scholarly journals Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies

Molecules ◽  
2017 ◽  
Vol 22 (12) ◽  
pp. 2081 ◽  
Author(s):  
Eric Block ◽  
Benjamin Bechand ◽  
Sivaji Gundala ◽  
Abith Vattekkatte ◽  
Kai Wang ◽  
...  
Keyword(s):  
Allium Sativum ◽  
Organosulfur Compounds ◽  
Fluorinated Analogs

scholarly journals The nutritional applications of garlic (Allium sativum) as natural feed additives in animals

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11934
Author(s):  
Jiashun Chen ◽  
Fang Wang ◽  
Yexin Yin ◽  
Xiaokang Ma
Keyword(s):  
Allium Sativum ◽  
Animal Feed ◽  
Animal Husbandry ◽  
Feed Additives ◽  
Bioactive Molecules ◽  
Herbal Remedies ◽  
Organosulfur Compounds ◽  
Beneficial Effects ◽  
Stress Markers

Garlic (Allium sativum) is an essential vegetable that has been widely utilized as seasoning, flavoring, culinary and in herbal remedies. Garlic contains several characteristic organosulfur compounds, such as diallyl sulfide, allicin (diallyl thiosulphate), γ-glutamylcysteine, and S-allyl cysteine (alliin) and ajoene, which garlic has beneficial effects on inflammation, oxidative stress markers, hypertension, hyperlipidaemia and endothelial function in vitro or in animal model. These bioactive molecules are also playing pivotal role in livestock and fisheries production apart from its application in humans. Supplementation of animal feed with garlic and its related products is consistent with the modern agricultural concept of organic animal husbandry. This review compiles the information describing the effects of feeding garlic and its extracts on selected performance parameters in animals (chicken, rabbits, ruminants, pigs and fish). This review may provide reference for scientists and entrepreneurs to investigate the applications of feeds added with garlic and allicin by-products for the improvement of animal husbandry and aquatic production.

The use of the ‘Cryogenic’ GC/MS and on-column injection for study of organosulfur compounds of the Allium sativum

2004 ◽  
Vol 17 (2) ◽  
pp. 235-245 ◽  
Author(s):  
Saleh Abu-Lafi ◽  
Jan W. Dembicki ◽  
Paulina Goldshlag ◽  
Lumı́r O. Hanuš ◽  
Valery M. Dembitsky
Keyword(s):  
Allium Sativum ◽  
Organosulfur Compounds

Composition of organosulfur compounds from cool- and warm-type garlic (Allium sativum L.) in Korea

2014 ◽  
Vol 23 (2) ◽  
pp. 337-344 ◽  
Author(s):  
Miyoung Yoo ◽  
Sanghee Lee ◽  
Sunyoung Kim ◽  
Jin-Bong Hwang ◽  
Jinyeong Choe ◽  
...  
Keyword(s):  
Allium Sativum ◽  
Organosulfur Compounds

scholarly journals Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data

2020 ◽  
Vol 104 ◽  
pp. 219-234 ◽  
Author(s):  
Razina Rouf ◽  
Shaikh Jamal Uddin ◽  
Dipto Kumer Sarker ◽  
Muhammad Torequl Islam ◽  
Eunus S. Ali ◽  
...  
Keyword(s):  
Clinical Data ◽  
Allium Sativum ◽  
Organosulfur Compounds

scholarly journals Alliin, a Garlic (Allium sativum) Compound, Prevents LPS-Induced Inflammation in 3T3-L1 Adipocytes

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Saray Quintero-Fabián ◽  
Daniel Ortuño-Sahagún ◽  
Manuel Vázquez-Carrera ◽  
Rocío Ivette López-Roa
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Allium Sativum ◽  
Serum Levels ◽  
Organosulfur Compounds ◽  
Inflammatory Gene Expression ◽  
Cytokine Levels ◽  
Anti Inflammatory ◽  
Neuroprotective Actions

Garlic (Allium sativumL.) has been used to alleviate a variety of health problems due to its high content of organosulfur compounds and antioxidant activity. The main active component is alliin (S-allyl cysteine sulfoxide), a potent antioxidant with cardioprotective and neuroprotective actions. In addition, it helps to decrease serum levels of glucose, insulin, triglycerides, and uric acid, as well as insulin resistance, and reduces cytokine levels. However its potential anti-inflammatory effect is unknown. We examined the effects of alliin in lipopolysaccharide- (LPS-) stimulated 3T3-L1 adipocytes by RT-PCR, Western blot, and microarrays analysis of 22,000 genes. Incubation of cells for 24 h with 100 μmol/L alliin prevented the increase in the expression of proinflammatory genes, IL-6, MCP-1, and Egr-1 in 3T3-L1 adipocytes exposed to 100 ng/mL LPS for 1 h. Interestingly, the phosphorylation of ERK1/2, which is involved in LPS-induced inflammation in adipocytes, was decreased following alliin treatment. Furthermore, the gene expression profile by microarrays evidentiate an upregulation of genes involved in immune response and downregulation of genes related with cancer. The present results have shown that alliin is able to suppress the LPS inflammatory signals by generating an anti-inflammatory gene expression profile and by modifying adipocyte metabolic profile.

scholarly journals Antibacterial Properties of Organosulfur Compounds of Garlic (Allium sativum)

2021 ◽  
Vol 12 ◽  
Author(s):  
Sushma Bagde Bhatwalkar ◽  
Rajesh Mondal ◽  
Suresh Babu Naidu Krishna ◽  
Jamila Khatoon Adam ◽  
Patrick Govender ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Allium Sativum ◽  
New Technologies ◽  
Antibacterial Properties ◽  
World Health ◽  
Health Concern ◽  
Organosulfur Compounds ◽  
Wide Range ◽  
The World ◽  
Novel Antibiotics

Garlic (Allium sativum), a popular food spice and flavoring agent, has also been used traditionally to treat various ailments especially bacterial infections for centuries in various cultures around the world. The principal phytochemicals that exhibit antibacterial activity are oil-soluble organosulfur compounds that include allicin, ajoenes, and allyl sulfides. The organosulfur compounds of garlic exhibit a range of antibacterial properties such as bactericidal, antibiofilm, antitoxin, and anti-quorum sensing activity against a wide range of bacteria including multi-drug resistant (MDR) strains. The reactive organosulfur compounds form disulfide bonds with free sulfhydryl groups of enzymes and compromise the integrity of the bacterial membrane. The World Health Organization (WHO) has recognized the development of antibiotic resistance as a global health concern and emphasizes antibiotic stewardship along with the urgent need to develop novel antibiotics. Multiple antibacterial effects of organosulfur compounds provide an excellent framework to develop them into novel antibiotics. The review provides a focused and comprehensive portrait of the status of garlic and its compounds as antibacterial agents. In addition, the emerging role of new technologies to harness the potential of garlic as a novel antibacterial agent is discussed.

scholarly journals Expatiating the Therapeutic Profile of Garlic (Allium sativum): a Bench to Bedside Approach

2021 ◽  
Vol 11 (6) ◽  
pp. 14225-14239
Keyword(s):  
Allium Sativum ◽  
Therapeutic Potential ◽  
Review Article ◽  
Diallyl Disulfide ◽  
Organosulfur Compounds ◽  
Microbial Characteristics ◽  
Clinical Models ◽  
Health And Disease ◽  
Anti Oxidant ◽  
Therapeutic Profile

Garlic (Allium sativum) is amongst the oldest medicinal plant in centuries. It is an amazing plant that contains numerous bioactive components such as organosulfur compounds, allicin, s-allyl cysteine, S-allyl-mercapto cysteine, diallyl sulfide, diallyl disulfide, and diallyl trisulfide. This review discusses numerous valuable effects and therapeutic potential of garlic in treating several diseases such as cancer, obesity, diabetes, liver injury, hypertension, inflammation, viral infection, and arthritis. The enormous immunomodulatory, anti-oxidant, and anti-microbial characteristics of garlic have also been explained briefly. This review article also gives insight into the nanotechnology-based phytopharmaceuticals of garlic; has summarized pre-clinical models, clinical trials, and patents published about garlic's therapeutic applications and its phytoconstituents in the management of several disease conditions. This review article brings more attention to garlic, providing effective scientific proof for improved utilization of garlic in human health and disease control.

scholarly journals Identification of NSP3 (SH2D3C) as a Prognostic Biomarker of Tumor Progression and Immune Evasion for Lung Cancer and Evaluation of Organosulfur Compounds from Allium sativum L. as Therapeutic Candidates

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1582
Author(s):  
Yuan-Chieh Yeh ◽  
Bashir Lawal ◽  
Michael Hsiao ◽  
Tse-Hung Huang ◽  
Chi-Ying F. Huang
Keyword(s):  
Lung Cancer ◽  
T Cell ◽  
Immune Evasion ◽  
In Silico ◽  
Allium Sativum ◽  
Therapy Resistance ◽  
Genetic Alterations ◽  
Organosulfur Compounds ◽  
Structural Protein ◽  
Molecular Docking Study

The multi-domain non-structural protein 3 (NSP3) is an oncogenic molecule that has been concomitantly implicated in the progression of coronavirus infection. However, its oncological role in lung cancer and whether it plays a role in modulating the tumor immune microenvironment is not properly understood. In the present in silico study, we demonstrated that NSP3 (SH2D3C) is associated with advanced stage and poor prognoses of lung cancer cohorts. Genetic alterations of NSP3 (SH2D3C) co-occurred inversely with Epidermal Growth Factor Receptor (EGFR) alterations and elicited its pathological role via modulation of various components of the immune and inflammatory pathways in lung cancer. Our correlation analysis suggested that NSP3 (SH2D3C) promotes tumor immune evasion via dysfunctional T-cell phenotypes and T-cell exclusion mechanisms in lung cancer patients. NSP3 (SH2D3C) demonstrated a high predictive value and association with therapy resistance in lung cancer, hence serving as an attractive target for therapy exploration. We evaluated the in silico drug-likeness and NSP3 (SH2D3C) target efficacy of six organosulfur small molecules from Allium sativum using a molecular docking study. We found that the six organosulfur compounds demonstrated selective cytotoxic potential against cancer cell lines and good predictions for ADMET properties, drug-likeness, and safety profile. E-ajoene, alliin, diallyl sulfide, 2-vinyl-4H-1,3-dithiin, allicin, and S-allyl-cysteine docked well into the NSP3 (SH2D3C)-binding cavity with binding affinities ranging from –4.3~–6.70 Ă and random forest (RF) scores ranging from 4.31~5.26 pKd. However, S-allyl-cysteine interaction with NSP3 (SH2D3C) is unfavorable and hence less susceptible to NSP3 ligandability. In conclusion, our study revealed that NSP3 is an important onco-immunological biomarker encompassing the tumor microenvironment, disease staging and prognosis in lung cancer and could serve as an attractive target for cancer therapy. The organosulfur compounds from A. sativum have molecular properties to efficiently interact with the binding site of NSP3 and are currently under vigorous preclinical study in our laboratory.

scholarly journals Assessment of potential use of garlic (Allium sativum) against growth of microbes

2019 ◽  
Vol 10 (4) ◽  
pp. 3508-3515
Author(s):  
Neha Sharma
Keyword(s):  
Nutritional Value ◽  
Allium Sativum ◽  
Antimicrobial Property ◽  
Antiviral Agent ◽  
Organosulfur Compound ◽  
Inhibitory Effect ◽  
Organosulfur Compounds ◽  
Garlic Bulb ◽  
Metabolic Activities ◽  
Potential Use

Garlic (Allium sativum) is cultivated worldwide for its medicinal and nutritional value. Garlic is an effective antibacterial, antifungal, antiprotozoal and antiviral agent. Garlic contains organosulfur compounds which impart antimicrobial property. Garlic is known to be highly effective in reducing growth of bacteria. Garlic bulb contains organosulfur compound, allicin, which is responsible for the efficacy of garlic against the growth of microbes. This compound can hinder the formation of bacterial acetyl-CoA, a precursor required for metabolic activities in bacteria. The present review indicates that garlic shows considerable inhibitory effect on microbial growth. Thus garlic can be used as a sustainable alternative to treat diseases and provide a solution to minimize our dependence on chemical-based drugs in future.

scholarly journals Antileishmanial and Immunomodulatory Activity of Allium sativum (Garlic)

2016 ◽  
Vol 22 (1) ◽  
pp. 141-155 ◽  
Author(s):  
Masoud Foroutan-Rad ◽  
Khosrow Hazrati Tappeh ◽  
Shahram Khademvatan
Keyword(s):  
Allium Sativum ◽  
Web Of Science ◽  
Scientific Information ◽  
Immunomodulatory Activity ◽  
Organosulfur Compounds ◽  
Obligate Intracellular ◽  
Leishmania Spp ◽  
Information Database

Leishmaniasis is caused by an obligate intracellular protozoa belonging to Leishmania genus. The current drugs for treatment of leishmaniasis possess many disadvantages; therefore, researchers are continuously looking for the more effective and safer drugs. The aim of this study is to review the effectiveness, toxicities, and possible mechanisms of pharmaceutical actions of different garlic extracts and organosulfur compounds isolated from garlic against Leishmania spp. in a variety of in vitro, in vivo and clinical trials reports. All relevant databases were searched using the terms “ Allium sativum,” “Garlic,” “Allicin,” “Ajoene,” “ Leishmania,” “in vitro,” “in vivo,” and “clinical trial,” alone or in combination from 5 English databases (Web of Science, PubMed, Science Direct, Scopus, Google Scholar) and 3 Persian databases (Scientific Information Database, Iran Medex, and Magiran) from 1990 to 2014. In summary, garlic with immunomodulatory effects and apoptosis induction contributes to the treatment of leishmaniasis.

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