scholarly journals Future of Chondroprotectors in the Treatment of Degenerative Processes of Connective Tissue

2020 ◽  
Vol 13 (9) ◽  
pp. 220
Author(s):  
Stanislav Sukhikh ◽  
Olga Babich ◽  
Alexander Prosekov ◽  
Nikolai Patyukov ◽  
Svetlana Ivanova
Keyword(s):  
Hyaluronic Acid ◽  
Connective Tissue ◽  
Chondroitin Sulfate ◽  
Raw Materials ◽  
The Elderly ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Epidemiological Studies ◽  
Plant Raw Materials ◽  
Kellgren And Lawrence

Osteoarthritis is one of the most common diseases of the connective tissue of the elderly. It was found that most epidemiological studies used the Kellgren and Lawrence system for classification of osteoarthritis, which indicates one of the 5 degrees (0–4) of osteoarthritis in various joints according to the radiographic atlas. It has been proven that chondroprotectors are represented by the following active substances: chondroitin sulfate, glucosamine sulfate or hydrochloride, hyaluronic acid, glycosaminoglycans, extraction preparations from animal or plant raw materials. The sources of raw materials for the manufacture of combined chondroprotectors are known, methods for their preparation and use are described. The main drugs on the chondroprotective market are presented. The effectiveness of their use for the treatment of osteoarthritis has been proven. It was found that preparations containing chondroitin sulfate have anti-inflammatory activity, affecting mainly the cellular component of inflammation, stimulate the synthesis of hyaluronic acid and proteoglycans. Methods of treating osteoarthritis using cell therapy (the use of readily available, highly proliferative, and multipotent mesenchymal stromal cells) are presented.

scholarly journals USING OF THE WAVE TECHNOLOGIES IN INTENSIFICATION PROCESSES OF HEAT AND MASS TRANSFER

2017 ◽  
Vol 4 ◽  
pp. 18-24 ◽  
Author(s):  
Oleg Burdo ◽  
Valentyna Bandura ◽  
Aleksandr Zykov ◽  
Igor Zozulyak ◽  
Julia Levtrinskaya ◽  
...  
Keyword(s):  
Mass Transfer ◽  
Heat And Mass Transfer ◽  
Targeted Delivery ◽  
Raw Materials ◽  
Experimental Studies ◽  
Plant Raw Materials ◽  
Mass Transfer Processes ◽  
Innovative Products ◽  
Directed Energy

The advantages of wave technologies in comparison with traditional thermal technologies are considered. The aim of research is using of innovative wave technologies to intensify the processes of heat and mass transfer in the processes of dehydration and extraction, while reducing energy costs. A classification of the mechanisms of intensification of heat and mass transfer processes is proposed. Technical methods for intensifying heat and mass transfer during the processing of plant raw materials using technologies for targeted delivery of energy are developed. Samples of equipment are presented that implement technologies of directed energy action and innovative products obtained at these facilities. The results of experimental studies of drying in the microwave and infrared fields are shown.

Epilepsy

2020 ◽  
pp. 313-330
Author(s):  
Ettore Beghi ◽  
Giorgia Giussani ◽  
Torbjorn Tomson
Keyword(s):  
High Risk ◽  
Neurological Disease ◽  
Premature Mortality ◽  
The Elderly ◽  
Epidemiological Studies ◽  
Standardized Mortality Ratio ◽  
Worldwide Distribution ◽  
Prolonged Seizure ◽  
Mortality Ratio

Epilepsy is a chronic neurological disease affecting both sexes and all ages with worldwide distribution and peaks in children and the elderly. The pooled incidence of epilepsy is 61.4/100,000/year, with peaks in LMICs; the point prevalence is 6.4/1000 and the lifetime prevalence 7.6/1000. A documented aetiology is present in about one-half of cases. The overall prognosis is mostly favourable, with 55–68% of cases achieving prolonged seizure remission. Mortality ranges from 1 to 8 per 100,000/year, with a standardized mortality ratio of 1.3–6.0. Since 1990, a significant decrease of persisting disability and premature mortality has been observed, while age-standardized prevalence remained stable. Despite the decrease in the burden, epilepsy is still an important cause of disability and mortality. Future epidemiological studies will be affected by the new definition (now including people with a single seizure at high risk of recurrence) and the classification of seizures and epilepsy.

COMPARATIVE ANALYSIS OF BIOACTIVE SUBSTANCES CONTENT IN THE LEAVES AND FRUITS OF A ROWAN-TREE (SORBUS AUCUPARIA FRUCTUS) AND ASSESSMENT OF PROSPECTS IN MEDICINE AND PHARMACY

2020 ◽  
pp. 58-62
Author(s):  
Chernichkina A.D.
Keyword(s):  
Raw Materials ◽  
Wide Distribution ◽  
Biologically Active ◽  
Bioactive Substances ◽  
Plant Raw Materials ◽  
Mountain Ash ◽  
The Russian Federation ◽  
Materials Used ◽  
Active Substances ◽  
Pectin Substances

A large number of biologically active substances, organic acids, tannins, and pectin substances were detected during the study of fruits, leaves, and pulp of the fruits of mountain Ash. The content of these substances in leaves and pulp will significantly expand the arsenal of medicinal plant raw materials used. Given the wide distribution of mountain Ash in the territory of the Russian Federation, harvesting leaves from the same plants after harvesting the fruit and using pulp will make it possible to obtain new phytopreparations.

TECHNOLOGICAL ASPECTS OF HIGH QUALITY RAW MATERIAL OBTAINING FOR PECTIN PRODUCTION

1970 ◽  
pp. 47-50
Author(s):  
I. A. Ilina ◽  
I. A. Machneva ◽  
E. S. Bakun
Keyword(s):  
Raw Materials ◽  
Thermal Characteristics ◽  
Environmental Safety ◽  
Raw Material ◽  
High Quality ◽  
Temperature Conductivity ◽  
Drying Temperature ◽  
Plant Raw Materials ◽  
Gel Forming Ability

  The article is devoted to the study of the chemical composition, physical and thermal-pfysical characteristics of damp apple pomaces and the identifying patterns of influence of drying temperature the functional composition and gel-forming ability of pectin. The research is aimed at obtaining initial data for the subsequent calculation of the main technological, hydro-mechanical, thermal, structural and economic characteristics of devices for drying the plant raw materials, ensuring the environmental safety and high quality of pectin-containing raw materials, the reducing heat and energy costs. As a result of the study of the thermal characteristics of apple pomaces, the critical points (temperature conductivity – 16.5 x 10-8 m2/s, thermal conductivity – 0.28 W/m K, heat capacity – 1627 j/(kg K)) at a humidity of 56 % are determined, which characterizing the transition from the extraction of weakly bound moisture to the extraction of moisture with strong bonds (colloidal, adsorption). It was found that the pomaces obtained from apples of late ripening have a higher content of solids (21-23 %), soluble pectin and protopectin (2.5-4.5 %). Dried pomaces obtained from apple varieties of late ripening contain up to 25 % pectin, which allow us to recommend them as a source of raw materials for the production of pectin. The optimum modes of preliminary washing of raw materials are offered, allowing to the remove the ballast substances as much as possible. It is established that when the drying temperature increases, the destructive processes are catalyzed: the strength of the pectin jelly and the uronide component and the degree of pectin esterification are reduced. The optimum drying temperature of damp apple pomaces is 80 0C, at which the quality of pectin extracted from the dried raw materials is maintained as much as possible. It is shown that the most effective for the pectin production is a fraction with a particle size of 3-5 mm, which allow us to extract up to 71 % of pectin from raw materials.

Sustainable regional development as a problem of managing the socio-economic system

Ergodesign ◽  
2020 ◽  
Vol 2020 (2) ◽  
pp. 58-62
Author(s):  
Alexander Anishenko ◽  
Tatyana Krotenko ◽  
Dmitriy Erokhin
Keyword(s):  
Sustainable Development ◽  
Regional Development ◽  
Economic System ◽  
Raw Materials ◽  
Resource Model ◽  
Systematic Analysis ◽  
Development Control ◽  
Sustainable Regional Development ◽  
Three Factor

A systematic analysis of the concept of "sustainable development of the region" is carried out . The classification of factors that affect the process of sustainable development is given. A three -factor resource model for the formation of sustainable development of the region , including human, financial and raw materials, is described. The necessity of systematic monitoring as an element of regional development control is substantiated.

On the diagnostics of Adonis L. species (Ranunculaceae) of the Russian flora

2020 ◽  
pp. 3-14
Author(s):  
Aleksandr Luferov
Keyword(s):  
Raw Materials ◽  
Natural Populations ◽  
Structural Features ◽  
Biologically Active ◽  
Scientific Medicine ◽  
Diagnostic Features ◽  
Plant Raw Materials ◽  
Similar Chemical ◽  
Chemical Studies ◽  
Alternative Sources

The article provides brief information about cardiotonic, sedative, cytostatic, diuretic, and antibacterial effects of biologically active compounds of Adonis L. (Ranunculaceae) species. Chemical studies allowed to identify the cardiac glycosides, or cardenolides: or cardenolides: adontoxin, adonitol, adonitoxigenin, acetyldigitoxin and others. In scientific medicine, it is currently allowed to use Adonis vernalis L. Other types of Adonis have a similar chemical composition and are offered as substitutes for this official species, for example, Adonis apennina L. Many Adonis species have limited natural resources, and in some regions are rare, requiring conservation of their natural populations. The search for alternative sources of medicinal plant raw materials, based on this, is relevant. The experimental part of our research was carried out using the morphological and geographical method with the involvement of information on ecology and phenology. For the first time summarizes the diagnostic features of Adonis flora of Russian flora. Previously unknown structural features (shape and size of anthers) were identified that characterize the subgenera Adonanthe and Adonis. Taxonomic study of the genus Adonis of the Russian flora allowed us to determine its species composition, clarify its systematic affiliation, and nomenclature synonyms. 9 species were identified. Of these, 6 are perennials belonging to the subgenus Adonanthe, section Consiligo, which includes 2 subsections: Amurenses (2 species) and Vernales, which is differentiated into 2 rows: Apenninae (2 species) and Vernales (2 species). Subgenus Adonis is represented by 2 sections: Adonis (1 species) and Lophocarpa with sections Aestivales (1 species) and Dentatae (1 species). For all the considered species and varieties, the main distribution areas are given. A key has been compiled to determine the wild Adonis species distributed in Russia.

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