scholarly journals Recent Trends in Morphology-Controlled Synthesis and Application of Mesoporous Silica Nanoparticles

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2122
Author(s):  
Nabanita Pal ◽  
Jun-Hyeok Lee ◽  
Eun-Bum Cho
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
High Surface Area ◽  
Porous Silica ◽  
The United States ◽  
Structural Features ◽  
Energy Applications ◽  
Silica Materials

The outstanding journey towards the investigation of mesoporous materials commences with the discovery of high surface area porous silica materials, named MCM-41 (Mobil Composition of Matter-41) according to the inventors’ name Mobile scientists in the United States. Based on a self-assembled supramolecular templating mechanism, the synthesis of mesoporous silica has extended to wide varieties of silica categories along with versatile applications of all these types in many fields. These silica families have some extraordinary structural features, like highly tunable nanoscale sized pore diameter, good Brunauer–Emmett–Teller (BET) surface areas, good flexibility to accommodate different organic and inorganic functional groups, metals etc., onto their surface. As a consequence, thousands of scientists and researchers throughout the world have reported numerous silica materials in the form of published articles, communication, reviews, etc. Beside this, attention is also given to the morphology-oriented synthesis of silica nanoparticles and their significant effects on the emerging fields of study like catalysis, energy applications, sensing, environmental, and biomedical research. This review highlights a consolidated overview of those morphology-based mesoporous silica particles, emphasizing their syntheses and potential role in many promising fields of research.

scholarly journals Hyper-Crosslinked Polymer Nanocomposites Containing Mesoporous Silica Nanoparticles with Enhanced Adsorption Towards Polar Dyes

Polymers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1388
Author(s):  
Marco Guerritore ◽  
Rachele Castaldo ◽  
Brigida Silvestri ◽  
Roberto Avolio ◽  
Mariacristina Cocca ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Organic Dyes ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
High Surface Area ◽  
Reactive Dye ◽  
New Strategy ◽  
Enhanced Adsorption

The development of new styrene-based hyper-crosslinked nanocomposites (HCLN) containing mesoporous silica nanoparticles (MSN) is reported here as a new strategy to obtain functional high surface area materials with an enhanced hydrophilic character. The HCLN composition, morphology and porous structure were analyzed using a multi-technique approach. The HCLN displayed a high surface area (above 1600 m2/g) and higher microporosity than the corresponding hyper-crosslinked neat resin. The enhanced adsorption properties of the HCLN towards polar organic dyes was demonstrated through the adsorption of a reactive dye, Remazol Brilliant Blue R (RB). In particular, the HCLN containing 5phr MSN showed the highest adsorption capacity of RB.

scholarly journals Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 152
Author(s):  
Eleen Dayana Mohamed Isa ◽  
Haslina Ahmad ◽  
Mohd Basyaruddin Abdul Rahman ◽  
Martin R. Gill
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Silica Nanoparticles ◽  
High Stability ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
High Surface Area ◽  
Surgical Removal

Cancer treatment and therapy have made significant leaps and bounds in these past decades. However, there are still cases where surgical removal is impossible, metastases are challenging, and chemotherapy and radiotherapy pose severe side effects. Therefore, a need to find more effective and specific treatments still exists. One way is through the utilization of drug delivery agents (DDA) based on nanomaterials. In 2001, mesoporous silica nanoparticles (MSNs) were first used as DDA and have gained considerable attention in this field. The popularity of MSNs is due to their unique properties such as tunable particle and pore size, high surface area and pore volume, easy functionalization and surface modification, high stability and their capability to efficiently entrap cargo molecules. This review describes the latest advancement of MSNs as DDA for cancer treatment. We focus on the fabrication of MSNs, the challenges in DDA development and how MSNs address the problems through the development of smart DDA using MSNs. Besides that, MSNs have also been applied as a multifunctional DDA where they can serve in both the diagnostic and treatment of cancer. Overall, we argue MSNs provide a bright future for both the diagnosis and treatment of cancer.

scholarly journals DESIGN AND DEVELOPMENT OF LULICONAZOLE LOADED MESOPOROUS SILICA NANOPARTICLES AS HYDROGEL FOR MYCOTIC DISEASES

2021 ◽  
Vol 10 (4) ◽  
pp. 3148-3153
Author(s):  
Aachal Anil Gosavi
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
High Surface Area ◽  
Specific Area ◽  
Water Soluble ◽  
Drug Dissolution

The aim of the present work was to design and synthesize of mesoporous silica nanoparticles as topical hydrogel formulation for inclusion of poorly water soluble antifungal drug like Luliconazole as a drug delivery platform. The SBA-15 was prepared to evaluate its application as a carrier for Luliconazole drug delivery. Its molecular size was suitable for incorporation in to the mesoporous of the SBA-15 materials. The SBA-15 was characterized by FTIR, UV analysis, Particle size, Transmission electron microscopy. The Synthesized Mesoporous silica i.e. SBA-15 was of mean particle size of 15 nm and specific area 283.763m2/g respectively. The results revealed that prepared mesoporous silica have small particle size, high surface area, and enhanced drug dissolution rate. The results obtained showed that Luliconazole was loaded with great efficiency into the SBA-15 which leads to enhanced diffusion of drug. Luliconazole hydrogel formulations improved medication permeation across the skin appropriate polymer was used to produce the formulation (Carbopol 934p and HPMC). The physiochemical parameters of all the established luliconazole formulations were assessed, including gel appearance, pH, viscosity, spreadability, globule size, Zeta potential, and drug content. Many of the above parameters yielded positive outcomes but F1 and F3 batch results was were unacceptable ranges. It can be assumed that the formulation F1 and F3 resulted in improved spreadability, stability, and homogeneity, as well as a stronger drug release analysis.

scholarly journals Photocatalytic decolorization of methylene blue using zinc oxide supported on mesoporous silica nanoparticles

2015 ◽  
Vol 11 (4) ◽  
Author(s):  
Anis Farhana Abdul Rahman ◽  
Ling Sy Mei ◽  
Aishah Abdul Jalil ◽  
Sugeng Triwahyono
Keyword(s):  
Methylene Blue ◽  
Zinc Oxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Heterogeneous Catalysts ◽  
Mechanical Stability ◽  
Uv Light ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
High Surface Area

Various dyes that are used in textile, paper, cosmetics and plastics industries may produce harmful effects on the health of living organisms and the environment if not treated properly before being discharged into water bodies. Among many techniques, photocatalytic process is one of the promising treatment for these dyes. Zinc oxide (ZnO) is well-known comparable with TiO2 due to its unique properties and numerous advantages. While, mesoporous silica nanoparticles (MSN) is an excellent solid support for heterogeneous catalysts due to its high surface area, thermal and mechanical stability, highly uniform pore distribution, tunable pore size, and unique hosting properties. Therefore, in this study, ZnO/MSN (ZM) catalysts were prepared and its physicochemical properties was characterized by X-Ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR). The catalyst was tested on the photodecolorization of methylene blue (MB) dye. The results showed that the interaction between ZnO and MSN support could enhanced the photocatalytic activity. The 0.5 g L-1 of 5ZM was found to give the highest degradation (80 %) of 10 mg L-1 of MB solution at pH 7 after 3 h under UV light irradiation. The photodecolorization followed the pseudo first-order Langmuir-Hinshelwood kinetic model. This study demonstrated that the prepared 5ZM has a potential to be used in photocatalytic degradation of various dyes as well as organic pollutants.

scholarly journals Mesoporous silica nanoparticles functionalized with folic acid for targeted release Cis-Pt to glioblastoma cells

2021 ◽  
Vol 60 (1) ◽  
pp. 25-37
Author(s):  
Emma Ortiz-Islas ◽  
Anahí Sosa-Arróniz ◽  
Ma Elena Manríquez-Ramírez ◽  
C. Ekaterina Rodríguez-Pérez ◽  
Francisco Tzompantzi ◽  
...  
Keyword(s):  
Folic Acid ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
High Surface Area ◽  
Release Mechanism ◽  
Hexadecyltrimethylammonium Bromide ◽  
Targeted Release

Abstract This work reports the preparation, characterization, and a drug release study of mesoporous silica nanoparticles (MNPSiO2) functionalized with folic acid (FA) and loaded with Cis-Pt as a targeted release system to kill glioblastoma cancer cells. The MNPSiO2 were synthesized by the Stöber method using hexadecyltrimethylammonium bromide as the templating agent, which was finally removed by calcination at 550°C. The folic acid was chemically anchored to the silica nanoparticles surface by a carbodiimide reaction. Several physicochemical techniques were used for the MNPSiO2 characterization, and a triplicate in vitro Cis-Pt release test was carried out. The release Cis-Pt experimental values were fitted to different theoretical models to find the Cis-Pt release mechanism. The cytotoxicity evaluation of the MNPSiO2 was performed using LN 18 cells (human GBM cells). Homogeneous and well-defined nanoparticles with well-distributed and homogeneous porosity were obtained. The spectroscopic results show the proper functionalization of the mesoporous nanoparticles; besides, MNPSiO2 showed high surface area and large pore size. High correlation coefficients were obtained. Though the best fitted was the Korsmeyer-Peppas kinetic model, the Higuchi model adjusted better to the results obtained for our system. The MNPSiO2-FA were highly biocompatible, and they increased the cytotoxic effect of Cis-Pt loaded in them.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

scholarly journals Effectiveness of Diverse Mesoporous Silica Nanoparticles as Potent Vehicles for the Drug L-DOPA

Materials ◽  
2019 ◽  
Vol 12 (19) ◽  
pp. 3202
Author(s):  
Sumita Swar ◽  
Veronika Máková ◽  
Ivan Stibor
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Vis Spectroscopy ◽  
Bet Analysis ◽  
Silica Materials ◽  
Different Types ◽  
Mesoporous Silica Materials ◽  
Drug Vehicle

Our study was focused on the synthesis of selective mesoporous silica nanoparticles (MSNs: MCM-41, MCM-48, SBA-15, PHTS, MCF) that are widely studied for drug delivery. The resulting mesoporous surfaces were conveniently prepared making use of verified synthetic procedures. The MSNs thus obtained were characterized by Brunauer-Emmett-Teller (BET) analysis and scanning electron microscopy (SEM). The selected MSNs with various pore diameters and morphologies were examined to evaluate the capability of L-DOPA drug loading and release. L-DOPA is a well-known drug for Parkinson’s disease. The L-DOPA drug loading and release profiles were measured by UV-VIS spectroscopy and SBA-15 was proved to be the most effective amongst all the different types of tested mesoporous silica materials as L-DOPA drug vehicle.

Naturally Occurring and Synthetic Mesoporous Nanosilica: Multimodal Applications in Frontier Areas of Science

2019 ◽  
Vol 18 (05) ◽  
pp. 1850027
Author(s):  
Sutanuka Mitra ◽  
Rajesh Kumar ◽  
Pradip Roy ◽  
Satakshi Basu ◽  
Samarendra Barik ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Structural Features ◽  
Cutting Edge ◽  
Present Review ◽  
Research Progress ◽  
Biological Production ◽  
Naturally Occurring ◽  
Structural Versatility

Mesoporous silica nanoparticles (MSNs) have gained attention worldwide due to their structural versatility for diverse applications in a number of frontier areas of sciences. The intrinsic chemical, textural and structural features of MSNs allow fabricating versatile multifunctional nanosystems. The present review provides an overview of the research progress in artificial and biological production of MSNs, their properties and various applications in cutting edge areas of sciences.

scholarly journals Macrophage-like THP-1 cells show effective uptake of silica nanoparticles carrying inactivated diphtheria toxoid for vaccination

2020 ◽  
Vol 22 (1) ◽  
Author(s):  
Xinyue Huang ◽  
Danielle Paixão Cavalcante ◽  
Helen E Townley
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Porous Silica ◽  
Diphtheria Toxoid ◽  
Similar Distribution ◽  
Antigen Delivery ◽  
Before And After ◽  
Post Synthesis

AbstractNanoparticles may be used in vaccinology as an antigen delivery and/or an immunostimulant to enhance immunity. Porous silica has been identified as an effective adjuvant for more than a decade, and we have therefore investigated the take up rate by an immortalized macrophage-like cell line of a number of mesoporous silica nanoparticles (MSNPs) with differing diameter and pore size. The MSNPs were synthesized using a sol-gel reaction and post-synthesis removal of the template. The MSNPs showed a clear distribution in take up rate peaking at 217 nm, whereas a comparison with solid spherical nanoparticles showed a similar distribution peaking at 377 nm. The MSNPs were investigated before and after loading with antigen. Diphtheria toxoid was used as a proof-of-concept antigen and showed a peak macrophage internalization of 53.42% for loaded LP3 particles which had a diameter of 217.75 ± 5.44 nm and large 16.5 nm pores. Optimal MSNP sizes appeared to be in the 200–400 nm range, and larger pores showed better antigen loading. The mesoporous silica particles were shown to be generally biocompatible, and cell viability was not altered by the loading of particles with or without antigen.

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