scholarly journals Evaluation of 2’-Fucosyllactose and Bifidobacterium longum Subspecies infantis on Growth, Organ Weights, and Intestinal Development of Piglets

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 199
Author(s):  
Victoria C. Daniels ◽  
Marcia H. Monaco ◽  
Mei Wang ◽  
Johanna Hirvonen ◽  
Henrik Max Jensen ◽  
...  
Keyword(s):  
Weight Gain ◽  
Infant Development ◽  
Body Weight Gain ◽  
Bifidobacterium Longum ◽  
Total Body Weight ◽  
Milk Replacer ◽  
Intestinal Development ◽  
Organ Weights ◽  
Body Weights ◽  
The Impact

Human milk is rich in oligosaccharides that influence intestinal development and serve as prebiotics for the infant gut microbiota. Probiotics and 2’-fucosyllactose (2’-FL) added individually to infant formula have been shown to influence infant development, but less is known about the effects of their synbiotic administration. Herein, the impact of formula supplementation with 2’-fucosyllactose (2’-FL) and Bifidobacterium longum subsp. infantis Bi-26 (Bi-26), or 2’-FL + Bi-26 on weight gain, organ weights, and intestinal development in piglets was investigated. Two-day-old piglets (n = 53) were randomized in a 2 × 2 design to be fed a commercial milk replacer ad libitum without (CON) or with 1.0 g/L 2’-FL. Piglets in each diet were further randomized to receive either glycerol stock alone or Bi-26 (109 CFU) orally once daily. Body weights and food intake were monitored from postnatal day (PND) 2 to 33/34. On PND 34/35, animals were euthanized and intestine, liver and brain weights were assessed. Intestinal samples were collected for morphological analyses and measurement of disaccharidase activity. Dry matter of cecum and colon contents and Bifidobacterium longum subsp. infantis abundance by RT-PCR were also measured. All diets were well tolerated, and formula intake did not differ among the treatment groups. Daily body weights were affected by 2’-FL, Bi-26, and day, but no interaction was observed. There was a trend (p = 0.075) for greater total body weight gain in CON versus all other groups. Jejunal and ascending colon histomorphology were unaffected by treatment; however, there were main effects of 2’-FL to increase (p = 0.040) and Bi-26 to decrease (p = 0.001) ileal crypt depth. The addition of 2’-FL and/or Bi-26 to milk replacer supported piglet growth with no detrimental effects on body and organ weights, or intestinal structure and function.

scholarly journals Evaluation of 2'fucosyllactose and Bifidobacterium longum subsp. infantis Supplementation to Formula on Growth, Organ Weights, and Intestinal Development of Piglets

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 789-789
Author(s):  
Marcia Monaco ◽  
Victoria Daniels ◽  
Mei Wang ◽  
Johanna Hirvonen ◽  
Henrik Max Jensen ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Fixed Effects ◽  
Dry Matter ◽  
Bifidobacterium Longum ◽  
Milk Replacer ◽  
Intestinal Development ◽  
Organ Weights ◽  
Body Weights ◽  
The Impact

Abstract Objectives Human milk contains both prebiotic oligosaccharides and live bacteria, which are thought to bring health benefits to breastfed infants. Herein, we investigated the impact of formula supplementation with 2'-fucosyllactose (2'FL) and Bifidobacterium longum subsp. infantis (Bi-26) alone or in combination on growth, organ weights, and intestinal development of neonatal piglets. Methods Two-day-old intact male piglets (N = 53) were randomized to be fed a nutritionally-adequate milk replacer ad libitum without (CON) or with 1.0 g/L 2'FL (FL). Pigs were further stratified to receive either 12% glycerol solution alone or Bi-26 (109 CFU) in glycerol orally once daily (BI and FLBI). Body weights and food intake were monitored from postnatal day (PND) 2 to 33/34. On PND 34/35, animals were euthanized, intestine, liver and brain weights were assessed, and intestinal samples were collected for morphological analyses and disaccharidase activity. Dry matter of intestinal contents was also measured. Growth and food intake were analyzed as a 3-way, repeated-measures ANOVA with fixed effects of prebiotic, probiotic, and day, whereas all other variables were analyzed by a 2-way ANOVA with fixed effects of prebiotic and probiotic. Level of significance was set at P ≤ 0.05 and trends are reported at 0.05 > P < 0.1. Results All diets were well tolerated and food intake did not differ among the treatment groups. Daily body weights were affected by 2’FL, Bi26, and day, but no interaction was observed. However, there was a trend (p = 0.075) for greater body weight gain in CON vs. all other groups. No differences were observed for intestine, liver, or brain weight per kg body weight, jejunal or ileal lactase or sucrase activities, or fecal dry matter among the groups. Histomorphological outcomes in jejunum, ileum, and ascending colon were similar in all groups, except for a trend (p = 0.069) for larger ileal crypt volume in FL vs. CON piglets. Conclusions The addition of 2'FL and/or Bi-26 to milk replacer supported piglet growth with no detrimental effects on body and organ weights, or intestinal structure and function. Funding Sources DuPont Nutrition & Biosciences.

scholarly journals Dampak Pemberian Mikroenkapsulasi Minyak Ikan dalam Pakan terhadap Kolesterol Darah dan Performa pada Domba

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ganesha Ade Riemas ◽  
Iman Hernaman ◽  
Diky Ramdani ◽  
Bambang Nurhadi
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Fish Oil ◽  
Body Weight Gain ◽  
Blood Cholesterol ◽  
Feed Conversion ◽  
Cholesterol Levels ◽  
Affect Body Weight ◽  
And Performance ◽  
The Impact

ABSTRAK. Tujuan penelitian ini untuk mengukur seberapa besar pengaruh minyak ikan yang sudah terenkapsulasi terhadap kolesterol darah dan performa pada Domba. Penelitian telah dilakukan di Sub Unit Pelayanan Pengembangan Pembibitan Ternak Domba dan Kambing (SUPPPTDK) Bunihayu, Subang pada tanggal 20 Januari 2020 sampai 27 Maret 2020. Sebanyak 18 ekor domba Ekor Tipis jantan dengan bobot 15,99±0,98 kg dialokasikan ke dalam 3 perlakuan secara acak. Domba tersebut diberi ransum perlakuan yang disuplementasi dengan mikroenkapsulasi minyak ikan sebanyak 0% (P0), 2,5% (P1), dan 5% (P2). Data yang terkumpul dilakukan analisis ragam dan bila hasil berbeda nyata maka dilanjutkan dengan uji Duncan. Hasil menunjukkan bahwa mikroenkapsulasi minyak ikan dapat menurunkan kolesterol darah (P0,05), namun tidak berpengaruh nyata terhadap pertambahan bobot badan, konsumsi dan konversi ransum (P0,05). Penurunan kadar kolesterol terjadi pada kelompok domba dengan perlakuan mikroenkapsulasi sebanyak 2,5% (P1) dan mikroenkapsulasi 5% (P2). Kadar kolesterol darah masing-masing perlakuan berturut-turut adalah 100,70 mg/dl (P0); 96,20 mg/dl (P1); dan 78,76 mg/dl (P2). Rataan yang terbaik pada pertambahan bobot badan, konsumsi bahan kering harian, dan konversi ransum terdapat pada P2 yaitu 63,96 g/hari, 574,13 g/hari, dan 9,08. Hasil penelitian dapat disimpulkan bahwa mikroenkapsulasi minyak ikan dapat menurunkan kolesterol darah, dengan penurunan tertinggi pada pemberian 5%.  (The impact of microencapsulation fish oil in feed on blood cholesterols and performance on sheep) ABSTRAK. This study measured the effect of encapsulated fish oil on blood cholesterol and sheep performance. The study was conducted at the Bunihayu Sheep and Goat Breeding Services Bunihayu, Subang on January 20, 2020 to March 27, 2020. A total of 18 male thin-tailed sheep 15.99±0.98 kg were allocated randomly into 3 treatments. The sheep were given feed supplemented with fish oil microencapsulation of 0% (P0), 2.5% (P1), and 5% (P2). The data were collected and analyzed by analysis of variance and, if the result is significantly different, continued by Duncan's test. The results showed that fish oil microencapsulation decreased blood cholesterol levels (P0.05). However, it did not affect body weight gain, consumption, and feed conversion (P0.05). Decreased levels of cholesterol occurred in the group of sheep with 2.5% microencapsulation (P1) and 5% microencapsulation (P2). Blood cholesterol levels of each treatment were 100.70 mg/dl (P0); 96.20 mg/dl (P1); and 78.76 mg/dl (P2), respectively. Averagely, the highest body weight gain, dry matter intake and feed conversion were found in P2 as much as 63.96 g/day, 574.13 g/day, and 9.08, respectively. The results can be concluded that microencapsulation of fish oil can reduce blood cholesterol, with the highest decrease at the level of 5%.

scholarly journals Effects of edible fats and oils on the body weight gain and on weights of some selected organs in rats removing the impact of unequal feed intake

1970 ◽  
pp. 107-110
Author(s):  
N Ahmad ◽  
S Majumder ◽  
MA Miah ◽  
MJ Uddin
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Feed Intake ◽  
Body Weight Gain ◽  
Fats And Oils ◽  
Male Rats ◽  
Edible Fats ◽  
Group A ◽  
Group B ◽  
The Impact

An investigation on Long Evans male rats fed with different edible fats and oils was conducted in the Department of Physiology, Bangladesh Agricultural University, Mymensingh during a period of 7 weeks (1st April to 19th May, 2005) to determine and to compare the effect of feeds on body weight gain and on weights of some selected organs (heart, liver and kidney) removing the impact of unequal feed intake. A total of 20, six-week old male rats were randomly divided into A, B, C and D groups. Each group consisted of 5 rats. Rats were fed rat pellets purchased from ICDDR,B, Dhaka supplemented with beef fat in group A, fish fat in group B and soybean oil in group C while group D was considered as control and fed only with rat pellets. The concentration of fats and oils were 7% of normal diet and fed for 7 weeks. The highest weekly mean body weight gain (19.90g) adjusted for unequal feed intake was achieved by the rats of beef fat supplemented group A, followed by the rats of soybean oil supplemented group C (19.76g) and fish fat supplemented group B (15.67g). But none of the adjusted means of weekly body weight gain differed significantly (p > 0.05) from the control. Insignificant increases in heart weight were recorded in all treated rats and the maximum weight was in fish oil treated ones. Not much differences were recorded in the kidney weights rather beef oil treated rats' kidney had the lowest mean weight. A significantly (p < 0.01) higher liver weight was recorded in group B & C compared to control (group D), though the differences between A & D were insignificant. It could be concluded that fats and oils are harmful for the rat's body especially on liver and heart. Key words: Edible fats and oils, rat, body weight, organ weight, analysis of variance, covariance DOI = 10.3329/bjvm.v5i1.1326 Bangl. J. Vet. Med. (2007). 5 (1 & 2): 107-110

scholarly journals Long-term consequences of maternal high-fat feeding on hypothalamic leptin sensitivity and diet-induced obesity in the offspring

2007 ◽  
Vol 293 (3) ◽  
pp. R1056-R1062 ◽  
Author(s):  
Jacqueline Férézou-Viala ◽  
Anne-France Roy ◽  
Colette Sérougne ◽  
Daniel Gripois ◽  
Michel Parquet ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Maternal Diet ◽  
The Body ◽  
Female Rats ◽  
Leptin Resistance ◽  
High Fat ◽  
Leptin Sensitivity ◽  
The Impact

Epidemiological and animal studies suggest that the alteration of hormonal and metabolic environment during fetal and neonatal development can contribute to development of metabolic syndrome in adulthood. In this paper, we investigated the impact of maternal high-fat (HF) diet on hypothalamic leptin sensitivity and body weight gain of offspring. Adult Wistar female rats received a HF or a control normal-fat (C) diet for 6 wk before gestation until the end of the suckling period. After weaning, pups received either C or HF diet during 6 wk. Body weight gain and metabolic and endocrine parameters were measured in the eight groups of rats formed according to a postweaning diet, maternal diet, and gender. To evaluate hypothalamic leptin sensitivity in each group, STAT-3 phosphorylation was measured in response to leptin or saline intraperitoneal bolus. Pups exhibited similar body weights at birth, but at weaning, those born to HF dams weighed significantly less (−12%) than those born to C dams. When given the HF diet, males and females born to HF dams exhibited smaller body weight and feed efficiency than those born to C dams, suggesting increased energy expenditure programmed by the maternal HF diet. Thus, maternal HF feeding could be protective against adverse effects of the HF diet as observed in male offspring of control dams: overweight (+17%) with hyperleptinemia and hyperinsulinemia. Furthermore, offspring of HF dams fed either C or HF diet exhibited an alteration in hypothalamic leptin-dependent STAT-3 phosphorylation. We conclude that maternal high-fat diet programs a hypothalamic leptin resistance in offspring, which, however, fails to increase the body weight gain until adulthood.

scholarly journals Effect of arginine or glutamine supplementation on production, organ weights, interferon gamma, interleukin 6 and antibody titre of broilers

2014 ◽  
Vol 62 (3) ◽  
pp. 348-361 ◽  
Author(s):  
József Szabó ◽  
Emese Andrásofszky ◽  
Tamás Tuboly ◽  
András Bersényi ◽  
Andrea Weisz ◽  
...  
Keyword(s):  
Immune Response ◽  
Body Weight ◽  
Weight Gain ◽  
Interferon Gamma ◽  
Interleukin 6 ◽  
Egg Production ◽  
Body Weight Gain ◽  
The Body ◽  
Glutamine Supplementation ◽  
Organ Weights

The objective of this study was designed to test whether supplementation of the diet with arginine (Arg) or glutamine (Gln) or their combination influences the production, organ weights and humoral immune response of broilers. A total of 432 one-day-old male Ross 308 broiler chickens were divided into 6 treatment groups: control, Arg-0.5%, Arg-1%, Gln-0.5%, Gln-1% and Arg-0.5%+Gln-0.5%. Drinking water and feed were provided ad libitum. On day 18 of the experiment 50% of chickens in each treatment group were immunised with bovine serum albumin. Ten and 21 days after immunisation blood samples were collected to determine the anti-albumin IgY titre, interleukin 6 (IL6) and interferon gamma (IFNG) and to measure the weight of the liver, spleen, bursa of Fabricius and thymus. Arg or Gln supplementation of the diets influenced neither the production nor the organ weights until 18 days of age. Between 18 and 39 days of age both Arg (0.5% and 1%) and Arg + Gln supplementation improved the feed conversion ratio (FCR) by 3.7%, 6.3% and 4.9%, respectively, while Gln-1% worsened it by 15%. Immunisation slightly (−0.79%) depressed the body weight gain of broilers fed the control diet, which was significantly improved by both Arg (0.5 or 1%) and Arg + Gln supplementation. Immunisation increased the weight of the spleen, bursa and thymus and decreased that of the liver. Supplementation with 1% Gln depressed (−5.13%) the body weight gain of the immunised chickens but strongly stimulated the immune response. Supplementations with Arg and Gln did not influence the IL6 and IFNG level of the blood; however, on day 10 after immunisation these two parameters showed a negative correlation with each other. Regarding production, organ weights and immunity, Arg supplementation should be recommended in the grower phase, while Gln supplementation can be useful in pullets raised for egg production, where a good immune response to vaccinations is an important factor.

The impact of laboratory chow for rats in the experiments: Chemical and biological evaluation of nine grain-based diet options

2017 ◽  
Vol 37 (3) ◽  
pp. 275-284 ◽  
Author(s):  
RS Ferreira ◽  
L de Souza Morelini ◽  
EMC de Azeredo ◽  
ECS Vieira ◽  
EB Ferreira ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Growth Performance ◽  
Soybean Meal ◽  
Body Weight Gain ◽  
Biological Evaluation ◽  
Efficiency Ratio ◽  
Protein Utilization ◽  
The Impact ◽  
Net Protein

Cereal-based diets formulated as semi-purified diets can provide flexibility for researchers, enabling open controlled formulas, besides being cheaper than purified diets. Seeking to widen the researchers’ options in their experimental design developments, we aimed at assaying the chemical score, growth performance and protein utilization of nine semi-purified experimental chows. These diets were formulated at 17.8%, 12% and 8% protein contents, using three variations of ingredients for each one, as follows: casein (C), casein+soybean meal (C+S, 1:1 w/w protein) and casein+soybean meal+corn gluten meal (C+S+G, 1:1:1 w/w protein), without cysteine supplementation and setting casein 17.8% (AIN-93G) as reference diet. The diets C and C+S (17.8%) had the Cys as the limiting amino acid once the addition of gluten turns the Lys as second limiting. All diets had the potential for promoting growth with body mass gain, feed conversion ratio (FCR; chow consumed per body weight gain, average 3.12) and feed efficiency ratio (FER; body weight gain per chow consumed, average 0.3), except for C+S+G 8% (FCR = 6 g; FER = 0.13). These variations were mainly due to the protein amounts independently from the protein ingredient used and could characterize the C+S+G 8% as unable to support growth. For the other parameters (digestibility, net protein ratio, net protein utilization and protein efficiency ratio), there were no relevant differences between the diets. We can conclude that 17.8%, 12% and 8% chows (C and C+S) allowed a proper combination of ingredients from the point of view of palatability, nutrient availability/utilization, metabolic processes, growth performance and feed utilization parameters.

A Study to Develop Methodology for Feeding 24-Hour-Old Neonatal Swine for 3 Weeks

2002 ◽  
Vol 21 (5) ◽  
pp. 361-370 ◽  
Author(s):  
John Wedig ◽  
Mildred S. Christian ◽  
Alan Hoberman ◽  
Robert M. Diener ◽  
Rita Thomas-Wedig
Keyword(s):  
Weight Gain ◽  
System Development ◽  
Body Weight Gain ◽  
Milk Formula ◽  
Normal Limits ◽  
Microscopic Evaluation ◽  
Body Weights ◽  
Group 3 ◽  
Ad Libitum ◽  
Group 2

Pediatric evaluations are useful only when the animal model and human neonate have similar timing in system development. The objective of this study was to compare the growth of 24-hour-old swine provided 3 different feeding regimens of a simulated sow milk formula for 3 weeks. Three groups of three swine per sex were used. Group 1 was fed every 4 hours for weeks 1 through 3. Group 2 was fed every 3 hours during week 1 and every 4 hours during weeks 2 and 3. Group 3 (as close to ad libitum as possible) was fed every 2 hours for the first 2 days; every 2.5 hours for the next 2 days; every 3 hours for the next 3 days; and every 4 hours during weeks 2 and 3. No mortality occurred. Body weights were within normal limits. Organ weights, physical and ophthahnologic examinations, hematology and serum chemistry parameters, gross necropsy observations, and microscopic evaluation of the brain, liver, and kidneys were not affected by the three feeding regimens. Day 21 body weight gain of group 3 was greater than that for groups 1 or 2. Mean formula consumption (ounces/day) over 21 days was significantly increased ( p <.01) for group 3 (males and combined sexes) compared to the two other groups, supporting the greater weight gain of group 3 versus groups 1 and 2 over the 21-day feeding period. Body weights of the piglets fed simulated sow milk and historical control 21-day-old suckling pigs were within the same range. Only the labor-intensive feeding of simulated sow milk in a regimen close to ad libitum produced maximal weight gain in 24-hour-old piglets during the initial 3 weeks postpartum.

scholarly journals Synbiotic Supplementation Modulates Gut Microbiota, Regulates Beta-Catenin Expression And Prevents Weight Gain in ob/ob Mice

2021 ◽  
Author(s):  
Sebastião Mauro Bezerra Duarte ◽  
José Tadeu Stefano ◽  
Lucas A. M. Franco ◽  
Roberta C. Martins ◽  
Bruna D. G. C. Moraes ◽  
...  
Keyword(s):  
Gene Expression ◽  
Weight Gain ◽  
Gut Microbiota ◽  
Body Weight Gain ◽  
Standard Diet ◽  
Beta Catenin ◽  
Reduced Body ◽  
Synbiotic Supplementation ◽  
And Control ◽  
The Impact

Abstract Background: The aim of this study was to examine the impact of synbiotic supplementation in obesity and microbiota in ob/ob mice. 20 animals were divided into four groups: Obese Treated (OT), Control (OC), Lean Treated (LT) and Control (LC). All animals received standard diet for 8 weeks. Treated groups received a synbiotic in water while nontreated groups received water. After 8 weeks, all animals were sacrificed and gut tissue mRNA isolation and stool samples by microbiota analysis were collected. Beta-catenin, occludin, cadherin and zonulin were analyzed in gut tissue by RT-qPCR. Results: The synbiotic supplementation reduced body weight gain in OT comparing with OC (p=0.0398), increase of Enterobacteriaceae (p=0.005) and decrease of Cyanobacteria (p=0.047), Clostridiaceae (p=0.026), Turicibacterales (p=0.005) and Coprococcus (p=0.047). A significant reduction of Sutterella bacteria (p=0.009) and Turicibacter (p=0.005) was observed in LT compared to LC. Alpha and beta diversities were differ between all treated groups. Beta-catenin gene expression was significantly decreased in the gut tissue of OT (p≤0.0001) when compared to other groups. No changes were observed in occludin, cadherin and zonulin gene expression in the gut tissue. Conclusion: The synbiotics supplementation prevents excessive weight gain, modulates the gut microbiota, and reduces beta-catenin expression in ob/ob mice.

scholarly journals Respiratory and Gut Microbiota in Commercial Turkey Flocks with Disparate Weight Gain Trajectories Display Differential Compositional Dynamics

2020 ◽  
Author(s):  
Kara J.M. Taylor ◽  
John M. Ngunjiri ◽  
Michael C. Abundo ◽  
Hyesun Jang ◽  
Mohamed Elaish ◽  
...  
Keyword(s):  
Weight Gain ◽  
Gut Microbiota ◽  
Body Weight Gain ◽  
Poor Performance ◽  
Rrna Gene ◽  
Body Weights ◽  
And Performance ◽  
Brood Stage ◽  
Commercial Turkey ◽  
Respiratory Microbiota

ABSTRACTHost-associated communities of bacteria (microbiota) substantially contribute to the overall poultry health and performance. Gut microbiota are known to play roles in resistance to pathogen infection and optimal weight gain in turkey flocks. However, knowledge of turkey respiratory microbiota and its link to gut microbiota is lacking. This study presents a 16S rRNA gene-based census of the turkey respiratory microbiota (nasal cavity and trachea) alongside gut microbiota (cecum and ileum) in two identical commercial Hybrid Converter turkey flocks raised in parallel under typical field commercial conditions. The flocks were housed in adjacent barns during the brood stage and in geographically separated farms during the grow-out stage. Several bacterial taxa that were acquired in the respiratory tract (RT) at the beginning of the brood stage persisted throughout the flock cycle, primarily Staphylococcus. Late-emerging predominant taxa in RT included Deinococcus and Corynebacterium. Tracheal and nasal microbiota of turkeys were identifiably distinct from one another and from gut microbiota. Nevertheless, gut and RT microbiota changed in parallel over time and appeared to share many taxa. During the brood stage, the two flocks generally acquired similar gut and RT microbiota, and their average body weights were comparable. Separating the flocks during the grow-out stage resulted in divergent microbial profiles and body weight gain trajectories. Lower weight gain corresponded with emergence of Deinococcus and Ornithobacterium in RT, and Fusobacterium and Parasutterella in gut. This study provides an overview of turkey microbiota under field conditions and suggests several hypotheses concerning the respiratory microbiome.IMPORTANCETurkey meat is an important source of animal protein, and the industry around its production contributes significantly to the agricultural economy. The nonpathogenic symbionts present in the gut of turkeys are known to impact bird health and flock performance. However, the respiratory microbiota in turkeys are entirely unexplored. This study has elucidated the microbiota of respiratory tracts of turkeys from two commercial flocks raised in parallel throughout a normal flock cycle. Further, the study suggests that bacteria originating in the gut or in poultry house environments may influence respiratory communities and consequently induce poor performance, either directly or indirectly. Future attempts to develop microbiome-based interventions for turkey health should delimit the contributions of respiratory microbiota and aim to limit disturbances to those communities.

scholarly journals A study of factors affecting weight gain among tuberculosis patients under DOTS in district Amritsar

2018 ◽  
Vol 5 (11) ◽  
pp. 4804
Author(s):  
Pooja Sadana ◽  
Harpreet Kaur ◽  
Vishal Verma
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Continuation Phase ◽  
Factors Affecting ◽  
Tuberculosis Patients ◽  
End Of Treatment ◽  
Body Weights ◽  
The Mean ◽  
The Difference

Background: Wasting is a common feature in tuberculosis and treatment is aimed at achieving weight gain in pulmonary tuberculosis patients. The aims and objectives of the study were to study the extent of body weight gain during treatment and to identify the effect of different factors on weight gain among TB patients.Methods: The study was conducted on a total of 326 patients residing in the area of PHC Verka and registered with District Tuberculosis Centre, Amritsar. Weight change was assessed by taking the difference of weight at initial diagnosis and after completion of continuation phase therapy.Results: A total of 228 patients participated in the study. The mean (±SD) body weights (in kg) for the patients were 44.92±12.7 at diagnosis and 48.79±12.9 at the end of treatment. The mean (±SD) weight gain was 3.86±4.55 kgs at the end of treatment. The gain in weight at the end of treatment was associated with supervision of treatment and outcome of the TB patient.Conclusions: The findings showed that there is an association between gain in weight with supervision of treatment and outcome of the TB patient.

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