neutrophils and different cell types and it is also associated with inflammation and pathological tissue remodeling. In this study, we aimed to evaluate relationship between the proinflammatory biomarkers YKL-40 and hs-CRP levels and vitamin D deficiency. Our study group includes 45 subjects with vitamin D deficiency (Group 1) (20 M, 25 F; mean age 37.72 ± 7.70 years) and 40 age and sex-matched healthy subjects with normal serum levels of vitamin D (Group 2) (19 M, 21 F; mean age 39.26 ± 7.41 years). Plasma 25 (OH) vitamin D levels were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Plasma YKL-40 analysis was performed by ELISA. Serum hs-CRP levels were measured by nephelometric method. Plasma vitamin D levels below 20 ng/mL were accepted as vitamin D deficiency. Although we could not find any significant differences by means of serum hs-CRP levels between Group 1 and Group 2 (2.21 (0.27–11.70); 1.79 (0.16–9.85) mg/L, p = 0.247), plasma YKL-40 levels were significantly higher in group 1 than group2 (70.47 (17.84–198.50); 47.14 (4.80–135.48) ng/mL, p = 0.047). In literature, vitamin D deficiency is associated with inflammation. In our study, we found similar hs-CRP levels between groups and higher YKL-40 levels in group 1. Vitamin D deficiency may be related to high YKL-40 levels in terms of causing chronic inflammation.

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The Association Between Vitamin D and Inflammation in Sickle Cell Disease

Blood ◽

10.1182/blood.v124.21.4923.4923 ◽

2014 ◽

Vol 124 (21) ◽

pp. 4923-4923

Author(s):

Selma Unal ◽

Yesim Oztas ◽

Gulcin Eskandari ◽

Lulufer Tamer Gumus ◽

Ozgunes Nuriman

Keyword(s):

Vitamin D ◽

Steady State ◽

Healthy Children ◽

Cell Disease ◽

Vitamin D Levels ◽

Tnf Α ◽

Normal Vitamin ◽

Group 3 ◽

Group 2 ◽

Group 1

Abstract Sickle Cell Disease (SCD) is characterized by periodic vaso-occlusive crises, chronic hemolysis and frequent infections that are accompanied by pain and organ damage. Inflammation has substantial role in SCD pathogenesis. Patients exhibit elevated leukocyte counts, abnormal activation of granulocytes, monocytes, and endothelial cells, and increased levels of multiple inflammatory mediators. Vitamin D, a secosteroid hormone synthesized in the skin or derived from nutritional sources, serves a variety of functions that include immunomodulation, bone homoeostasis and wound healing. Deficiency of vitamin D has been linked to autoimmune diseases, carcinogenesis, and importantly, different inflammatory diseases. Vitamin D deficiency is seen frequently in patients with SCD. However, relationship between inflammation and vitamin D deficiency in SCD pathogenesis has not been investigated, yet. In this study, we aimed to investigate the relation between vitamin D levels and inflammation in children with SCD. For this purpose, 64 patients with SCD, 21 SCD trait, and 21 healthy controls were included in this study. The local ethics committee approved the study and informed consent was obtained from the children and parents. Vitamin D status was expressed as low, if plasma vitamin D levels were lower than 20 ng/ml. The SCD patients were grouped as Group 0 which includes steady state patients with low vitamin D levels (n=21), Group 1 which includes vaso-occlusive crisis patients with low vitamin D levels (n=18), Group 2 which includes steady state patients with normal vitamin D levels (n=16), Group 3 which includes vaso-occlusive crisis patients with normal vitamin D levels (n=9). The SCD trait patients were grouped in Group 4 and healthy children were grouped in Group 5. Levels of vitamin D and inflammatory parameters were determined in all groups; bone parameters were studied in SCD patients and SCD traits. WBC count and levels of CRP, IL-2, IL-4, IL-6, IL-10, IL-12, TNF-α and IFN-γ were determined as inflammatory markers. Vitamin D levels lower than 20 ng/ml were found in 61% of SCD patients, in 33% of SCD traits and in 84% of healthy children. We could not find any relation between vitamin D levels and WBC, CRP and bone markers in SCD patients. Vitamin D is correlated to TNF-α in Group 0 (R=0.589 and P=0.005), to IL-10 in Group 1 (R=0.612 and P=0.046), to IL-12 in Group 2 (R=-0.549 and P=0.028) and to IL-4 (R=0.695 and P=0.038) and IL-6 (R=0.865 and P=0.003) in Group 3. TNF-α levels were higher in the groups who had vaso-occlusive crises (Group 1 and 3) than the groups who were at steady state (Group 0 and 2). Vaso-occlusive crisis are the result of interactions between sickle erythrocytes, inflammatory cytokines and endothelium. Deficiency of vitamin D that has effects on endothelial dysfunction and cytokines, has possibly contributed to the pathogenesis of SCD. However, we could not show a concrete association between vitamin D and inflammation, possibly there are other molecules or markers modulating this association. Additionally our patient number may not be high enough to show this association. Our study is valuable for it's the first study on investigating the possible association between vitamin D and inflammation in SCD. Research on this topic should be continued with larger groups and novel biomarkers. Disclosures No relevant conflicts of interest to declare.

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The prognostic value of visually assessing enamel microcracks: Do debonding and adhesive removal contribute to their increase?

The Angle Orthodontist ◽

10.2319/021115-93.1 ◽

2016 ◽

Vol 86 (3) ◽

pp. 437-447 ◽

Cited By ~ 10

Author(s):

Irma Dumbryte ◽

Tomas Jonavicius ◽

Laura Linkeviciene ◽

Tomas Linkevicius ◽

Vytaute Peciuliene ◽

...

Keyword(s):

Control Group ◽

Naked Eye ◽

Room Illumination ◽

Before And After ◽

Ceramic Brackets ◽

Group 3 ◽

The Mean ◽

Group 2 ◽

Adhesive Removal ◽

Group 1

ABSTRACT Objective: To find a correlation between the severity of enamel microcracks (EMCs) and their increase during debonding and residual adhesive removal (RAR). Materials and Methods: Following their examination with scanning electron microscopy (SEM), 90 extracted human premolars were divided into three groups of 30: group 1, teeth having pronounced EMCs (visible with the naked eye under normal room illumination); group 2, teeth showing weak EMCs (not apparent under normal room illumination but visible by SEM); and group 3, a control group. EMCs have been classified into weak and pronounced, based on their visibility. Metal brackets (MB) and ceramic brackets (CB), 15 of each type, were bonded to all the teeth from groups 1 and 2. Debonding was performed with pliers, followed by RAR. The location, length, and width of the longest EMCs were measured using SEM before and after debonding. Results: The mean overall width (Woverall) was higher for pronounced EMCs before and after debonding CB (P < .05), and after the removal of MB. Pronounced EMCs showed greater length values using both types of brackets. After debonding, the increase in Woverall of pronounced EMCs was 0.57 µm with MB (P < .05) and 0.30 µm with CB; for weak EMCs, − 0.32 µm with MB and 0.30 µm with CB. Conclusions: Although the teeth having pronounced EMCs showed higher width and length values, this did not predispose to greater EMCs increase after debonding MB and CB followed by RAR.

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