Facile and Rapid Isolation of Oxypeucedanin Hydrate and Byakangelicin from Angelica dahurica by Using [Bmim]Tf2N Ionic Liquid

Ionic liquids (ILs) have sparked much interest as alternative solvents for plant materials as they provide distinctive properties. Therefore, in this study, the capacity of ILs to extract oxypeucedanin hydrate and byakangelicin from the roots of Angelica dahurica (A. dahurica) was investigated. The back-extraction method was examined to recover target components from the IL solution as well. Herein, [Bmim]Tf2N demonstrated outstanding performance for extracting oxypeucedanin hydrate and byakangelicin. Moreover, factors including solvent/solid ratio, extraction temperature and time were investigated and optimized using a statistical approach. Under optimum extraction conditions (solvent/solid ratio 8:1, temperature 60 °C and time 180 min), the yields of oxypeucedanin hydrate and byakangelicin were 98.06% and 99.52%, respectively. In addition, 0.01 N HCl showed the most significant ability to back-extract target components from the [Bmim]Tf2N solution. The total content of both oxypeucedanin hydrate (36.99%) and byakangelicin (45.12%) in the final product exceeded 80%. Based on the data, the proposed approach demonstrated satisfactory extraction ability, recovery and enrichment of target compounds in record time. Therefore, the developed approach is assumed essential to considerably reduce drawbacks encountered during the separation of oxypeucedanin hydrate and byakangelicin from the roots of A. dahurica.

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Optimization of Ultrasonic Cellulase-Assisted Extraction and Antioxidant Activity of Natural Polyphenols from Passion Fruit

Molecules ◽

10.3390/molecules26092494 ◽

2021 ◽

Vol 26 (9) ◽

pp. 2494

Author(s):

Wei Wang ◽

Yu-Ting Gao ◽

Ji-Wen Wei ◽

Yin-Feng Chen ◽

Qing-Lei Liu ◽

...

Keyword(s):

Antioxidant Activity ◽

Extraction Method ◽

Ph Value ◽

Soxhlet Extraction ◽

Passion Fruit ◽

Total Phenol Content ◽

Extraction Temperature ◽

Scavenging Activity ◽

Solid Ratio ◽

Dpph Scavenging

In this paper, ultrasonic cellulase extraction (UCE) was applied to extract polyphenols from passion fruit. The extraction conditions for total phenol content (TPC) and antioxidant activity were optimized using response surface methodology (RSM) coupled with a Box-Behnken design (BBD). The results showed that the liquid-to-solid ratio (X2) was the most significant single factor and had a positive effect on all responses. The ANOVA analysis indicated quadratic models fitted well as TPC with R2 = 0.903, DPPH scavenging activity with R2 = 0.979, and ABTS scavenging activity with R2 = 0.981. The optimal extraction parameters of passion fruit were as follows: pH value of 5 at 30 °C for extraction temperature, 50:1 (w/v) liquid-to-solid ratio with extraction time for 47 min, the experimental values were found matched with those predicted. Infrared spectroscopy suggested that the extract contained the structure of polyphenols. Furthermore, three main polyphenols were identified and quantified by HPLC. The results showed the content of phenolic compounds and antioxidant activity of the optimized UCE were 1.5~2 times higher than that determined by the single extraction method and the Soxhlet extraction method, which indicates UCE is a competitive and effective extraction technique for natural passion fruit polyphenols.

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Optimization of Ultrasound-Assisted Extraction of Antioxidant Polyphenols from the Seed Coats of Red Sword Bean (Canavalia gladiate (Jacq.) DC.)

Antioxidants ◽

10.3390/antiox8070200 ◽

2019 ◽

Vol 8 (7) ◽

pp. 200 ◽

Cited By ~ 5

Author(s):

Yue Zhou ◽

Xiao-Yu Xu ◽

Ren-You Gan ◽

Jie Zheng ◽

Ya Li ◽

...

Keyword(s):

Extraction Method ◽

Natural Antioxidants ◽

Extraction Time ◽

Antioxidant Compounds ◽

Extraction Temperature ◽

Ultrasound Assisted Extraction ◽

Solid Ratio ◽

Assisted Extraction ◽

Ultrasound Assisted ◽

Seed Coats

The seed coat of red sword bean (Canavalia gladiata (Jacq.) DC.) is rich in antioxidant polyphenols. It is often discarded as a byproduct with the consumption of red sword bean, since it is very thick and not consumed by people. The aim of this study was to develop an ultrasound-assisted extraction method to extract natural antioxidants from the seed coats. The extraction process was optimized by using response surface methodology. After the single-factor experiments, three key factors, including ethanol concentration, liquid/solid ratio, and extraction time, were selected and their interactions were studied using a central composite design. The optimal extraction condition was 60.2% hydroethanol, a liquid/solid ratio of 29.3 mL/g, an extraction time of 18.4 min, an extraction temperature of 50 °C, and ultrasound power of 400 W. Under the optimal conditions, antioxidant activity of the extract was 755.98 ± 10.23 μmol Trolox/g dry weight (DW), much higher than that from maceration (558.77 ± 14.42 μmol Trolox/g DW) or Soxhlet extraction (479.81 ± 12.75 μmol Trolox/g DW). In addition, the main antioxidant compounds in the extract were identified and quantified by high-performance liquid chromatography–diode array detection–tandem mass spectrometry (HPLC–DAD–MS/MS). The concentrations of digalloyl hexoside, methyl gallate, gallic acid, trigalloyl hexoside, and digallic acid were 15.30 ± 0.98, 8.85 ± 0.51, 8.76 ± 0.36, 4.27 ± 0.21, and 2.89 ± 0.13 mg/g DW. This study provides an efficient and green extraction method for the extraction of natural antioxidants from the bean coat of red sword bean. The extract of antioxidants might be added into functional foods or nutraceuticals with potential beneficial functions.

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Effect of Temperature, Moisture Content, Particle Size and Roasting on Shea Butter Extraction Efficiency

International Journal of Food Engineering ◽

10.2202/1556-3758.1848 ◽

2010 ◽

Vol 6 (2) ◽

Cited By ~ 4

Author(s):

George Y. Obeng ◽

Michael K Adjaloo ◽

Peter Donkor

Keyword(s):

Particle Size ◽

Moisture Content ◽

Extraction Method ◽

Extraction Efficiency ◽

Low Pressure ◽

Oil Extraction ◽

Screw Press ◽

Shea Butter ◽

Extraction Temperature ◽

Optimum Extraction

The purpose of this study is to establish optimum extraction temperature, moisture content, particle size and the effect of roasting of shea kernels on extraction efficiency for optimum shea butter yield using low pressure (45kg/cm2) manual screw press. Extraction of shea butter is a major income generating activity in Ghana, particularly in the Northern Regions. It is estimated that about 80% of the shea butter produced in Ghana is processed by women using traditional aqueous extraction method. Commercial extraction using continuous screw press accounts for about 20% of production. Oil extraction rates for the traditional aqueous extraction method are relatively low. The traditional aqueous method involves roasting, milling, creaming and boiling, and relies on very low pressure, high moisture of 65-68% and temperatures of 100-140°C. In this study Intermediate Moisture Content (IMC) method was employed. The IMC method involves the use of a low pressure manual screw press to extract butter from shea kernels. The study established an optimum extraction temperature of 60°C and moisture content of 12% at which butter extraction efficiency was between 65.9% and 68.5%. The results revealed that oil extraction efficiency depends on the fineness of paste to be processed and that roasted kernels do not give higher butter yield than unroasted kernels. This is against the traditional belief that high shea butter yield can only be achieved when the kernels are roasted.

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Optimization of DHEA Extraction from Sweet Potato Pomace by Ultrasonic-Microwave Synergistic Employing Response Surface Methodology

Journal of AOAC International ◽

10.5740/jaoacint.18-0232 ◽

2019 ◽

Vol 102 (2) ◽

pp. 680-682

Author(s):

Junjian Ran ◽

Xinhong Liang ◽

Hanmei Du ◽

Junliang Sun

Keyword(s):

Response Surface Methodology ◽

Response Surface ◽

Sweet Potato ◽

Extraction Method ◽

Extraction Efficiency ◽

Extraction Yield ◽

Extraction Temperature ◽

Liquid Ratio ◽

Solid Liquid ◽

Optimum Extraction

Abstract Background: A lot of sweet potato residues (SPR) were discarded and wasted. Objective: To make full use of the SPR. Methods: Ultrasonic microwave synergistic (UMS) extraction method was used to extractdehydroepiandrosterone (DHEA) in SPR. The extraction conditions were optimized by response surface methodology based on single factors. Results: The optimum extraction conditions were 1:25 (solid–liquid ratio), 300 W (microwave power), 30 min (extraction time), and 30°C (extraction temperature). The extraction yield of DHEA from SPR reached 117.25 μg/100 g. Conclusions: The advantage of UMS extractiontechnology is to make full use of the synergistic effect of ultrasound and microwave to improve extraction efficiency. Highlights: The technology provides an effective way to improve the DHEA extraction yield from the SPR in industrial production.

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Optimization of extraction technology of polysaccharide from foxtail millet using response surface methodology

Chemical Industry and Chemical Engineering Quarterly ◽

10.2298/ciceq130926040z ◽

2014 ◽

Vol 20 (4) ◽

pp. 579-585 ◽

Cited By ~ 3

Author(s):

Ai-Shi Zhu ◽

Jin-Na Ye ◽

Fei-Na Yan

Keyword(s):

Response Surface Methodology ◽

Response Surface ◽

Foxtail Millet ◽

Polynomial Equation ◽

Extraction Time ◽

Extraction Temperature ◽

Extraction Technology ◽

Solid Ratio ◽

Experimental Yield ◽

Optimum Extraction

The experiment of extraction of polysaccharide from foxtail millet was investigated. Response Surface Methodology (RSM),based on a threelevel, three variablesBox-Behnken design (BBD), was employed to obtain the best possible combination of liquid-solid ratio(X1: 15.0-25.0 mL?g-1),extraction time (X2: 1.5-2.5h), and extraction temperature (X3: 65.0-75.0?C)for maximum polysaccharide yields. The experimental data obtained were fitted to a second-order polynomial equation using multiple regression analysis and also analyzed by appropriate statistical methods (ANOVA). The optimum extraction conditions were as follows: liquid-solid ratio 20.7mL?g-1, extraction time 2.0h, extraction temperature 72.3?C. Under these conditions, the experimental yield was 8.08mg?g-1, which is well in close agreement with8.02mg?g-1predicted value by the model.

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DES Based Efficient Extraction Method for Bioactive Coumarins from Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav.

Separations ◽

10.3390/separations9010005 ◽

2021 ◽

Vol 9 (1) ◽

pp. 5

Author(s):

Ting Wang ◽

Qian Li

Keyword(s):

Choline Chloride ◽

Radical Scavenging ◽

Deep Eutectic Solvents ◽

Extraction Yield ◽

Molar Ratio ◽

Angelica Dahurica ◽

Extraction Temperature ◽

Solid Ratio ◽

Before And After ◽

Ultrasonic Assisted

In this study, a simple and environmentally friendly method was developed for the extraction of seven active coumarins from Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav.(A. dahurica) based on deep eutectic solvents (DESs). Among the 16 kinds of DES based on choline chloride, the DES system with the molar ratio of choline chloride, citric acid, and water as 1:1:2 had the best extraction effect. Ultrasonic-assisted response surface methodology (RSM) was used to investigate the optimal extraction scheme. The results showed that the optimal extraction conditions were a liquid–solid ratio of 10:1 (mL/g), an extraction time of 50 min, an extraction temperature of 59.85 °C, and a moisture content of 49.28%. Under these conditions, the extraction yield reached 1.18%. In addition, scanning electron microscopy (SEM) was used to observe the degree of powder fragmentation before and after extraction with different solvents. The cells of A. dahurica medicinal materials obtained by DES ultrasonic-assisted treatment were the most seriously broken, indicating that DES had the highest efficiency in the treatment of A. dahurica. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) DPPH radical scavenging model was used to evaluate the biological activity of DES extract. The results showed that DES extract had better scavenging ability of DPPH free radical. Therefore, DES is a green solvent suitable for extracting coumarin compounds of A. dahurica, with great potential to replace organic solvents.

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Ultrasound-Assisted Extraction of Imperatorin and Isoimperatorin from Roots of Angelica dahurica

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.550-553.1845 ◽

2012 ◽

Vol 550-553 ◽

pp. 1845-1851

Author(s):

Yun Chen ◽

Si Yu Yang ◽

Ning Li ◽

Li Juan Zhang ◽

Yu Qian

Keyword(s):

Mass Transfer Rate ◽

Extraction Yield ◽

Angelica Dahurica ◽

Scanning Electron Micrographs ◽

Extraction Temperature ◽

Ultrasound Assisted Extraction ◽

Assisted Extraction ◽

Ultrasound Assisted ◽

Fast Extraction ◽

Optimum Extraction

Imperatorin and isoimperatorin are important components of Angelica dahurica with many beneficial functions to human health. In this study, an ultrasound-assisted extraction technique has been developed for the fast extraction of imperatorin and isoimperatorin from Angelica dahurica root. The high extraction yield of imperatorin and isoimperatorin was obtained under optimum extraction conditions: ultrasonication time 20 min, extraction temperature 30°C, ultrasound power 240w, ethanol concentration 80%, and ratio of solvent volume to sample weight 12:1 (ml/g), particle size 60 meshes. Compared to heat-reflux extraction, ultrasound-assisted extraction reduced extraction time and obtained higher percentage extracted of imperatorin and isoimperatorin. Scanning electron micrographs revealed that ultrasound could result in the destruction of cell walls, which increased the mass transfer rate of the solvents into the root materials

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Optimization of Extraction Condition of Mycelium Polysaccharide from Tricholoma mongolium by Response Surface Methodology

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.361-363.770 ◽

2011 ◽

Vol 361-363 ◽

pp. 770-776

Author(s):

Xiao Tong Wu ◽

Qi Wei Ren ◽

Jie Zhang ◽

Ji Zhao ◽

Su Ting Han ◽

...

Keyword(s):

Response Surface Methodology ◽

Response Surface ◽

Hot Water ◽

The Other ◽

Extraction Temperature ◽

Single Factor ◽

Extraction Condition ◽

Hot Water Extraction ◽

Solid Ratio ◽

Optimum Extraction

In this paper, the hot water extraction conditions of mycelium polysaccharide ofTricholoma mongoliumwere investigated. By single-factor experiments, ethanol amount was determined at three times and the other factors (liquid–solid ratio, extraction temperature and time) were chosen to further optimize extraction conditions using response surface methodology (RSM). The Center Composite experimental results showed the optimum extraction conditions as follows: a temperature of 85.38°C, a liquid–solid ratio of 31.78 g/ mL and a extraction time of 2.18 h. Under these conditions, two extractions sufficiently reached the maximal the rate of mycelium polysaccharide 7.23%.

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Experimental Study on Extracting Humic Acid from Lignite

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.158.56 ◽

2010 ◽

Vol 158 ◽

pp. 56-63 ◽

Cited By ~ 3

Author(s):

Peng Wei Jiang ◽

Zhi Jun Ma ◽

Yue Xin Han

Keyword(s):

Humic Acid ◽

Acid Production ◽

Sodium Hydroxide Solution ◽

Processing Condition ◽

Total Content ◽

Coal Industry ◽

Acid Extraction ◽

Extraction Temperature ◽

Temperature Oxidation ◽

Solid Ratio

Humic acid has been extensively used in the fields like industry, agriculture, medicine, environment protection, etc. As a kind of potential organic resources that being developed and utilized, humic acid is drawing more and more attention from the world. China is abundant in coal resource; the lignite of China contains a lot of humic acid. Extraction humic acid from lignite creates favorable conditions for the development of coal industry and agriculture industry, has broad utilization prospect. By combining the method of nitric acid preoxidation and the method of alkali solution and acid eduction, the humic acid was extracted from the lignite. The orthogonal experimental method and FTIR were integrated in this study. The influences of nitrate concentrations, acid-coal proportion, oxidized temperature, oxidation time, extraction liquid concentration, liquid-solid ratio, extraction temperature and extraction time etc. on the process of extracting humic acid were examined. The results indicate the optimal processing condition can achieved when using sodium pyrophosphate and sodium hydroxide solution as the extraction agents, the rate of humic acid production can reach to 39.25%. And the total content of humic acid production can reach to 46.14%.

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Orthogonal Optimization of Polysaccharide Extraction from Millet Bran

E3S Web of Conferences ◽

10.1051/e3sconf/20197802011 ◽

2019 ◽

Vol 78 ◽

pp. 02011

Author(s):

Songling Cai ◽

Min Pang

Keyword(s):

Extraction Method ◽

Extraction Process ◽

Orthogonal Test ◽

Extraction Rate ◽

Extraction Time ◽

Alkali Concentration ◽

Extraction Temperature ◽

Solid Ratio ◽

Optimum Parameters ◽

Orthogonal Optimization

This paper investigated the effects of liquid-solid ratio, extraction time, extraction temperature and alkali concentration on the extraction rate of millet bran polysaccharides by the enzymatic hydrolysis and alkaline extraction method, then the L9 (34) orthogonal test was designed to optimize the extraction process according to the single factor experiment.The optimum parameters were obtained as follow: 15:1 liquid-solid ratio, five hours extraction time, 80° extraction temperature, and 0.7 mol/l concentration of sodium hydroxide. The extraction rate of millet bran polysaccharide reached 11.46% through the verification experiments under these conditions,and the RSD was 1.79%. Therefore, it can provide some experimental basis for the scientific research of millet bran polysaccharides in the future.

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