Growth Velocity and Interleukin 6 Concentrations in Juvenile Idiopathic Arthritis

2008 ◽  
Vol 35 (11) ◽  
pp. 2265-2271 ◽  
Author(s):  
LETÍCIA S. SOUZA ◽  
SANDRA H. MACHADO ◽  
CLAITON V. BRENOL ◽  
JOÃO CARLOS T. BRENOL ◽  
RICARDO M. XAVIER
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Growth Velocity ◽  
Interleukin 6 ◽  
Negative Influence ◽  
World Health ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Secondary Factor ◽  
Health Organization

ObjectiveTo evaluate associations of growth velocity with inflammatory markers and cumulative dose of glucocorticoid in a cohort of patients with juvenile idiopathic arthritis (JIA) followed during 1 year.MethodsSeventy-nine patients were evaluated. Disease activity was evaluated by a pediatric rheumatologist. Anthropometric data were classified according to the World Health Organization standards. Tanner growth velocity curves were used; values below the Z-score≤ −2 were considered low growth velocity. Serum concentrations of interleukin 6 (IL-6) were measured by ELISA, and values > 1 pg/ml were considered elevated.ResultsThe prevalence of low growth velocity was 25.3%, and it was associated with active disease on followup visit, elevated IL-6, erythrocyte sedimentation rate and C-reactive protein, and higher cumulative glucocorticoid doses. In the multiple linear regression with growth velocity as the dependent variable, only elevated IL-6 level was independently and negatively associated with growth velocity.ConclusionLow growth velocity is highly prevalent in children with JIA. Elevated IL-6 levels seem to have an important negative influence on growth in these children, while total glucocorticoid exposure appears to be a secondary factor.

scholarly journals A brief-review of the risk factors for covid-19 severity

2020 ◽  
Vol 54 ◽  
pp. 60 ◽  
Author(s):  
J. E. Rod ◽  
Oscar Oviedo-Trespalacios ◽  
Javier Cortes-Ramirez
Keyword(s):  
Risk Factors ◽  
Disease Severity ◽  
World Health ◽  
Future Research ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
History Of ◽  
Health Organization ◽  
High Consistency ◽  
D Dimer

The World Health Organization has emphasized that one of the most important questions to address regarding the covid-19 pandemic is to understand risk factors for disease severity. We conducted a brief review that synthesizes the available evidence and provides a judgment on the consistency of the association between risk factors and a composite end-point of severe-fatal covid-19. Additionally, we also conducted a comparability analysis of risk factors across 17 studies. We found evidence supporting a total of 60 predictors for disease severity, of which seven were deemed of high consistency, 40 of medium and 13 of low. Among the factors with high consistency of association, we found age, C-reactive protein, D-dimer, albumin, body temperature, SOFA score and diabetes. The results suggest that diabetes might be the most consistent comorbidity predicting disease severity and that future research should carefully consider the comparability of reporting cases, factors, and outcomes along the different stages of the natural history of covid-19.

scholarly journals SARS-CoV-2 INFECTED PATIENTS: FROM A HEMATOLOGIST PERSPECTIVE

2020 ◽  
Vol 12 (1) ◽  
pp. e2020078
Author(s):  
Firas Kreidieh ◽  
Sally Temraz
Keyword(s):  
Distress Syndrome ◽  
Severity Of Illness ◽  
World Health ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Management Plans ◽  
Careful Revision ◽  
Pharmacologic Thromboprophylaxis ◽  
American Society ◽  
Health Organization

Introduction: According to the World Health Organization (WHO), COVID-19 has become a Public Health Emergency of International Concern (PHEIC). Understanding the hematologic findings of patients with SARS-CoV-2 infection is essential to promote their care and improve outcomes.   Objective:In this review, we aim at summarizing changes in the hematopoietic system and hemostasis that occur in SARS-CoV-2 infected patients.   Findings: COVID-19 infection is often associated with laboratory hematologic findings that can have important clinical implications. Careful revision of baseline hematologic findings at diagnosis can predict severity of illness and help clinicians tailor their management and approach to patients whose condition can be guarded or critical.This can be of therapeutic and prognostic value in severely ill patients and can reduce the mortality rate from COVID-19.  Such markers include D-dimer, procalcitonin, C-reactive protein, viral load, cytokine storm, and lymphopenia.Studies have also shown an association between these markers and severe COVID-19 infection requiring admission to the intensive care unit or complicated by acute respiratory distress syndrome (ARDS). According to the American Society of Hematology (ASH), all hospitalized patients with COVID-19 should receive pharmacologic thromboprophylaxis with LMWH.   Conclusion:Until more data arises, the summary we provide can be used by hematologists to better understand hemostasis in COVID-19 infected patients.We are in need for more studies to define appropriate management plans in the setting of hematologic findings.  

scholarly journals Erythrocyte sedimentation rate, C-reactive protein, and interleukin-6 as inflammatory biomarkers in dogs naturally infected with Ehrlichia canis

2021 ◽  
pp. 2325-2331
Author(s):  
Thanaporn Asawapattanakul ◽  
Tanagorn Pintapagung ◽  
Supawadee Piratae ◽  
Siriluck Juntautsa ◽  
Pawarat Chancharoen
Keyword(s):  
Sedimentation Rate ◽  
Interleukin 6 ◽  
Infected Group ◽  
Inflammatory Biomarkers ◽  
C Reactive Protein ◽  
Healthy Group ◽  
Reactive Protein ◽  
Inflammatory Parameters ◽  
Erythrocyte Sedimentation ◽  
The Mean

Background and Aim: Canine monocytotropic ehrlichiosis (CME), a tick-borne disease, leads to a systemic inflammatory response syndrome; it is thus important to assess the intensity of inflammation in order to treat it appropriately. The current study was designed to evaluate hematological, biochemical, and inflammatory parameters in dogs naturally infected with Ehrlichia canis compared with those in healthy dogs. We also assessed the relationship among several inflammation-related parameters and considered these parameters for use as inflammatory biomarkers of CME. Materials and Methods: Twenty-eight dogs were divided into two groups based on the results of nested polymerase chain reaction for detecting E. canis, comprising a healthy group (n=11) and an infected group (n=17). A blood sample was collected from each dog to evaluate hematological, biochemical, and inflammatory parameters, with the obtained results being statistically compared between the groups. Moreover, the correlations of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and interleukin-6 (IL-6) were investigated in the 28 dogs. Results: In the infected group, the mean levels of red blood cells, hemoglobin, and hematocrit were significantly lower than in the healthy group, while the mean lymphocyte and monocyte counts were higher. The mean levels of ESR and CRP were significantly higher (p<0.05) in the infected group, whereas no significant differences were found in IL-6 levels between the two groups. In the correlation analysis, ESR and CRP levels were highly correlated (p<0.01, r=0.531). Conclusion: Elevated ESR and CRP levels were found in dogs naturally infected with E. canis, which also presented mild to moderate inflammation in this study. Moreover, CRP was significantly correlated with ESR, so ESR and CRP may serve as inflammatory biomarkers for monitoring CME.

scholarly journals Blood routine test in mild and common 2019 coronavirus (COVID-19) patients

2020 ◽  
Vol 40 (8) ◽  
Author(s):  
Dodji Kossi Djakpo ◽  
Zhiquan Wang ◽  
Rong Zhang ◽  
Xin Chen ◽  
Peng Chen ◽  
...  
Keyword(s):  
Social Sciences ◽  
Complete Blood Count ◽  
World Health ◽  
C Reactive Protein ◽  
Routine Test ◽  
Reactive Protein ◽  
The Social ◽  
Blood Routine Test ◽  
Health Organization ◽  
The City

Abstract The new 2019 coronavirus disease (COVID-19), according to the World Health Organization (WHO), has been characterized as a pandemic. As more is being discovered about this virus, we aim to report findings of the complete blood count (CBC) of COVID-19 patients. This would serve in providing physicians with important knowledge on the changes that can be expected from the CBC of mild and normal COVID-19 patients. A total of 208 mild and common patients were admitted at the Dongnan Hospital located in the city of Xiaogan, Hubei, China. The CBCs of these patients, following a confirmed diagnosis of COVID-19, were retrospectively analyzed and a significant P&lt;0.05 was found after a full statistical analysis was conducted using the Statistical Package for the Social Sciences (IBM SPSS). CBC analysis revealed changes in the levels of red blood cells (RBCs), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), and C-reactive protein (CRP). Clinicians should expect similar findings when dealing with the new COVID-19.

scholarly journals Association of Circulating COMP and YKL-40 as Markers of Metabolic Changes of Cartilage with Adipocytokines in Juvenile Idiopathic Arthritis

Metabolites ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 61
Author(s):  
Katarzyna Winsz-Szczotka ◽  
Kornelia Kuźnik-Trocha ◽  
Anna Gruenpeter ◽  
Magdalena Wojdas ◽  
Klaudia Dąbkowska ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Clinical Improvement ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Metabolic Changes ◽  
C Reactive Protein ◽  
Human Cartilage ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Before And After

The aim of this study was to evaluate the association of circulating cartilage oligomeric matrix protein (COMP) and human cartilage glycoprotein-39 (YKL-40) as markers of metabolic changes of cartilage, with leptin, adiponectin, and resistin in juvenile idiopathic arthritis (JIA) patients before and after treatment. A significant decrease of COMP and an increase of YKL-4 were found in blood of untreated patients. JIA treatment leading to clinical improvement resulted in normalization of COMP levels only. Concentrations of both markers in treated patients, while showing no clinical improvement, differed from those in controls and patients with remission. The leptin level decreased (p < 0.05) in untreated patients; however, concentrations of adiponectin and resistin increased (p < 0.05) as compared to controls. JIA treatment resulted in normalization of adipocytokine levels in remissive patients but not those with active JIA. Untreated patients showed a correlation between COMP and leptin, adiponectin, and body mass index (BMI) and between YKL-40 and leptin, adiponectin, BMI, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). In inactive JIA, a correlation between YKL-40 and leptin was shown. Treated patients with an active JIA demonstrated a correlation between COMP and adiponectin and between YKL-40 and leptin, adiponectin, BMI, CRP, and ESR. The results of this work indicate that leptin and adiponectin but not resistin may be involved in the development and progression of joint dysfunction in JIA. Additionally, we suggest that YKL-40 may be a useful biomarker of disease activity and may be used to assess treatment towards remission, as compared to COMP.

scholarly journals Utility of C-Reactive Protein Levels for Early Prediction of Dengue Severity in Adults

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Chien-Chih Chen ◽  
Ing-Kit Lee ◽  
Jien-Wei Liu ◽  
Shi-Yu Huang ◽  
Lin Wang
Keyword(s):  
Characteristic Curve ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
World Health ◽  
Severe Dengue ◽  
Early Prediction ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Health Organization

Dengue has broad clinical presentation with unpredictable clinical evolution and outcome. We aimed to evaluate the utility of C-reactive protein (CRP) levels for distinguishing between mild and severe cases in the early phase of the dengue illness. We retrospectively evaluated adults with dengue from 2006 to 2014, according to 1997 and 2009 World Health Organization (WHO) criteria for severity. Of 191 included patients, 32.9% had nonshock dengue hemorrhagic fever (DHF), 3.1% dengue shock syndrome (DSS), and 7.9% severe dengue. The risk of DHF/DSS and severe dengue is significantly related to the increasing levels of CRP. Of 191 patients, 97 had CRP levels measured during the febrile (days 1–3); 85 during the critical (days 4–6); and 9 during the convalescent (days 7–10) illness phases. During the febrile phase, there was significant higher CRP level for DSS versus DF/nonshock DHF and severe dengue versus nonsevere dengue, with CRP cutoff level 30.1 mg/L (area under the receiver operating characteristic curve (AUC), 0.938; 100% sensitivity, 76.3% specificity) and 24.2 mg/L (AUC, 0.717; 70% sensitivity, 71.3% specificity), respectively. Our study highlights the utility of the CRP levels in early prediction of DSS and severe dengue in adult patients.

scholarly journals The Association of Serum IL-10 Levels with the Disease Activity in Systemic-Onset Juvenile Idiopathic Arthritis Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yu Peng ◽  
Xiaohui Liu ◽  
Zhao Duan ◽  
Junkai Duan ◽  
Yulan Zhou
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Disease Activity ◽  
Sedimentation Rate ◽  
Serum Levels ◽  
Interleukin 10 ◽  
C Reactive Protein ◽  
Clinical Marker ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Systemic Onset

Objectives. Interleukin-10 (IL-10) has been suggested as a biomarker of disease activity in patients with adult-onset Still’s disease (AOSD). In this study, we evaluated the serum IL-10 levels and investigated its clinical relevance in systemic-onset juvenile idiopathic arthritis (SoJIA). Methods. IL-10 levels were determined in 21 patients diagnosed with SoJIA and 35 patients with fever diseases which were suspected as SoJIA, and IL-10 levels were compared between SoJIA patients with regard to disease activity, disease courses, and other biomarkers. Results. Patients with SoJIA had significantly higher levels of IL-10 compared to patients with other febrile diseases. The serum levels of IL-10 were significantly higher in active SoJIA compared to inactive and positively correlated with known disease activity markers such as erythrocyte sedimentation rate (ESR), C-reactive protein level (CRP), ferritin (FER), and IL-6 levels. Moreover, the levels of IL-10 at diagnosis were significantly higher in SoJIA patients with a nonmonocyclic pattern than in patients with a monocyclic pattern. Compared to CRP, ESR, FER, and IL-6, IL-10 levels were superior in predicting monocyclic patients from nonmonocyclic patients. Conclusion. Compared to other febrile diseases, SoJIA patients have markedly higher levels of IL-10 which may assist with diagnosis. And a clear association of serum IL-10 levels with disease activity and disease courses in SoJIA was found. These results suggest that serum IL-10 might be a reliable clinical marker in SoJIA.

scholarly journals Pretreatment elevated erythrocyte sedimentation rate and C-reactive protein as a predictor of malarial complications

2016 ◽  
Vol 10 (12) ◽  
pp. 1332-1337
Author(s):  
Sachin Vemula ◽  
Vidyalakshmi Katara ◽  
Unnikrishnan Bhaskaran ◽  
Sushma Adappa ◽  
Mahabala Chakrapani
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Statistical Significance ◽  
Characteristic Curve ◽  
Subsequent Development ◽  
Elevated Erythrocyte Sedimentation Rate ◽  
World Health ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation

Introduction: Complications of malaria can develop suddenly and unexpectedly. Although various parameters have been associated with severity of malaria, they have not been studied as predictors of these events. Many of the malarial complications are inflammatory in nature, and C-reactive protein (CRP) and elevated erythrocyte sedimentation rate (ESR) could be early markers of these complications and might precede and predict the development of complications. Methodology: A total of 122 inpatients with uncomplicated newly diagnosed malaria were studied. CRP, ESR, hemoglobin, and platelets were measured before initiating treatment. Patients were monitored closely for the subsequent development of complications based on the World Health Organization’s definition of severe malaria. Results: Seven patients (5.7%) had worsening of symptoms compared to the day of admission and had higher pretreatment CRP and increased ESR compared to those patients who did not develop complications. Area under receiver operator characteristic curve was 0.761(p=0.02) for CRP and 0.739 (p = 0.035) for ESR. CRP>124 mg/L and increased ESR (>34.5 mm in the first hour) had a sensitivity of 71.4% and specificity of 79.1%, respectively, for predicting complications of malaria. Other parameters did not reach statistical significance for predicting complications. Elevated CRP and elevated ESR had a negative predictive value of 97.8%. Conclusions: Elevated CRP>124mg/L and increased ESR>34.5 mm in the first hour at the time of diagnosis in patients with uncomplicated malaria identifies patients who might subsequently develop complications of malaria.

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