Antitumor Activity and Potential Mechanism of Novel Fullerene Derivative Nanoparticles

The development of novel nanoparticles as a new generation therapeutic drug platform is an active field of chemistry and cancer research. In recent years, fullerene nanoparticles have received extensive attention due to their unique physical and chemical properties. Properly modified fullerene nanoparticles have excellent biocompatibility and significant anti-tumor activity, which makes them have broad application prospects in the field of cancer therapy. Therefore, understanding the anti-tumor mechanism of fullerene nanoparticles is of great significance for the design and development of anti-tumor drugs with low toxicity and high targeting. This review has focused on various anti-tumor mechanisms of fullerene derivatives and discusses their toxicity and their distribution in organisms. Finally, the review points out some urgent problems that need solution before fullerene derivatives as a new generation of anti-tumor nano-drug platform enter clinical research.

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Carbon Dots: Synthesis, Properties and Biomedical Applications

Journal of Materials Chemistry B ◽

10.1039/d1tb01077h ◽

2021 ◽

Author(s):

Guili Ge ◽

Lin Li ◽

Dan Wang ◽

Mingjian Chen ◽

Zhaoyang Zeng ◽

...

Keyword(s):

Carbon Dots ◽

Biomedical Applications ◽

Chemical Properties ◽

Physical And Chemical Properties ◽

Synthesis Properties ◽

New Type ◽

Low Toxicity ◽

Good Biocompatibility ◽

Physical And Chemical ◽

And Chemical Properties

Carbon dots (CDs) are a new type of carbon nanomaterial that have unique physical and chemical properties, good biocompatibility, low toxicity, easy surface functionalization, making them widely used in biological...

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Study on the Properties and Application of Optim™ Fine Fibers

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.287-290.2561 ◽

2011 ◽

Vol 287-290 ◽

pp. 2561-2564

Author(s):

Jiang Wei Yao ◽

Wei Dong Yu

Keyword(s):

Chemical Properties ◽

Wool Fabric ◽

Physical And Chemical Properties ◽

Performance Difference ◽

Merino Wool ◽

Fine Fiber ◽

The Difference ◽

New Generation ◽

Physical And Chemical ◽

And Chemical Properties

Optim™ fine is a new generation of ultrafine wool fibres, which are transformed by stretching and setting from merino wool. The Optim™ fine retains some of the physical and chemical properties of merino wool, but the morphology and other properties changes, such as the diameter, length, lusture, breaking extension and shrinkage. These changes results in the performance difference btween the fabric woven from Optim™ fine and fine wool fiber. To clearly understande the reason of the difference, the morphological and physical properties changes of Optim™ fine was examined in this paper, and the performance difference between wool fabric and Optim™ fine fabric was evaluated by Fabric Assurance by Simple Testing(FAST). It was found that the decreasing in breaking extension and increasing in shrinkage of Optim™ fine resulted in the declining in formability and dimensional stability of Optim™ fine fabric. Suggestions on the ways of constructing Optim™ fine into fabric were also given according to the anlysis of relationship between the properties changes of Optim™ fine fiber and that of its fabric.

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Synthesis and Characterization of Allyl Terpene Maleate Monomer

Scientific Reports ◽

10.1038/s41598-019-55356-8 ◽

2019 ◽

Vol 9 (1) ◽

Author(s):

Yan Gu ◽

Matthew Hummel ◽

Kasiviswanathan Muthukumarappan ◽

Zhendong Zhao ◽

Zhengrong Gu

Keyword(s):

Substitution Reaction ◽

Allyl Chloride ◽

Chemical Properties ◽

Simple Method ◽

Renewable Chemicals ◽

Important Intermediate ◽

Low Toxicity ◽

Exploratory Experimentation ◽

Physical And Chemical ◽

First Time

AbstractTerpenes and their derivatives are sustainable, renewable chemicals that can be used as a complementary hydrocarbon. The exceptions are fossil-based feedstocks and lignin-based feedstocks. A simple method has been found to prepare allyl terpene maleate monomer by substitution reaction at lower reaction temperatures. Using terpenes from turpentine, maleic anhydride and allyl chloride as reactants, the synthesized monomer, terpene-diallyl maleate adduct, was prepared by D-A addition, hydrolysis, and substitution reaction. The resultant monomer was characterized for the first time. The synthesized product will be a versatile monomer and a very important intermediate, having broad application prospects. The synthesized monomer will replace similar aromatic compounds in certain applications because of its low-toxicity and sustainability. The synthesized monomer with two terminal olefin structures has great free radical polymerization potential, according to its physical and chemical properties and exploratory experimentation.

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Synergistic effect of antitumor activity of doxorubicin and bicomponent nanostructures based on aluminum oxide

Siberian Journal of Oncology ◽

10.21294/1814-4861-2020-19-2-82-89 ◽

2020 ◽

Vol 19 (2) ◽

pp. 82-89

Author(s):

O. V. Bakina ◽

N. V. Svarovskaya ◽

A. A. Miller ◽

A. S. Lozhkomoev ◽

A. V. Avgustinovich ◽

...

Keyword(s):

Synergistic Effect ◽

Biomedical Application ◽

Chemical Properties ◽

Integrated System ◽

X Ray Diffraction ◽

Joint Application ◽

Transmission Electron ◽

Combined Use ◽

Low Toxicity ◽

Physical And Chemical

Introduction. There are high-thech methods of nanoparticle production with controlled morphology and physical and chemical properties. Alumina-based mesoporous nanostructures have low toxicity and biocompatibility. FDI recommends alumina for biomedical application. Alumina inhibits the grow of cancer due to positive zeta-potential and low solubility in water. We observed the synergistic effect of joint application of doxorubicin and nanostructures. This approach reduces drug concentration and its toxicity.Purpose: to synthesize nanostructures with different surface potentials and to study toxicity of these nanostructures alone and in combination with doxorubicin.Material and Methods. The alumina-based nanostructures were obtained by the hydrolysis of nanopowder. The morphology of nanostructures was investigated by transmission electron microscopy with an integrated system of energy dispersive analysis. The phase composition of the particles was determined by x-ray diffraction. The effect of the synthesized nanostructures on the viability of cell lines was determined using the MTT test.Results. The synthesized nanostructures have a low toxicity and can be used as an adjuvant for doxorubicin.Conclusion. The combined use of doxorubicin and bicomponent nanostructures leads to an increase in the damaging effect of doxorubicin on Neuro-2a cells.

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Synthesis, physical and chemical properties of 5-(phenoxymethylene)-4-R-1,2,4-triazol-3-thiones derivatives, which contain alkyl- and arylnitrile fragments

Farmatsevtychnyi zhurnal ◽

10.32352/0367-3057.4.15.01 ◽

2018 ◽

pp. 52-58

Author(s):

Yu. M. Kucheryavyi ◽

A. G. Kaplaushenko

Keyword(s):

Chemical Properties ◽

Biologically Active ◽

Physical And Chemical Properties ◽

Chemical Methods ◽

The Core ◽

Physical And Chemical ◽

Tumor Drugs ◽

Derivatives Of ◽

Active Substances ◽

And Chemical Properties

Ukraine takes the second place in Europe for the dissemination of cancer. Ukrainian pharmaceutical market practically doesn’t have domestic anti-tumor drugs. That’s why, many scientists of pharmaceutical industry work in this direction. The searching of biologically active substances among derivatives of 1,2,4-triazole is actually for today. Anastrozole and Letrozole are enough known like anti-tumor drugs which contain in their structures the core of 1,2,4-triazole and nitrile groups. The aim of our work is purposeful synthesis a number of new highly effective compounds 2-((5-(phenoxymethylene)-4-R-4H-1,2,4-triazole-3-yl)thio)acetonitriles and 2-, 3-, 4-(((5-(phenoxymethylene)-4-R-4H-1,2,4-triazole-3-yl)thio)methyl)benzo-nitriles, research of its physical and chemical properties. The 5-(phenoxymethylene)-4-R-1,2,4-triazole-3-thiones, which contain alkyl- and arylnitrile groups has been synthesized and its effective methods obtaining have been set. The structure of synthesized compounds has been confirmed by modern complex of physical and chemical methods of analysis. The synthesized compounds with alkyl- and arylnitrile functional groups will become the basis for further modification of the structure to increase results or expand the range of the biological activity.

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The Janus Faces of Nanoparticles

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2007.18113 ◽

2007 ◽

Vol 7 (12) ◽

pp. 4607-4611 ◽

Cited By ~ 39

Author(s):

Ken Donaldson ◽

Anthony Seaton

Keyword(s):

Chemical Properties ◽

Cardiovascular Effects ◽

Adverse Health Effects ◽

Low Toxicity ◽

Physical And Chemical ◽

Testing Protocols ◽

Case Basis ◽

And Oxidative Stress ◽

Potential Use ◽

Gain Access

There is an paradox apparent in the fact that nanoparticles have potential use in nanomedicine for imaging and therapy, whereas combustion-derived NP are thought to be responsible for adverse health effects of air pollution. The nanotechnology industry is in the process of producing a number of new nanoparticles which are as-yet unquantified with regard to both hazard and potential for human exposure. The toxicology of combustion-derived nanoparticles is developing and there is now considerable understanding of how they might drive both adverse lung and cardiovascular effects, including the importance of small size, large relative surface area and oxidative stress. Medicinal nanoparticles are being developed and tested on a case-by-case basis using testing protocols from biomaterials and drug safety and with regard to risk-benefit. There are considerable differences in physical and chemical properties and biodegradability between medicinal nanoparticles and the industrial and combustion-derived nanoparticles studied by particle toxicologists and we would anticipate that the bulk of medicinal NP types will be of low toxicity. However, to resolve the nanoparticle paradox there is a need to advance understanding of the characteristics that control acute and chronic toxicity, translocation, biodegradation and elimination of all of the types of particles likely to gain access to the human body. Much would be gained in this area by collaboration between particle toxicologists and nanopharmacologists.

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SiO2@TiO2 Composite Synthesis and Its Hydrophobic Applications: A Review

Catalysts ◽

10.3390/catal10020171 ◽

2020 ◽

Vol 10 (2) ◽

pp. 171

Author(s):

Alicia Rosales ◽

Karen Esquivel

Keyword(s):

Composite Material ◽

Chemical Properties ◽

Physical And Chemical Properties ◽

Research Information ◽

Chemical Methods ◽

Wide Range ◽

Methods Of Synthesis ◽

Low Toxicity ◽

Physical And Chemical ◽

And Chemical Properties

Titanium dioxide is well known for its photocatalytic properties and low toxicity, meanwhile, silicone dioxide exhibits hydrophobic and hydrophilic properties and thermal stability. The union of these two materials offers a composite material with a wide range of applications that relate directly to the combined properties. The SiO2-TiO2 composite has been synthesized through physical methods and chemical methods and, with adequate conditions, morphology, crystallinity, boundaries between SiO2-TiO2, among other properties, can be controlled. Thus, the applications of this composite are wide for surface applications, being primarily used as powder or coating. However, the available research information on this kind of composite material is still novel, therefore research in this field is still needed in order to clarify all the physical and chemical properties of the material. This review aims to encompass the available methods of synthesis of SiO2-TiO2 composite with modifiers or dopants, the application and known chemical and physical properties in surfaces such as glass, mortar and textile, including aspects for the development of this material.

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Study on the Physical and Chemical Properties of Lueyang’s Basalt Fiber

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.239-242.1376 ◽

2011 ◽

Vol 239-242 ◽

pp. 1376-1381 ◽

Cited By ~ 1

Author(s):

Jian Jun Li ◽

Ying Meng ◽

Yan Chun Liu

Keyword(s):

Basalt Fiber ◽

Chemical Properties ◽

Melting Process ◽

Composite Fiber ◽

Chemical Components ◽

Physical And Chemical Properties ◽

Fiber Materials ◽

New Generation ◽

Physical And Chemical ◽

And Chemical Properties

By deeply analyzing and studying the physical and chemical properties of Lueyang’s basalt fiber, its characteristics such as the chemical components, the crystallization’s upper limit temperature and lower limit temperature during the melting process, and the the viscosity and temperature change during melting process are verified to provide theoretical bases for the industrial production of a new type composite materials, and meanwhile to offer grounds for the development of a new generation of composite fiber materials.

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