Association of Two Indices of Insulin Resistance Marker with Abnormal Liver Function Tests: A Cross-Sectional Population Study in Taiwanese Adults

Background and objectives: Insulin resistance (IR) is frequently associated with chronic low-grade inflammation and has an important role as a mediator in the development of liver disease. Thus, this study aimed to explore the relationship between two indexes of IR and abnormal liver function parameters. Materials and Methods: This cross-sectional study obtained data of 41,510 men and 92,357 women aged ≥30 years from a private health screening institute in Taiwan. Two IR indexes namely triglyceride-glucose (TyG) index and triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio were used to examine their relationship to predict abnormal liver function parameters (aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and alkaline phosphatase (ALP)). Results: Positive trend was shown for the association of TyG index in the highest quintile (Q5) and risk of high AST (OR = 1.45, 95% CI: 1.33–1.57), high ALT (OR = 1.85, 95% CI: 1.73–1.97), high GGT (OR = 2.04, 95% CI: 1.93–2.15), and high ALP (OR = 1.13, 95% CI: 1.07–1.19) compared with the median quintile (Q3) in the fully adjusted model. Similarly, participants in the Q5 of the TG/HDL-C ratio were associated with 1.38 (95% CI: 1.27–1.49), 1.71 (95% CI: 1.61–1.82), 1.75 (95% CI: 1.66–1.84), and 1.21 (1.16–1.27) odds for having high AST, ALT, GGT, and ALP respectively. The AUC (95% CI) value of the TyG index for predicting high AST, high ALT, and high GGT was 0.699 (0.692–0.705), 0.738 (0.734–0.742), and 0.752 (0.749–0.755), respectively. Meanwhile, the AUC (95% CI) of the TG/HDL-C ratio for predicting high AST, high ALT, and high GGT was 0.680 (0.673–0.686), 0.738 (0.734–0.742), 0.734 (0.731–0.738), respectively. Conclusions: Our study supported that the TyG index and TG/HDL-C ratio may be useful as non-invasive methods to predict the existence of impaired liver function in the early stage.

Download Full-text

COVID-19 associated variations in liver function parameters: a retrospective study

Postgraduate Medical Journal ◽

10.1136/postgradmedj-2020-138930 ◽

2020 ◽

pp. postgradmedj-2020-138930

Author(s):

Ram Krishan Saini ◽

Neha Saini ◽

Sant Ram ◽

Shiv Lal Soni ◽

Vikas Suri ◽

...

Keyword(s):

Liver Injury ◽

Liver Function ◽

Liver Enzyme ◽

Inflammatory Markers ◽

Liver Enzymes ◽

Tertiary Care ◽

Abnormal Liver Function ◽

Gamma Glutamyl Transferase ◽

Number Of Patients ◽

Glutamyl Transferase

BackgroundCharacteristics of laboratory findings of COVID-19 patients are of great significance for diagnosis and treatment. Studies that have analysed the variations in hepatic profile in correlation with the inflammatory markers in SARS-CoV-2 are limited.MethodsWe retrospectively analysed liver function tests and inflammatory markers of 170 admitted patients with conﬁrmed COVID-19 in the tertiary care centre, Post Graduate Institute of Medical Education and Research (PGIMER), India, using Roche Cobas Autoanalyzer.ResultsNumber of patients with normal liver enzyme levels were 63 (41.5%), while with raised levels of any of the liver enzymes were 89 (58.5%), out of which 43 (48.31%) had liver injury which manifested as increased severity in terms of intensive care unit (ICU) requirement (p=0.0005). Significantly raised levels of liver enzymes and liver injury were observed with age (p<0.0001) and in males (p=0.004). Significantly decreased levels of albumin and total proteins and increased levels of total bilirubin (p<0.0001) were seen in patients with abnormal liver enzyme levels and liver injury as compared to patients with normal levels. Significant increase in the levels of alanine transaminase and gamma-glutamyl transferase was seen on the 7th day, CRP and ferritin (p<0.0001) peaks were observed on 2nd and 3rd day respectively. A significant positive correlation was found between the levels of these inflammatory markers and liver function parameters.ConclusionsMore than half of patients admitted to the hospital with SARS-CoV-2 infection had an abnormal liver function which was found to be associated with raised levels of inflammatory markers. Signiﬁcantly higher proportions of patients with abnormal liver function were elderly and males and were at higher risk of progressing to severe disease.

Download Full-text

Relationship between Alcohol Consumption and Impaired Liver Function

JURNAL INFO KESEHATAN ◽

10.31965/infokes.vol18.iss2.474 ◽

2020 ◽

Vol 18 (2) ◽

pp. 163-170

Author(s):

Agustina W. Djuma ◽

Novian A. Yudhaswara ◽

Suzanne Patricia Dardeau

Keyword(s):

Alcohol Consumption ◽

Liver Function ◽

Gamma Glutamyl Transferase ◽

Research Subjects ◽

Impaired Liver Function ◽

Cross Sectional ◽

Impaired Liver ◽

Glutamyl Transferase ◽

The Impact ◽

The Relationship

East Nusa Tenggara is a province of high alcohol abuse in Indonesia. Ngada Regency has a prevalence of 38.8%. The high prevalence is inseparable from traditional factors and socio-cultural norms which strongly influence the habit of consuming alcohol, the cold temperature in this area further strengthens this habit. The impact of alcohol consumption is the emergence of various types of diseases, one of which is impaired liver function such as alcoholic liver disease. The objective of this study is to determine the relationship between alcohol consumption and impaired liver function in communities in Bajawa and Golewa Districts, Ngada Regency. This research method is an observational analytic with cross-sectional design. The research subjects were 55 people who consumed alcohol in Golewa and Bajawa Districts, who had met the inclusion criteria. Alcohol consumption was measured by the AUDIT (The Alcohol Use Disorders Identification Test) questionnaire, while the parameter for liver disorders was the level of Gamma Glutamyl Transferase (GGT). The prevalence of liver dysfunction based on GGT examination was 15%. Meanwhile, the relationship between alcohol consumption and impaired liver function was tested with the Spearman correlation with α 0.05, the correlation value was p = 0.413, which means it has a moderate or significant, not too strong relationship. It is recommended that the people of Ngada Regency reduce alcohol consumption so that it can reduce the risk of impaired liver function.

Download Full-text

Gangguan Fungsi Hati pada Coronavirus Disease 2019

Medical Scope Journal ◽

10.35790/msj.2.2.2021.31959 ◽

2021 ◽

Vol 2 (2) ◽

Author(s):

Tasha Salsabila ◽

Bradley J. Waleleng ◽

Karel Pandelaki

Keyword(s):

Alkaline Phosphatase ◽

Liver Function ◽

Literature Review ◽

Aspartate Aminotransferase ◽

Alanine Aminotransferase ◽

Total Bilirubin ◽

Abnormal Liver Function ◽

Gamma Glutamyl Transferase ◽

Elevated Alkaline Phosphatase ◽

Glutamyl Transferase

Abstract: The incidence and death rate of COVID-19 in North Sulawesi Province continues to increase and data regarding abnormal liver function in COVID-19 is not yet available. This study was aimed to obtain the liver function in COVID-19 patients. This was a literature review study using two databases, namely Pubmed and ClinicalKey. Keywords used were abnormal liver function AND COVID-19, elevated alanine aminotransferase AND COVID-19, elevated aspartate aminotransferase AND COVID-19, elevated gamma-glutamyl transferase AND COVID-19, elevated alkaline phosphatase AND COVID-19, elevated total bilirubin AND COVID-19. After being selected, 10 literatures were obtained based on inclusion and exclusion criteria. The results showed that increased liver function often occurred in cases of COVID-19, but the increase did not reach twice of the normal value. The most frequent increases were in GGT, followed by ALT and AST, total bilirubin, and the least was the increase in ALP. All literatures reported that increased liver function was more common in males, and in severe COVID-19 patients reported by eight literatures. Five literatures reported that elevated liver function increased mortality in COVID-19 cases. In conclusion, there are increases in ALT, AST, ALP, GGT, and total bilirubin levels in COVID-19 patients.Keywords: abnormal liver function, COVID-19 Abstrak: Angka kejadian dan angka kematian COVID-19 di Provinsi Sulawesi Utara terus bertambah sedangkan data mengenai gambaran gangguan fungsi hati pada COVID-19 belum tersedia. Penelitian ini bertujuan untuk mengetahui gambaran fungsi hati pada COVID-19. Jenis penelitian ialah literature review dengan pencarian data menggunakan dua database yaitu Pubmed dan ClinicalKey. Kata kunci yang digunakan yaitu abnormal liver function AND COVID-19, elevated alanine aminotransferase AND COVID-19, elevated aspartate aminotransferase AND COVID-19, elevated gamma-glutamyl transferase AND COVID-19, elevated alkaline phosphatase AND COVID-19, elevated total bilirubin AND COVID-19. Setelah diseleksi, didapatkan 10 literatur berdasarkan kriteria inklusi dan eksklusi. Penelitian ini mendapatkan bahwa peningkatan fungsi hati sering terjadi pada kasus COVID-19 namun peningkatannya tidak mencapai dua kali nilai normal. Peningkatan paling sering terjadi pada GGT, diikuti oleh ALT dan AST, bilirubin total, dan paling sedikit yaitu pada peningkatan ALP. Seluruh literatur melaporkan peningkatan fungsi hati lebih sering terjadi pada laki-laki dan pada kasus COVID-19 gejala berat dilaporkan oleh delapan literatur. Lima literatur melaporkan peningkatan fungsi hati meningkatkan mortalitas pada kasus COVID-19. Simpulan penelitian ini ialah, terdapat peningkatan kadar ALT, AST, ALP, GGT, dan bilirubin total pada penderita COVID-19.Kata kunci: gangguan fungsi Hati, COVID-19

Download Full-text

Monitoring of liver function in major depressive disorder treated with SSRI

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.299 ◽

2016 ◽

Vol 33 (S1) ◽

pp. S158-S158

Author(s):

P. Ifteni ◽

A. Teodorescu

Keyword(s):

Major Depressive Disorder ◽

Liver Function ◽

Depressive Disorder ◽

Selective Serotonin Reuptake Inhibitors ◽

Gamma Glutamyl Transferase ◽

Major Depressive ◽

Drug Induced ◽

Cross Sectional ◽

Number Of Patients ◽

Glutamyl Transferase

BackgroundMajor depressive disorder is one of the most prevalent psychiatric illnesses in the world affecting more than 12% of men and more than 21% of women in their lifetime. Selective serotonin reuptake inhibitors (SSRIs) are worldwide prescribed to treat depression. SSRIs drugs can cause drug-induced liver injury (DILI).AimsThe aim of the study was to evaluate the liver function in patients treated with SSRI in order to detect DILI.MethodsAll the patients with first major depressive episode treated with the same SSRI antidepressant for at least 3 months between September 2013 and September 2015 were entered into the study. The hepatic function panel included aminotransferases, total and direct bilirubin, albumin, total protein, gamma glutamyl transferase (GGT), LDH cholesterol, hepatitis B virus (HBV), and hepatitis C virus (HCV).ResultsOf 134 subjects with MDD according to The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) who met inclusion criteria, 98 patients entered into study. Seventy-seven (76.5%) were treated with SSRI for at least 3 months with mean age were 45.4 (SD = 6.3), 65 women (66.3%). Five patients (5.1%) were newly diagnosed with hepatitis, and 10 (10.2%) presented elevated values of ALT, AST. The mean duration of depressive symptoms was 9.2 months (SD = 6.9).ConclusionsThe treatment with SSRI seems to be effective and safe in our sample. A relative small number of patients with MDD were diagnosed with viral hepatitis during this cross-sectional study. Further randomized and controlled trials are needed.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Download Full-text

Dynamic changes in liver function parameters in patients with coronavirus disease 2019: a multicentre, retrospective study

BMC Infectious Diseases ◽

10.1186/s12879-021-06572-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Qing-Lei Zeng ◽

Zu-Jiang Yu ◽

Fanpu Ji ◽

Guang-Ming Li ◽

Guo-Fan Zhang ◽

...

Keyword(s):

Retrospective Study ◽

Liver Disease ◽

Liver Function ◽

Chronic Liver Disease ◽

Chronic Liver ◽

Gamma Glutamyl Transferase ◽

Dynamic Changes ◽

Viral Shedding ◽

Glutamyl Transferase ◽

Multicentre Retrospective Study

Abstract Background Liver injuries have been reported in patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the clinical role played by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods In this multicentre, retrospective study, the parameters of liver function tests in COVID-19 inpatients were compared between various time-points in reference to SARS-CoV-2 shedding, and 3 to 7 days before the first detection of viral shedding was regarded as the reference baseline. Results In total, 70 COVID-19 inpatients were enrolled. Twenty-two (31.4%) patients had a self-medication history after illness. At baseline, 10 (14.3%), 7 (10%), 9 (12.9%), 2 (2.9%), 15 (21.4%), and 4 (5.7%) patients already had abnormal alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), albumin, and total bilirubin (TBIL) values, respectively. ALT and AST abnormal rates and levels did not show any significant dynamic changes during the full period of viral shedding (all p > 0.05). The GGT abnormal rate (p = 0.008) and level (p = 0.033) significantly increased on day 10 of viral shedding. Meanwhile, no simultaneous significant increases in abnormal ALP rates and levels were observed. TBIL abnormal rates and levels significantly increased on days 1 and 5 of viral shedding (all p < 0.05). Albumin abnormal decrease rates increased, and levels decreased consistently from baseline to SARS-CoV-2 clearance day (all p < 0.05). Thirteen (18.6%) patients had chronic liver disease, two of whom died. The ALT and AST abnormal rates and levels did not increase in patients with chronic liver disease during SARS-CoV-2 shedding. Conclusions SARS-CoV-2 does not directly lead to elevations in ALT and AST but may result in elevations in GGT and TBIL; albumin decreased extraordinarily even when SARS-CoV-2 shedding ended.

Download Full-text

STUDY ON EVALUATION OF SERUM GAMMA-GLUTAMYL TRANSFERASE (GGT) LEVELS IN ACUTE CORONARY SYNDROME

10.36106/ijar/4109004 ◽

2021 ◽

pp. 39-40

Author(s):

Avtar Singh Dhanju ◽

Deepshikha Singla ◽

Pashaura Singh ◽

Ajay Chhabra ◽

Sukhraj Kaur

Keyword(s):

Acute Coronary Syndrome ◽

Cross Sectional Study ◽

Gamma Glutamyl Transferase ◽

Cross Sectional ◽

Gamma Glutamyl ◽

Coronary Syndrome ◽

Healthy Control ◽

Group A ◽

Group B ◽

Glutamyl Transferase

Aim: The present study was undertaken with the aim to evaluate serum Gamma Glutamyl Transferase (GGT) levels in patients of acute coronary syndrome. Methodology: This cross-sectional study was conducted on 50 cases with acute coronary syndrome (Group A) and 50 healthy control subjects (Group B) meeting inclusion and exclusion criteria. Results: There is signicant rise in serum GGT levels in patients presenting with ACS in Group A as compared to Group B. Conclusion: Higher levels of GGT in ACS patients with risk factors such as hypertension, dyslipidemia and smoking may serve as biomarker to predict the occurrence of ACS.

Download Full-text

Insulin resistance and obesity, and their association with depression in relatively young people: findings from a large UK birth cohort

Psychological Medicine ◽

10.1017/s0033291719000308 ◽

2019 ◽

Vol 50 (4) ◽

pp. 556-565 ◽

Cited By ~ 4

Author(s):

B. I. Perry ◽

G. M. Khandaker ◽

S. Marwaha ◽

A. Thompson ◽

S. Zammit ◽

...

Keyword(s):

Insulin Resistance ◽

Young People ◽

Birth Cohort ◽

Lifestyle Factors ◽

Low Grade ◽

Cross Sectional ◽

Parents And Children ◽

Show Evidence ◽

Longitudinal Associations ◽

And Gender

AbstractBackgroundDepression frequently co-occurs with disorders of glucose and insulin homeostasis (DGIH) and obesity. Low-grade systemic inflammation and lifestyle factors in childhood may predispose to DGIH, obesity and depression. We aim to investigate the cross-sectional and longitudinal associations among DGIH, obesity and depression, and to examine the effect of demographics, lifestyle factors and antecedent low-grade inflammation on such associations in young people.MethodsUsing the Avon Longitudinal Study of Parents and Children birth cohort, we used regression analyses to examine: (1) cross-sectional and (2) longitudinal associations between measures of DGIH [insulin resistance (IR); impaired glucose tolerance] and body mass index (BMI) at ages 9 and 18 years, and depression (depressive symptoms and depressive episode) at age 18 years and (3) whether sociodemographics, lifestyle factors or inflammation [interleukin-6 (IL-6) at age 9 years] confounded any such associations.ResultsWe included 3208 participants. At age 18 years, IR and BMI were positively associated with depression. These associations may be explained by sociodemographic and lifestyle factors. There were no longitudinal associations between DGIH/BMI and depression, and adjustment for IL-6 and C-reactive protein did not attenuate associations between IR/BMI and depression; however, the longitudinal analyses may have been underpowered.ConclusionsYoung people with depression show evidence of DGIH and raised BMI, which may be related to sociodemographic and lifestyle effects such as deprivation, smoking, ethnicity and gender. In future, studies with larger samples are required to confirm this. Preventative strategies for the poorer physical health outcomes associated with depression should focus on malleable lifestyle factors.

Download Full-text

Liver function tests and fibrosis scores in a rural population in Africa: a cross-sectional study to estimate the burden of disease and associated risk factors

BMJ Open ◽

10.1136/bmjopen-2019-032890 ◽

2020 ◽

Vol 10 (3) ◽

pp. e032890 ◽

Cited By ~ 2

Author(s):

Geraldine O'Hara ◽

Jolynne Mokaya ◽

Jeffrey P Hau ◽

Louise O Downs ◽

Anna L McNaughton ◽

...

Keyword(s):

Liver Disease ◽

Alcohol Consumption ◽

Liver Function ◽

Reference Range ◽

Liver Function Tests ◽

Sub Saharan Africa ◽

Reference Ranges ◽

Cross Sectional ◽

Function Tests ◽

Glutamyl Transferase

ObjectivesLiver disease is a major cause of morbidity and mortality in sub-Saharan Africa, but its prevalence, distribution and aetiology have not been well characterised. We therefore set out to examine liver function tests (LFTs) and liver fibrosis scores in a rural African population.DesignWe undertook a cross-sectional survey of LFTs. We classified abnormal LFTs based on reference ranges set in America and in Africa. We derived fibrosis scores (aspartate aminotransferase (AST) to Platelet Ratio Index (APRI), fibrosis-4, gamma-glutamyl transferase (GGT) to platelet ratio (GPR), red cell distribution width to platelet ratio and S-index). We collected information about alcohol intake, and infection with HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV).SettingWe studied a population cohort in South-Western Uganda.ParticipantsData were available for 8099 adults (median age 30 years; 56% female).ResultsThe prevalence of HBV, HCV and HIV infection was 3%, 0.2% and 8%, respectively. The prevalence of abnormal LFTs was higher based on the American reference range compared with the African reference range (eg, for AST 13% vs 3%, respectively). Elevated AST/ALT ratio was significantly associated with self-reported alcohol consumption (p<0.001), and the overall prevalence of AST/ALT ratio >2 was 11% (suggesting alcoholic hepatitis). The highest prevalence of fibrosis was predicted by the GPR score, with 24% of the population falling above the threshold for fibrosis. There was an association between the presence of HIV or HBV and raised GPR (p=0.005) and S-index (p<0.001). By multivariate analysis, elevated LFTs and fibrosis scores were most consistently associated with older age, male sex, being under-weight, HIV or HBV infection and alcohol consumption.ConclusionsFurther work is required to determine normal reference ranges for LFTs in this setting, to evaluate the specificity and sensitivity of fibrosis scores and to determine the aetiology of liver disease.

Download Full-text

Fasting triglycerides and glucose index: a useful screening test for assessing insulin resistance in patients diagnosed with rheumatoid arthritis and systemic lupus erythematosus

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-019-0495-x ◽

2019 ◽

Vol 11 (1) ◽

Author(s):

Betsabe Contreras-Haro ◽

Sandra Ofelia Hernandez-Gonzalez ◽

Laura Gonzalez-Lopez ◽

Maria Claudia Espinel-Bermudez ◽

Leonel Garcia-Benavides ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Systemic Lupus Erythematosus ◽

Insulin Resistance ◽

Lupus Erythematosus ◽

Screening Test ◽

Systemic Lupus ◽

Cross Sectional ◽

Factors Associated ◽

Tyg Index ◽

Surrogate Index

Abstract Background Insulin resistance (IR) is frequently observed in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). In clinical practice, IR assessment is limited to a low proportion of patients due to cost and equipment and technical expertise requirements. The surrogate index of triglycerides and glucose (TyG index) has been validated in non-rheumatic populations, showing adequate sensitivity and specificity for IR, although this index has not yet been used in connective tissue disorders. The aim of this study was to evaluate the frequency of insulin resistance (IR) using the validated surrogate index of triglycerides and glucose (TyG index) and to explore factors associated with IR in Mexican women with RA or SLE. Methods Ninety-five female RA and 57 SLE patients were included in a cross-sectional study. Clinical and epidemiological variables were evaluated. IR was assessed using the TyG index with a cutoff value of > 4.68. Logistic regression analysis was performed to identify factors associated with IR excluding confounders. Results IR frequency in the entire sample was 50%, higher than the 10% observed in non-rheumatic controls (p < 0.001). The frequency of IR was similar in SLE (49.1%) and RA (50.5%, p = 0.8) patients. IR was associated with a longer duration of hypertension and higher total cholesterol and low density lipoprotein cholesterol levels. Based on multivariate analysis, the duration of hypertension (OR: 1.06; 95% CI 1.002–1.12, p = 0.04), waist circumference (OR: 1.04; 95% CI 1.01–1.08, p = 0.007), uric acid levels (OR: 1.46; 95% CI 1.08–1.97, p = 0.01), RA (OR: 4.87; 95% CI 1.31–18.78, p = 0.01) and SLE (OR: 4.22; 95% CI 1.06–16.74, p = 0.04) were the main risk factors for IR. Conclusions This study shows that the TyG index is a useful screening test for IR in RA and SLE patients. Future longitudinal studies should be performed with the aim of identifying the predictive value of TyG index results for identifying complications linked to IR.

Download Full-text

Serum Adropin Levels Are Reduced in Adult Patients with Nonalcoholic Fatty Liver Disease

Medical Principles and Practice ◽

10.1159/000500106 ◽

2019 ◽

Vol 28 (5) ◽

pp. 463-469 ◽

Cited By ~ 6

Author(s):

Orkide Kutlu ◽

Özgür Altun ◽

Okan Dikker ◽

Şerife Aktaş ◽

Neslihan Özsoy ◽

...

Keyword(s):

Insulin Resistance ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Adult Patients ◽

Gamma Glutamyl Transferase ◽

Nonalcoholic Fatty Liver ◽

Healthy Control ◽

Glutamyl Transferase

Objectives: Adropin is a novel marker of metabolic syndrome and insulin resistance. The aim of this study was to explore the association of serum adropin levels with hepatosteatosis among adult patients. Materials and Methods: Serum biochemical parameters including liver and renal function tests, insulin levels, and serum adropin levels were compared between adult patients with nonalcoholic fatty liver disease (NAFLD) and healthy control cases. Results: A total of 51 patients with a mean age of 37.9 ± 9.96 years diagnosed with grade 2–3 hepatosteatosis and 30 healthy control cases with a mean age of 34.8 ± 9.5 years were included in the study. Serum adropin levels in the NAFLD group were statistically significantly lower than in the control cases (588.4 ± 261.0 vs. 894.2 ± 301.2, respectively; p < 0.001). The study participants were further subdivided into 2 groups as patients with (n = 35) or without (n = 46) insulin resistance using the serum homeostatic model of assessment-insulin resistance (HOMA-IR). Serum adropin levels were statistically significantly lower in patients with insulin resistance (p < 0.01). There was a negative correlation between adropin levels and serum insulin, HOMA-IR, urea, gamma-glutamyl transferase, total cholesterol, and triglyceride levels. Conclusion: We observed a decrease in serum adropin levels among adult patients with NAFLD. We also found lower levels of serum adropin in patients with insulin resistance, supporting previous data in the literature. Studies investigating the association of adropin levels with other inflammatory parameters are warranted to define its exact role in the pathogenesis of hepatosteatosis.

Download Full-text