scholarly journals Design and Fabrication of a Microfluidic Chip for Particle Size-Exclusion and Enrichment

Micromachines ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1218
Author(s):  
Luxia Yang ◽  
Tian Ye ◽  
Xiufeng Zhao ◽  
Taotao Hu ◽  
Yanlong Wei
Keyword(s):  
Flow Rate ◽  
Microfluidic Chip ◽  
Electromagnetic Force ◽  
Three Dimensional ◽  
Deionized Water ◽  
Sample Solution ◽  
Microfluidic Channels ◽  
Pdms Substrate ◽  
Polyethylene Particles ◽  
Micropillar Array

Based on the size of particles, a microfluidic chip integrating micro particles capture, controlled release and counting analysis was designed and fabricated in this paper. The chip is composed of a polydimethylsiloxane (PDMS) cover sheet and a PDMS substrate. The PDMS substrate is made of a sample inlet, microfluidic channels, a micropillar array, a three-dimensional (3D) focusing channel, and a sample outlet. The chip was fabricated by the multistep SU-8 lithography and PDMS molding method in this study. The micropillar array and channels in the chip can be molded in one step and can be replicated multiple times, which reduces the production cost and increases the practicability of the chip. Using a homemade electromagnetic drive device, the detection function of the chip was tested using a deionized water solution containing 22 μm polyethylene particles. The results showed that under the action of electromagnetic force, the chip enriched polyethylene particles; when the electromagnetic force disappeared, the enriched polyethylene particles were released by injecting buffer solution, and it was looked at as new sample solution. The flow rate of the sample solution and the sheath flow solution (deionized water) was injected into the three-dimensional focusing channel at a flow rate ratio of 1:4, and the polyethylene particles sample solution was focused, which could be used for the counting and analysis of polyethylene particles. The work of this paper can provide a reference for the subsequent detection of circulating tumor cells (CTCs).

Preparation of Monodisperse PEG Microspheres by a T-Junction Microfluidic Chip

2012 ◽  
Vol 465 ◽  
pp. 178-181 ◽  
Author(s):  
Yu Min Ren ◽  
Bing Yu ◽  
Hai Lin Cong ◽  
Yu Rong Ma ◽  
Zhen Zhen Ma ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Flow Rate ◽  
Microfluidic Chip ◽  
Uv Exposure ◽  
Microfluidic Channels ◽  
Microfluidic Chips ◽  
Silicon Oil ◽  
Sample Flow Rate ◽  
Rate Ratios

Monodisperse polyethylene glycol (PEG) microspheres were prepared using microfluidic chips coupled with photopolymerization technique. Based on sheath effect in T-junction microfluidic channels, dispersions of uniform PEG prepolymer droplets in silicon oil are formed. The diameters of the formed PEG prepolymer droplets in the dispersions were controlled very well by altering the relative sheath/sample flow rate ratios. After photopolymerization under UV exposure, the uniform PEG prepolymer droplets isolated by silicon oil underwent photocrosslinking and became monodisperse PEG microspheres.

scholarly journals Design and Analysis of a Laminar Diffusion-Based Micromixer with Microfluidic Chip

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Osman Ulkir ◽  
Oguz Girit ◽  
Ishak Ertugrul
Keyword(s):  
Diffusion Coefficient ◽  
Flow Rate ◽  
Microfluidic Chip ◽  
Input Parameter ◽  
Diffusion Control ◽  
Microfluidic Channels ◽  
Inlet Flow ◽  
Inlet Flow Rate ◽  
Fuzzy Logic Method ◽  
Velocity Pressure

This study aims to perform optimizatione to achieve the best diffusion control between the channels by designing and analysing a microfluidic-based micromixer. The design and analysis of the micromixer were made with the COMSOL Multiphysics program. Some input and output parameters must be defined for diffusion control of the micromixer. Among these parameters, inputs are the diffusion coefficient and inlet flow rate, while outputs are velocity, pressure, and concentration. Each input parameter in the microfluidic chip affects the output of the system. To make the diffusion control in the most optimum way, the data were obtained by making much analysis. The data obtained from this program was also provided with the Fuzzy Logic method to optimize the microfluidic chip. The diffusion coefficient value (5E-11 m2/s) should be given to the channels to achieve the optimum diffusion between the micromixer channels, if the inlet flow rate value (15E-15 m3/s) is the output value of the system, the velocity is 0.09 mm/s. The pressure is 2 Pa, and the concentration is 0.45 mol/m3. These values are the optimum values obtained from the analysis without damaging the liquid’s microfluidic channels supplied to the micromixer’s inlet.

scholarly journals A Numerical Study of Sub-Millisecond Integrated Mix-and-Inject Microfluidic Devices for Sample Delivery at Synchrotron and XFELs

2021 ◽  
Vol 11 (8) ◽  
pp. 3404
Author(s):  
Majid Hejazian ◽  
Eugeniu Balaur ◽  
Brian Abbey
Keyword(s):  
Molecular Dynamics ◽  
Flow Rate ◽  
Numerical Study ◽  
Three Dimensional ◽  
Microfluidic Devices ◽  
Liquid Jets ◽  
Mixing Efficiency ◽  
X Ray Diffraction ◽  
Cross Sectional ◽  
Time Required

Microfluidic devices which integrate both rapid mixing and liquid jetting for sample delivery are an emerging solution for studying molecular dynamics via X-ray diffraction. Here we use finite element modelling to investigate the efficiency and time-resolution achievable using microfluidic mixers within the parameter range required for producing stable liquid jets. Three-dimensional simulations, validated by experimental data, are used to determine the velocity and concentration distribution within these devices. The results show that by adopting a serpentine geometry, it is possible to induce chaotic mixing, which effectively reduces the time required to achieve a homogeneous mixture for sample delivery. Further, we investigate the effect of flow rate and the mixer microchannel size on the mixing efficiency and minimum time required for complete mixing of the two solutions whilst maintaining a stable jet. In general, we find that the smaller the cross-sectional area of the mixer microchannel, the shorter the time needed to achieve homogeneous mixing for a given flow rate. The results of these simulations will form the basis for optimised designs enabling the study of molecular dynamics occurring on millisecond timescales using integrated mix-and-inject microfluidic devices.

scholarly journals Energy Loss in Steep Open Channels with Step-Pools

Water ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 72
Author(s):  
Suresh Kumar Thappeta ◽  
S. Murty Bhallamudi ◽  
Venu Chandra ◽  
Peter Fiener ◽  
Abul Basar M. Baki
Keyword(s):  
Energy Loss ◽  
Flow Rate ◽  
Recirculation Zone ◽  
Three Dimensional ◽  
Nonlinear Function ◽  
Open Channels ◽  
Geometrical Parameters ◽  
Transition Flow ◽  
Cumulative Energy ◽  
Zone Velocity

Three-dimensional numerical simulations were performed for different flow rates and various geometrical parameters of step-pools in steep open channels to gain insight into the occurrence of energy loss and its dependence on the flow structure. For a given channel with step-pools, energy loss varied only marginally with increasing flow rate in the nappe and transition flow regimes, while it increased in the skimming regime. Energy loss is positively correlated with the size of the recirculation zone, velocity in the recirculation zone and the vorticity. For the same flow rate, energy loss increased by 31.6% when the horizontal face inclination increased from 2° to 10°, while it decreased by 58.6% when the vertical face inclination increased from 40° to 70°. In a channel with several step-pools, cumulative energy loss is linearly related to the number of step-pools, for nappe and transition flows. However, it is a nonlinear function for skimming flows.

Thermal Characterization of Interlayer Microfluidic Cooling of Three-Dimensional Integrated Circuits With Nonuniform Heat Flux

2010 ◽  
Vol 132 (4) ◽  
Author(s):  
Yoon Jo Kim ◽  
Yogendra K. Joshi ◽  
Andrei G. Fedorov ◽  
Young-Joon Lee ◽  
Sung-Kyu Lim
Keyword(s):  
Integrated Circuits ◽  
Mass Flow Rate ◽  
Thermal Management ◽  
Mass Flow ◽  
Flow Rate ◽  
Single Phase ◽  
Hot Spot ◽  
Three Dimensional ◽  
Two Phase ◽  
Two Phase Cooling

It is now widely recognized that the three-dimensional (3D) system integration is a key enabling technology to achieve the performance needs of future microprocessor integrated circuits (ICs). To provide modular thermal management in 3D-stacked ICs, the interlayer microfluidic cooling scheme is adopted and analyzed in this study focusing on a single cooling layer performance. The effects of cooling mode (single-phase versus phase-change) and stack/layer geometry on thermal management performance are quantitatively analyzed, and implications on the through-silicon-via scaling and electrical interconnect congestion are discussed. Also, the thermal and hydraulic performance of several two-phase refrigerants is discussed in comparison with single-phase cooling. The results show that the large internal pressure and the pumping pressure drop are significant limiting factors, along with significant mass flow rate maldistribution due to the presence of hot-spots. Nevertheless, two-phase cooling using R123 and R245ca refrigerants yields superior performance to single-phase cooling for the hot-spot fluxes approaching ∼300 W/cm2. In general, a hybrid cooling scheme with a dedicated approach to the hot-spot thermal management should greatly improve the two-phase cooling system performance and reliability by enabling a cooling-load-matched thermal design and by suppressing the mass flow rate maldistribution within the cooling layer.

scholarly journals Porous PLAs with Controllable Density by FDM 3D Printing and Chemical Foaming Agent

Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 866
Author(s):  
A. R. Damanpack ◽  
André Sousa ◽  
M. Bodaghi
Keyword(s):  
3D Printing ◽  
Flow Rate ◽  
Three Dimensional ◽  
Poly Lactic Acid ◽  
Layer By Layer ◽  
Printing Technology ◽  
Material Density ◽  
Foaming Agent ◽  
3D Printing Technology ◽  
Fabrication Parameters

This paper shows how fused decomposition modeling (FDM), as a three-dimensional (3D) printing technology, can engineer lightweight porous foams with controllable density. The tactic is based on the 3D printing of Poly Lactic Acid filaments with a chemical blowing agent, as well as experiments to explore how FDM parameters can control material density. Foam porosity is investigated in terms of fabrication parameters such as printing temperature and flow rate, which affect the size of bubbles produced during the layer-by-layer fabrication process. It is experimentally shown that printing temperature and flow rate have significant effects on the bubbles’ size, micro-scale material connections, stiffness and strength. An analytical equation is introduced to accurately simulate the experimental results on flow rate, density, and mechanical properties in terms of printing temperature. Due to the absence of a similar concept, mathematical model and results in the specialized literature, this paper is likely to advance the state-of-the-art lightweight foams with controllable porosity and density fabricated by FDM 3D printing technology.

scholarly journals A Three-Dimensional Shock Loss Model Applied to an Aft-Swept, Transonic Compressor Rotor

1996 ◽  
Author(s):  
Steven L. Puterbaugh ◽  
William W. Copenhaver ◽  
Chunill Hah ◽  
Arthur J. Wennerstrom
Keyword(s):  
Flow Rate ◽  
Pressure Ratio ◽  
Three Dimensional ◽  
Numerical Results ◽  
Design Flow ◽  
Design System ◽  
Loss Model ◽  
Transonic Compressor ◽  
Compressor Rotor ◽  
Shock Loss

An analysis of the effectiveness of a three-dimensional shock loss model used in transonic compressor rotor design is presented. The model was used during the design of an aft-swept, transonic compressor rotor. The demonstrated performance of the swept rotor, in combination with numerical results, is used to determine the strengths and weaknesses of the model. The numerical results were obtained from a fully three-dimensional Navier-Stokes solver. The shock loss model was developed to account for the benefit gained with three-dimensional shock sweep. Comparisons with the experimental and numerical results demonstrated that shock loss reductions predicted by the model due to the swept shock induced by the swept leading edge of the rotor were exceeded. However, near the tip the loss model under-predicts the loss because the shock geometry assumed by the model remains swept in this region while the numerical results show a more normal shock orientation. The design methods and the demonstrated performance of the swept rotor is also presented. Comparisons are made between the design intent and measured performance parameters. The aft-swept rotor was designed using an inviscid axisymmetric streamline curvature design system utilizing arbitrary airfoil blading geometry. The design goal specific flow rate was 214.7 kg/sec/m2 (43.98 lbm/sec/ft2), the design pressure ratio goal was 2.042, and the predicted design point efficiency was 94.0. The rotor tip sped was 457.2 m/sec (1500 ft/sec). The design flow rate was achieved while the pressure ratio fell short by 0.07. Efficiency was 3 points below prediction, though at a very high 91 percent. At this operating condition the stall margin was 11 percent.

Base-Vented Hydrofoils of Finite Span Under a Free Surface: An Experimental Investigation

1984 ◽  
Vol 28 (02) ◽  
pp. 90-106
Author(s):  
Jacques Verron ◽  
Jean-Marie Michel
Keyword(s):  
Experimental Investigation ◽  
Free Surface ◽  
Flow Rate ◽  
Cavity Length ◽  
Three Dimensional ◽  
Leading Edge ◽  
Pulsation Frequency ◽  
Cavity Pressure ◽  
Air Flow Rate ◽  
Cavity Configuration

Experimental results are given concerning the behavior of the flow around three-dimensional base-vented hydrofoils with wetted upper side. The influence of planform is given particular consideration so that the sections of the foils are simple wedges with rounded noses. Results concern cavity configuration, the relation between the air flow rate and cavity pressure, leading-edge cavitation, cavity length, pulsation frequency, and force coefficients.

Effect of Outer Fin Axial Gap on the Sealing Effectiveness and Fluid Dynamics of Radial Rim Seal

2017 ◽  
Author(s):  
Zhigang Li ◽  
Jun Li ◽  
Liming Song ◽  
Qing Gao ◽  
Xin Yan ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Flow Rate ◽  
Gas Turbines ◽  
Flow Behavior ◽  
Three Dimensional ◽  
Numerical Approach ◽  
Coolant Flow ◽  
Coolant Flow Rate ◽  
Navier Stokes ◽  
Hot Gas

The modern gas turbine is widely applied in the aviation propulsion and power generation. The rim seal is usually designed at the periphery of the wheel-space and prevented the hot gas ingestion in modern gas turbines. The high sealing effectiveness of rim seal can improve the aerodynamic performance of gas turbines and avoid of the disc overheating. Effect of outer fin axial gap of radial rim seal on the sealing effectiveness and fluid dynamics was numerically investigated in this work. The sealing effectiveness and fluid dynamics of radial rim seal with three different outer fin axial gaps was conducted at different coolant flow rates using three-dimensional Reynolds-Averaged Navier-Stokes (RANS) and SST turbulent model solutions. The accuracy of the presented numerical approach for the prediction of the sealing performance of the turbine rim seal was demonstrated. The obtained results show that the sealing effectiveness of radial rim seal increases with increase of coolant flow rate at the fixed axial outer fin gap. The sealing effectiveness increases with decrease of the axial outer fin gap at the fixed coolant flow rate. Furthermore, at the fixed coolant flow rate, the hot gas ingestion increases with the increase of the axial outer fin gap. This flow behavior intensifies the interaction between the hot gas and coolant flow at the clearance of radial rim seal. The preswirl coefficient in the wheel-space cavity is also illustrated to analyze the flow dynamics of radial rim seal at different axial outer fin gaps.

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