scholarly journals Aquilaria Species (Thymelaeaceae) Distribution, Volatile and Non-Volatile Phytochemicals, Pharmacological Uses, Agarwood Grading System, and Induction Methods

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7708
Author(s):  
Yichen Wang ◽  
Mubasher Hussain ◽  
Zhenbin Jiang ◽  
Zhaohong Wang ◽  
Jing Gao ◽  
...  
Keyword(s):  
Biological Activity ◽  
Chinese Medicine ◽  
Research Progress ◽  
Grading System ◽  
Pharmacological Properties ◽  
High Quality ◽  
Activity Screening ◽  
Scientific Nature ◽  
Development Prospects ◽  
Anti Inflammation

Agarwood is a highly valuable fragrant wood of Aquilaria spp. (Thymelaeaceae) which has been widely utilized in traditional medicine, religious rites, and cultural activities. This study summarizes a review on the identification of Aquilaria cultivars, volatile and non-volatile phytochemicals, pharmacological uses, and agarwood grading system to determine its quality, and different agarwood induction methods. Due to the highly demanding and depleted natural resources, the research on agarwood is still insufficient, and it has broad research and development prospects in many industries. However, due to the significant scientific nature of agarwood application, developing high-quality products and drugs from agarwood have become highly important, while no one has discussed in detail the phytochemicals uses and provided a summary until now. The main phytochemicals of agarwood include terpenoids, dominated by sesquiterpenes. For centuries, terpenoids have been used in traditional Chinese medicine and have been shown to possess various pharmacological properties, including bacteriostatic, antibacterial, sedation, analgesia, anti-inflammation, anti-asthmatic, hypoglycemic, antidepressant, and many others. Alongside biological activity screening, phytochemical advances and pharmacological research have also made certain progress. Therefore, this review discusses the research progress of agarwood in recent years and provides a reference basis for further study of Aquilaria plants and agarwood.

scholarly journals MAJOR BIOACTIVE TRITERPENOIDS FROM GANODERMA SPECIES AND THEIR THERAPEUTIC ACTIVITY: A REVIEW

2019 ◽  
pp. 22-30 ◽  
Author(s):  
ZAHOOR AHMAD BHAT Bhat ◽  
ABDUL HAMID WANI ◽  
MOHD YAQUB BHAT ◽  
ABDUL RASHID MALIK
Keyword(s):  
Human Immunodeficiency Virus ◽  
Biological Activity ◽  
Chinese Medicine ◽  
Ganoderma Lucidum ◽  
Therapeutic Effects ◽  
High Grade ◽  
Therapeutic Activity ◽  
Immunodeficiency Virus ◽  
Medicinal Properties ◽  
Anti Inflammation

Ganoderma a traditional Chinese medicine popularly used for complementary cancer therapy and longevity for centuries. The vast amount of study has been performed on the medicinal properties of Ganoderma lucidum. G. lucidum contains various compounds with a high grade of biological activity, which increase the immunity. Several of these substances belong to the triterpenoids and polysaccharides. Proteins, sterols, phenols, lipids, etc., are also present. Ganoderma triterpenes are important secondary metabolites of G. lucidum. Ganoderma triterpenes are limestone-tetracyclic terpenes which have been reported to possess antioxidant, antitumor, anti-human immunodeficiency virus, anticancer, anti-inflammation, cytotoxic, hepatoprotective, and neuroprotective activities. This review deals with most important triterpenes isolated from Ganoderma and their therapeutic effects.

scholarly journals Research progress on quality assurance of genuine Chinese medicinal in Sichuan

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Hua Luo ◽  
Yi Zhao ◽  
Hua Hua ◽  
Yan Zhang ◽  
Xiaobo Zhang ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Chinese Medicine ◽  
Quality Evaluation ◽  
Technology Development ◽  
Wide Distribution ◽  
Research Progress ◽  
High Quality ◽  
Ecological Protection ◽  
Medicine Quality

AbstractThe genuine Chinese medicinal (GCM), also known as Dao-di Herbs, is a synonym for high quality Chinese medicinal materials, which has been established in thousands of years of clinical practice and is a comprehensive standard for evaluating the quality of Chinese medicinal materials. The newest data from the Fourth National Survey of Chinese Medicinal Resources showed that Sichuan Province has 7290 types of Chinese medicine and 86 GCM, both ranking highly in China. The characteristics like diverse species, wide distribution, higher yield, and good quality are considered as advantages of geo-herbals grown in Sichuan. Resources guarantee and high-quality development of those medicine materials make a difference in local Chinese medicine quality promotion and Chinese medicine industry and technology development to serve the public's needs, assist targeted poverty alleviation, and strengthen ecological protection. This review aims to outline significant progress in the recent ten years regarding regionalization, germplasm resources, and quality evaluation around the quality assurance of GCM in Sichuan, China.

scholarly journals Methodologies in the Analysis of Phenolic Compounds in Roselle (Hibiscus sabdariffa L.): Composition, Biological Activity, and Beneficial Effects on Human Health

Horticulturae ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 35
Author(s):  
Bety W. Hapsari ◽  
Manikharda ◽  
Widiastuti Setyaningsih
Keyword(s):  
Biological Activity ◽  
Phenolic Compounds ◽  
Human Health ◽  
Analytical Methods ◽  
Environmental Influence ◽  
Biological Activities ◽  
Research Progress ◽  
Hibiscus Sabdariffa ◽  
Beneficial Effects ◽  
Positive Effects

Roselle (Hibiscus sabdariffa L.), as an edible flower, has long provided an array of positive effects on human health. This benefit is a result of phenolic compounds that are naturally present mainly in the calyx. Plentiful medicinal remedies and functional foods based on this flower are available worldwide, as supported by the studies of phenolic compounds in recent decades. This paper aims to provide a comprehensive review of the composition, biological activity, and beneficial effects on human health of phenolic compounds in roselle. This review was performed in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. A structured search in the published literature for phenolics compositions in roselle was required prior to the evaluation on the validity of the reported analytical methods. Reliable identification and quantification of phenolic compounds in roselle can be achieved by employing the proper extraction and separation methods. With ample alternative analytical methods discussed here, this review provided an aid for comprehending and selecting the most appropriate method for a particular study. The applications of the analytical methods highlighted indicated that phenolic acids, flavonoids, and their derivatives have been identified and quantified in roselle with a range of biological activities and beneficial effects on human health. It was also disclosed that the composition and concentration of phenolic compounds in roselle vary due to the growth factors, cultivars, and environmental influence. Finally, apart from the research progress carried out with roselle during the last ten years, this review also proposed relevant future works.

scholarly journals Isolation, Structure Elucidation, and Biological Activity of a New Alkaloid from Zanthoxylum rhetsa

2011 ◽  
Vol 6 (11) ◽  
pp. 1934578X1100601
Author(s):  
Karsten Krohn ◽  
Stephan Cludius-Brandt ◽  
Barbara Schulz ◽  
Mambatta Sreelekha ◽  
Pottachola Mohamed Shafi
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Medicinal Plant ◽  
Plant Extract ◽  
Structure Elucidation ◽  
Biologically Active ◽  
Reduction Product ◽  
Pharmacological Properties ◽  
Evergreen Tree

Several biologically active alkaloids (1-4, 6), including a new quinazoline-6-carboxylic acid (1), were isolated from the medicinal plant Zanthoxylum rhetsa, an evergreen tree, native to subtropical areas. Whereas the pharmacological properties of the plant extract and single constituents have been widely tested, we now show that all of the metabolites have antialgal activities, all but 6 are antibacterial, and 6 and the reduction product 5 (derived from 4) are also antifungal.

scholarly journals Research progress in use of traditional Chinese medicine for treatment of spinal cord injury

2020 ◽  
Vol 127 ◽  
pp. 110136 ◽  
Author(s):  
Yubao Lu ◽  
Jingjing Yang ◽  
Xuexi Wang ◽  
Zhanjun Ma ◽  
Sheng Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Research Progress ◽  
Cord Injury

Biochanin A from Chinese Medicine: An Isoflavone with Diverse Pharmacological Properties

2021 ◽  
pp. 1-21
Author(s):  
Jia Yan ◽  
Panda Qiu ◽  
Xinyu Zhang ◽  
Yuanyuan Zhang ◽  
Linjing Mi ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Clinical Application ◽  
Trifolium Pratense ◽  
Safety Evaluation ◽  
Therapeutic Use ◽  
Biochanin A ◽  
Drug Candidate ◽  
Pharmacological Properties ◽  
Biological Availability ◽  
Trifolium Pratense L

Biochanin A (BCA) is a dietary isoflavone, isolated from the leaves and stems of Trifolium pratense L and many other herbs of Chinese medicine. Recent findings indicated BCA as a promising drug candidate with diverse bioactive effects. On the purpose of evaluating the possibility of BCA in clinical application, this review is trying to provide a comprehensive summary of the pharmacological actions of BCA. The publications collected from PubMed, ScienceDirect, and Wiley databases were summarized for the last 10 years. Then, the potential therapeutic use of BCA on the treatment of various diseases was discussed according to its pharmacological properties, namely, anticancer, anti-inflammatory, anti-bacterial, anti-diabetic, and anti-obesity effects as well as neuroprotective, hepatoprotective, cardioprotective, and osteoprotective effects. BCA might mainly regulate the MAPK, PI3K, NRF2, and NF-kB pathways, respectively, to exert its bioactive effects. However, the limited definitive targets, poor biological availability, and insufficient safety evaluation might block the clinical application of BCA. This review may provide new insights for the development of BCA in the application of related diseases.

scholarly journals Patent landscape of Chinese Classical Formulas

2021 ◽  
Author(s):  
Ruipeng Shi ◽  
Hua Luo ◽  
Yi Zhao ◽  
Yuyang Tang ◽  
Zhangfeng Zhong ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Mechanism Of Action ◽  
Future Development ◽  
Market Potential ◽  
High Quality ◽  
Preparation Methods ◽  
Good Market ◽  
Patent Landscape ◽  
Patent Applications ◽  
Large Decline

Abstract BackgroundChinese Classical Formulas (經典名方, CCFs) are clinically employed formulas that have been documented in the literature since before the Ming era. In 2010, China began focusing on the development and product transformation of CCFs and issued a list of 100 CCFs as a reference. Patents are key components of the process for transferring technology to product; however, they are rarely employed in current CCF research. Therefore, the present study aims to explore the current situation of CCFs based on the China National Intellectual Property Administration (CNIPA) and provide a reference for researchers, investors, and policymakers to make relevant decisions. MethodsInformation on CCF publication numbers was obtained from the CNIPA, and data for patent applications made before June 30, 2021, on inventors, titles, and abstracts were searched in the patent database, Derwent Innovation. Duplicate application numbers were removed, applications were standardized, and inventors were categorized. The processed data were then used for subsequent analyses. ResultsA total of 287 patents were included in this analysis, and 61 CCFs were patented. Two major policies regarding CCFs in 2011 and 2019 greatly stimulated related patent applications, but lacked sustainability, followed by a relatively large decline in 2012 and 2020. Among the granted patents, 42.59% are analytical methods-related inventions and 24.07% for preparation methods. The percentage of core patents on substance basis and mechanism of action is relatively small. ConclusionPolicies have a significant impact on CCF R&D. The number of CCF patent applications is increasing every year and there is an increasing number of companies as patent applicants, which indicates that CCF is considered to have a good market potential. However, the lack of high quality patents may create difficulties for future development and this will be an important issue to be addressed. Keywords Chinese classical formulations, Chinese medicine, patent, product transformation

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