Outcomes of Total Hip Arthroplasty in Patients with Osteonecrosis of the Femoral Head Following Surgical Treatment of Brain Tumors

Corticosteroids have been widely used in patients with brain tumors to reduce tumor-associated edema and neurological deficits. This study examined the outcomes of total hip arthroplasty (THA) in patients with osteonecrosis of the femoral head (ONFH) following brain tumor surgery. We identified 34 THAs performed in 26 patients with steroid-induced ONFH among 9254 patients undergoing surgical treatment for primary brain tumors. After propensity score matching with demographics, 68 THAs (52 patients) in ONFH unrelated to brain tumors were selected as the control group. At the time of THA, 54% of brain tumor patients had neurological sequelae and 46% had adrenal insufficiency. After THA, patients with brain tumor required longer hospital stay, reported a lower functional score, and showed a higher rate of heterotopic ossification compared to the control group. However, hip pain score improved significantly after THA in the brain tumor group, and did not differ from that of the control group (P-value = 0.168). Major complication rates were similar (2.9% and 1.5% for the brain tumor and control groups, respectively; P-value = 1.000), and implant survivorships were not different at 7 years (100% and 98.1% for the brain tumor and control groups, respectively; P-value = 0.455). Our findings suggest that THA can be safely performed to reduce hip pain in patients with steroid-induced ONFH after surgical treatment of primary brain tumors.

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PENGGUNAAN SELAPUT AMNION SEGAR PADA INSISI LUKA OPERASI SEKSIO SESAREA

JOURNAL OBGIN EMAS ◽

10.25077/aoj.1.2.47-55.2017 ◽

2019 ◽

Vol 1 (2) ◽

pp. 47-55

Author(s):

Syahredi Syaiful Adnani ◽

Hafni Bachtiar

Keyword(s):

Wound Healing ◽

Caesarean Section ◽

Amniotic Membrane ◽

Healing Time ◽

Cost Of Care ◽

Control Group ◽

P Value ◽

Control Groups ◽

And Control ◽

Wound Healing Time

In the last few decades, the incidence of caesarean section is increasing in the world, especially in Indonesia. One of the way to treat tissue scar is through biologic and synthetic dressing where nowadays, amnion has been used as biologic dressing frequently. This study was conducted to determine the effect of the use of fresh amniotic membrane on wound incision Caesarean section compared with Caesarean section incision wound covered using regular gauze bandages and fixated with plaster in RS. Dr. Reksodiwiryo Padang. The design of this study is an experimen-tal study with Post test design with control group design. Sampling was done using a formula consecutive sampling two different test samples obtained an average of 72 people for each group. The analysis used include univariate and bivariate analyzes. The average wound healing time the difference was statistically significant (p value <0.05) in the treatment and control groups. There was highly significant difference in the proportion of local infection on day 3 between the treatment and control groups (p value <0.05). There were very significant differences in the proportion of local allergic reactions at day 3, and 5 between the treatment and control group (p <0.05). There are significant differences in terms of the cost of care per day between treatment and control groups (p <0.05). From this study, the average wound healing time has a very significant difference.Keywords: Fresh Amniotic Membrane, Wound Cesarean Section, Wound Healing

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Effect of an extract of Aloe vera on the biodistribution of sodium pertechnetate (Na99mTcO4) in rats

Acta Cirurgica Brasileira ◽

10.1590/s0102-86502009000500008 ◽

2009 ◽

Vol 24 (5) ◽

pp. 383-386 ◽

Cited By ~ 5

Author(s):

Cecília Maria de Carvalho Xavier Holanda ◽

Monique Batista da Costa ◽

Natália Chilinque Zambão da Silva ◽

Maurício Ferreira da Silva Júnior ◽

Vanessa Santos de Arruda Barbosa ◽

...

Keyword(s):

Aqueous Extract ◽

Aloe Vera ◽

Treated Group ◽

Control Group ◽

Blood Levels ◽

Control Groups ◽

High Increase ◽

Tropical Plant ◽

And Control ◽

The Brain

PURPOSE: Aloe vera is a tropical plant popularly known in Brazil as babosa. We have investigated the effect of aqueous extract of Aloe vera on the biodistribution of Na99mTcO4 and laboratorial parameters in Wistar rats. METHODS: Twelve animals were divided into treated and control groups. In the treated group, Aloe vera was given by gavage (5mg/mL/day) during 10 days. The control group received sorbitol by the same way and period. One hour after the last dose, we injected 0.1mL of Na99mTcO4 by orbital plexus. After 60 min, all the animals were killed. Samples were harvested from the brain, liver, heart, muscle, pancreas, stomach, femur, kidneys, blood, testis and thyroid and the percentage of radioactivity (%ATI/g) was determined. Biochemical dosages were performed. RESULTS: There was a significant increase of %ATI/g in blood, femur, kidneys, liver, stomach, testis and thyroid and also in blood levels of AST and ALT. A significant decrease in levels of glucose, cholesterol, triglycerides, creatinine and urea occurred. The statistical analyses were performed by Mann-Whitney test and T-Student test (p<0.05). CONCLUSION: The aqueous extract of Aloe vera facilitated the uptake of Na99mTcO4 in organs of rats and it was responsible to a high increase of levels of AST and ALT.

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Android-Based Education toward the Role of Postpartum Primipara Mothers in Fulfilling the Independent Perinium Care

Women, Midwives and Midwifery ◽

10.36749/wmm.1.2.55-67.2021 ◽

2021 ◽

Vol 1 (2) ◽

pp. 55-67

Author(s):

Werna Nontji ◽

Dwi Kartika Sari ◽

Sitti Maria Ulfa ◽

Syafruddin Syarif ◽

Inez Vravty Lestari ◽

...

Keyword(s):

Treatment Group ◽

Intervention Group ◽

Wilcoxon Test ◽

Control Group ◽

P Value ◽

Control Groups ◽

Post Test ◽

Android App ◽

And Control ◽

Perineal Care

Background: Educating mothers during their postpartum period could potentially help them to overcome some important phases after giving birth. The process of education is evaluated based on the mothers’ knowledge about their independent self-care. Independency is an activity that is started individually and is done based on self-capability. The independency in the postpartum care is not only important to decrease the mother’s mortality and morbidity rate, but it is also crucial to strengthen and improve the post-partum mother’s healthy behavior during the perineal care. Providing education using Android-based application called BUBI Care could be potential to facilitate a more dynamic transfer of knowledge to the postpartum mothers.Aims: To analyze the knowledge, skills, and independence of primipara postpartum mothers in independent perineal care before and after accessing BUBI Care app. Research Method: employing quasi experimental research with pre-test and post-test design with control group design. The sample for this research were 19 pregnant mothers TM III (pregnancy age of ? 38 weeks) on each group. The treatment group was educated using BUBI Care Android app that was conducted at one of Public Health Center. The control group was educated without BUBI Care that was conducted at a Midwife Practice Clinic. The research was conducted on September to October 2020. Study Result: According to the Wilcoxon test, there was a difference in the pre-test knowledge of the treatment and control groups with the similar median of 53 and p-value of 0.666, the treatment group showed their scores improved to 80 on the post-test while the control group stayed at 53 with the p-value of 0.000. It means that BUBI Care app education influences the post-test. On the other hand, the perineal care skill saw a difference between the intervention and control groups. The intervention group had a mean of 70.05 and 56.68 for the control group with the p-value of 0.002 which means that there was an influence from the BUBI Care app education. Additionally, Mann Whitney test showed that the intervention group had a mean score of 78.95, but the control group only had 49.26, the total difference between the two are 29.69 with the p-value of 0.000. It can be concluded that there is a significance in difference in the independency rate from the provision of BUBI Care Android app education.Conclusion: there is a significance effect on the intervention group in terms of Android based usage.

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Pirzi Doll”: A Method for Increasing Children’s Knowledge and Attitude in Balanced Nutrition

International Journal of Recent Technology and Engineering - 2 ◽

10.35940/ijrte.b1036.0982s919 ◽

2019 ◽

Vol 8 (2S9) ◽

pp. 165-169

Keyword(s):

Nutrition Education ◽

Control Group ◽

P Value ◽

Nutritional Education ◽

Control Groups ◽

School Aged Children ◽

The Mean ◽

Knowledge And Attitude ◽

And Control ◽

Experimental Group

Nutrition is one of the main problems in the world, where the number of malnourished patients reaches less than 104 million children and one third of all causes of child mortality worldwide are still caused by malnutrition. Nutrition knowledge in school-aged children is one of the factors determining patterns food consumption and nutritional status. Nutrition education in school-aged children can improve children's nutritional knowledge and play a role in food selection and eating habits. Nutrition education should start from an early age. Nutrition and health education began to be directed at kindergarten and elementary school students, since this age group has a habit of attitude that is relatively easy to be formed. This study aims to determine the effect of nutrition education by story’s telling with pirzi doll media to increase knowledge and attitude of children about balanced nutrition. This study used quasi-experimental design with two group pre and post-test design sampling was carried out with a systematic random sampling. Sample of research were children enrolled in Kindergarten IT Rabbani and IT Menara Fitrah in Ogan Ilir District. There were 37 samples on control group dan 39 samples on experimental group. The results of statistical analysis using Mann-Whitney test. The mean score of knowledge after being given a nutritional education was 26.15 ± 3.10 in the experimental group and in the control group was 26.05± 3.16 (p-value=0.817). The mean score of attitudes after being given a nutritional education was 13.69 ± 1.97 in the experimental group and in the control group was 11.24 ± 3.67 (p-value=0.002). There was no difference in mean score of knowledge between the experimental and control groups after being given a nutritional education. There was a difference in mean values of attitudes between the experimental and control groups after being given a nutritional education.

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The significance of polymorphisms of gene coagulation factors VII and XIII in the pathogenesis of non-traumatic avascular necrosis of the femoral head

Genij Ortopedii ◽

10.18019/1028-4427-2021-27-1-43-47 ◽

2021 ◽

Vol 27 (1) ◽

pp. 43-47

Author(s):

M.A. Panin ◽

◽

N.V Zagorodnii ◽

A.V. Boiko ◽

L.M. Samokhodskaya ◽

...

Keyword(s):

Femoral Head ◽

Avascular Necrosis ◽

Coagulation Factors ◽

Group Differences ◽

Unknown Etiology ◽

Control Group ◽

Study Group ◽

Control Groups ◽

Aseptic Necrosis ◽

And Control

Introduction Non-traumatic avascular necrosis of the femoral head (ANFH) is a poly-etiologic and socially significant disease in the age of 20 to 50 years and is associated with disability. Research on the identification of necrosis causes/predictors is a relevant issue. Purpose To study the contribution of polymorphisms in the genes of coagulation factors F7 and F13 in the aetiology of non-traumatic avascular necrosis of the femoral head. Methods Polymorphisms of the genes of coagulation factors F7 and F13 were studied; comparative analysis of the frequency of important allelic variants of F7genes (Arg353Gln) and F13 (Val134Leu) in patients with a verified diagnosis of aseptic necrosis (study group) and in healthy patients (control group) was performed. The study group included 41 patients (all males) with aseptic necrosis of the femoral head of unknown etiology. Results The frequency of gene alleles in the F7 Arg353Gln in the study group were: GG in 30 out of 41 patients (73.2 %), GA in 11 out of 41 patients (26.8 %), and none of 41 patients had a polymorphic variant AA. The frequency of alleles of this type of gene in the control group was as follows: GG in 7 out of 320 subjects (2.2 %), GA in 66 out of 320 patients (20.6 %), AA in 247 out of 320 (77.2 %). Significant differences were identified in the frequencies of homozygous genotypes, AA (χ2 = 100.215, p < 0.001) and GG (χ2 = 205.770, p < 0.001) in the study and control groups respectively. As for the heterozygous GA genotype, the differences were not significant (χ2 = 0.834, p = 0.362). The GG genotype of the gene Val134Leu F13 WAS 2.8 times more frequent in patients of the study group, differences were statistically significant (26.8 % against 9.7 %, χ2 = 10.388; p = 0.002). The presence of the TT genotype of the gene Val134Leu F13 was almost five times more frequent (χ2 = 18.956, p < 0.001) in healthy individuals (control group). Differences in the frequency of allele T in homo/ and heterozygous combinations (TT and GT) in the study and control groups was also significant (72.7 % vs 90.1 %, respectively, χ2 = 4.946, p = 0.027). Discussion Polymorphisms of coagulation factors genes F7 and F13 have a significant effect on the genesis of non-traumatic avascular necrosis of the femoral head. Risk factor of ANFH development is homozygous GG genotype in the gene Arg353Gln F7. Low probability of the disease is due to a protective role of AA genotype of the gene Arg353Gln F7 and TT genotype of the gene Val134Leu F13.

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THE EFFECT OF PRENATAL GENTLE YOGA AND HYPNOTHERAPY ON ANXIETY LEVEL AND SLEEP QUALITY IN THE THIRD TRIMESTER PREGNANT WOMAN AT PUSKESMAS SUMBER CIREBON REGENCY IN 2019

International Seminar of Gender Equity Maternal and Child Health ◽

10.34305/gemic.v1i1.311 ◽

2021 ◽

Vol 1 (1) ◽

pp. 32-38

Author(s):

Nurlaela Kurnia Rahayu ◽

Pepi Hapitria ◽

Rani Widiyanti

Keyword(s):

Sleep Quality ◽

Pregnant Women ◽

Intervention Group ◽

Anxiety Level ◽

Control Group ◽

P Value ◽

Third Trimester ◽

Control Groups ◽

The Third ◽

And Control

As the pregnancy gets older, the attention and thoughts of pregnant women begin to focus on something that is considered as a climax, so that the anxiety experienced will intensify just before the childbirth. Excessive anxiety and sleep disorders during pregnancy can cause mental disorders in pregnant women and inhibit fetal growth. To determine the effect of prenatal gentle yoga and hypnotherapy on anxiety level and sleep quality in the third trimester pregnant women. This is a quasi-experimental study with a pre-post test with a control group. The sample was 32 respondents consisting of 16 respondents as an intervention group and 16 respondents as a control group taken by purposive sampling. The analysis used was the Paired T-test. There is a difference in the average of anxiety level in the third trimester pregnant women in the intervention and control groups with a p value 0,000; there is a difference in the average of sleep quality in the third trimester pregnant women in the intervention and control groups with a p value 0,000; and there is no difference in the average of anxiety level and sleep quality in the third trimester pregnant women in the intervention and control groups with a p value 0,64. Prenatal Gentle Yoga and Hypnotherapy have an effect in reducing the anxiety level and improving the sleep quality in the third trimester pregnant women.

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DISTRACTION TECHNIQUES: TELLING STORIES TO DECREASE PAIN FOR PRESCHOOL CHILDREN DURING INFUSION

Jurnal Keperawatan Indonesia ◽

10.7454/jki.v22i1.887 ◽

2019 ◽

Vol 22 (1) ◽

pp. 23-30

Author(s):

Lina Dewi Anggraeni ◽

Widiyanti Widiyanti

Keyword(s):

Demographic Data ◽

Intervention Group ◽

Pain Scale ◽

Control Group ◽

P Value ◽

Pediatric Nurses ◽

Control Groups ◽

Analysis Technique ◽

Quasi Experimental ◽

And Control

Hospital procedures, such as infusions, are often associated with pain. Preschool-aged children who are hospitalized for infusions will often exhibit a strong fearful response because their concept of body integrity has not fully developed. One way to reduce the fear of infusion pain is by using stories as a distraction technique. The purpose of this study was to identify differences in the scale of pain between members of an intervention group, to which the distraction technique was applied, and a control group, to which it was not applied. The study used quasi-experimental methods, with intervention and control groups. The study was conducted on 46 preschool aged respondents (3-6 years old), divided into a 34 member intervention group and a 12 member control group and ran from September to December 2017 in one of the private hospitals in the East Bekasi. The research employed a questionnaire to collect demographic data and used the Wong-Baker Faces Pain Scale to assess pain levels. The data analysis technique used was the independent t-test. The results showed there was a difference of pain response between the intervention and control groups with P value < 0.05. Pediatric nurses are advised to use storytelling therapy as an option for providing atraumatic care intervention. Keywords: Distraction Technique, Infusion installation, Pain, Stories, Preschool Abstrak Teknik Distraksi: Bercerita Menurunkan Nyeri Pada Anak Usia Pra Sekolah Selama Penggunaan Infus. Rasa sakit seringkali dikaitkan dengan salah satu prosedur rumah sakit yakni pemasangan infus. Reaksi anak prasekolah yang dipasang infus menunjukkan ketakutan yang luar biasa, hal itu disebabkan karena konsep integritas tubuhnya belum berkembang dengan baik. Salah satu cara untuk mengurangi ketakutan akibat nyeri pemasangan infus pada prasekolah adalah teknik distraksi bercerita. Tujuan penelitian ini untuk mengidentifikasi perbedaan skala nyeri antara kelompok intervensi dan kelompok kontrol. Penelitian ini merupakan penelitian kuantitatif dengan metode quasy eksperimen, yang menggunakan kelompok intervensi dan kelompok kontrol. Penelitian dilakukan terhadap 46 responden usia prasekolah (3-6 tahun) yang terdiri dari 34 kelompok intervensi dan 12 kelompok kontrol dari bulan September-Desember 2017 di salah satu Rumah Sakit Swasta di wilayah Bekasi Timur. Instrumen penelitian menggunakan kuisioner data demografi dan lembar observasi skala nyeri Wong Baker Faces Pain. Teknik analisis data menggunakan Uji Independent T test.Hasil penelitian menunjukkan terdapat perbedaan respon nyeri antara kelompok intervensi dan kelompok kontrol dengan nilai p= 0,012 (< 0.05). Perawat anak sebaiknya menggunakan metode bercerita sebagai sarana asuhan keperawatan atraumatik. Kata kunci: Cerita, Nyeri, Pemasangan infus, Prasekolah, Teknik distraksi

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Prophylactic Effect of Memantine in Docetaxel Induced Neuropathy in Patients With Breast Cancer

10.21203/rs.3.rs-692391/v1 ◽

2021 ◽

Author(s):

Pegah Mohammadzadeh ◽

Elnaz Shaseb ◽

Zohreh Sanaat ◽

Parvin Sarbakhsh ◽

Nasrin Gholami ◽

...

Keyword(s):

Breast Cancer ◽

Peripheral Neuropathy ◽

Intervention Group ◽

Metastatic Breast ◽

Control Group ◽

P Value ◽

Control Groups ◽

Significant Difference ◽

And Control

Abstract Purpose Peripheral neuropathy is a complication of taxane that in severe cases can limit the optimal treatment. The aim of this study was to evaluate the efficacy of memantine in prevention of docetaxel induced peripheral neuropathy in patients with breast cancer. Methods In this randomized clinical trial, 40 women between the ages of 18 and 64 years with non-metastatic breast cancer (stages I to III) were included (registry number: IRCT20160310026998N9 and registry date: 26 March 2019). All patients were treated with the AC-T regimen (with docetaxel). Patients in intervention group received memantine at a dose of 20 mg for 8 weeks at the beginning of the first cycle of docetaxel. Patients in control group did not take any medication for neuropathy prevention. To assess the neuropathy, DN4 and CTCAE questionnaires were used at baseline, one months, three months and six months after the intervention. Results The DN4 questionnaire score was remarkably less in memantine group in follow up one (p-value: 0.033) and three (p < 00.1). The CTCAE follow up score did not change during study. The Neuropathy duration and Neuropathy onset, were shown significant difference between the intervention and control groups, p = 0.050 and p = 0.001, respectively. From 40 patients, 8 (40%) in memantine group and 2 (10%) in control group, did not experience any kind of neuropathy. Conclusion Data showed that prophylactic administration of memantine 20 mg/day has been effective in prevention of severity and incidence of docetaxel induced neuropathy in patients with breast cancer.

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A High Protein Model Alters the Endometrial Transcriptome of Mares

Genes ◽

10.3390/genes10080576 ◽

2019 ◽

Vol 10 (8) ◽

pp. 576 ◽

Cited By ~ 4

Author(s):

Boakari ◽

Ali ◽

Dini ◽

Loux ◽

Fernandes ◽

...

Keyword(s):

Ion Homeostasis ◽

Control Group ◽

P Value ◽

Epithelial Tissue ◽

Control Groups ◽

Urea Treatment ◽

Protein Model ◽

Group A ◽

Urea Group ◽

And Control

High blood urea nitrogen (BUN) decreases fertility of several mammals; however, the mechanisms have not been investigated in mares. We developed an experimental model to elevate BUN, with urea and control treatments (7 mares/treatment), in a crossover design. Urea-treatment consisted of a loading dose of urea (0.03 g/kg of body weight (BW)) and urea injections over 6 hours (0.03 g/kg of BW/h). Control mares received the same volume of saline solution. Blood samples were collected to measure BUN. Uterine and vaginal pH were evaluated after the last intravenous infusion, then endometrial biopsies were collected for RNA-sequencing with a HiSeq 4000. Cuffdiff (2.2.1) was used to identify the differentially expressed genes (DEG) between urea and control groups (false discovery rate-adjusted p-value < 0.1). There was a significant increase in BUN and a decrease of uterine pH in the urea group compared to the control group. A total of 193 genes were DEG between the urea and control groups, with five genes identified as upstream regulators (ETV4, EGF, EHF, IRS2, and SGK1). The DEG were predicted to be related to cell pH, ion homeostasis, changes in epithelial tissue, and solute carriers. Changes in gene expression reveal alterations in endometrial function that could be associated with adverse effects on fertility of mares.

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EFFECTIVENESS OF AN EDUCATIONAL PROGRAM ABOUT BREAST CANCER AND BREAST CANCER SELF-EXAMINATION ON PERCEPTION AND PRACTICE AMONG WOMEN IN ALJEERAIF WEST ADMINISTRATIVE UNIT (2)

10.36106/ijsr/4646294 ◽

2021 ◽

pp. 38-42

Author(s):

Amel Eltaib Elagib ◽

Ibrahim Ismail Mohammed ◽

SamiaYousif Idris ◽

Jaafar Abdelrahman Omar ◽

Somia Bilal Babiker ◽

...

Keyword(s):

Breast Cancer ◽

Educational Program ◽

Intervention Group ◽

T Test ◽

Control Group ◽

P Value ◽

Control Groups ◽

Administrative Unit ◽

Self Examination ◽

And Control

In Sudan, cancer incidence has been growing considerably in recent years and is likely to continue to grow creating a big burden on the health system resources. The aim of this study is to assess the baseline Perception and Practice about breast cancer and breast self-examination (BSE) and to nd out the effectiveness of an educational program about breast cancer and BSE on Perception and Practice among women in AlJeeraif West Administrative Unit. Community based intervention study with pre-post and control was carried out among 200 women who were recruited by means of multistage sampling. The sample size was divided equally into intervention and control groups. Baseline data was collected from both groups through direct interview, using structured close ended questionnaire. Educational program was implemented for the intervention group. Four months after the intervention, women in the study and control groups were exposed to the same questionnaire. Chi-square, paired t-test and independent t-test (difference of difference) were conducted in the course of the data analyses. There was statistically signicant difference in the intervention group pre-post program in all of the HBM components in the intervention group (p value0.000), while in the control group statistically signicant difference existed only in perceived barrier (p value.004) and perceived benet (p value.000) and over all perception (p value .016) with no signicant difference in other (HBM) components. In the intervention group practice and performance scores were highly signicant pre-post program (p value 0.000), where as in the control group only practice was signicant (p value 0.001). There were statistically signicant differences in the mean difference of performance, practice and perceptions between the intervention and control groups (p-value .000). The results of this study have conrmed the effectiveness of educational program based on the health belief model on improving perceptions and practice of breast cancer and breast self-examination.

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