scholarly journals Aptamer-Functionalized Natural Protein-Based Polymers as Innovative Biomaterials

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1115
Author(s):  
Alessandra Girotti ◽  
Sara Escalera-Anzola ◽  
Irene Alonso-Sampedro ◽  
Juan González-Valdivieso ◽  
Francisco Javier Arias
Keyword(s):  
Mechanical Properties ◽  
Active Targeting ◽  
Hybrid Protein ◽  
Therapeutic Delivery ◽  
Natural Protein ◽  
Polymeric Biomaterials ◽  
Innovative Biomaterials ◽  
Functional Features ◽  
Cell Material Interactions ◽  
Spatiotemporal Control

Biomaterials science is one of the most rapidly evolving fields in biomedicine. However, although novel biomaterials have achieved well-defined goals, such as the production of devices with improved biocompatibility and mechanical properties, their development could be more ambitious. Indeed, the integration of active targeting strategies has been shown to allow spatiotemporal control of cell–material interactions, thus leading to more specific and better-performing devices. This manuscript reviews recent advances that have led to enhanced biomaterials resulting from the use of natural structural macromolecules. In this regard, several structural macromolecules have been adapted or modified using biohybrid approaches for use in both regenerative medicine and therapeutic delivery. The integration of structural and functional features and aptamer targeting, although still incipient, has already shown its ability and wide-reaching potential. In this review, we discuss aptamer-functionalized hybrid protein-based or polymeric biomaterials derived from structural macromolecules, with a focus on bioresponsive/bioactive systems.

Effect of the mechanical properties of carbon-based coatings on the mechanics of cell–material interactions

2021 ◽  
Vol 197 ◽  
pp. 111359 ◽  
Author(s):  
K. Trembecka-Wójciga ◽  
M. Kopernik ◽  
M. Surmiak ◽  
R. Major ◽  
M. Gawlikowski ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Cell Material ◽  
Cell Material Interactions ◽  
Carbon Based

scholarly journals Coating of ZnO Nanoparticle on Cotton Fabric to Create a Functional Textile with Enhanced Mechanical Properties

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2701
Author(s):  
Imana Shahrin Tania ◽  
Mohammad Ali
Keyword(s):  
Mechanical Properties ◽  
Cotton Fabric ◽  
Xrd Analysis ◽  
Woven Fabrics ◽  
Zno Nanoparticle ◽  
Functional Characteristics ◽  
Nano Zno ◽  
Fixation Techniques ◽  
Functional Features ◽  
Protection Property

The goal of this research is to develop a functional textile with better mechanical properties. Therefore, nano ZnO is synthesized, characterized, and applied to cotton fabric by mechanical thermo-fixation techniques. The synthesized nanoparticles are characterized by SEM and XRD analysis. The ZnO nanoparticle alone, ZnO nanoparticle with a binder, and ZnO with a binder and wax emulsion are then applied on cotton woven fabrics using three different recipes. The surface morphology of the treated fabric is studied using SEM and EDS. Antimicrobial activity, UV protection property, and crease resistance are all tested for their functional characteristics. In addition, all vital mechanical characteristics are assessed. The results suggest that using only nano ZnO or nano ZnO with a binder enhances functional features while deteriorating mechanical capabilities. Nano ZnO treatment with the third recipe, which includes the addition of an emulsion, on the other hand, significantly enhances mechanical and functional characteristics. Consequently, this study provides information to optimize the confidence of textile researchers and producers in using nano ZnO and understanding its features in key functional fabrics.

scholarly journals Mechanical properties of polymeric biomaterials: Modified ePTFE using gamma irradiation

2021 ◽  
Vol 19 (1) ◽  
pp. 1216-1224
Author(s):  
Nur Ain Mohd Radzali ◽  
Norsyahidah Mohd Hidzir ◽  
Irman Abdul Rahman ◽  
Abdul Khaliq Mokhtar
Keyword(s):  
Mechanical Properties ◽  
Gamma Irradiation ◽  
Permanent Deformation ◽  
Contact Angle Measurement ◽  
Mechanical Tests ◽  
Angle Measurement ◽  
Hydroxyethyl Methacrylate ◽  
Elongation At Break ◽  
Polymeric Biomaterials ◽  
Modification Process

Abstract Evaluating the mechanical properties of expanded polytetrafluoroethylene (ePTFE) is essential to measure its resistance to permanent deformation from an applied force. These mechanical ePTFE properties must be comparable to the properties of real tissue. Various hydrophilic comonomers 2-hydroxyethyl methacrylate (HEMA), N-isopropylacrylamide (NIPAAM), and N-vinylcaprolactam were used individually for copolymerization with acrylic acid (AA) to be grafted onto ePTFE using the gamma irradiation-induced grafting method. After surface modification, the hydrophobic and mechanical properties of ePTFE were altered. The water uptake and contact angle measurement showed that the modified ePTFE was less hydrophobic (∼500%, θ < 90°) than the unmodified ePTFE (0%, θ = 140°). Moreover, the mechanical properties of ePTFE changed after the modification process due to the polymer grafted onto the ePTFE surface. The data from mechanical tests, such as Young’s modulus (74–121 MPa), ultimate tensile strength (5–9 MPa), and elongation at break (56–121%), obtained for the sample AA-co-HEMA and AA-co-NIPAAM remain within the ranges and are considered desirable for use as a biomaterial. The mechanical strength correlates well with the percentage of the grafting yield after the modification process and is dependent on the parameters used, such as irradiation dose and type of comonomer.

scholarly journals Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein–peptide system

2015 ◽  
Vol 7 (11) ◽  
pp. 897-904 ◽  
Author(s):  
Karla E. Inostroza-Brito ◽  
Estelle Collin ◽  
Orit Siton-Mendelson ◽  
Katherine H. Smith ◽  
Amàlia Monge-Marcet ◽  
...  
Keyword(s):  
Hybrid Protein ◽  
Peptide System ◽  
Spatiotemporal Control

scholarly journals Micro-Architectural Investigation of Teleost Fish Rib Inducing Pliant Mechanical Property

Materials ◽  
2020 ◽  
Vol 13 (22) ◽  
pp. 5099
Author(s):  
Yu Yang Jiao ◽  
Masahiro Okada ◽  
Emilio Satoshi Hara ◽  
Shi Chao Xie ◽  
Noriyuki Nagaoka ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Tissue ◽  
Teleost Fish ◽  
Layer Structure ◽  
Bone Tissue Regeneration ◽  
Bone Collagen ◽  
Layer By Layer ◽  
First Rib ◽  
Tissue Manipulation ◽  
Functional Features

Despite the fact that various reports have been discussing bone tissue regeneration, precise bone tissue manipulation, such as controlling the physical properties of the regenerated bone tissue, still remains a big challenge. Here, we focused on the teleost fish ribs showing flexible and tough mechanical properties to obtain a deeper insight into the structural and functional features of bone tissue from different species, which would be valuable for the superior design of bone-mimicking materials. Herein, we examined their compositions, microstructure, histology, and mechanical properties. The first rib of Carassius langsdorfii showed a higher Young’s modulus with a small region of chondrocyte clusters compared with other smaller ribs. In addition, highly oriented collagen fibers and osteocytes were observed in the first rib, indicating that the longest first rib would be more mature. Moreover, the layer-by-layer structure of the oriented bone collagen was observed in each rib. These microarchitectural and compositional findings of fish rib bone would give one the useful idea to reproduce such a highly flexible rib bone-like material.

scholarly journals An aligned fibrous and thermosensitive hyaluronic acid-puramatrix interpenetrating polymer network hydrogel with mechanical properties adjusted for neural tissue

2022 ◽  
Author(s):  
Negar Abbasi Aval ◽  
Rahmatollah Emadi ◽  
Ali Valiani ◽  
Mahshid Kharaziha ◽  
Anna Finne-Wistrand
Keyword(s):  
Mechanical Properties ◽  
Hyaluronic Acid ◽  
Brain Tissue ◽  
Polymer Network ◽  
3D Structure ◽  
Interpenetrating Polymer Network ◽  
Great Promise ◽  
Sem Images ◽  
Rheological Measurements ◽  
Cell Material Interactions

AbstractCentral nervous system (CNS) injuries such as stroke or trauma can lead to long-lasting disability, and there is no currently accepted treatment to regenerate functional CNS tissue after injury. Hydrogels can mimic the neural extracellular matrix by providing a suitable 3D structure and mechanical properties and have shown great promise in CNS tissue regeneration. Here we present successful synthesis of a thermosensitive hyaluronic acid-RADA 16 (Puramatrix™) peptide interpenetrating network (IPN) that can be applied in situ by injection.Thermosensitive hyaluronic acid (HA) was first synthesized by combining HA with poly(N-isopropylacrylamide). Then, the Puramatrix™ self-assembled peptide was combined with the thermosensitive HA to produce a series of injectable thermoresponsive IPNs. The HA-Puramatrix™ IPNs formed hydrogels successfully at physiological temperature. Characterization by SEM, rheological measurements, enzymatic degradation and swelling tests was performed to select the IPN optimized for neurologic use. SEM images of the optimized dry IPNs demonstrated an aligned porous structure, and the rheological measurements showed that the hydrogels were elastic, with an elastic modulus of approximately 500 Pa, similar to that of brain tissue. An evaluation of the cell–material interactions also showed that the IPN had biological characteristics required for tissue engineering, strongly suggesting that the IPN hydrogel possessed properties beneficial for regeneration of brain tissue.

Phase Transformations in Ti-7w/oMo-3w/oMe Alloy

1974 ◽  
Vol 32 ◽  
pp. 514-515
Author(s):  
S. Fujishiro
Keyword(s):  
Electron Microscopy ◽  
Mechanical Properties ◽  
Transmission Electron Microscopy ◽  
Tensile Strength ◽  
Mechanical Processing ◽  
Ray Method ◽  
X Ray ◽  
Transmission Electron ◽  
Water Quench ◽  
Alpha Beta

The mechanical properties of three titanium alloys (Ti-7Mo-3Al, Ti-7Mo- 3Cu and Ti-7Mo-3Ta) were evaluated as function of: 1) Solutionizing in the beta field and aging, 2) Thermal Mechanical Processing in the beta field and aging, 3) Solutionizing in the alpha + beta field and aging. The samples were isothermally aged in the temperature range 300° to 700*C for 4 to 24 hours, followed by a water quench. Transmission electron microscopy and X-ray method were used to identify the phase formed. All three alloys solutionized at 1050°C (beta field) transformed to martensitic alpha (alpha prime) upon being water quenched. Despite this heavily strained alpha prime, which is characterized by microtwins the tensile strength of the as-quenched alloys is relatively low and the elongation is as high as 30%.

Effects of cooling rate on the mechanical properties of dual phase treated vanadium steels

1983 ◽  
Vol 41 ◽  
pp. 220-221
Author(s):  
L.J. Chen ◽  
H.C. Cheng ◽  
J.R. Gong ◽  
J.G. Yang
Keyword(s):  
Mechanical Properties ◽  
Cooling Rate ◽  
Automobile Industry ◽  
High Strength ◽  
Weight Percent ◽  
Low Alloy Steels ◽  
Dual Phase ◽  
Resource Requirement ◽  
Alloy Steels ◽  
Potential Weight

For fuel savings as well as energy and resource requirement, high strength low alloy steels (HSLA) are of particular interest to automobile industry because of the potential weight reduction which can be achieved by using thinner section of these steels to carry the same load and thus to improve the fuel mileage. Dual phase treatment has been utilized to obtain superior strength and ductility combinations compared to the HSLA of identical composition. Recently, cooling rate following heat treatment was found to be important to the tensile properties of the dual phase steels. In this paper, we report the results of the investigation of cooling rate on the microstructures and mechanical properties of several vanadium HSLA steels.The steels with composition (in weight percent) listed below were supplied by China Steel Corporation: 1. low V steel (0.11C, 0.65Si, 1.63Mn, 0.015P, 0.008S, 0.084Aℓ, 0.004V), 2. 0.059V steel (0.13C, 0.62S1, 1.59Mn, 0.012P, 0.008S, 0.065Aℓ, 0.059V), 3. 0.10V steel (0.11C, 0.58Si, 1.58Mn, 0.017P, 0.008S, 0.068Aℓ, 0.10V).

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