Contributions of Glycolipid Biosurfactants and Glycolipid-Modified Materials to Antimicrobial Strategy: A Review

Glycolipid biosurfactants are natural amphiphiles and have gained particular interest recently in their biodegradability, diversity, and bioactivity. Microbial infection has caused severe morbidity and mortality and threatened public health security worldwide. Glycolipids have played an important role in combating many diseases as therapeutic agents depending on the self-assembly property, the anticancer and anti-inflammatory properties, and the antimicrobial properties, including antibacterial, antifungal, and antiviral effects. Besides, their role has been highlighted as scavengers in impeding the biofilm formation and rupturing mature biofilm, indicating their utility as suitable anti-adhesive coating agents for medical insertional materials leading to a reduction in vast hospital infections. Notably, glycolipids have been widely applied to the synthesis of novel antimicrobial materials due to their excellent amphipathicity, such as nanoparticles and liposomes. Accordingly, this review will provide various antimicrobial applications of glycolipids as functional ingredients in medical therapy.

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Gold Nanoparticles Synthesis and Antimicrobial Effect on Fibrous Materials

Nanomaterials ◽

10.3390/nano11051067 ◽

2021 ◽

Vol 11 (5) ◽

pp. 1067

Author(s):

Behnaz Mehravani ◽

Ana Isabel Ribeiro ◽

Andrea Zille

Keyword(s):

Gold Nanoparticles ◽

Antimicrobial Properties ◽

Antimicrobial Effect ◽

Environmental Concerns ◽

Fibrous Materials ◽

Barrier Material ◽

Future Studies ◽

Textile Materials ◽

Promising Strategy ◽

Antimicrobial Materials

Depositing nanoparticles in textiles have been a promising strategy to achieve multifunctional materials. Particularly, antimicrobial properties are highly valuable due to the emergence of new pathogens and the spread of existing ones. Several methods have been used to functionalize textile materials with gold nanoparticles (AuNPs). Therefore, this review highlighted the most used methods for AuNPs preparation and the current studies on the topic in order to obtain AuNPs with suitable properties for antimicrobial applications and minimize the environmental concerns in their production. Reporting the detailed information on the functionalization of fabrics, yarns, and fibers with AuNPs by different methods to improve the antimicrobial properties was the central objective. The studies combining AuNPs and textile materials have opened valuable opportunities to develop antimicrobial materials for health and hygiene products, as infection control and barrier material, with improved properties. Future studies are needed to amplify the antimicrobial effect of AuNPs onto textiles and minimize the concerns related to the synthesis.

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A colon-targeted podophyllotoxin nanoprodrug: synthesis, characterization, and supramolecular hydrogel formation for the drug combination

Journal of Materials Chemistry B ◽

10.1039/d0tb02719g ◽

2021 ◽

Vol 9 (14) ◽

pp. 3200-3209

Author(s):

Wei Ha ◽

Xiao-Bo Zhao ◽

Wei-Hua Zhao ◽

Jiang-Jiang Tang ◽

Yan-Ping Shi

Keyword(s):

Self Assembly ◽

Drug Combination ◽

Therapeutic Agents ◽

Supramolecular Hydrogel ◽

Assembly Strategy ◽

Hydrogel Formation

An ingeniously designed podophyllotoxin nanoprodrug was synthesized and offered an effective platform for co-delivery of multiple therapeutic agents for drug combination via the hierarchical self-assembly strategy.

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Silver-Derived Antimicrobial Coatings for the Prevention of Microbial Biofilms in Metal Pipes

Water Air & Soil Pollution ◽

10.1007/s11270-021-05264-3 ◽

2021 ◽

Vol 232 (8) ◽

Author(s):

M. Vela-Cano ◽

C. Garcia-Fontana ◽

F. Osorio ◽

A. González-Martinez ◽

J. González-López

Keyword(s):

Biofilm Formation ◽

Antimicrobial Properties ◽

Pilot Scale ◽

Biological Factors ◽

Antimicrobial Coatings ◽

Microbial Biofilms ◽

Physical Chemical ◽

Silver Zeolite ◽

Metal Pipes ◽

Pipeline Corrosion

AbstractBiodeterioration is one of the most important processes in metal pipeline corrosion, and it can be due to physical, chemical, and biological factors. Coatings rich in silver have been used to inhibit this undesirable phenomenon. In this study, the antimicrobial properties of several silver-containing products used as a coating in pipelines were determined on a pilot scale in order to evaluate the ability of silver to inhibit biofilm formation. The results showed that the coating with silver zeolite at a concentration of 2000 mg L–1 inhibited the formation of a microbial biofilm and prevented the biodeterioration process. Therefore, from our study, it can be concluded that silver zeolite shows greater protection capacity than other silver preparations and presents advantages in relation to other silver coatings that are currently available

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Emerging Scientists Supplementary Issue II: Nature inspired Antimicrobial Nanotextured Surfaces

Molecular Frontiers Journal ◽

10.1142/s2529732520970032 ◽

2020 ◽

Vol 04 (Supp01) ◽

pp. 1-6

Author(s):

Tan Yee Lin

Keyword(s):

Public Health ◽

Antimicrobial Resistance ◽

Antimicrobial Properties ◽

Physical Contact ◽

Health Security ◽

Naturally Occurring ◽

Promising Strategy ◽

Contact Killing ◽

Supplementary Issue

The development of cross infections arising from bacteria transmission on frequently touched facilities has led to an urgent need to promptly disinfect these surfaces, such as hand railings, door handles and elevator buttons. Conventional antimicrobial disinfectants are not ideal as they contribute to the growing antimicrobial resistance crisis. In recent years, the discovery that the wings of insects such as the Clanger cicada (Psaltoda claripennis) possess naturally occurring antimicrobial properties has led to a growing interest to synthetically recreate these surfaces. The use of a physical contact killing mechanism on such nanotextured surfaces is a promising strategy for curbing the proliferation of bacteria, as it is unlikely to contribute to the formation of antimicrobial resistance. Here, I highlight the key advantages of using these antimicrobial nanotextured materials and how they could play a role in safeguarding public health security, especially during the current COVID-19 pandemic.

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Salivary polypeptide/hyaluronic acid multilayer coatings act as “fungal repellents” and prevent biofilm formation on biomaterials

Journal of Materials Chemistry B ◽

10.1039/c7tb02592k ◽

2018 ◽

Vol 6 (10) ◽

pp. 1452-1457 ◽

Cited By ~ 5

Author(s):

Jianchuan Wen ◽

Chih-Ko Yeh ◽

Yuyu Sun

Keyword(s):

Hyaluronic Acid ◽

Self Assembly ◽

Biofilm Formation ◽

Design Principle ◽

Multilayer Coatings ◽

Layer By Layer ◽

Denture Stomatitis ◽

Polyelectrolyte Layer ◽

Assembly Technology ◽

Systemic Health

Candida-associated denture stomatitis (CADS) is a common, recurring clinical complication in denture wearers that can lead to serious oral and systemic health problems. Polyelectrolyte layer-by-layer (LBL) self-assembly technology on denture materials offers a new design principle for controlling fungal biofilm formation.

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The Ascidian-Derived Metabolites with Antimicrobial Properties

Antibiotics ◽

10.3390/antibiotics9080510 ◽

2020 ◽

Vol 9 (8) ◽

pp. 510 ◽

Cited By ~ 3

Author(s):

Marcello Casertano ◽

Marialuisa Menna ◽

Concetta Imperatore

Keyword(s):

Direct Evidence ◽

Marine Invertebrates ◽

Antimicrobial Properties ◽

Therapeutic Agents ◽

Symbiotic Association ◽

Heterogeneous Habitat ◽

Microbial Infections ◽

Sulfur Containing ◽

Shed Light ◽

Antibacterial Potential

Among the sub-phylum of Tunicate, ascidians represent the most abundant class of marine invertebrates, with 3000 species by heterogeneous habitat, that is, from shallow water to deep sea, already reported. The chemistry of these sessile filter-feeding organisms is an attractive reservoir of varied and peculiar bioactive compounds. Most secondary metabolites isolated from ascidians stand out for their potential as putative therapeutic agents in the treatment of several illnesses like microbial infections. In this review, we present and discuss the antibacterial activity shown by the main groups of ascidian-derived products, such as sulfur-containing compounds, meroterpenes, alkaloids, peptides, furanones, and their derivatives. Moreover, the direct evidence of a symbiotic association between marine ascidians and microorganisms shed light on the real producers of many extremely potent marine natural compounds. Hence, we also report the antibacterial potential, joined to antifungal and antiviral activity, of metabolites isolated from ascidian-associate microorganisms by culture-dependent methods.

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Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies

Molecules ◽

10.3390/molecules24122316 ◽

2019 ◽

Vol 24 (12) ◽

pp. 2316 ◽

Cited By ~ 8

Author(s):

Qiuchen Zheng ◽

Micheal T. Kebede ◽

Merc M. Kemeh ◽

Saadman Islam ◽

Bethany Lee ◽

...

Keyword(s):

Self Assembly ◽

Complex Disease ◽

Red Wine ◽

Amyloid Β ◽

Amyloid Plaques ◽

Therapeutic Agents ◽

Mechanistic Studies ◽

Naturally Occurring ◽

Aβ Oligomerization ◽

Β Sheet

The amyloid-β (Aβ) peptide and tau protein are thought to play key neuropathogenic roles in Alzheimer’s disease (AD). Both Aβ and tau self-assemble to form the two major pathological hallmarks of AD: amyloid plaques and neurofibrillary tangles, respectively. In this review, we show that naturally occurring polyphenols abundant in fruits, vegetables, red wine, and tea possess the ability to target pathways associated with the formation of assemblies of Aβ and tau. Polyphenols modulate the enzymatic processing of the amyloid-β precursor protein and inhibit toxic Aβ oligomerization by enhancing the clearance of Aβ42 monomer, modulating monomer–monomer interactions and remodeling oligomers to non-toxic forms. Additionally, polyphenols modulate tau hyperphosphorylation and inhibit tau β-sheet formation. The anti-Aβ-self-assembly and anti-tau-self-assembly effects of polyphenols increase their potential as preventive or therapeutic agents against AD, a complex disease that involves many pathological mechanisms.

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Effect of Coriander Oil (Coriandrum sativum) on Planktonic and Biofilm Cells of Acinetobacter baumannii

Natural Product Communications ◽

10.1177/1934578x1300800532 ◽

2013 ◽

Vol 8 (5) ◽

pp. 1934578X1300800 ◽

Cited By ~ 8

Author(s):

Andreia F. Duarte ◽

Susana Ferreira ◽

Rosário Oliveira ◽

Fernanda C. Domingues

Keyword(s):

Essential Oil ◽

Acinetobacter Baumannii ◽

Biofilm Formation ◽

Antimicrobial Properties ◽

Hospital Acquired Infections ◽

Microtiter Plates ◽

Crystal Violet Assay ◽

Hospital Acquired ◽

Microdilution Broth ◽

Susceptibility Assay

The increasing incidence of hospital-acquired infections caused by multi-drug resistant pathogens, such as Acinetobacter baumannii, coupled with the low efficacy of drugs and rising treatment costs has created interest in the potential antimicrobial properties of natural products. The main objective of this work was to determine the effect of coriander essential oil on Acinetobacter baumannii in different growth phases, as well as its ability to inhibit the formation or eradication of biofilms. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of coriander oil using a microdilution broth susceptibility assay was determined. The effects of different concentrations of coriander oil (ranging from 0.125 to 4×MIC) on biofilm formation and on established biofilm were tested using 96-well microtiter plates. Crystal violet assay was used as indicator of total biofilm biomass and the biofilm viability was assessed with a XTT staining method. It was found that coriander oil presented significant antibacterial activity against all tested strains of A. baumannii, with MIC values between 1 and 4 μL/mL. The MBC values were the same as the MIC, being an indicator of the bactericidal activity of this essential oil. In what concerns the effect of this essential oil on biofilm formation inhibition was observed of at least 85% of biomass formation by all A. baumannii strains using 2×MIC of coriander oil, in addition to a decrease in the metabolic activity of the cells. After exposure to coriander oil, a decrease in 24 h and 48 h-old biofilm biomass and metabolism was seen for all tested concentrations, even with sub-inhibitory concentrations. Coriander essential oil proved to have a significant antibacterial and anti-biofilm activity and should be considered in the development of future disinfectants to control A. baumannii dissemination.

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Potassium sorbate release from poly(vinyl alcohol)-bacterial cellulose films

Chemical Papers ◽

10.2478/s11696-011-0068-4 ◽

2012 ◽

Vol 66 (2) ◽

Cited By ~ 11

Author(s):

Iuliana Jipa ◽

Anicuta Stoica ◽

Marta Stroescu ◽

Loredana-Mihaela Dobre ◽

Tanase Dobre ◽

...

Keyword(s):

Bacterial Cellulose ◽

Antimicrobial Properties ◽

Potassium Sorbate ◽

Poly Vinyl Alcohol ◽

Packaging Materials ◽

Cellulose Powder ◽

Cellulose Films ◽

Antimicrobial Materials ◽

Biocomposite Films ◽

The Subject

AbstractActive packaging materials are the subject of research because their performance exceeds that of traditional packaging. From this class, antimicrobial materials extend the shelf-life of products and reduce the risk of contamination by pathogens. In this paper, new composite materials with antimicrobial properties are obtained by using polyvinyl alcohol and bacterial cellulose powder. Potassium (2E,4E)-hexa-2,4-dienoate was used as the antimicrobial agent. The films thus obtained were characterised using Fourier-transform infrared spectroscopy and scanning electron microscopy. Mass transfer phenomena concerning the release of potassium (2E,4E)-hexa-2,4-dienoate were investigated. The results indicated that the new biocomposite films could be used as antimicrobial packaging materials.

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