scholarly journals Microangiopathy in Naifold Videocapillaroscopy and Its Relations to sE- Selectin, Endothelin-1, and hsCRP as Putative Endothelium Dysfunction Markers among Adolescents with Raynaud’s Phenomenon

2019 ◽  
Vol 8 (5) ◽  
pp. 567 ◽  
Author(s):  
Stanislaw Gorski ◽  
Marta Bartnicka ◽  
Anna Citko ◽  
Beata Żelazowska-Rutkowska ◽  
Konrad Jablonski ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Raynaud’S Phenomenon ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Raynaud's Phenomenon ◽  
Endothelial Damage ◽  
Control Group ◽  
Endothelium Dysfunction ◽  
Endothelin 1

The aim of this study was to analyze the relationship between the qualitative abnormalities on nailfold videocapillaroscopy (NVC), and the concentrations of selected biomarkers (sE-selectin, endothelin-1, high-sensitivity c-reactive protein (hsCRP)) and lipid metabolism parameters in children and adolescents with Raynaud’s phenomenon (RP). Raynaud’s phenomenon, to assess whether nailfold capillary changes may reflect the degree of systemic blood vessel abnormalities. The study group included 66 patients (34 undifferentiated—uRP and 32 secondary—sRP) aged 6–19 years and the control group. In both groups, NVC was performed and the selected biomarkers were measured (sE-selectin, endothelin-1, hsCRP) and lipid profile. Endothelin-1, sE-selectin and hsCRP concentrations in patients from both RP groups were significantly higher; concentration of HDL fraction was significantly lower compared with the control group. The analysis of multiple linear regression demonstrated that megacapillaries most strongly determine the sE-selectin value (p = 0.04) and hsCRP (p = 0.03). Both the total cholesterol and low-density lipoprotein (LDL) fraction concentrations were determined by the presence of avascular areas (p = 0.02). In conclusion, specific pathologic NVC changes were associated with higher endothelial damage biomarkers concentration and adverse changes in the lipid profile.

Effect of Turmeric and Ginger on Lipid Profile in Male Rats Exposed to Oxidative Stress

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Eman A. Al-Rekabi ◽  
Dheyaa K. Alomer ◽  
Rana Talib Al-Muswie ◽  
Khalid G. Al-Fartosi
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Drinking Water ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density

The present study aimed to investigate the effect of turmeric and ginger on lipid profile of male rats exposed to oxidative stress induced by hydrogen peroxide H2O2 at a concentration of 1% given with consumed drinking water to male rats. Methods: 200 mg/kg from turmeric and ginger were used, and the animals were treatment for 30 days. Results: the results showed a significant increase in cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), whereas it explained a significant decrease in high density lipoprotein (HDL) of male rats exposed to oxidative stress when compared with control group. the results showed a significant decrease in cholesterol, triglycerides, (LDL), (VLDL), whereas it explained a significant increase in (HDL) of rats treated with turmeric and ginger at dose 200 mg/kg when compared with male rats exposed to oxidative stress.

scholarly journals Effect of Whole Quail (Coturnix japonica) Egg Consumption on some Reproductive Parameters and Lipid Profile of Male Albino Rat (Rattus norvegicus)

2017 ◽  
Vol 9 (3) ◽  
pp. 315-320 ◽  
Author(s):  
Chidozie N. OKOYE ◽  
Samuel O. EKERE ◽  
Onyinyechukwu A. AGINA ◽  
Ikechukwu J. UDEANI ◽  
Chukwunonso K. EZEASOR
Keyword(s):  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Low Density ◽  
Epididymal Sperm ◽  
Treatment Groups ◽  
Egg Consumption ◽  
Group A ◽  
The Mean

The present study evaluated the effect of whole egg consumption on the liver, testes, cauda epididymal sperm reserve and lipid profile of male rats. These evaluations were carried out on adult twenty (20) male albino rats, which were randomly selected into four groups of 5 rats each, designated groups A, B, C and D. Group A was the control group and received only equivalent volume of distilled water, while groups B, C and D received 0.25mg/kg, 0.5mg/kg; and 1.0mg/kg body weight of the quail egg respectively. Standard procedures were carried out in the tissue processing, cauda epididymal sperm reserve and in lipid profile determinations. On days 35 and 49, the mean serum total cholesterol value of group D was significantly lower than that of the control group. On day 35, the mean serum low density lipoprotein and high density lipoprotein (LDL and HDL cholesterol) values of all the treatment groups were significantly lower and higher than that of the control group, respectively. However, on days 49 and 63, the mean serum very low density lipoprotein (VLDL cholesterol) and triglyceride values of all the treatment groups were significantly higher than that of the control group. A significant increase in cadual epididymal sperm count (CESR) was recorded on day 63 at the mid and high doses. No obvious pathological lesions were observed in the histomorphology of the testes and liver when compared to the control. Therefore, whole quail egg consumption caused an increase in serum triglyceride and very low density lipoprotein concentration, and also improved fertility. In other words, prolonged consumption of quail egg should be done with caution as it may predispose one to cardiovascular disease.

scholarly journals Cytomegalovirus Infection as Risk of Atherogenic Lipid Profile in Iraqi Aborted Women

2020 ◽  
Vol 31 (2) ◽  
pp. 47-51
Author(s):  
Dalya Basil Hanna ◽  
Huda Jaber Waheed ◽  
Zahraa Qasim Ali ◽  
Maysaa Ali Abdul Khaleq
Keyword(s):  
Lipid Profile ◽  
Cytomegalovirus Infection ◽  
Density Lipoprotein ◽  
Predictive Marker ◽  
Endothelial Damage ◽  
Control Group ◽  
Cmv Infection ◽  
Significant Elevation ◽  
Monocyte Chemoattractant Protein 1 ◽  
Significant Difference

Introducion: Atherosclerosis is a form of the cardiovascular diseases which may occur due to a chronic inflammatory reaction to endothelial damage caused by multiple causes which include infection by microorganisms like Cytomegalovirus (CMV). Methods: The present study aims to evaluate the effect of cytomegalovirus infection in patients and its relation to atherosclerosis and to measure the monocyte chemoattractant protein-1 (MCP-1) as a predictive marker for inflammatory process. A total of 30 women who were attending the Gynecology outpatient clinics and were suffering from abortion for first time or with recurrent abortion due to CMV infection were enrolled in the current study. For comparison, twenty blood samples were collected from healthy apparent women as a control group in this study. Serum MCP-1, IL-6 and CMV-IgM were measured by using ELISA technique. Lipid profile which includes total cholesterol, triglycerides, high density lipoprotein (HDL), and low density lipoprotein (LDL) was measured by spectrophotometer. Results: The results of this study showed a significant difference in mean of IL-6 in patients was (570.67 ± 199.27) when compared to control group (pÃ0.0001). While there is no significant difference of MCP-1 level between patients and control group (P=0.134). And the results showed a significant elevation of cholesterol (P<0.05) and a highly significant elevation of triglyceride and LDL in CMV infected patients (P<0.01), while no elevation occurred in HDL values (P=0.977). Conclusion: According to the present data there is a correlation between CMV infection and atherosclerosis. Bangladesh J Medicine July 2020; 31(2) : 47-51

scholarly journals Plasma lipid profile of mice fed diet supplemented with broiler fat

2014 ◽  
Vol 43 (1) ◽  
pp. 21-24 ◽  
Author(s):  
GB Das ◽  
ME Hossain ◽  
MA Akbar
Keyword(s):  
Lipid Profile ◽  
Palm Oil ◽  
Low Density Lipoprotein ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Dietary Treatment ◽  
Blood Lipid ◽  
Blood Cholesterol ◽  
Control Group ◽  
Blood Lipid Profile

This study was conducted with 180 female Swiss albino mice to examine the effects of supplementing broiler fat in the diets of mice on blood lipid profile. Twenty one days old mice were collected from ICDDRB, Mohakhali, Dhaka. They were randomly distributed in four groups having three replications each. Each replicate group had 15 mice. Results revealed that supplementation of broiler fat in mice diet significantly changed (p<0.05) triglyceride (TG) and low density lipoprotein (LDL) among groups. The control group (T0) had the highest level of cholesterol and LDL. Cholesterol, TG and LDL markedly increased (p<0.05) in all dietary treatment groups, while high density lipoprotein (HDL) significantly (p<0.01) decreased after supplementation of experimental diets. It was concluded that all the dietary treatments in general increased blood cholesterol, TG and LDL in mice fed broiler fat with different oil supplements. However, the soybean and palm oil group was comparatively better than other groups in respect of cholesterol, HDL and LDL at the blood lipid profile of mice. Therefore, it can be concluded that consumption of broiler fat with soybean and palm oil could be less harmful for mice.DOI: http://dx.doi.org/10.3329/bjas.v43i1.19380 Bang. J. Anim. Sci. 2014. 43 (1): 21-24

scholarly journals Effect of Parkia biglobosa seed on lipid profile of dexamethasone-treated pregnant rats

2021 ◽  
Vol 8 (3) ◽  
pp. 030-039
Author(s):  
Funmilola Comfort Oladele ◽  
Bashirat Motunrayo Oluokun ◽  
Omotola Blessing Adam
Keyword(s):  
Lipid Profile ◽  
Plasma Glucose ◽  
Animal Feed ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Low Density ◽  
Open Market ◽  
Parkia Biglobosa ◽  
Pregnant Rats

This study was aimed at evaluating the effect of Parkia biglobosa seed on dexamethasone-treated pregnant rats. Locust bean seeds were purchased from an open market in Ado Ekiti, Nigeria. It was processed and ground into powder which was subsequently used in formulating feed for experimental animals. Fifteen female pregnant rats were divided in three groups of five each. Animals in group A were exposed to standard animal feed only. This served as the control group. Those in group B were exposed to animal feed mixed with locust beans + 0.3 mg/kg body weight of dexamethasone, while those in group C were exposed to animal feed mixed with locust beans. At the end of eight days treatment, animals were sacrificed and blood sample was collected into EDTA bottles and centrifuged. Plasma was separated and used for the determination of glucose and lipid profile. Exposure of animals to dexamethasone was observed to significantly (p<0.05) increased the concentration of plasma glucose concentration when compared with the control as well as animals treated with P. biglobosa only. Animals treated with dexamethasone along with P. biglobosa were observed to have higher concentrations of triglyceride, total cholesterol, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) when compared with those in animals in the control group as well as those treated with P. biglobosa only. Observations from this study revealed that dexamethasone adversely perturbed and unhinged plasma glucose and lipid profile in female pregnant rats while P. biglobosa-formulated diet was observed to be a potent hypoglycemic and hypolipidemic agent.

scholarly journals Effect of COVID-19 on Lipid Profile and its Correlation with Acute Phase Reactants

2021 ◽  
Author(s):  
Jahanzeb Malik ◽  
Uzma Ishaq ◽  
Talha Laique ◽  
Amna Ashraf ◽  
Asmara Malik ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Acute Phase ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Control Group ◽  
Acute Phase Reactants ◽  
And Gender ◽  
Thyroid Profile ◽  
A Prospective Study

Background and Objective Coronavirus disease 2019 (COVID-19) manifests as multiple clinical and pathological organ dysfunctions. It also disrupts metabolic profile due to the release of pro-inflammatory cytokines causing a systemic inflammation reaction. However, the development and correlation of dyslipidemia with acute phase reactants is unknown. This investigation was performed to assess the pathological alterations of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein (HDL), triglycerides, and total cholesterol levels in COVID-19 patients. Methods This was a prospective study performed on real-world patients to assess serum levels of LDL-C, HDL, TG, TC on COVID-19 patients (mild: 319; moderate: 391; critical: 357) hospitalized at our center between April 2020 through January 2021. Age- and gender-matched controls who had their lipid profiles in the same period were included as the control group. Results LDL-C, HDL, TG, and TC levels were significantly lower in COVID-19 patients when compared with the control group (P < 0.001, 0.047, 0.045, < 0.001, respectively). All parameters decreased gradually with COVID-19 disease severity (LDL-C: median (IQR), mild: 98 (91,134); moderate: 97 (81,113); critical: 68 (68,83); HDL: mild: 45 (37,50); moderate: 46 (41,50); critical: 40 (37,46); TG: mild: 186 (150,245); moderate: 156 (109,198); critical: 111 (98,154); TC: mild: 224 (212,238); moderate: 212 (203,213); critical: 154 (125,187)). LDL-C, TC, and TG were inversely correlated with acute phase reactants (interleukin-6 (IL-6), Procalcitonin, C-reactive protein (CRP), and D-dimers). Logistic regression demonstrated lipid profile, thyroid profile, and acute phase reactants as predictors of severity of COVID-19 disease. Conclusion Hypolipidemia develops in increasing frequency with severe COVID-19 disease. It inversely correlates with levels of acute-phase reactants, indicating SARS-COV-2 as the causative agent for alteration in lipid and thyroid levels.

scholarly journals Effects of Nigerian Piliostigma thonningii Species Leaf Extract on Lipid Profile in Wistar Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
O. M. Ighodaro ◽  
J. O. Omole
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Leaf Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cardiovascular Complications ◽  
Control Group ◽  
Piliostigma Thonningii ◽  
Aqueous Leaf Extract

Cardiovascular complications and associated conditions remain a major cause of death, globally. Piliostigma thonningii has been used for different and several medicinal purposes. On this background, the effect of aqueous leaf extract of the plant on the lipid profile of physiologically normal rats was examined. Graded doses of the extract, 0.0, 0.2, and 0.4 g/kg of body weight (bwt) were orally administered to rats for a period of 14 days. The effect of the extract was assessed on the basis of comparative determinations of the evaluated indices in treated rats vis-à-vis the nontreated group as well as in respect to the differences between the basal and final concentrations of the indices in each group. The extract, especially at 0.2 g per kg body weight caused a significant decrease in the total cholesterol, triglycerides, and low-density lipoprotein (LDL) cholesterol in the treated rats when compared to the control group and basal concentrations. Though, the level of high-density lipoprotein (HDL) cholesterol increased in the treated rats, the increase was not significant when compared to the basal concentration. The LDL/HDL ratio in all the experimental groups was less than 0.9. The results obtained in this study suggest that P. thonningii aqueous leaf extract likely contains antilipidaemic and anticholesterolaemic substance(s), which may be useful in the prophylactic and curative management of lipid peroxidation, high blood pressure, and cardiovascular disorders.

scholarly journals The effect of different intensities of magnetically treated water on lipid profile of Turkish- Awassi rams

2012 ◽  
Vol 36 (0A) ◽  
pp. 181-186
Author(s):  
Suad A. Jashamy
Keyword(s):  
Lipid Profile ◽  
Blood Sample ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Experimental Period ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Treated Water ◽  
The Third

A total of 15 Turkish- Awassi rams at ages ranged 2 - 2.5 years, and their weight rangedbetween 79.5 – 80.3 kg, Rams were randomly divided into 3 equal groups of 5 rams eachgroup. The first group were taken1000 while the second group were taken 2000 gaussmagnetic water, the third group were taken normal streaming water which is considered as a(control group). Blood sample were taken at the beginning of the experiment, and repeatedevery two weeks during the experimental period (four months). Results revealed that treatedthe rams with magnetically treated water resulted in significantly decreased (p<0.01) incholesterol (1.78-4.08), triglycerides (0.94-0.054), low density lipoprotein (LDL) (1.4-0.2),Very low density lipoprotein (VLDL) (1.87-0.14) and significant increase (p<0.01) in highdensity lipoprotein (HDL)(0.17-0.49) .It could be concluded that rams received magneticallytreated water resulted in significant improvement in level of lipid involved in this experiment.

scholarly journals Randomized Control Trial Study On The Effect Of Wet Cupping On Lipid Profile

2020 ◽  
Vol 16 (2) ◽  
Author(s):  
Suhaily MH ◽  
Ismail AA ◽  
Najib MY
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Controlled Trial ◽  
Low Density Lipoprotein ◽  
Venous Blood ◽  
Intervention Group ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
The Third

Introduction: Dyslipidaemia is one of the risk factors contributing to the pathogenesis of cardiovascular   diseases (CVDs). This study was conducted to investigate the effect of wet cupping on lipid profile. Methods: This randomized controlled trial was conducted in 2012 at the School of Medical Sciences, Universiti Sains Malaysia, Malaysia. Sixty-two healthy volunteers ranging from 30 to 60 years old were randomized into control and intervention groups. Subjects in the intervention group were assigned to two sessions of wet cupping at the beginning of the study and at the third month; individuals in the control group did not undergo any cupping procedure. Venous blood sample was collected for serum lipid profile: Total Cholesterol (TC), High Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol (LDL-C), and triglycerides; measured at baseline, first, third and fourth month. Results: Subjects in the cupping group had significant improvements from baseline to third and fourth month for TC (MD=-0.56, P=0.004), HDL-C (MD=-0.22, P<0.001) and LDL-C (MD=0.58, P=0.001). There was also a significant reduction from baseline to one month for triglycerides (MD=0.38, P<0.001). Subjects in the cupping group had significantly better values in HDL-C and LDL-C as compared with the control group at the third and fourth month. Significantly lower levels of TC and triglycerides in the cupping group of the fourth month. In the control group, there were no significant changes in any serum lipid profiles. Conclusion: After two sessions of wet cupping, TC, HDL-C, LDL-C and triglycerides were significantly improved by 8.2%, 13.7%, 16.4% and 20.8% respectively.

scholarly journals Influence of the polymorphism of apolipoprotein E in cerebral vascular disease

2003 ◽  
Vol 61 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Dorotéia R.S. Souza ◽  
Bernadete F. Campos ◽  
Érika F. de Arruda ◽  
Lucy J. Yamamoto ◽  
Daniel M. Trindade ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Lipid Profile ◽  
Clinical Symptoms ◽  
Statistical Significance ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Reduced Frequency ◽  
Apo E ◽  
The Relationship

The genetic heterogeneity of apolipoprotein E (apo E) has been associated with lipid profile and atherothrombotic stroke, however this association remains inconclusive. OBJECTIVE: To evaluate the relationship between the isoforms of apo E and atherothrombotic stroke, by ascertaining the frequency of its alleles and genotypes associated with the lipid profile in patients with stroke. METHOD: A total of 207 individuals were divided into two groups, consisting of 107 patients with stroke and 100 individuals without clinical symptoms of the disease. Blood samples were taken from patients and controls for molecular investigation of the apo E (epsilon2, epsilon3 and epsilon4 alleles) for the analysis of the lipid profile. RESULTS: The epsilon3 allele was the most common and its prevalence was significantly higher in patients (0.93) compared to the controls (0.86; p=0.024). The epsilon2 allele was rarely seen specifically in patients (0.02 versus 0.05 in controls, p=0.191). The epsilon4 allele was not associated with stroke showing a reduced frequency in patients (0.05) when compared to controls (0.09; p=0.011). Although higher average levels of lipid profile were found in patients when compared to controls, with statistical significance for the values of total cholesterol (TC) (203.6mg/dL±57.98 and 181.9mg/dL±68.47 respectively; p=0.003) and low-density lipoprotein cholesterol (LDLc) (131.4mg/dL±52.60 and 116mg/dL±56.38, respectively; p=0.014), these were independent of the presence of the epsilon4 allele. In control group the higher TC and LDLc values occurred in the absence of the epsilon4 allele, confirming the conflicting effect of the alleles of apo E on the plasmatic lipids and atherothrombotic stroke. CONCLUSION: The isoforms of apo E cannot be regarded as an isolated risk factor for stroke and do not show association with lipid profile in this study.

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