The Methylene-Cycloalkylacetate (MCA) Scaffold in Terpenyl Compounds with Potential Pharmacological Activities
Keyword(s):
Recently, the methylene-cycloakylacetate (MCA) scaffold has been reported as a potential pharmacophore for neurite outgrowth activity. In this work, natural diterpenes that embed MCA fragments are reviewed, as they are major components of Halimium viscosum: ent-halimic acid, the prototype for these bioactive compounds. Herein, structures, sources, and activities for the natural diterpenes, as well as their synthetic derivatives of interest, are reviewed.
2020 ◽
Vol 27
(40)
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pp. 6864-6887
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2019 ◽
Vol 16
(4)
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pp. 377-391
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2019 ◽
Vol 18
(10)
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pp. 1417-1424
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Keyword(s):
2017 ◽
Vol 2017
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pp. 1-24
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