scholarly journals Secondary Metabolites Found among the Species Trattinnickia rhoifolia Willd

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7661
Author(s):  
Agerdânio Andrade de Souza ◽  
Brenda Lorena Sánchez Ortíz ◽  
Rosemary de Carvalho Rocha Koga ◽  
Priscila Faimann Sales ◽  
Divino Bruno da Cunha ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Neglected Tropical Diseases ◽  
Scientific Information ◽  
Folk Medicine ◽  
African Species ◽  
The Family ◽  
The Face ◽  
Pharmacological Potential ◽  
Therapeutic Activities ◽  
Trees And Shrubs

Plant-derived products may represent promising strategies in the treatment of Neglected Tropical Diseases (NTDs). From this perspective, it is observed that the Amazon phytogeographic region contains the tribe Canarieae of the Burseraceae family, composed of trees and shrubs supplied with resin channels. Its uses in folk medicine are related to aromatic properties, which have numerous medicinal applications and are present in reports from traditional peoples, sometimes as the only therapeutic resource. Despite its economic and pharmacological importance in the region, and although the family is distributed in all tropical and subtropical regions of the world, most of the scientific information available is limited to Asian and African species. Therefore, the present work aimed to review the secondary metabolites with possible pharmacological potential of the species Trattinnickia rhoifolia Willd, popularly known as “Breu sucuruba”. To this end, an identification key was created for chemical compounds with greater occurrence in the literature of the genus Trattinnickia. The most evident therapeutic activities in the consulted studies were antimicrobial, antioxidant, anti-inflammatory, antiviral, antifungal, anesthetic and antiparasitic. An expressive chemical and pharmacological relevance of the species was identified, although its potential is insufficiently explored, mainly in the face of the NTDs present in the Brazilian Amazon.

scholarly journals PHYTOCHEMICAL ANALYSIS OF Turnera diffusa WILLD

2020 ◽  
Vol 8 (11) ◽  
pp. 402-411
Author(s):  
Maria Regina de Oliveira Silva ◽  
Maria Herbênia Lima Cruz Santos ◽  
Xirley Pereira Nunes ◽  
Emanuel Ernesto Fernandes Santos ◽  
Eugênio Bispo da Silva Júnior
Keyword(s):  
Secondary Metabolites ◽  
Folk Medicine ◽  
Phytochemical Analysis ◽  
Pharmacological Effects ◽  
Phytochemical Screening ◽  
Turnera Diffusa ◽  
Pharmacological Potential ◽  
Ethanol Extracts ◽  
Layer Chromatography ◽  
Chemical Class

Turnera diffusa WILLD is a plant used in folk medicine as a natural stimulant, and the objective of this research is to perform the phytochemical analysis of the secondary metabolites of the damiana of occurrence in the Juazeiro region, northern Bahia - Brazil. A phytochemical screening was performed from three Crude Ethanol Extracts (BSE), EEB1: leaves and flowers; EEB2: stems and EEB3: root. A thin analytical layer chromatography was performed using specific developers to detect each chemical class. Alkaloids, coumarins, anthranic derivatives, phenolic compounds, mono, sequi and diterpenes, naphthoquinones, triterpenes and steroids, saponins, hydrolyzed tannins and xanthines were identified in the three extracts. Only in the BSE of leaves and flowers observed the presence of antroquinones and aglycones. The secondary metabolites identified in the study evidence the pharmacological potential of Turnera diffusa. Phytochemical screening concluded the presence of fourteen classes of secondary metabolites in damiana, indicating important medicinal potential with pharmacological effects reported in the literature.

scholarly journals Campomanesia genus – a literature review of nonvolatile secondary metabolites, phytochemistry, popular use, biological activities, and toxicology

2020 ◽  
Vol 45 (2) ◽  
pp. 12 ◽  
Author(s):  
Luiza De Souza Duarte ◽  
Mariana Toledo Martins Pereira ◽  
Vinicius D’Ávila Bitencourt Pascoal ◽  
Aislan Cristina Rheder Fagundes Pascoal
Keyword(s):  
Secondary Metabolites ◽  
Literature Review ◽  
Plant Extracts ◽  
Food Industry ◽  
Biological Activities ◽  
Antidiarrheal Activity ◽  
Pharmacological Potential ◽  
Treatment Of Wounds ◽  
Toxic Potential ◽  
Therapeutic Activities

The genus Campomanesia belongs to the Myrtaceae family and has about 30 species. It is characterized by citrus-flavored fruits. Several articles describe the extensive use of its fruit, such as in the food industry, however, other parts of the plants are also used for food or pharmacological purposes such as the leaves, flowers, seeds, and roots. Analyzing works published on the genus in the period 2005-2019, we observed that the classes of main flavonoid compounds present are anthocyanins, chalcones, coumarins, tannins, and saponins. Species of this genus are also used as a medicine in the treatment of wounds, toothaches, fractures, and bruises.  Therapeutic activities have also been detected for Campomanesia, such as antimicrobial, antiulcerogenic, antiprotozoal, anti-inflammatory, and antidiarrheal activity, antiproliferative and antioxidant potential, antiplatelet, antithrombotic, and fibrinolytic activities, as well as hypotensive effects. There are a small number of works demonstrating the low toxic potential of plant extracts. Thus, the Campomanesia genus presents pharmacological potential to be explored.

scholarly journals LEMNA MINOR L. AS A SOURCE OF ANTIOXIDANTS

2020 ◽  
Vol 18 (Suppl.1) ◽  
pp. 157-162
Author(s):  
V. Petrova-Tacheva ◽  
V. Ivanov ◽  
A. Atanasov
Keyword(s):  
Antioxidant Activity ◽  
Aquatic Plant ◽  
Lemna Minor ◽  
Scientific Information ◽  
Folk Medicine ◽  
Biologically Active ◽  
Vegetable Fibers ◽  
The Family ◽  
Other Substances ◽  
Active Substances

Lemna Minor L. (LM) is a perennial aquatic plant that belongs to the genus Lemna, the family Lemnaceae and is spread almost ubiquitously. In folk medicine, it is used in the treatment of allergies, asthma, vitiligo, jaundice, glaucoma, rheumatism, gout, and others. In recent years it has become clear that its chemical composition consists of: proteins (up to 35%), vegetable fibers (up to 17%), fats (up to 5%), polysaccharides, flavonoids, amino acids, aliphatic acids, phenolic acids, triterpene compounds, vitamins, micro- and macro-elements and other substances. А significant part of these substances exhibit the antioxidant activity. The scientific information for 12 biologically active substances with antioxidant activity isolated from Lemna Minor is presented in the review.

Peculiarities of family roles distribution in the marrige subsystem

2020 ◽  
Vol 3 (152) ◽  
pp. 57-64
Author(s):  
O. O. Oliinyk ◽  
Keyword(s):  
Research Methods ◽  
Scientific Information ◽  
Married Couples ◽  
Research Problem ◽  
Psychological Climate ◽  
Theoretical Research ◽  
Problem Analysis ◽  
Family Roles ◽  
Marital Relations ◽  
The Family

Changing the system of family values, views of the society on the significance and functioning of the family institution contribute to the transformation of marital role relationships in modern families. The already formed model of role interaction, the ability of spouses to define and clearly distribute family roles and to treat them responsibly is the important factors in building constructive marital relations and creating a favorable psychological climate in the family. Objective. The research deals with the analysis of the essence of the “family role” concept and the classification of family roles; experimental definition and analysis of the main types of family roles in marital relations. Methods. Theoretical research methods were used to solve the research problem: analysis of scientific psychological literature, generalization method, systematization of scientific information. To solve the second part of the set objective, the empirical research methods were used, such as: conversation, psychodiagnostic method “Distribution of roles in the family” by Yu.Ye. Alioshyna, L.Ya. Hofman, O.M. Dubrovska, and also the method of processing and quantitative and qualitative interpretation of results. The research was conducted during September-October 2020. The study involved 11 married couples (husband and wife) with different marital experience of 22 people aged 25 to 47 years (Kyiv). All the couples have children aged 1 to 20 years. The results of an empirical study of the peculiarities of family roles distribution showed that the roles of entertainment organizer (63.64 %), master (mistress), (72.73 % and 63.64 %), the family subculture organizer (54, 55 % and 45.45 %) women and men share almost equally; the roles of educator and “psychotherapist” is more typical for women (90.91 % and 81.82 %); The role of sexual partner and the partner responsible for material support is more often performed by men (90.91 % and 72.73 %). The prospects for further research are seen in the study of role interaction in the parental families of adolescents and young people as a prerequisite for their future family roles.

The impact of traditional plants and their secondary metabolites in the discovery of COVID-19 treatment

2020 ◽  
Vol 26 ◽  
Author(s):  
Shabana Bibi ◽  
Ayesha Sarfraz ◽  
Ghazala Mustafa ◽  
Zeeshan Ahmed ◽  
Muhammad Aurang Zeb ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Test System ◽  
Chemical Information ◽  
System Type ◽  
The Family ◽  
Comprehensive Search ◽  
Coronavirus Infection ◽  
The Impact ◽  
First Time ◽  
Plant Sources

Background: Coronavirus Disease-2019 belongs to the family of viruses which cause a serious pneumonia along with fever, breathing issues and infection of lungs for the first time in China and later spread worldwide. Objective: Several studies and clinical trials have been conducted to identify potential drugs and vaccines for Coronavirus Disease-2019. The present study listed natural secondary metabolites identified from plant sources with antiviral properties and could be safer and tolerable treatment for Coronavirus Disease-2019. Methods: A comprehensive search on the reported studies was conducted using different search engine such as Google scholar, SciFinder, Sciencedirect, Medline PubMed, and Scopus for the collection of research articles based on plantderived secondary metabolites, herbal extracts, and traditional medicine for coronavirus infections. Results: Status of COVID-19 worldwide and information of important molecular targets involved in COVID-19 is described and through literature search, is highlighted that numerous plant species and their extracts possess antiviral properties and studied with respect to Coronavirus treatments. Chemical information, plant source, test system type with mechanism of action for each secondary metabolite is also mentioned in this review paper. Conclusion: The present review has listed plants that have presented antiviral potential in the previous coronavirus pandemics and their secondary metabolites which could be significant for the development of novel and a safer drug which could prevent and cure coronavirus infection worldwide.

Naphthoquinones and derivatives for chemotherapy: perspectives and limitations of their anti-trypanosomatids activities

2020 ◽  
Vol 26 ◽  
Author(s):  
Luíza Dantas-Pereira ◽  
Edézio F. Cunha-Junior ◽  
Valter V. Andrade-Neto ◽  
John F. Bower ◽  
Guilherme A. M. Jardim ◽  
...  
Keyword(s):  
Large Scale ◽  
Neglected Tropical Diseases ◽  
Folk Medicine ◽  
Leishmania Species ◽  
Parasitic Infections ◽  
Mechanistic Analysis ◽  
Leishmania Spp ◽  
Nanomolar Range

: Chagas disease, Sleeping sickness and Leishmaniasis, caused by trypanosomatids Trypanosoma cruzi, Trypanosoma brucei and Leishmania spp., respectively, are considered neglected tropical diseases, and they especially affect impoverished populations in the developing world. The available chemotherapies are very limited and a search for alternatives is still necessary. In folk medicine, natural naphthoquinones have been employed for the treatment of a great variety of illnesses, including parasitic infections. This review is focused on the anti-trypanosomatid activity and mechanistic analysis of naphthoquinones and derivatives. Among all the series of derivatives tested in vitro, naphthoquinone-derived 1,2,3-triazoles were very active on T. cruzi infective forms in blood bank conditions, as well as in amastigotes of Leishmania spp. naphthoquinones containing a CF3 on a phenyl amine ring inhibited T. brucei proliferation in the nanomolar range, and naphthopterocarpanquinones stood out for their activity on a range of Leishmania species. Some of these compounds showed a promising selectivity index (SI) (30 to 1900), supporting further analysis in animal models. Indeed, high toxicity to the host and inactivation by blood components are crucial obstacles to be overcome to use naphthoquinones and/or their derivatives for chemotherapy. Multidisciplinary initiatives embracing medicinal chemistry, bioinformatics, biochemistry, and molecular and cellular biology need to be encouraged to allow the optimization of these compounds. Large scale automated tests are pivotal for the efficiency of the screening step, and subsequent evaluation of both the mechanism of action in vitro and pharmacokinetics in vivo are essential for the development of a novel, specific and safe derivative, minimizing adverse effects.

An overview on therapeutic potential of Iris Persica

2020 ◽  
Vol 06 ◽  
Author(s):  
Faiq H. S. Hussain ◽  
Hawraz Ibrahim M. Amin ◽  
Dinesh kumar Patel ◽  
Omji Porwal
Keyword(s):  
Therapeutic Potential ◽  
Biological Activities ◽  
Folk Medicine ◽  
Underground Storage ◽  
Kurdistan Region ◽  
Traditional Medicines ◽  
The Family ◽  
Storage Organs ◽  
Radical Generation ◽  
Perennial Herbs

: The family Iridaceae contains 92 genera and more than 1800 species, mostly perennial herbs with underground storage organs called rhizomes (bulbs). Some genera are important in traditional medicines, especially Iris and Gladiolus. The genus Iris belongs to this family and comprises about hundreds species among them, 12 species are found in Iraq. It has been widely used various medicines worldwide especially Iris persica is used in folk medicine in the Kurdistan region of Iraq as an effective treatment against tumours, antibacterial, antifungal and treating inflammation. Earlier finding confirmed that Iris persica and its constituents play role in the scavenging of free radical generation and prevention of disease pathogenesis. Each part of the Iris persica herb has some medicinal property. This review gives a eagle eye view mainly on the biological activities of the Iris persica and some of their compounds isolated, pharmacological actions of the Iris persica extracts and products, and plausible medicinal and therapeutically applications.

Mansfield Park

2008 ◽  
Author(s):  
Jane Austen ◽  
Jane Stabler
Keyword(s):  
The Novel ◽  
Mansfield Park ◽  
Sexual Jealousy ◽  
The Family ◽  
The World ◽  
The Face

‘Me!’ cried Fanny … ‘Indeed you must excuse me. I could not act any thing if you were to give me the world. No, indeed, I cannot act.’ At the age of ten, Fanny Price leaves the poverty of her Portsmouth home to be brought up among the family of her wealthy uncle, Sir Thomas Bertram, in the chilly grandeur of Mansfield Park. There she accepts her lowly status, and gradually falls in love with her cousin Edmund. When the dazzling and sophisticated Henry and Mary Crawford arrive, Fanny watches as her cousins become embroiled in rivalry and sexual jealousy. As the company starts to rehearse a play by way of entertainment, Fanny struggles to retain her independence in the face of the Crawfords’ dangerous attractions; and when Henry turns his attentions to her, the drama really begins… This new edition does full justice to Austen’s complex and subtle story, placing it in its Regency context and elucidating the theatrical background that pervades the novel.

scholarly journals Bufadienolides from the Skin Secretions of the Neotropical Toad Rhinella alata (Anura: Bufonidae): Antiprotozoal Activity against Trypanosoma cruzi

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4217
Author(s):  
Candelario Rodriguez ◽  
Roberto Ibáñez ◽  
Luis Mojica ◽  
Michelle Ng ◽  
Carmenza Spadafora ◽  
...  
Keyword(s):  
Vero Cells ◽  
Chemical Diversity ◽  
Hydroxyl Group ◽  
Antitrypanosomal Activity ◽  
The Family ◽  
Toad Venom ◽  
Skin Secretions ◽  
Pharmacological Potential ◽  
First Time ◽  
Mcf 7

Toads in the family Bufonidae contain bufadienolides in their venom, which are characterized by their chemical diversity and high pharmacological potential. American trypanosomiasis is a neglected disease that affects an estimated 8 million people in tropical and subtropical countries. In this research, we investigated the chemical composition and antitrypanosomal activity of toad venom from Rhinella alata collected in Panama. Structural determination using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy led to the identification of 10 bufadienolides. Compounds identified include the following: 16β-hydroxy-desacetyl-bufotalin-3-adipoyl-arginine ester (1), bufotalin (2), 16β-hydroxy-desacetyl-bufotalin-3-pimeloyl-arginine ester (3), bufotalin-3-pimeloyl-arginine ester (4), 16β-hydroxy-desacetyl-bufotalin-3-suberoyl-arginine ester (5), bufotalin-3-suberoyl-arginine ester (6), cinobufagin-3-adipoyl-arginine ester (7), cinobufagin-3-pimeloyl-arginine ester (8), cinobufagin-3-suberoyl-arginine ester (9), and cinobufagin (10). Among these, three new natural products, 1, 3, and 5, are described, and compounds 1–10 are reported for the first time in R. alata. The antitrypanosomal activity assessed in this study revealed that the presence of an arginyl-diacid attached to C-3, and a hydroxyl group at C-14 in the structure of bufadienolides that is important for their biological activity. Bufadienolides showed cytotoxic activity against epithelial kidney Vero cells; however, bufagins (2 and 10) displayed low mammalian cytotoxicity. Compounds 2 and 10 showed activity against the cancer cell lines MCF-7, NCI-H460, and SF-268.

scholarly journals A Comprehensive Review of the Ethnotraditional Uses and Biological and Pharmacological Potential of the Genus Mimosa

2021 ◽  
Vol 22 (14) ◽  
pp. 7463
Author(s):  
Ismat Majeed ◽  
Komal Rizwan ◽  
Ambreen Ashar ◽  
Tahir Rasheed ◽  
Ryszard Amarowicz ◽  
...  
Keyword(s):  
Web Of Science ◽  
Scientific Literature ◽  
Therapeutic Potential ◽  
Current Knowledge ◽  
Folk Medicine ◽  
Nutritional Values ◽  
Biological Potential ◽  
The World ◽  
The Future ◽  
Pharmacological Potential

The Mimosa genus belongs to the Fabaceae family of legumes and consists of about 400 species distributed all over the world. The growth forms of plants belonging to the Mimosa genus range from herbs to trees. Several species of this genus play important roles in folk medicine. In this review, we aimed to present the current knowledge of the ethnogeographical distribution, ethnotraditional uses, nutritional values, pharmaceutical potential, and toxicity of the genus Mimosa to facilitate the exploitation of its therapeutic potential for the treatment of human ailments. The present paper consists of a systematic overview of the scientific literature relating to the genus Mimosa published between 1931 and 2020, which was achieved by consulting various databases (Science Direct, Francis and Taylor, Scopus, Google Scholar, PubMed, SciELO, Web of Science, SciFinder, Wiley, Springer, Google, The Plant Database). More than 160 research articles were included in this review regarding the Mimosa genus. Mimosa species are nutritionally very important and several species are used as feed for different varieties of chickens. Studies regarding their biological potential have shown that species of the Mimosa genus have promising pharmacological properties, including antimicrobial, antioxidant, anticancer, antidiabetic, wound-healing, hypolipidemic, anti-inflammatory, hepatoprotective, antinociceptive, antiepileptic, neuropharmacological, toxicological, antiallergic, antihyperurisemic, larvicidal, antiparasitic, molluscicidal, antimutagenic, genotoxic, teratogenic, antispasmolytic, antiviral, and antivenom activities. The findings regarding the genus Mimosa suggest that this genus could be the future of the medicinal industry for the treatment of various diseases, although in the future more research should be carried out to explore its ethnopharmacological, toxicological, and nutritional attributes.

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