scholarly journals Expatiating the Therapeutic Profile of Garlic (Allium sativum): a Bench to Bedside Approach

2021 ◽  
Vol 11 (6) ◽  
pp. 14225-14239
Keyword(s):  
Allium Sativum ◽  
Therapeutic Potential ◽  
Review Article ◽  
Diallyl Disulfide ◽  
Organosulfur Compounds ◽  
Microbial Characteristics ◽  
Clinical Models ◽  
Health And Disease ◽  
Anti Oxidant ◽  
Therapeutic Profile

Garlic (Allium sativum) is amongst the oldest medicinal plant in centuries. It is an amazing plant that contains numerous bioactive components such as organosulfur compounds, allicin, s-allyl cysteine, S-allyl-mercapto cysteine, diallyl sulfide, diallyl disulfide, and diallyl trisulfide. This review discusses numerous valuable effects and therapeutic potential of garlic in treating several diseases such as cancer, obesity, diabetes, liver injury, hypertension, inflammation, viral infection, and arthritis. The enormous immunomodulatory, anti-oxidant, and anti-microbial characteristics of garlic have also been explained briefly. This review article also gives insight into the nanotechnology-based phytopharmaceuticals of garlic; has summarized pre-clinical models, clinical trials, and patents published about garlic's therapeutic applications and its phytoconstituents in the management of several disease conditions. This review article brings more attention to garlic, providing effective scientific proof for improved utilization of garlic in human health and disease control.

scholarly journals Ethnobotany, Phytochemical, Pharmacological Potentials of Murraya koenigii, and Its Health Benefits – A Review

2020 ◽  
pp. 29-38
Author(s):  
Priyanka Goyal ◽  
Rohit Chhabra ◽  
Lavanya Vij
Keyword(s):  
Therapeutic Potential ◽  
Health Benefits ◽  
Biological Properties ◽  
Review Article ◽  
Murraya Koenigii ◽  
Potential Health ◽  
Traditional Medicines ◽  
Whole Plant ◽  
Anti Oxidant ◽  
Anti Fungal

Murraya koenigii, also widely known as curry leaves and curry patta, is a noticeably significant plant recognized all around the world for its tremendous therapeutic, medicinal worth and characteristic aromatic properties. It is one of the major export commodities originated from east and southern part of India bringing good foreign revenue. This review article is designed to assess and compile all the currently available literature on ethnobotanical aspects and phytochemical, pharmacological potentials of M. koenigii. Morphologically, it is a semi deciduous small shrub or aromatic shrub having slender but strong woody stem with branches covered with grey bark. The whole plant of M. koenigii viz., as stem, leaf, fruits, root and seeds have been accounted to have anti-oxidant, anti-fungal, anti-candidal, anti-bacterial, anti-hypersensitive and various biological properties. It is also additionally used in hormonal therapy in traditional medicines as a dysenteric, blood purifier, diuretic, febrifuge, hair tonic, anti-inflammatory, analgesic, antipyretic and anti-diarrheal. M. koenigii oil is said to have massive impact in the pharmaceuticals and in aromatherapy enterprises as a powerful ingredient. Many researchers have worked on all parts of M. koenigii, from roots, stem, leaves up its bark. This review is an attempt to summarize all the diverse literature available so as to compile a reliable review article on M. koenigii providing detailed information on therapeutic potential, health benefits and pharmacological applications of the plant.

scholarly journals Allium sativum, a potential phytopharmacological source of natural medicine for better health

2021 ◽  
Vol 06 (03) ◽  
pp. 220-232
Author(s):  
Bhushan R. Gudalwar ◽  
Minakshee G. Nimbalwar ◽  
Wrushali A. Panchale ◽  
Ashish B. Wadekar ◽  
Jagdish V. Manwar ◽  
...  
Keyword(s):  
Functional Food ◽  
Functional Foods ◽  
Allium Sativum ◽  
Therapeutic Potential ◽  
Bioactive Constituents ◽  
Natural Medicine ◽  
Potential Benefits ◽  
Crude Drugs ◽  
Therapeutic Profile ◽  
Improve Health

Allium sativum, is a perennial flowering bulb which has been consumed worldwide as a functional food and known from thousands of years for its medicinal and culinary properties. Therapeutic potential of garlic is attributed to presence of its vital phytoconstituents. In present review, a complete therapeutic profile of drug is summarized by discussing its potential benefits highlighting the bioactive constituents. Phytoconstituents of crude drugs are used as antiviral, antioxidant, anti-inflammatory, antibacterial, antifungal, immunomodulatory, cardioprotective, anticancer, hepatoprotective, anti-diabetic, anti-obesity, neuroprotective, etc. Thus, it could conclude that garlic is one of the superior natural sources of bioactive compounds and has promising applications in the development of functional foods and nutraceuticals to improve health, and to prevent chronic diseases in the human.

In Vitro Immunodetection of Prothymosin Alpha in Normal and Pathological Conditions

2020 ◽  
Vol 27 (29) ◽  
pp. 4840-4854 ◽  
Author(s):  
Chrysoula-Evangelia Karachaliou ◽  
Hubert Kalbacher ◽  
Wolfgang Voelter ◽  
Ourania E. Tsitsilonis ◽  
Evangelia Livaniou
Keyword(s):  
Mammalian Cells ◽  
Therapeutic Potential ◽  
Prothymosin Alpha ◽  
Disease States ◽  
Leading Role ◽  
Tissue Extracts ◽  
Biologic Response ◽  
Health And Disease ◽  
Almost All

Prothymosin alpha (ProTα) is a highly acidic polypeptide, ubiquitously expressed in almost all mammalian cells and tissues and consisting of 109 amino acids in humans. ProTα is known to act both, intracellularly, as an anti-apoptotic and proliferation mediator, and extracellularly, as a biologic response modifier mediating immune responses similar to molecules termed as “alarmins”. Antibodies and immunochemical techniques for ProTα have played a leading role in the investigation of the biological role of ProTα, several aspects of which still remain unknown and contributed to unraveling the diagnostic and therapeutic potential of the polypeptide. This review deals with the so far reported antibodies along with the related immunodetection methodology for ProTα (immunoassays as well as immunohistochemical, immunocytological, immunoblotting, and immunoprecipitation techniques) and its application to biological samples of interest (tissue extracts and sections, cells, cell lysates and cell culture supernatants, body fluids), in health and disease states. In this context, literature information is critically discussed, and some concluding remarks are presented.

Critical Review on the Chemical Aspects of Cannabidiol (CBD) and Harmonization of Computational Bioactivity Data

2020 ◽  
Vol 28 (2) ◽  
pp. 213-237 ◽  
Author(s):  
Andrea Mastinu ◽  
Giovanni Ribaudo ◽  
Alberto Ongaro ◽  
Sara Anna Bonini ◽  
Maurizio Memo ◽  
...  
Keyword(s):  
In Silico ◽  
Cannabis Sativa ◽  
Therapeutic Potential ◽  
The Novel ◽  
In Silico Studies ◽  
Computational Data ◽  
Synthetic Approaches ◽  
Analytical Approaches ◽  
Yield Sensitivity ◽  
Therapeutic Profile

: Cannabidiol (CBD) is a non-psychotropic phytocannabinoid which represents one of the constituents of the “phytocomplex” of Cannabis sativa. This natural compound is attracting growing interest since when CBD-based remedies and commercial products were marketed. This review aims to exhaustively address the extractive and analytical approaches that have been developed for the isolation and quantification of CBD. Recent updates on cutting-edge technologies were critically examined in terms of yield, sensitivity, flexibility and performances in general, and are reviewed alongside original representative results. As an add-on to currently available contributions in the literature, the evolution of the novel, efficient synthetic approaches for the preparation of CBD, a procedure which is appealing for the pharmaceutical industry, is also discussed. Moreover, with the increasing interest on the therapeutic potential of CBD and the limited understanding of the undergoing biochemical pathways, the reader will be updated about recent in silico studies on the molecular interactions of CBD towards several different targets attempting to fill this gap. Computational data retrieved from the literature have been integrated with novel in silico experiments, critically discussed to provide a comprehensive and updated overview on the undebatable potential of CBD and its therapeutic profile.

scholarly journals BOARD INVITED REVIEW: The pig microbiota and the potential for harnessing the power of the microbiome to improve growth and health1

2019 ◽  
Vol 97 (9) ◽  
pp. 3741-3757 ◽  
Author(s):  
Nirosh D Aluthge ◽  
Dana M Van Sambeek ◽  
Erin E Carney-Hinkle ◽  
Yanshuo S Li ◽  
Samodha C Fernando ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Gut Microbiota ◽  
Therapeutic Potential ◽  
Animal Health ◽  
Microbial Colonization ◽  
Critical Importance ◽  
Specific Host ◽  
Microbiome Research ◽  
Health And Disease ◽  
The Impact

Abstract A variety of microorganisms inhabit the gastrointestinal tract of animals including bacteria, archaea, fungi, protozoa, and viruses. Pioneers in gut microbiology have stressed the critical importance of diet:microbe interactions and how these interactions may contribute to health status. As scientists have overcome the limitations of culture-based microbiology, the importance of these interactions has become more clear even to the extent that the gut microbiota has emerged as an important immunologic and metabolic organ. Recent advances in metagenomics and metabolomics have helped scientists to demonstrate that interactions among the diet, the gut microbiota, and the host to have profound effects on animal health and disease. However, although scientists have now accumulated a great deal of data with respect to what organisms comprise the gastrointestinal landscape, there is a need to look more closely at causative effects of the microbiome. The objective of this review is intended to provide: 1) a review of what is currently known with respect to the dynamics of microbial colonization of the porcine gastrointestinal tract; 2) a review of the impact of nutrient:microbe effects on growth and health; 3) examples of the therapeutic potential of prebiotics, probiotics, and synbiotics; and 4) a discussion about what the future holds with respect to microbiome research opportunities and challenges. Taken together, by considering what is currently known in the four aforementioned areas, our overarching goal is to set the stage for narrowing the path towards discovering how the porcine gut microbiota (individually and collectively) may affect specific host phenotypes.

scholarly journals Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1609
Author(s):  
Lutfun Nahar ◽  
Shaymaa Al-Majmaie ◽  
Afaf Al-Groshi ◽  
Azhar Rasul ◽  
Satyajit D. Sarker
Keyword(s):  
Medicinal Plant ◽  
Critical Appraisal ◽  
Therapeutic Potential ◽  
Therapeutic Agents ◽  
Review Article ◽  
Natural Distribution ◽  
Antiplatelet Aggregation ◽  
Ruta Chalepensis ◽  
The Family ◽  
Novel Therapeutic

Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis L. (Fam: Rutaceae) but also distributed in various species of the genera Boenminghausenia, Clausena and Ruta. The distribution of these compounds appears to be restricted to the plants of the family Rutaceae. To date, there have been a considerable number of bioactivity studies performed on coumarins 1 and 2, which include their anticancer, antidiabetic, antifertility, antimicrobial, antiplatelet aggregation, antiprotozoal, antiviral and calcium antagonistic properties. This review article presents a critical appraisal of publications on bioactivity of these 3-prenylated coumarins in the light of their feasibility as novel therapeutic agents and investigate their natural distribution in the plant kingdom, as well as a plausible biosynthetic route.

scholarly journals Melatonin: A Novel Indolamine in Oral Health and Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
V. K. Chava ◽  
K. Sirisha
Keyword(s):  
Gastrointestinal Tract ◽  
Oral Health ◽  
Oral Cavity ◽  
Salivary Glands ◽  
In Vivo Studies ◽  
Systemic Level ◽  
A Cell ◽  
Health And Disease ◽  
Anti Oxidant

This paper attempts to summarise the findings accumulated within the last few years concerning the hormone of darkness “melatonin.” Based on its origin, from the pineal gland until recently it was portrayed exclusively as a hormone. Due to its lipophilic nature, it is accessible to every cell. Thus, in the classic sense it is a cell protector rather than a hormone. Recent studies, by Claustrat et al. (2005), detected few extrapineal sources of melatonin like retina, gastrointestinal tract, and salivary glands. Due to these sources, research by Cutando et al. (2007), is trying to explore the implications of melatonin in the oral cavity, in addition to its physiologic anti-oxidant, immunomodulatory and oncostatic functions at systemic level that may be receptor dependent or independent. Recently, certain in vivo studies by Shimozuma et al. (2011), detected the secretion of melatonin from salivary glands further emphasising its local activity. Thus, within our confines the effects of melatonin in the mouth are reviewed, adding a note on therapeutic potentials of melatonin both systemically and orally.

Pharmacological activities and Therapeutic potential of kaempferitrin in medicine for the treatment of human disorders: A review of medicinal importance and health benefits

2021 ◽  
Vol 21 ◽  
Author(s):  
Dinesh Kumar Patel
Keyword(s):  
Broiler Chickens ◽  
Therapeutic Potential ◽  
Scientific Information ◽  
Aloe Vera ◽  
Crocus Sativus ◽  
Related Complication ◽  
Food Material ◽  
Biological Potential ◽  
Anti Oxidant ◽  
Anti Inflammatory

Background: Herbal drugs and their derived phytochemicals are valuable for human being as a source of vital component of food material and drugs. Flavonoids are naturally occurring phytochemical produced in plants through metabolisms and they are having anti-hyperlipidemia, anti-inflammatory, anti-oxidant and anti-apoptotic activity. Flavonoids have been identified in the fruits, nuts, vegetables, seeds, stem, flowers and tea. Kaempferol is a natural flavonoidal compound present in edible plants such as apples, broccoli, strawberries, beans, grapefruit, propolis and medicinal plants such as Aloe vera, Ginkgo biloba, Rosmarinus officinalis, Crocus sativus L., Hypericum perforatum L. Kaempferol have anti-oxidant, anti-inflammatory, anti-apoptotic, pro-apoptotic, cardio-protective and anti-cancer activities. Methods: Glycosides of kaempferol such as kaempferitrin also called kaempferol 3,7-dirhamnoside are known to be more abundant than their flavonoid monomers in plants. Various literature databases have been searched to collect all the scientific information of kaempferitrin in the present investigation and analyzed in order to know the therapeutic benefit and biological potential of kaempferitrin. Moreover all the information has been presented here in two broad sections i.e. pharmacological and analytical. Results: From the analysis of all the collected and presented information, it was found that kaempferitrin has potent insulin-mimetic potential and could be used for the treatment of diabetes and related complication. However, it has also shown anti-oxidant, anti-inflammatory, anti-convulsant, anti-osteoporotic, anti-depressant, anthelmintic, immunostimulatory and natriuretic properties and inhibits cell proliferation and apoptosis. Kaempferitrin also improves meat quality of broiler chickens. Conclusions: The presented information in this work will be valuable to justify the biological importance and therapeutic potential of kaempferitrin in the scientific field.

scholarly journals Fecal Virome Transplantation

2021 ◽  
Author(s):  
Derek Lin ◽  
Henry C. Lin
Keyword(s):  
Immune System ◽  
Human Health ◽  
Bacterial Communities ◽  
Therapeutic Potential ◽  
Large Population ◽  
Current Understanding ◽  
Host Immune System ◽  
Full Extent ◽  
Health And Disease ◽  
Established Role

The gut virome consists of a large population of eukaryotic and prokaryotic viruses that have an emerging role in human health and disease. Growing evidence for the importance of the virome includes recent findings on fecal virome transplantation (FVT) that suggest FVT may have therapeutic potential for the resolution of dysbiosis and treatment of dysbiosis-related disorders. Most viruses in the gut virome are bacteriophages (phages), which have a well-established role in regulating bacterial communities across environments. Phages also influence health and disease by interacting directly with the host immune system. The full extent to which gut phages should be considered as both a target and a tool for microbiome modulation remains to be seen. This chapter will explore the current understanding of the gut virome and the therapeutic potential for FVT.

scholarly journals The nutritional applications of garlic (Allium sativum) as natural feed additives in animals

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11934
Author(s):  
Jiashun Chen ◽  
Fang Wang ◽  
Yexin Yin ◽  
Xiaokang Ma
Keyword(s):  
Allium Sativum ◽  
Animal Feed ◽  
Animal Husbandry ◽  
Feed Additives ◽  
Bioactive Molecules ◽  
Herbal Remedies ◽  
Organosulfur Compounds ◽  
Beneficial Effects ◽  
Stress Markers

Garlic (Allium sativum) is an essential vegetable that has been widely utilized as seasoning, flavoring, culinary and in herbal remedies. Garlic contains several characteristic organosulfur compounds, such as diallyl sulfide, allicin (diallyl thiosulphate), γ-glutamylcysteine, and S-allyl cysteine (alliin) and ajoene, which garlic has beneficial effects on inflammation, oxidative stress markers, hypertension, hyperlipidaemia and endothelial function in vitro or in animal model. These bioactive molecules are also playing pivotal role in livestock and fisheries production apart from its application in humans. Supplementation of animal feed with garlic and its related products is consistent with the modern agricultural concept of organic animal husbandry. This review compiles the information describing the effects of feeding garlic and its extracts on selected performance parameters in animals (chicken, rabbits, ruminants, pigs and fish). This review may provide reference for scientists and entrepreneurs to investigate the applications of feeds added with garlic and allicin by-products for the improvement of animal husbandry and aquatic production.

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